A new study provides information to empower consumers and policymakers about the degree of processing of foods available at three large grocery retailers. The researchers analyzed ingredient lists, nutrition facts, and prices to create a database with over 50,000 food items, featuring a processing score and nutrition facts.
A new study found that inhibiting TBK1 increases CAR-T cell activity and makes cancer cells more susceptible to immune cell targeting. The researchers used patient-derived organotypic tumor spheroids (PDOTS) models to investigate the mechanisms of treatment resistance in solid tumors.
Researchers developed a novel approach using lipid nanoparticles to deliver mRNA and siRNA, restoring tumor suppressors and inhibiting tumor drivers in prostate cancer cells. This technique holds promise for treating various types of cancer by targeting specific pathways related to tumor growth and suppression.
Researchers analyzed data from over 700 patients with kidney injury and found that glucarpidase treatment improved kidney recovery rates. Glucarpidase rapidly clears methotrexate from the blood, reducing the risk of kidney toxicity.
The study identified a modified imaging approach and volumetric measurements as more accurate in predicting survival compared to other methods. These approaches worked well even for small tumors, suggesting they should be included in future studies.
A new study by Mass General Brigham researchers reveals that a novel immunotherapy can eliminate precancerous spots and prevent skin cancer through the activation of specific immune cells. The therapy successfully cleared over 95% of facial lesions and showed long-term efficacy, with benefits lasting up to five years after treatment.
A study by Mass General Brigham researchers found that only 8.4% of Medicare Advantage plans offered a comprehensive dental benefit, leaving many beneficiaries without access to necessary care. The research suggests that regulations could prevent low-quality dental plans from being offered, ensuring consumers know what they're getting.
A new study found that large language models can provide useful physical exam recommendations and instructions based on patient symptoms. The researchers used GPT-4 to recommend physical exam instructions and evaluated its performance by three attending physicians, scoring at least 80% of the possible points.
A Mass General Brigham study found that taxi and ambulance drivers had lower rates of death from Alzheimer's disease compared to other professions, possibly due to real-time spatial and navigational processing. The study analyzed data from nearly 9 million people across various occupations.
Researchers have made significant breakthroughs in treating liver cancer, with a new study revealing the potential of anti-CXCR4 therapy to reprogram the 'cold' microenvironment. The combination of anti-CXCR4 and PD1 blockades enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma.
A new study suggests that individual patients have a unique 'setpoint' around which blood counts fluctuate, allowing for earlier diagnosis of diseases. This personalized approach could enable more precise treatment plans and improved health outcomes.
Empagliflozin was associated with a 22% lower risk of diabetic retinopathy progression in patients with early-stage non-proliferative DR. The study found that empagliflozin may be beneficial in slowing down progression to more advanced stages of DR in type 2 diabetes patients.
Researchers discovered a potential mechanism behind statin therapy's heart-related benefits in people with HIV. Statin treatment increases the levels of an enzyme called procollagen C-endopeptidases enhancer 1, which helps stabilize vulnerable plaques and prevent their rupture.
A team of researchers from Mass General Brigham has identified changes in immune cells that can predict patient recovery after cardiac arrest. The study suggests that a particular population of cells may provide protection against brain injury and a drug that can activate these cells, improving neurological outcomes in preclinical stud...
Mass General Brigham researchers presented research discoveries and outcomes from clinical trials on immune thrombocytopenia, early phase therapies, myeloproliferative syndromes, advances in treatment of lymphomas and leukemias. A novel prognostic score for relapsed/refractory mature T-cell and NK-cell lymphomas was also developed.
Researchers at Mass General Brigham developed an AI tool called EVOLVEpro that can engineer proteins to be more stable, precise, and efficient. The tool has shown promise in improving medications used for treating autoimmune diseases, genetic diseases, and cancer.
A new study by Mass General Brigham researchers found that excessive sedentary behavior increases the risk of heart failure and cardiovascular death. Even among individuals who meet guideline levels of moderate-to-vigorous physical activity, sitting for extended periods can still pose significant health risks. The study's findings sugg...
A phase 3 clinical trial has demonstrated that inebilizumab significantly reduced the risk of symptoms in patients with immunoglobulin G4-related disease (IgG4-RD) by 87%. The treatment, which depletes CD19-expressing B cells, shows promise for improving patient outcomes and reducing the need for immunosuppressive treatment.
The institute's Spark Grant program recognizes innovative research in gene and cell therapy, with recipients working on projects spanning disease fields such as neuroinflammation, cancer, and tuberous sclerosis. The $1.15M grant will support the development of novel treatments and commercialization outcomes.
The Healthcare AI Challenge enables healthcare professionals to evaluate and compare AI solutions for their effectiveness in various clinical situations. By crowdsourcing input from experts, the challenge aims to create continuous and reliable expert evaluations of AI technologies in medicine.
Researchers found that vaccinating earlier in pregnancy, closer to 32 weeks, could provide better protection against RSV for newborns. Maternal vaccination resulted in significantly higher and longer-lasting maternal and cord RSV antibody levels.
Researchers at Mass General Brigham developed an AI algorithm to identify long COVID cases in patients' health records, revealing a higher prevalence rate than previously thought. The tool uses 'precision phenotyping' to sift through individual records and track symptoms over time, reducing bias in diagnosis.
A higher Brain Care Score (BCS) significantly reduces the risk of stroke, late-life depression, and dementia in individuals with a higher genetic predisposition to these conditions. The study's findings suggest that adopting healthy lifestyle choices can protect brain health regardless of genetic risk.
Researchers developed an AI model that can identify and measure aggressive prostate cancer lesions with high accuracy. The model's estimates of tumor size were associated with the likelihood of cancer recurrence or metastasis.
The toolkit provides a base plan for collecting, processing, and reporting laboratory test results from VHF suspects, as well as guidance on infection prevention and control. It aims to bolster local preparedness efforts by offering scalable resources for healthcare facilities to develop practical action plans for isolation and initial...
Mass General Brigham has been awarded $3.29 million by ARPA-H to develop a wearable device that monitors the brain's glymphatic system during sleep, which may lead to early detection of neurodegenerative diseases like Alzheimer's in women. The project aims to create a tool for personalized interventions and make it widely accessible.
Researchers have successfully used adenine base editors to correct disease-causing mutations in stem cells from patients with X-CGD, a rare genetic disorder. The approach has shown high efficiency and minimal off-target effects, paving the way for a first-in-human clinical trial.
A clinical trial of 32 patients with cerebral adrenoleukodystrophy found that six years after treatment, most remained free of major disabilities. However, the study also highlighted safety concerns about blood cancers post-treatment, including myelodysplastic syndrome and acute myeloid leukemia.
Researchers at Mass General Brigham discovered that combining two therapeutic agents can selectively kill tumor cells in triple negative breast cancer, differentiating them and triggering a process similar to involution. The study provides support for clinical trials testing this new approach.
A new study of nearly 2,000 former NFL players shows that about one-third believe they have chronic traumatic encephalopathy (CTE), a condition linked to repeated head trauma. Players who believed they had CTE reported more cognitive problems and higher rates of treatable conditions such as depression and low testosterone.
A clinical trial found that an oral cancer drug reduced nosebleed severity and improved quality of life in patients with hereditary hemorrhagic telangiectasia (HHT). The PATH-HHT study showed significant improvements in disease manifestations, including severe nosebleeds and chronic gastrointestinal bleeding.
A meta-analysis by Mass General Brigham researchers found that Black women face higher mortality rates from breast cancer across all tumor subtypes, attributed to socioeconomic inequality, delayed diagnosis, and inadequate access to timely quality treatment. This disparity is not limited to hormone-positive tumors, with differences als...
A new study from Mass General Brigham researchers found that large language models demonstrated no racial or gender discrimination in opioid treatment recommendations. The results suggest that these AI models have the potential to reduce bias and improve health equity in pain management, which is a critical area where disparities exist.
A new study by Mass General Brigham has found that obesity may be an important risk factor for infection from the virus that causes COVID-19. Individuals with obesity were 34% more likely to become COVID positive after reported exposure than those without obesity, indicating a possible link between obesity and increased transmission risk.
Researchers discovered that aficamten, a cardiac myosin inhibitor, significantly improved exercise capacity and cardiac structure and function measures in patients with HOCM. The study found marked improvements in peak oxygen uptake, workload achieved, breathing efficiency, and submaximum exercise capacity.
Researchers have identified a specific immune cell type and signaling pathway that leads to itching in people with allergies. By targeting this pathway, they hope to develop novel therapeutics for preventing allergic responses and sensitization.
A Mass General Brigham-led study found that a large language model improves the accuracy of immune-related adverse event detection, identifying additional cases not picked up by manual adjudication. The model demonstrated excellent specificity and sensitivity, opening up opportunities for collaboration among institutions.
A recent study published in the New England Journal of Medicine found that brain scans can detect consciousness in some unresponsive patients with severe brain injury. The study, co-led by Mass General Brigham, discovered that 25% of participants with severe brain injury who appeared unresponsive responded to instructions covertly.
A Mass General Brigham study highlights inconsistencies in generative AI that can affect patient safety if not addressed. The researchers found 'drift' (model performance changes over time) and 'nondeterminism' (inconsistent results between runs) in their tests, emphasizing the need for repeated testing and monitoring.
A Phase 1 study evaluates an individualized neoantigen therapy, showing it is well-tolerated and boosts immune activity against cancer-causing cells. The therapy induces multiple forms of T cell proliferation and sustained responses in patients with melanoma and lung cancer.
A study published in Psychiatry Research found significant associations between sleep difficulties and suicidal ideation among adolescents with a history of depression. The research also highlighted the amplifying effect of illicit drug and/or alcohol abuse/dependence on these associations.
A study published in JAMA Oncology found that regular aspirin use significantly lowers the risk of colorectal cancer in individuals with higher lifestyle-related risk factors. The benefits were most pronounced among those with unhealthiest lifestyles, where treating 78 patients with aspirin would prevent one case of colorectal cancer o...
A higher brain care score is associated with a lower risk of late-life depression, dementia, and stroke. The tracker tool evaluates 12 modifiable factors, including physical, lifestyle, and social elements.
Researchers identified two risk factors that indicate higher risk of aggressive prostate cancer, including high PSA levels and positive biopsy samples. Patients with these indicators are at increased risk of adverse pathology, early recurrence, and death.
A new study found that 5% of outpatient patients experience adverse drug events (ADEs), with 22% being preventable. The most frequent drug classes resulting in ADEs were cardiovascular, central nervous system, and anti-infective agents.
A study published in JMIR Medical Informatics found that machine learning can accurately classify patients into differing levels of opioid use disorder (OUD) risk, demonstrating substantial agreement with clinicians' reviews. The research suggests that this technology can enhance personalized and safer care for patients early in opioid...
The study identified 72 genes commonly expressed in chronically activated CD8+ T cells across seven types of cancer. One gene, CXCR6, supports the survival of these cells by promoting CD28 signaling. This finding may inform targets for broadly active cancer therapies and treatments.
Researchers found that carrying just one copy of the Christchurch variant delayed cognitive decline and dementia in family members, with some showing lower levels of tau proteins. The study suggests potential benefits for drug development targeting this genetic pathway.
A recent study by Mass General Brigham researchers found that adults with a family history of Alzheimer's disease on their mother's side had higher amyloid levels in their brains. This suggests that maternal inheritance may play a role in identifying individuals at heightened risk for developing the disease.
Researchers developed a rapid genotyping test for patients with central nervous system lesions, detecting key mutations associated with brain cancers in samples taken during a lumbar puncture. The test eliminated the need for surgical brain biopsies in seven cases and significantly accelerated time to treatment, from an average of 12 d...