A new radiology screening tool can help detect intimate partner violence (IPV) in patients, enabling healthcare providers to identify victims earlier. The study found that imaging studies and injury patterns differ between women who have reported IPV and those who have not.
A nasal spray being tested for Alzheimer's disease could also reduce neuroinflammation in traumatic brain injury, according to a Mass General Brigham-led study. The treatment modulates the immune response, reducing anxiety, cognitive decline, and improving motor skills in mouse models of TBI.
Researchers developed a polygenic risk score that examines genes associated with endothelial cell function to identify individuals with higher cardiovascular disease risk. The study found that individuals with intact endothelial function may have protection, while those with EC dysfunction may be more sensitive to LDL-C concentrations.
A multi-ancestry genome-wide study has identified 16 novel Alzheimer's disease-associated genetic signals, expanding the understanding of the disease in underrepresented groups. The study aims to improve predictions of Alzheimer's disease risk and guide new treatment targets for diverse populations.
Researchers found that patients receiving telemedicine care had lower rates of low-value tests, such as cervical cancer screening and imaging for uncomplicated low back pain. However, virtual options may reduce barriers to care but also deter clinicians and patients from completing some low-value tests.
A new study reveals that most well-known national suicide prevention organizations do not have easily accessible resources targeting older adults, who are at the highest risk of suicide. The findings highlight the urgent need for targeted campaigns and tailored prevention programs that address the unique healthcare needs of older adults.
Researchers at Mass General Brigham used a generative AI tool to screen patients for a heart failure clinical trial, significantly improving speed and efficiency compared to manual screening. The study found that the AI-assisted screening process screened 458 eligible patients compared to 284 in the manual group.
The PARADIGM program aims to create a scalable, multi-purpose Care Delivery Platform to deliver advanced services in rural areas. The project will integrate various medical devices and technologies to provide hospital-level care without the need for fixed locations.
Researchers found that long-term yogurt intake was associated with lower rates of proximal colon cancer positive for Bifidobacterium, a bacterial species found in yogurt. The study showed that higher yogurt consumption over time may protect against colorectal cancer through changes in the gut microbiome.
Researchers re-analyzed data for 111 products and found significant associations between production process, ingredient composition, and benzene levels. The study suggests opportunities to improve formulation, production, and distribution of benzoyl peroxide containing products to reduce the likelihood of them degrading into benzene.
A study projects the impact of PEPFAR funding cuts on South Africa, finding that eliminating funding would lead to significant increases in HIV infections and related deaths. The analysis highlights the devastating consequences of abrupt funding cuts, including a $1.7 billion increase in healthcare expenditure.
A team of researchers at Mass General Brigham has discovered that granzyme K activates the complement system against own tissues, driving inflammation and tissue damage. Inhibiting this pathway could preserve anti-microbial functions while targeting chronic inflammatory diseases.
The Kraft Center for Community Health at Mass General Brigham is awarding the Kraft Prize to recognize transformative organizations or innovations making a measurable impact on community health. The $100,000 prize includes travel accommodations and support from Mass General Brigham's Innovation MESH Network.
A large genetic dataset and multi-omics approach identified 58 novel drug targets for both heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). The study highlights the importance of developing targeted therapies for both subtypes, which have limited therapeutic options.
A new study has developed a polygenic risk score for COPD that improves identification of individuals with the disease in the community. The test uses genetic samples from a cheek swab or blood test, and when combined with a case-finding questionnaire, it identifies undiagnosed cases more accurately.
A new TB risk scoring tool has been developed to assess patients for potential TB infections, enabling accurate decisions on isolation precautions. The tool has been validated and is now in use at all MGB sites, positively impacting patient care and clinician workflows.
Scientists from Mass General Brigham create bioprinted tissues that can be remotely stimulated by light to generate electrical activity, enabling non-invasive control of heart tissue. This breakthrough has the potential to promote long-term tissue regeneration and integration into the heart's biology.
Researchers have developed a novel stem cell treatment strategy for leptomeningeal brain metastasis, a severe form of metastatic brain cancer. The new therapy, which combines allogeneic dual stem cells with oncolytic herpes simplex virus and single chain variable fragment of anti-PD-1, shows promise in preclinical models.
A new method can detect tiny amounts of SARS-CoV-2 virus in blood, stool, and saliva from patients with acute COVID-19 infections. The technology has potential for guiding treatment of long COVID and monitoring viral loads for future infectious diseases.
The study found that a new class of anticoagulants, Factor XI inhibitors, significantly reduced bleeding events compared to standard-of-care treatment. The researchers report that abelacimab, a Factor XI inhibitor, reduced bleeding by 62% in patients with atrial fibrillation.
A global study of individuals with HIV found that current risk models underestimated cardiovascular events, particularly for women and black men in high-income countries. The researchers developed correction factors to fine-tune these models, highlighting the need for nuanced, region-specific predictions.
A new study identifies the molecular mechanisms underlying increased osteoarthritis risk in postmenopausal females, revealing that menopause-induced changes in sex hormone levels contribute to joint degeneration. Restoring these hormones may protect against cartilage degeneration, paving the way for novel treatments.
A new study from Mass General Brigham found that approximately 1-in-5 patients experience acne recurrence after isotretinoin treatment. The researchers identified factors that increase the risk of recurrence, including female gender and lower cumulative dosages.
A new study published in Neurology found that eating greater quantities of red meat, especially in processed forms, increases the risk of dementia. Replacing processed red meat with protein sources like nuts and legumes or fish may decrease dementia risk by approximately 20 percent.
A study from Mass General Brigham and Washington University School of Medicine found that Xenon gas inhalation reduced brain atrophy, neuroinflammation, and improved nest-building behaviors in mouse models of Alzheimer's disease. The treatment also induced a protective microglial response associated with clearing amyloid and improving ...
Researchers found that despite higher supplemental benefits, Medicare Advantage beneficiaries use fewer services and pay similar out-of-pocket costs. Out-of-pocket expenses for supplemental benefits were modestly lower for Medicare Advantage enrollees, with some services costing up to 9% less.
A new study provides information to empower consumers and policymakers about the degree of processing of foods available at three large grocery retailers. The researchers analyzed ingredient lists, nutrition facts, and prices to create a database with over 50,000 food items, featuring a processing score and nutrition facts.
A new study found that inhibiting TBK1 increases CAR-T cell activity and makes cancer cells more susceptible to immune cell targeting. The researchers used patient-derived organotypic tumor spheroids (PDOTS) models to investigate the mechanisms of treatment resistance in solid tumors.
Researchers developed a novel approach using lipid nanoparticles to deliver mRNA and siRNA, restoring tumor suppressors and inhibiting tumor drivers in prostate cancer cells. This technique holds promise for treating various types of cancer by targeting specific pathways related to tumor growth and suppression.
Researchers analyzed data from over 700 patients with kidney injury and found that glucarpidase treatment improved kidney recovery rates. Glucarpidase rapidly clears methotrexate from the blood, reducing the risk of kidney toxicity.
The study identified a modified imaging approach and volumetric measurements as more accurate in predicting survival compared to other methods. These approaches worked well even for small tumors, suggesting they should be included in future studies.
A new study by Mass General Brigham researchers reveals that a novel immunotherapy can eliminate precancerous spots and prevent skin cancer through the activation of specific immune cells. The therapy successfully cleared over 95% of facial lesions and showed long-term efficacy, with benefits lasting up to five years after treatment.
A study by Mass General Brigham researchers found that only 8.4% of Medicare Advantage plans offered a comprehensive dental benefit, leaving many beneficiaries without access to necessary care. The research suggests that regulations could prevent low-quality dental plans from being offered, ensuring consumers know what they're getting.
A new study found that large language models can provide useful physical exam recommendations and instructions based on patient symptoms. The researchers used GPT-4 to recommend physical exam instructions and evaluated its performance by three attending physicians, scoring at least 80% of the possible points.
A Mass General Brigham study found that taxi and ambulance drivers had lower rates of death from Alzheimer's disease compared to other professions, possibly due to real-time spatial and navigational processing. The study analyzed data from nearly 9 million people across various occupations.
Researchers have made significant breakthroughs in treating liver cancer, with a new study revealing the potential of anti-CXCR4 therapy to reprogram the 'cold' microenvironment. The combination of anti-CXCR4 and PD1 blockades enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma.
A new study suggests that individual patients have a unique 'setpoint' around which blood counts fluctuate, allowing for earlier diagnosis of diseases. This personalized approach could enable more precise treatment plans and improved health outcomes.
Empagliflozin was associated with a 22% lower risk of diabetic retinopathy progression in patients with early-stage non-proliferative DR. The study found that empagliflozin may be beneficial in slowing down progression to more advanced stages of DR in type 2 diabetes patients.
Researchers discovered a potential mechanism behind statin therapy's heart-related benefits in people with HIV. Statin treatment increases the levels of an enzyme called procollagen C-endopeptidases enhancer 1, which helps stabilize vulnerable plaques and prevent their rupture.
A team of researchers from Mass General Brigham has identified changes in immune cells that can predict patient recovery after cardiac arrest. The study suggests that a particular population of cells may provide protection against brain injury and a drug that can activate these cells, improving neurological outcomes in preclinical stud...
Mass General Brigham researchers presented research discoveries and outcomes from clinical trials on immune thrombocytopenia, early phase therapies, myeloproliferative syndromes, advances in treatment of lymphomas and leukemias. A novel prognostic score for relapsed/refractory mature T-cell and NK-cell lymphomas was also developed.
Researchers at Mass General Brigham developed an AI tool called EVOLVEpro that can engineer proteins to be more stable, precise, and efficient. The tool has shown promise in improving medications used for treating autoimmune diseases, genetic diseases, and cancer.
A new study by Mass General Brigham researchers found that excessive sedentary behavior increases the risk of heart failure and cardiovascular death. Even among individuals who meet guideline levels of moderate-to-vigorous physical activity, sitting for extended periods can still pose significant health risks. The study's findings sugg...
A phase 3 clinical trial has demonstrated that inebilizumab significantly reduced the risk of symptoms in patients with immunoglobulin G4-related disease (IgG4-RD) by 87%. The treatment, which depletes CD19-expressing B cells, shows promise for improving patient outcomes and reducing the need for immunosuppressive treatment.
The institute's Spark Grant program recognizes innovative research in gene and cell therapy, with recipients working on projects spanning disease fields such as neuroinflammation, cancer, and tuberous sclerosis. The $1.15M grant will support the development of novel treatments and commercialization outcomes.
The Healthcare AI Challenge enables healthcare professionals to evaluate and compare AI solutions for their effectiveness in various clinical situations. By crowdsourcing input from experts, the challenge aims to create continuous and reliable expert evaluations of AI technologies in medicine.
Researchers found that vaccinating earlier in pregnancy, closer to 32 weeks, could provide better protection against RSV for newborns. Maternal vaccination resulted in significantly higher and longer-lasting maternal and cord RSV antibody levels.
Researchers at Mass General Brigham developed an AI algorithm to identify long COVID cases in patients' health records, revealing a higher prevalence rate than previously thought. The tool uses 'precision phenotyping' to sift through individual records and track symptoms over time, reducing bias in diagnosis.
A higher Brain Care Score (BCS) significantly reduces the risk of stroke, late-life depression, and dementia in individuals with a higher genetic predisposition to these conditions. The study's findings suggest that adopting healthy lifestyle choices can protect brain health regardless of genetic risk.
Researchers developed an AI model that can identify and measure aggressive prostate cancer lesions with high accuracy. The model's estimates of tumor size were associated with the likelihood of cancer recurrence or metastasis.