The toolkit provides a base plan for collecting, processing, and reporting laboratory test results from VHF suspects, as well as guidance on infection prevention and control. It aims to bolster local preparedness efforts by offering scalable resources for healthcare facilities to develop practical action plans for isolation and initial...
Mass General Brigham has been awarded $3.29 million by ARPA-H to develop a wearable device that monitors the brain's glymphatic system during sleep, which may lead to early detection of neurodegenerative diseases like Alzheimer's in women. The project aims to create a tool for personalized interventions and make it widely accessible.
Researchers have successfully used adenine base editors to correct disease-causing mutations in stem cells from patients with X-CGD, a rare genetic disorder. The approach has shown high efficiency and minimal off-target effects, paving the way for a first-in-human clinical trial.
A clinical trial of 32 patients with cerebral adrenoleukodystrophy found that six years after treatment, most remained free of major disabilities. However, the study also highlighted safety concerns about blood cancers post-treatment, including myelodysplastic syndrome and acute myeloid leukemia.
Researchers at Mass General Brigham discovered that combining two therapeutic agents can selectively kill tumor cells in triple negative breast cancer, differentiating them and triggering a process similar to involution. The study provides support for clinical trials testing this new approach.
A new study of nearly 2,000 former NFL players shows that about one-third believe they have chronic traumatic encephalopathy (CTE), a condition linked to repeated head trauma. Players who believed they had CTE reported more cognitive problems and higher rates of treatable conditions such as depression and low testosterone.
A clinical trial found that an oral cancer drug reduced nosebleed severity and improved quality of life in patients with hereditary hemorrhagic telangiectasia (HHT). The PATH-HHT study showed significant improvements in disease manifestations, including severe nosebleeds and chronic gastrointestinal bleeding.
A meta-analysis by Mass General Brigham researchers found that Black women face higher mortality rates from breast cancer across all tumor subtypes, attributed to socioeconomic inequality, delayed diagnosis, and inadequate access to timely quality treatment. This disparity is not limited to hormone-positive tumors, with differences als...
A new study from Mass General Brigham researchers found that large language models demonstrated no racial or gender discrimination in opioid treatment recommendations. The results suggest that these AI models have the potential to reduce bias and improve health equity in pain management, which is a critical area where disparities exist.
A new study by Mass General Brigham has found that obesity may be an important risk factor for infection from the virus that causes COVID-19. Individuals with obesity were 34% more likely to become COVID positive after reported exposure than those without obesity, indicating a possible link between obesity and increased transmission risk.
Researchers discovered that aficamten, a cardiac myosin inhibitor, significantly improved exercise capacity and cardiac structure and function measures in patients with HOCM. The study found marked improvements in peak oxygen uptake, workload achieved, breathing efficiency, and submaximum exercise capacity.
Researchers have identified a specific immune cell type and signaling pathway that leads to itching in people with allergies. By targeting this pathway, they hope to develop novel therapeutics for preventing allergic responses and sensitization.
A Mass General Brigham-led study found that a large language model improves the accuracy of immune-related adverse event detection, identifying additional cases not picked up by manual adjudication. The model demonstrated excellent specificity and sensitivity, opening up opportunities for collaboration among institutions.
A recent study published in the New England Journal of Medicine found that brain scans can detect consciousness in some unresponsive patients with severe brain injury. The study, co-led by Mass General Brigham, discovered that 25% of participants with severe brain injury who appeared unresponsive responded to instructions covertly.
A Mass General Brigham study highlights inconsistencies in generative AI that can affect patient safety if not addressed. The researchers found 'drift' (model performance changes over time) and 'nondeterminism' (inconsistent results between runs) in their tests, emphasizing the need for repeated testing and monitoring.
A Phase 1 study evaluates an individualized neoantigen therapy, showing it is well-tolerated and boosts immune activity against cancer-causing cells. The therapy induces multiple forms of T cell proliferation and sustained responses in patients with melanoma and lung cancer.
A study published in Psychiatry Research found significant associations between sleep difficulties and suicidal ideation among adolescents with a history of depression. The research also highlighted the amplifying effect of illicit drug and/or alcohol abuse/dependence on these associations.
A study published in JAMA Oncology found that regular aspirin use significantly lowers the risk of colorectal cancer in individuals with higher lifestyle-related risk factors. The benefits were most pronounced among those with unhealthiest lifestyles, where treating 78 patients with aspirin would prevent one case of colorectal cancer o...
A higher brain care score is associated with a lower risk of late-life depression, dementia, and stroke. The tracker tool evaluates 12 modifiable factors, including physical, lifestyle, and social elements.
Researchers identified two risk factors that indicate higher risk of aggressive prostate cancer, including high PSA levels and positive biopsy samples. Patients with these indicators are at increased risk of adverse pathology, early recurrence, and death.
A new study found that 5% of outpatient patients experience adverse drug events (ADEs), with 22% being preventable. The most frequent drug classes resulting in ADEs were cardiovascular, central nervous system, and anti-infective agents.
A study published in JMIR Medical Informatics found that machine learning can accurately classify patients into differing levels of opioid use disorder (OUD) risk, demonstrating substantial agreement with clinicians' reviews. The research suggests that this technology can enhance personalized and safer care for patients early in opioid...
The study identified 72 genes commonly expressed in chronically activated CD8+ T cells across seven types of cancer. One gene, CXCR6, supports the survival of these cells by promoting CD28 signaling. This finding may inform targets for broadly active cancer therapies and treatments.
Researchers found that carrying just one copy of the Christchurch variant delayed cognitive decline and dementia in family members, with some showing lower levels of tau proteins. The study suggests potential benefits for drug development targeting this genetic pathway.
A recent study by Mass General Brigham researchers found that adults with a family history of Alzheimer's disease on their mother's side had higher amyloid levels in their brains. This suggests that maternal inheritance may play a role in identifying individuals at heightened risk for developing the disease.
Researchers developed a rapid genotyping test for patients with central nervous system lesions, detecting key mutations associated with brain cancers in samples taken during a lumbar puncture. The test eliminated the need for surgical brain biopsies in seven cases and significantly accelerated time to treatment, from an average of 12 d...
Researchers at Mass General Brigham developed a generative AI process that screens patients for clinical trial eligibility with high accuracy and reduced cost. The process, called RECTIFIER, was compared to traditional screening methods and found to be more accurate and cost-effective, with an estimated cost of $0.11 per patient.
A study published in Frontiers of Public Health found that educational interventions, including telesimulation-based team training and customized tools, can significantly reduce child mortality rates in pediatric intensive care units (PICUs) in low- and middle-income countries. The interventions led to a sustained decline in mortality ...
Researchers from Mass General Brigham created an algorithm to generate personalized DBS treatment plans based on four major PD symptoms. The algorithm improved patients' symptoms in four of five cases, demonstrating its potential to improve treatment beyond standard-of-care approaches.
Researchers from Mass General Cancer Center are set to present key findings on palliative care delivery via telehealth versus in-person for patients with advanced lung cancer. The presentations also cover advances in colorectal and breast cancer treatments, as well as results from a phase 1b/2 study on a novel BRAF inhibitor.
A new study published in JAMA Network Open found that virtual scribes can significantly reduce the time physicians spend on electronic health records. The study analyzed data from 144 physicians across specialties who used real-time or asynchronous virtual scribe services for at least three months, resulting in reduced time spent on no...
A recent study uses AI to analyze body composition in patients with lung cancer treated with immunotherapy, finding that changes in muscle mass and fat quality are important indicators of outcomes. The research provides a more nuanced understanding of the relationship between body composition and response to immunotherapy.
Researchers found that 82 percent of patients had one year free from atrial fibrillation after an ablation procedure with procedural complications under 2 percent. The study used real-world clinical data from the REAL-AF registry, which showed improved outcomes compared to previous clinical trials.
Researchers analyzed data from 1,392 TBI patients and found that some who died after withdrawing life support may have survived and recovered independence. The study suggests delaying decisions on withdrawal might be beneficial for certain patients, as assumptions about poor outcomes can lead to a self-fulfilling prophecy.
Researchers from top institutions argue that 'subconcussion' is a misleading term that should be replaced with more specific alternatives to better understand the risks of brain injuries. The authors recommend using 'nonconcussive' to describe head impacts without a concussion, highlighting the importance of accurate nomenclature for e...
Researchers developed Tripath to analyze 3D tissue samples, predicting clinical outcomes based on 3D morphological features. This approach outperformed traditional methods, providing promising potential for guiding critical treatment decisions.
A research team at Mass General Brigham developed a foundation model that identified patterns predicting anatomical site, malignancy, and prognosis from radiological images. The approach remained powerful even with limited data, outperforming existing methods in specialized tasks.
A study published in The Annals of Internal Medicine found that 7% of patients experienced at least one adverse event and 1.9% experienced a preventable adverse event in outpatient settings, emphasizing the need for evidence-based interventions to improve patient safety.
A new study suggests that proteins detectable in the blood could improve predictions about risk of liver cancer, potentially leading to earlier therapeutic interventions. The researchers used proteomics to develop a prediction model and identified 56 plasma proteins associated with liver cancer.
Researchers at Mass General Brigham have identified Th2-multipotent progenitor (Th2-MPP) cells, which may play a crucial role in sustaining type 2 inflammation and contribute to disease symptoms. These findings provide potential targets for therapeutic interventions and lay the groundwork for future disease-modifying approaches.
A study by Mass General Brigham demonstrates that large language models can help reduce physician workload and improve patient education, but also identifies limitations that may affect patient safety. The researchers emphasize the need for vigilant oversight and a measured approach to LLM implementation.
A new study by Mass General Brigham researchers found that larger 'foundation models' can help mitigate disparities between different demographic groups and enhance model accuracy. The findings emphasize the need for more diverse training datasets and demographic-stratified evaluations of AI systems.
A new study found that ChatGPT can consistently recommend deprescribing medications in patients without a history of cardiovascular disease. However, the AI model was more cautious when considering patients with cardiovascular disease and varied its responses depending on the chat session.
A new case study suggests that hypoglossal nerve stimulation can improve sleep quality and cognitive development in children with Down syndrome. The procedure has shown promising results in reducing obstructive apnea-hypopnea index and improving neurocognition, offering a potential treatment option for young patients.
Researchers at Mass General Cancer Center presented advancements in rapid nucleic acid detection for cervical cancer screening using CRISPR technology. They also showcased improvements to CAR T cell therapy for pancreatic cancer, highlighting the importance of dynamic functional control to enhance its efficacy.
A new study found that nighttime gunshots are twice as common as daytime gunshots in American cities, potentially disrupting the sleep of nearby residents due to loud sirens. Low-income neighborhoods are disproportionately affected by these sounds, with millions of person nights potentially impacted annually.
Researchers at Mass General Brigham have developed two AI foundation models, UNI and CONCH, to advance computational pathology. These models excel in diagnostic accuracy, prognostic insights, and predicting therapeutic responses, with universal applications in anatomic pathology.
Researchers at Mass General Cancer Center have achieved dramatic tumor regression in glioblastoma patients after receiving next generation CAR-T therapy. The treatment, known as INCIPIENT, combines two forms of therapy to target mixed cell populations within tumors.
A new review paper from Brigham and Women's Hospital concludes that menopause does not uniformly elevate the risk of depression and other mental health conditions. Certain groups, such as those with a history of depression or severe sleep disturbances, are more likely to experience depressive symptoms during menopause.
A Mass General Brigham study found that emergency department visits and deaths rose by 1.22% and 1.4%, respectively, one week after major climate-driven weather events, with elevated mortality rates persisting for six weeks.