Researchers at Mass General Brigham developed a generative AI process that screens patients for clinical trial eligibility with high accuracy and reduced cost. The process, called RECTIFIER, was compared to traditional screening methods and found to be more accurate and cost-effective, with an estimated cost of $0.11 per patient.
A study published in Frontiers of Public Health found that educational interventions, including telesimulation-based team training and customized tools, can significantly reduce child mortality rates in pediatric intensive care units (PICUs) in low- and middle-income countries. The interventions led to a sustained decline in mortality ...
Researchers from Mass General Brigham created an algorithm to generate personalized DBS treatment plans based on four major PD symptoms. The algorithm improved patients' symptoms in four of five cases, demonstrating its potential to improve treatment beyond standard-of-care approaches.
Researchers from Mass General Cancer Center are set to present key findings on palliative care delivery via telehealth versus in-person for patients with advanced lung cancer. The presentations also cover advances in colorectal and breast cancer treatments, as well as results from a phase 1b/2 study on a novel BRAF inhibitor.
A new study published in JAMA Network Open found that virtual scribes can significantly reduce the time physicians spend on electronic health records. The study analyzed data from 144 physicians across specialties who used real-time or asynchronous virtual scribe services for at least three months, resulting in reduced time spent on no...
A recent study uses AI to analyze body composition in patients with lung cancer treated with immunotherapy, finding that changes in muscle mass and fat quality are important indicators of outcomes. The research provides a more nuanced understanding of the relationship between body composition and response to immunotherapy.
Researchers found that 82 percent of patients had one year free from atrial fibrillation after an ablation procedure with procedural complications under 2 percent. The study used real-world clinical data from the REAL-AF registry, which showed improved outcomes compared to previous clinical trials.
Researchers analyzed data from 1,392 TBI patients and found that some who died after withdrawing life support may have survived and recovered independence. The study suggests delaying decisions on withdrawal might be beneficial for certain patients, as assumptions about poor outcomes can lead to a self-fulfilling prophecy.
Researchers from top institutions argue that 'subconcussion' is a misleading term that should be replaced with more specific alternatives to better understand the risks of brain injuries. The authors recommend using 'nonconcussive' to describe head impacts without a concussion, highlighting the importance of accurate nomenclature for e...
Researchers developed Tripath to analyze 3D tissue samples, predicting clinical outcomes based on 3D morphological features. This approach outperformed traditional methods, providing promising potential for guiding critical treatment decisions.
A research team at Mass General Brigham developed a foundation model that identified patterns predicting anatomical site, malignancy, and prognosis from radiological images. The approach remained powerful even with limited data, outperforming existing methods in specialized tasks.
A study published in The Annals of Internal Medicine found that 7% of patients experienced at least one adverse event and 1.9% experienced a preventable adverse event in outpatient settings, emphasizing the need for evidence-based interventions to improve patient safety.
A new study suggests that proteins detectable in the blood could improve predictions about risk of liver cancer, potentially leading to earlier therapeutic interventions. The researchers used proteomics to develop a prediction model and identified 56 plasma proteins associated with liver cancer.
Researchers at Mass General Brigham have identified Th2-multipotent progenitor (Th2-MPP) cells, which may play a crucial role in sustaining type 2 inflammation and contribute to disease symptoms. These findings provide potential targets for therapeutic interventions and lay the groundwork for future disease-modifying approaches.
A study by Mass General Brigham demonstrates that large language models can help reduce physician workload and improve patient education, but also identifies limitations that may affect patient safety. The researchers emphasize the need for vigilant oversight and a measured approach to LLM implementation.
A new study by Mass General Brigham researchers found that larger 'foundation models' can help mitigate disparities between different demographic groups and enhance model accuracy. The findings emphasize the need for more diverse training datasets and demographic-stratified evaluations of AI systems.
A new study found that ChatGPT can consistently recommend deprescribing medications in patients without a history of cardiovascular disease. However, the AI model was more cautious when considering patients with cardiovascular disease and varied its responses depending on the chat session.
A new case study suggests that hypoglossal nerve stimulation can improve sleep quality and cognitive development in children with Down syndrome. The procedure has shown promising results in reducing obstructive apnea-hypopnea index and improving neurocognition, offering a potential treatment option for young patients.
Researchers at Mass General Cancer Center presented advancements in rapid nucleic acid detection for cervical cancer screening using CRISPR technology. They also showcased improvements to CAR T cell therapy for pancreatic cancer, highlighting the importance of dynamic functional control to enhance its efficacy.
A new study found that nighttime gunshots are twice as common as daytime gunshots in American cities, potentially disrupting the sleep of nearby residents due to loud sirens. Low-income neighborhoods are disproportionately affected by these sounds, with millions of person nights potentially impacted annually.
Researchers at Mass General Brigham have developed two AI foundation models, UNI and CONCH, to advance computational pathology. These models excel in diagnostic accuracy, prognostic insights, and predicting therapeutic responses, with universal applications in anatomic pathology.
Researchers at Mass General Cancer Center have achieved dramatic tumor regression in glioblastoma patients after receiving next generation CAR-T therapy. The treatment, known as INCIPIENT, combines two forms of therapy to target mixed cell populations within tumors.
A new review paper from Brigham and Women's Hospital concludes that menopause does not uniformly elevate the risk of depression and other mental health conditions. Certain groups, such as those with a history of depression or severe sleep disturbances, are more likely to experience depressive symptoms during menopause.
A Mass General Brigham study found that emergency department visits and deaths rose by 1.22% and 1.4%, respectively, one week after major climate-driven weather events, with elevated mortality rates persisting for six weeks.
Researchers identified six blood biomarkers associated with increased cardiovascular risk in patients with rheumatoid arthritis. These biomarkers improved the ability to predict arterial inflammation, an indicator of cardiovascular risk, compared to standard clinical indices.
A consortium of 50 renowned researchers from 34 prestigious universities identifies five primary medical challenges that can be addressed with advanced biomedical engineering approaches, aiming to improve human health. The paper outlines a roadmap for groundbreaking research and funding to achieve technological and medical breakthroughs.
A team of pediatric clinicians developed 45 multilingual videos to educate providers on pediatric care topics, using generative AI and synthetic voice avatars. The videos were recorded in English and translated into Spanish, emphasizing Latin American variations.
A new study from Mass General Brigham used deep brain stimulation to identify specific brain circuits associated with different disorders, such as Parkinson's disease and obsessive compulsive disorder. The researchers were able to apply these findings to fine-tune DBS treatments and demonstrate preliminary improved results in three cases.
A new machine learning model predicts how ingested drugs interact with transport proteins in the body, identifying previously unknown interactions and potential dangers.
A recent study found that a commercial machine learning tool was moderately successful in predicting hospitalization-related kidney injury, but struggled to identify high-risk patients. The tool performed better for low-risk patients and Stage 1 HA-AKI cases.
Researchers found that SGLT2 inhibitors reduced kidney stone rates by 30% compared to GLP1 agonists and 25% compared to DPP4 inhibitors. The study included data from 716,406 adults with type 2 diabetes who took these medications.
Researchers found that patients with severe immunosuppression, such as those with hematologic malignancies or organ transplants, were most likely to have chronic, prolonged infections. In contrast, patients with mild immunosuppression had similar viral shedding dynamics to non-immunocompromised participants.
A meta-analysis of 5,000 participants found that daily multivitamins showed benefits for memory and global cognition. The study suggests that taking a daily multivitamin can help prevent memory loss and slow down cognitive aging by the equivalent of two years compared to placebo.
Researchers developed AI models that can extract information on social determinants of health from clinicians' notes, identifying 93.8% of patients with adverse social factors. The models were less prone to bias than generalist models, offering a potential solution to address health disparities.
A national study by Mass General Brigham researchers found that patients treated at home had a 0.5% mortality rate, compared to those in traditional hospitals. Home hospital care also resulted in fewer readmissions and adverse events, with consistent outcomes across diverse demographic groups.
A new study from Mass General Brigham researchers found that women who experienced more preconception stress had higher blood sugar levels during pregnancy, a predictor of current and long-term cardiovascular health. The study also discovered that socioeconomic status was associated with preconception stress and blood glucose levels.
A new study found that exercise-induced Pgc-1α expression inhibits fat accumulation in aged skeletal muscles. The researchers identified Pgc-1α as a key player in FAP regulation and suggested that its upregulation leads to increased mitochondrial fatty acid oxidation, inhibiting FAP fat accumulation.
Researchers at Mass General Brigham have developed a new class of proteasome inhibitors that specifically target the β2 active site in cancer cells. The newly synthesized compounds effectively inhibit multiple myeloma cell growth and show promise for reducing therapeutic resistance and side effects when combined with existing drugs.
A new study published in the American Journal of Clinical Nutrition suggests that taking cocoa extract supplements containing 500 mg of flavanols daily may improve cognitive function in older adults with lower habitual diet quality. In contrast, participants with healthy dietary patterns showed no cognitive benefits.
Researchers from the Mass General Cancer Center presented studies on psychiatric and substance use disorders as independent predictors of treatment response and outcomes in United States Veterans with Newly Diagnosed Acute Myeloid Leukemia (AML) treated with Venetoclax Combinations. Additionally, a Phase 1 Study of CAR-T-ddBCMA for the...
A new study suggests that a fourth dose of the mRNA vaccine significantly reduces risk of infection and severe COVID-19 in patients with autoimmune rheumatic diseases. The study found a 41% reduction in risk for infection and 65% reduction for admission/death compared to those who did not receive a fourth dose.
A team of researchers developed a gel delivery system that overcomes challenges in intratumoral therapy. The gel contains an imaging agent and can hold a high concentration of drug for slow release. In preclinical models, the treatment induced tumor regression and improved survival in immunotherapy-resistant colon and breast cancer.
Researchers from Mass General Brigham found that patients experiencing virologic rebound after treatment may remain contagious. The study suggests that individuals shed live virus when experiencing a rebound, implying the potential for transmission after initially recovering from the virus.
Mutations in the PIK3CA gene lead to elevated production of the PI3Ka protein, found in approximately 40% of hormone receptor-positive breast cancers. Next-generation PI3Kalpha inhibitors targeting a different region of the mutant protein show promise in overcoming resistance.
A team of researchers has developed a new visualization tool combining high-speed cameras and fluorescent injection to distinguish tumor tissue from normal tissue across cancer types. The technique, known as fluorescence lifetime (FLT) imaging, achieved an accuracy of over 97% in distinguishing tumor tissue from healthy tissue.
Researchers developed a low-cost, ultrasensitive blood test to detect a highly specific biomarker for multiple common cancers. The test showed promise for early cancer detection and disease monitoring, detecting levels of the biomarker in the blood of patients with many types of cancers.
A team of researchers from Mass General Brigham has developed a monoclonal antibody that reduces abnormal tau proteins associated with Alzheimer's disease in a preclinical model. The therapy, inspired by a genetic variant that provides resistance against the disease, offers an alternative approach to existing treatments.
A randomized controlled trial found that cognitive behavioral therapy (CBT) significantly reduces fibromyalgia pain by decreasing pain-catastrophizing, a negative response that amplifies pain. CBT participants showed reduced connectivity between brain regions associated with self-awareness and emotional processing.
Researchers from Mass General Brigham find that traumatic brain injury increases risk of cardiovascular and cognitive dysfunction. Non-neurological conditions associated with TBI, such as hypertension and changes in the brain-gut connection, contribute to elevated cardiovascular risk.
A new study suggests that collecting and sharing positive feedback among healthcare workers can increase mutual appreciation and improve the work culture. Researchers analyzed peer-to-peer positive feedback and found that it is a feasible way to foster teamwork, collegiality, and civility.