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Feds fund study of drug that may prevent radiation injury

A new study funded by the Defense Department aims to develop a drug based on carbon nanotubes to prevent acute radiation injury deaths. The experimental drug, Nanovector Trojan Horses (NTH), has shown promising results in preliminary tests, with mice showing enhanced protection when given first-generation NTH drugs prior to exposure.

New property found in ancient mineral lodestone

Researchers at Rice University have discovered a surprising new electronic property in magnetite, a well-studied magnetic mineral, by using nanofabrication methods. They were able to get the material to revert from an insulator to a conductor at temperatures colder than minus 250 degrees Fahrenheit.

SourceRice University·JournalNature Materials·DateDec 17, 2007

Study: Re-engineered Gleevec reduces heart risks

Researchers re-engineered imatinib to specifically target gastrointestinal stromal tumor and reduce cardiotoxic side effects. The new drug, WBZ-4, was found to be equally effective against gastrointestinal cancer while significantly reducing the risk of heart failure in animal tests.

SourceRice University·JournalJournal of Clinical Investigation·DateDec 3, 2007

Changing environment organizes genetic structure

A study by Deem and Jun Sun found that genetic information becomes increasingly modular when exposed to a changing environment and horizontal gene transfer. This modularity arises spontaneously due to selective pressure, resulting in complex biological structures.

SourceRice University·JournalPhysical Review Letters·DateNov 13, 2007

Proteins pack tighter in crowded native state

A new study from Rice University and the University of Houston found that proteins pack more tightly in their natural environment, with increased structural content and stability. The research suggests that protein structure is affected by crowding, even when proteins are in their folded state.

SourceRice University·JournalProceedings of the National Academy of Sciences·DateNov 12, 2007

Could 'hairy roots' become biofactories?

Rice scientists have successfully grown hairy roots for 4-and-a-half years, a breakthrough that could lead to mass production of medicines like vincristine and vinblastine. The transgenic roots contain genes from both the host plant and bacteria, offering a stable alternative to traditional cell cultures.

SourceRice University·JournalBiotechnology Progress·DateOct 30, 2007

BCM, Rice scientists map flu's chemical key

Researchers at Baylor College of Medicine and Rice University have developed a molecular map of the influenza B virus's hemagglutinin protein. The study reveals similarities between the protein's sequence and function in flu A and B strains, suggesting that minor mutations could enable bird flu to spread among humans.

SourceRice University·JournalProceedings of the National Academy of Sciences·DateOct 15, 2007

Research at Rice may help explain aspects of synesthesia

A Rice University research team has found that damage to the ventrolateral nucleus (VL) of the thalamus can lead to cross-wiring in the brain, resulting in synesthesia. The study, led by Tony Ro, used neuroimaging and behavioral studies on a patient with a rare stroke to demonstrate the VL's role in sensory processing.

SourceRice University·JournalAnnals of Neurology·DateSep 25, 2007

Taxol bristle ball: a wrench in the works for cancer

Researchers at Rice University have discovered a way to load dozens of molecules of the anti-cancer drug paclitaxel onto tiny gold spheres, creating a uniform delivery system that targets cancer cells more effectively. The new approach aims to reduce side effects and improve the effectiveness of chemotherapy.

SourceRice University·JournalJournal of the American Chemical Society·DateSep 12, 2007

New cancer weapon: nuclear nanocapsules

Researchers at Rice University have developed a way to package radioactive particles inside DNA-sized carbon tubes to target tiny tumors. The alpha-emitting nanocapsules are designed to deliver a single, direct hit to cancer cells, making them potentially more effective than traditional beta-particle radiation.

SourceRice University·JournalSmall·DateAug 23, 2007

Which came first, the moth or the cactus?

A rare mutualistic relationship between a moth and cactus in the Sonoran Desert shows that one species can control the population of the other, challenging traditional ecological theory. The research has implications for understanding community ecology and the stability of mutualistic communities.

Zebrafish: It's not your parents' lab rat

A team of researchers at Rice University studied the gene LMO4 in zebrafish, discovering its role in regulating brain growth and development. They found that overexpression of the gene led to shrinkage of brain areas, while underexpression caused their enlargement.

SourceRice University·JournalDevelopmental Biology·DateJul 30, 2007

Nanotube flickering reveals single-molecule rendezvous

Researchers used nanotechnology to study exciton mobility on carbon nanotubes, revealing that each excition travels about 90 nanometers and visits some 10,000 carbon atoms during its lifespan. The unique properties of carbon nanotubes made them an ideal system for observing single-molecule reactions.

SourceRice University·JournalScience·DateJun 7, 2007

Quasicrystals: Somewhere between order and disorder

Quasicrystals, crystal-like materials with atomic structures in between order and disorder, are shown to not conduct electricity like traditional crystals. Mathematician David Damanik offers a key proof for this, revealing that electrons behave uniquely within quasicrystals.

SourceRice University·JournalJournal of the American Mathematical Society·DateMay 23, 2007

Quantum dot recipe may lead to cheaper solar panels

Rice University scientists have developed a breakthrough method for producing molecular specks of semiconductors called quantum dots, which could lead to better and cheaper solar energy panels. The new chemical method produces four-legged cadmium selenide quantum dots with over 90% tetrapod structure.

SourceRice University·JournalSmall·DateMay 2, 2007

'Wrapping' Gleevec fights drug-resistant cancer

A new study finds that the re-engineered Gleevec variant WBZ-7 is effective against both drug-resistant and nonresistant gastrointestinal cancer cells. The wrapping prototype seals out water molecules from a critical area, preventing resistance to the drug, and demonstrates promising results in laboratory studies.

SourceRice University·JournalCancer Research·DateMay 1, 2007

BCM, Rice make major advance in structural biology

Scientists from BCM and Rice University discover a new way to analyze protein movement, making it easier to classify and scrutinize active sites implicated in cancer and other diseases. The breakthrough uses a mathematical algorithm in conjunction with X-ray crystallography to narrow down possible ways a protein might flex and bend.

SourceRice University·JournalProceedings of the National Academy of Sciences·DateApr 30, 2007

Simulated populations used to probe gene mapping

A new study published in PLoS Genetics used computer simulations to trace genetic changes over thousands of generations in a simulated population, testing the effectiveness of statistical genetic methods in identifying multiple genes causing complex diseases. The researchers found that known methods are limited and identified which met...

SourceRice University·JournalPLOS Genetics·DateMar 23, 2007

Nanotube, heal thyself

Researchers discovered that carbon nanotubes can repair themselves by moving blemishes across the surface of the material, sewing up larger holes as they go. This self-repair mechanism allows the nanotube to retain its strength despite severe damage, but comes with a price: releasing energy and mass in the form of gaseous carbon atoms.

SourceRice University·JournalPhysical Review Letters·DateFeb 15, 2007

Does evolution select for faster evolvers?

New research by Rice University scientists reveals that horizontal gene transfer (HGT) contributes to the speed of evolution, allowing life forms to adapt faster. The study proposes a mathematical model that accounts for HGT and its impact on the dynamics of evolution.

SourceRice University·JournalPhysical Review Letters·DateJan 29, 2007

Buckyballs used as 'passkey' into cancer cells

Researchers at Rice University have developed a novel way to deliver drugs directly into cancer cells using buckyball nanoparticles as passkeys. The technique, which mimics viral proteins, shows promise in penetrating the defenses of liver and neuroblastoma cancer cells, two types often difficult to treat.

SourceRice University·JournalOrganic & Biomolecular Chemistry·DateJan 18, 2007

Tracing the pathways of neurofibromatosis

A recent study by researchers at Rice University has identified a key role for the protein Ras in promoting nerve cell growth and tumorigenesis in individuals with neurofibromatosis. The study found that defects in the Nf1 gene disrupt the normal regulatory mechanism, leading to an overactive signaling pathway.

Rice's Drezek wins $3M grant for breast cancer research

Drezek's research focuses on developing high-resolution in situ imaging of the molecular hallmarks of breast cancer, enabling doctors to detect biomarkers without tissue removal. The grant will be used to develop microendoscope and needle-compatible fiber optic systems for various diagnostic and therapeutic applications.

Protein's tail may be flu virus's achilles heel

Researchers at Rice University and UT Austin have identified a promising antiviral drug target in the long, flexible tail of the nucleoprotein protein. Minor changes to this region prevent the protein from fulfilling its role in structural columns that transmit viral copies.

SourceRice University·JournalNature·DateDec 6, 2006

Pure carbon nanotubes pass first in vivo test

Researchers at Rice University and The University of Texas M. D. Anderson Cancer Center found that carbon nanotubes injected into lab animals cause no immediate harm and circulate in the blood and liver for over an hour before being eliminated. The study provides promising results for biomedical applications of carbon nanotubes.

SourceRice University·JournalProceedings of the National Academy of Sciences·DateNov 27, 2006

Bio-inspired assembly of nanoparticle building blocks

Researchers at Rice University have discovered a novel method for assembling gold and silver nanoparticle building blocks into larger structures, inspired by the self-assembly of lipid membranes that surround every living cell. The new technique allows for the creation of ultra-potent cancer drugs and efficient catalysts.

SourceRice University·JournalJournal of the American Chemical Society·DateNov 27, 2006

Rice chemists create, grow nanotube seeds

Rice University chemists have successfully created and grown carbon nanotube seeds, which can be used to produce large quantities of pure nanotubes. The breakthrough offers significant potential for various materials applications, including energy storage and electronics.

SourceRice University·JournalJournal of the American Chemical Society·DateNov 17, 2006

ICON issues survey of nanotechnology practices

A comprehensive survey of nanotechnology workplace safety practices found that many companies and laboratories are using conventional EHS practices despite the potential for nanoparticles to pose specific environmental and health risks. The survey, conducted by Rice University's International Council on Nanotechnology, collected data f...

'Nanorust' cleans arsenic from drinking water

Researchers at Rice University's Center for Biological and Environmental Nanotechnology have developed a revolutionary, low-cost technology to clean arsenic from drinking water. The nanorust technique reduces arsenic levels in contaminated water to below EPA thresholds, offering a sustainable solution for millions of people worldwide.

SourceRice University·JournalScience·DateNov 9, 2006

Why exercising muscles tire when needed most

During intense exercise, muscles rely on anaerobic metabolism for force production, leading to muscle fatigue and impaired performance. The study found that the mechanisms of muscular fatigue are similar to those discovered in laboratory research on cell and tissue samples.