Researchers at Scripps Research and Mayo Clinic have identified a new class of senolytic drugs that can slow the aging process. These compounds, dasatinib and quercetin, selectively induce death in senescent cells, leading to improved cardiovascular function, exercise endurance, and extended healthspan.
Chemists at Scripps Research Institute have developed a broadly useful technique for building new drug molecules and other chemical products by expanding the meta-C-H activation method. The new method enables the attachment of functional groups at the meta position, previously difficult to achieve.
Researchers have determined the basic structural organization of the dynein-dynactin complex, a molecular motor responsible for cellular activities such as cell division and intracellular transport. The findings shed light on diseases like Alzheimer's, Parkinson's, and ALS, and could lead to new treatments.
Scientists from Scripps Research Institute found a mechanism causing long-term memory loss due to age by identifying connectivity defects between neurons, preventing the formation of long-term memories. This discovery could lead to ways of rebuilding those connections to improve memory.
Researchers at TSRI have published two studies showing how ABC transporters like P-gp change shape and react to therapeutic drugs. The findings provide clues for designing better molecules to inhibit or evade multidrug resistance.
A Scripps Research Institute team has discovered an antibody that can target both Marburg and Ebola viruses, paving the way for new treatment options. The antibody works by binding to a vulnerable site on the virus's surface, preventing it from entering human cells.
A study published in Genes, Brain and Behavior found that animal models with autism risk gene mutations exhibit decreased aggressive behavior towards strangers, instead engaging in repetitive patterns. The research suggests a potential counter-narrative to the widespread perception of increased aggression in individuals with autism.
A new study at The Scripps Research Institute shows that certain stem cell culture conditions can reduce DNA mutations. Researchers developed a method using feeder cells and manual passaging to minimize genetic instability.
Researchers from Scripps Florida have developed an anti-HIV agent that blocks all strains of HIV-1, HIV-2, and SIV, offering potential protection for at least eight months after injection. The new compound binds to the virus's envelope, preventing entry into host cells.
A study by scientists from Scripps Research Institute found that certain microbes promote nutritional harvest in fruit flies, rescuing their health and longevity when fed nutrient-poor diets. This natural symbiosis may offer a new strategy to treat and prevent malnutrition in humans.
Researchers have discovered a novel mechanism of neuronal death involved in neurodegenerative protein-misfolding diseases like Alzheimer's and Parkinson's. The study found that the loss of NAD+ is the primary cause of neuronal demise, and restoring it can rescue neurons.
Researchers at The Scripps Research Institute have identified a new cellular pathway affected in cystinosis, which could lead to new drug treatments for reducing or preventing renal failure. The study found that concentrations of LAMP2A, a lysosomal surface protein, were down by 50-80% in cystinotic cells.
Researchers fuse human hormones with cow antibodies to create long-lasting treatment options for hormone deficiencies and other diseases. The new therapy shows promise in reducing the frequency of injections needed for conditions like Turner syndrome and low birth weight.
Researchers at Scripps Research Institute have identified a crucial pathway that shields cells against death caused by environmental stress. The study found that Rheb inhibits protein synthesis by amplifying the phosphorylation of eIF2α, conserving cell resources during challenging conditions.
Researchers found diverse genomic changes in single neurons from Alzheimer's patients, showing that over 90% of sporadic Alzheimer's disease brains display highly significant DNA increases. Neurons from patients with sporadic Alzheimer's disease were four times as likely to contain more than two copies of the Alzheimer's-linked gene APP.
A new TSRI study explains how booster shots prompt immune memory to improve, a crucial step toward longer-lasting vaccines. The research demonstrates how immune cells evolve and adapt to recognize viruses, leading to more diverse and effective antibody responses.
A San Diego team has won a $1.7 million grant to develop quality control methods for stem cells, enabling researchers to detect abnormal cells and ensure the safety and efficacy of potential therapies.
Researchers at Scripps Research Institute have identified drug candidates targeting biological pathways involved in brain cell destruction in Parkinson's disease. The new compounds selectively inhibit JNK kinases, which play a central role in the disease, and show promise as potential therapeutics.
Researchers produced method protecting animal models from Syngap1 gene mutation effects, disrupting memory and anxiety levels. Early developmental period critical for treatment of psychiatric disorders caused by damaging Syngap1 mutations.
Researchers at Scripps Research Institute discover a promising new treatment for aggressive breast and pancreatic cancers, using a synthetic compound called SR1848. The compound targets the LRH-1 protein, which is involved in hormone synthesis and cholesterol metabolism.
Researchers at TSRI have developed a more effective nicotine vaccine by targeting only the left-handed version of nicotine, eliciting four times as many antibodies. The new vaccine has shown promise in animal studies and could lead to treatments for smoking addiction.
Researchers at TSRI identify an enzyme that produces inflammatory lipid molecules in the brain, which causes a rare neurodegenerative disorder. The team finds a potential treatment approach by targeting this enzyme and discovers a weight-loss drug that can block its activity.
Researchers at Scripps Research Institute reveal new insights into nicotinamide nucleotide transhydrogenase (TH), a metabolic enzyme found in most forms of life, shedding light on its structure and function. The discovery sheds light on TH's dynamic structure and how it alternates functions to maintain cell health.
A new study from The Scripps Research Institute suggests a drug compound can benefit not only parents but also their children by changing genetic expression, leading to improved memory and motor skills in offspring with Huntington's disease. This breakthrough discovery offers promising potential for treating the inherited disorder.
Researchers found that resveratrol activates an ancient stress response in human cells, activating key genes like p53 and FOXO3A. This pathway may explain how moderate red wine consumption could provide health benefits.
Researchers at Scripps Research Institute and UC San Diego create microfluidic device to rapidly heat and cool biomolecules, allowing for the observation of rapid folding events. This breakthrough enables the study of normal and abnormal biomolecules, including those implicated in human diseases.
Chemists at Scripps Research Institute invent powerful method for joining complex organic molecules, allowing venture into previously inaccessible territory. The new technique enables the creation of new chemical entities with potential applications in pharmaceuticals, materials and agricultural chemistry.
Researchers from Scripps Florida are investigating microRNAs as a potential key to treating posttraumatic stress disorder (PTSD) by erasing traumatic memories without altering other, more benign ones. The study aims to understand how the brain stores toxic memories and develop new targets to selectively target harmful memories.
Researchers at TSRI have identified Piezo2 as the primary mechanoreceptor protein mediating the sense of touch in mammals. Mice lacking Piezo2 lose sensitivity to ordinary light touch but retain pain-related touch sensitivity.
Researchers create cellPACK software to explore viruses, bacteria, and human components in 3D, demonstrating its power by modeling HIV structure. The tool solves the challenge of visualizing mid-size structures, reducing model creation time from weeks to hours.
Researchers at Scripps Research Institute have developed a method to convert human skin cells into sensory neurons, allowing for the study of pain and itch in a laboratory setting. This breakthrough enables the examination of neurodegenerative diseases such as Friedreich's ataxia and the testing of potential therapies.
Researchers at The Scripps Research Institute (TSRI) have discovered how a mutant gene called Tmie can cause deafness from birth. They found that reintroducing the gene in mice restored the process underpinning hearing, suggesting new treatment options for hearing loss.
A new study found that a cellular defense system against protein misfolding can overreact in chronic cases, worsening disease symptoms and reducing therapeutic effectiveness. Inhibiting this response with certain drugs showed promise as a treatment approach.
Researchers at TSRI found a link between the reward and stress systems in the brain, suggesting that specific neurons play a key role in nicotine addiction. By targeting these neurons, scientists hope to develop drugs or genetic therapies to reduce withdrawal symptoms and cravings.
Researchers at Scripps Research Institute have identified vulnerable sites on the surface of Ebola virus that are targeted by the antibodies in ZMapp, a drug cocktail administered to patients during the 2014 outbreak. The study provides insights into how ZMapp works and suggests strategies to improve it.
Scientists at Scripps Research Institute found that moving forward trains the brain to perceive the world normally and calibrates time perception. The study's findings have implications for treating sensory processing disorders like autism and could lead to retraining the brain after stroke or other conditions.
Scientists have identified new therapeutic targets for memory disorders and developed a high-throughput screening test to uncover compounds that may treat these conditions. The study reveals the importance of kinesin proteins in regulating synaptic function and identifies potential drug candidates.
Chemists at Scripps Research Institute developed a new method to modify organic compounds, overcoming a major limitation in previous techniques. The technique generates a reactive catalyst at the desired site on a molecule, allowing for the modification of a wide range of chemical structures.
Scientists at TSRI found that brief workouts can reduce the risk of relapse in rats withdrawing from methamphetamine. Exercise affected a brain region previously unassociated with meth withdrawal, suggesting new avenues for therapy.
Biologists at Scripps Research Institute have described the atomic-level workings of microRNA molecules, which control gene expression in all animals and plants. The findings will help guide the development of therapies that harness microRNA's power to regulate key biological processes.
Researchers at Scripps Research Institute have devised an enzyme with unique properties that may have contributed to the origin of life on Earth. The new ribozyme works by knitting together a 'copy' strand of RNA using an original template, with the ability to make copies of its own left-hand mirror image.
Researchers found that huntingtin protein activates signaling by mTORC1, leading to premature disease onset and worsening symptoms. The study offers new target for drug development, potentially preventing neurodegeneration through reduced mTORC1 activation.
A team from TSRI has established a new C-H activation technique that expands options for making pure batches of one-handed molecules, opening up a new avenue for creating chirally pure molecules for drug discovery. The method uses metal palladium and an amino acid catalyst to break C-H bonds at room temperature.
Researchers at TSRI have discovered a process that can catch unstable proteins before they form toxic clusters, reducing their secretion and aggregation. The approach targets the Unfolded Protein Response pathway and involves activating transcription factor ATF6 to increase protein folding and trafficking.
Researchers identified alpha-glycosylceramides as the activating molecules for natural killer T (NKT) cells, a crucial subset of immune cells. The discovery reveals a surprising link between mammalian immune systems and bacterial communication systems.
The Scripps Research Institute team is investigating the deadly Lassa fever virus with a $6.6 million NIH grant. The five-year study aims to understand how the immune system fights off the virus and develops new treatments for the disease. Researchers will analyze cells, chemicals, and genetics of patients to uncover key findings.
A new study suggests that ALS progression is linked to increased protein instability, particularly in mutant superoxide dismutase (SOD) proteins. The researchers found that SOD clusters or aggregates are common in affected motor neurons and support cells, suggesting a potential target for therapy.
Researchers at The Scripps Research Institute have created a synthetic molecule that mimics 'good' cholesterol, reducing plaque buildup in animal models. After two weeks, the molecule improved cholesterol levels, pointing toward a new method for treating atherosclerosis.
The Scripps Research Institute and Scripps Translational Science Institute will receive funding for a new Center for Excellence in Big Data Computing, enabling the collective mining of biomedical data. The initiative aims to accelerate research efforts on rare diseases using open approaches and citizen science platforms.
Researchers found that an ancient protein-making enzyme, TyrRS, has a second major function: protecting DNA during cellular stress. This discovery could lead to better therapies for radiation injuries and hereditary disorders like Charcot-Marie-Tooth disease.