Researchers found large droplets of triglycerides within neurons of mice modeling the disease, leading to potential therapies and a new investigative strategy. The study points to triglyceride metabolism as a key factor in hereditary spastic paraplegia.
Researchers have discovered a surprisingly diverse family of antibodies that can broadly neutralize different strains of HIV, providing new options for vaccine design. The findings offer clues on how to elicit high levels of these antibodies in people.
Scientists from Scripps Research Institute will develop an artificial immune system using a $7.9 million DARPA grant, creating vast libraries of molecules to detect and neutralize biological threats. The team will leverage automation and advanced technologies to rapidly synthesize and screen compounds.
Scientists at Scripps Research Institute have devised a new vancomycin analog that is powerfully effective against vancomycin-resistant strains of MRSA and other disease-causing bacteria. The new compound has two distinct mechanisms of action, making it difficult for bacteria to develop resistance.
Researchers develop a novel method to determine how T cells differentiate into specialized types of cells that help eradicate infected cells. The study identifies two previously unknown factors, Cyclin T1 and Cdk9, which work together during T cell differentiation.
Researchers develop a novel approach to synthesize molecules in diseased cells, targeting RNA repeats and demonstrating potent inhibitors for myotonic dystrophy. This breakthrough could lead to highly specific treatments for various debilitating diseases.
Researchers identified the neurofibromatosis type 1 (Nf1) gene as a key regulator of gamma-aminobutyric acid (GABA), a neurotransmitter that lowers anxiety and increases feelings of relaxation. Variations in the human Nf1 gene are linked to alcohol-dependence risk and severity, suggesting a potential genetic basis for excessive drinking.
Researchers developed small-molecule drug candidates that interfere with the synthesis of an abnormal protein, playing a key role in both diseases. The study also discovered biomarkers to test the efficacy of these therapies and found toxic proteins in spinal fluid that could become an enrollment tool in human clinical trials.
Researchers have developed a powerful new reactivity called SuFEx that enables the creation of stable, non-polar linkers for making drugs, diagnostics, and smart materials. The breakthrough opens up vast numbers of new molecules for production, with potential applications in fields such as drug discovery, biology, and materials science.
Researchers have identified a key gene linked to Huntington's disease as also playing a crucial role in normal long-term memory formation. The study used the marine snail Aplysia to explore this connection and found that eliminating the protein disrupted memory formation.
Scientists at Scripps Research Institute have successfully disrupted MYC, a cancer regulator thought to be undruggable, using a credit card-like molecule called KJ-Pyr-9. This breakthrough discovery shows the drug candidate can stop tumor growth in animal models and may offer new hope for cancer treatment.
Researchers at The Scripps Research Institute have identified a signaling pathway that activates the powerful calorie-burning process in brown fat cells. The study found that a protein called GADD45γ works alongside PGC-1α to boost thermogenesis, offering new possibilities for treating obesity and diabetes.
Researchers at Scripps Florida have identified a link between genetic mutations and mucoepidermoid carcinoma, an oral cancer affecting the salivary glands. The discovery could lead to targeted therapies that target the underlying genetic causes of the cancer.
Researchers from Scripps Florida have discovered a gene called Spns1 that plays a critical role in combating aging. The study found that manipulating the function of this gene can affect both developmental senescence and long-term biological aging.
Scientists have discovered that ancient protein-building enzymes have acquired new functions in humans, including producing variants with diverse biological activities. These variants are produced only in specific cell types and appear during certain stages of development, highlighting a previously unrecognized layer of biology.
Researchers at Scripps Florida have shed light on the complex process of nerve cell growth, revealing a key protein's role in regulating axon extension. The study shows that RPM-1 coordinates the growth of axons with synaptic connection construction, providing new insights into neuronal development.
Researchers from Scripps Research Institute have identified two compounds, CoPP and ZnPP, which bind to REV-ERBs and inhibit their activation by heme. These findings suggest that altering the metal ion chemistry of these compounds could be a way to target REV-ERB for treating metabolic disorders.
Researchers at Scripps Research Institute found that the drug rapamycin can improve the delivery of genes to blood stem cells, increasing efficiency from 30-40% to up to 80%. This breakthrough could lead to more effective and affordable treatments for leukemia and sickle cell anemia.
Researchers discovered the protein SerRS acts as a brake on new blood vessel growth and pairs with c-Myc to promote proper vascular development. The study found that SerRS suppresses VEGFA transcription by recruiting SIRT2, a partner enzyme that had never been linked to angiogenesis.
Researchers at Scripps Florida have discovered how a specific genetic mutation damages the developing brain, leading to intellectual disability. The study suggests new possibilities for therapeutic intervention and highlights potential biomarkers for cognitive failure.
Scientists have found new targets for potential intervention in breast cancer, which could increase effectiveness and reduce undesirable side effects. The study used hydrogen-deuterium exchange mass spectrometry to map the intricate interactions between the progesterone receptor's AF1 and AF2 domains.
Researchers found that high-intensity exercise activates a single protein called CRTC2, which integrates signals from two pathways to direct muscle adaptation and growth. This results in increased muscle size and improved metabolic parameters.
Researchers at Scripps Research Institute generate accurate structural map of Mediator, a critical genetic machinery. The mapping reveals the precise locations of protein subunits and their interactions with RNA polymerase II.
Researchers at Scripps Research Institute have found a major clue to the mystery of hemorrhagic fever syndromes, linking them to the body's antiviral response and identifying Interferon Type I proteins as key drivers of disease. Blocking IFN-I signaling may be a good therapeutic strategy against hemorrhagic fevers.
A team led by Scripps Research Institute scientists has received a $13 million grant to study antibodies to the human immunodeficiency virus (HIV) in pursuit of an effective vaccine. The goal is to elicit broadly neutralizing antibodies that can neutralize most circulating HIV strains.
Researchers aim to develop drug candidates that could reverse effects of poor early diets, potentially improving human healthspan. Early nutrition plays a critical role in lifelong health, with imbalanced diets during childhood increasing risk of obesity, diabetes, and heart disease.
Researchers at TSRI discover that Ring1b promotes fusion between telomeres, a process that can lead to cancer. Inhibiting this protein reduces the burden on cells affected by telomere dysfunction.
Researchers at Scripps Research Institute found that a protein with a propensity to form aggregates protects against Alzheimer's disease when produced in the brain. Boosting its production specifically in neurons could help ward off Alzheimer's disease, according to the study published in the Journal of Neuroscience.
Chemists at Scripps Research Institute have determined the correct structure of TIC10, a promising anticancer compound approved by FDA for clinical trials. The correct structure differs from an earlier published version and describes a molecule with potent anticancer effects in animals.
Researchers at TSRI have developed a new stem cell therapy that shows promise for treating multiple sclerosis in humans. In a mouse model, the therapy resulted in significant recovery of mobility and function after implantation of human stem cells into the spinal cord.
Scientists at the Scripps Research Institute have discovered that a single site on the surface protein of HIV can be targeted by an AIDS vaccine, potentially neutralizing nearly all strains of the virus. The study suggests that this approach could lead to a highly effective vaccine that targets a specific site on the Env protein.
Researchers at Scripps Research Institute engineered a bacterium to replicate unnatural DNA bases, which could lead to breakthroughs in medicine, nanotechnology, and protein therapeutics. The unique organism can contain three pairs of DNA bases instead of the traditional two, providing new possibilities for genetic coding.
Researchers from Scripps Research Institute will develop new technology to diagnose three diseases using a unique group of enzymes known as protein arginine deiminases (PAD). PADs have been linked to inflammatory diseases like rheumatoid arthritis, cancer, and Alzheimer's disease.
Resveratrol has been found to control the body's inflammatory response by binding to the estrogen receptor without stimulating cell proliferation. This study reveals a new pathway for resveratrol's beneficial effects in aging, inflammation, and metabolism.
Researchers found that mutations in the PTEN gene result in specific social interaction deficits in mice, despite broader brain overgrowth. The study suggests a selective effect on behavior and cognitive development, with sex-specific impairments observed.
Researchers have discovered a new vulnerable site on the HIV virus that can be attacked by human antibodies, neutralizing its infectivity across various strains. This finding is crucial in developing an effective vaccine against HIV.
A team of scientists at The Scripps Research Institute has deciphered the pheromone code used by mice to trigger countermarking behavior, which involves distinguishing territory from others.
Researchers at TSRI identified a critical protein complex, RGS7, that regulates memory formation by modulating GABA signaling. Mice lacking RGS7 exhibited deficits in learning and memory, highlighting the complex's importance in cognitive function.
Researchers will investigate alternative binding sites for existing diabetes medications, aiming to design more effective and safer treatments. The new grant will aid in the development of better drug models to improve glucose uptake by cells.
A team at The Scripps Research Institute has identified a long-sought protein called SWELL1 that regulates cell volume to prevent excessive swelling. The discovery solves a decades-old mystery of cell biology and may lead to new insights into diseases such as immune deficiency, stroke, and diabetes.
Researchers at Scripps Research Institute receive $472,500 grant to study impact of pain medication exposure in womb on developing brain. The two-year study will use rodent models to understand how subtle changes in brain wiring might lead to later changes in behavior.
Scientists at Scripps Research Institute have discovered a new binding site on peroxisome proliferator-activated receptor-gamma (PPARG) that could lead to improved insulin-sensitizing drugs. This alternative site may provide clues to the adverse effects of existing anti-diabetic medications, such as bone loss and congestive heart failure.
Researchers at Scripps Research Institute discover a dual-sensor system for the sense of touch, involving Merkel cells and nerves. The study provides new insights into how gentle touch sensations are detected by the skin.
A new study published in the journal Cancer has identified a novel biomarker, CCTα, associated with improved survival rates in patients with head and neck cancers and non-small cell lung cancer. The findings suggest that CCTα may be a more important predictor of patient outcomes than previously established ERCC1.
Researchers measured fruit fly food consumption using radioisotope labeling and paired it with the capillary feeder assay to achieve the most accurate measurements. The team's findings provide a best practices guide for nutrition measurement in studies of metabolism and disease.
Researchers pinpoint specific neurons where certain types of memory formation occur, a breakthrough that could help predict disease-damaged neurons in humans. The study used imaging technology to follow changes in the brains of live flies and found that certain dopaminergic neurons respond to elevated levels of cAMP.
The NIH has awarded a five-year grant of up to $28 million to establish a center for excellence in finding an antibody cocktail to fight the deadly Ebola virus. Researchers from 15 institutions, led by Erica Ollmann Saphire at Scripps Research Institute, will collaborate on definitive experiments.
Researchers at Scripps Research Institute found a gene called stumble that helps detect leg-joint angles in fruit flies, similar to human nerve cells. This discovery could improve understanding and treatment of balance and limb movement disorders.
Researchers have developed a new technique for making unnatural amino acids, which are sought after by the pharmaceutical industry for their medical uses. The method employs special ligand compounds to enhance the ability of a palladium catalyst to break carbon-hydrogen bonds.
Scientists from Scripps Research Institute have devised a new method to convert major components of natural gas into useable fuels and chemicals at lower temperatures. This could lead to cheaper energy and materials with lower emissions.