Researchers at the University of Rochester Medical Center have found a way to selectively block the ability of white blood cells to migrate toward sites of injury and infection, which drives disease. This discovery suggests a new approach for treating autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis.
Researchers at the University of Rochester Medical Center have developed a new graft technique using freeze-dried tendon grafts loaded with gene therapy, showing significantly fewer adhesions than traditional autografts. The study demonstrates promising results in restoring range of motion and accelerating healing after hard-to-treat i...
Researchers discover polyphenols in winemaking waste inhibit the ability of bacteria to cause cavities and form biofilms, potentially leading to new treatments for oral diseases. The findings also suggest the compounds may hold clues for lessening the ability of bacteria to cause life-threatening infections.
Scientists are developing a novel treatment strategy to target the key enzyme responsible for tooth decay in Streptococcus mutans bacteria. By disrupting this enzyme, researchers hope to render the bacteria more vulnerable to acid damage and prevent the formation of cavity-causing acid.
Researchers find that adenosine, a sleep-inducing brain chemical, plays a central role in deep brain stimulation's success. The technique disrupts abnormal nerve signals and alleviates symptoms in patients with Parkinson's disease and other brain disorders.
Researchers at the University of Rochester Medical Center have made a promising discovery in treating Batten disease, a rare neurodegenerative disorder. By administering a drug that partially blocks AMPA receptors, they improved motor skills in diseased mice, paving the way for potential clinical trials and future treatments.
Researchers have developed a new method to monitor peripheral neuropathy by analyzing tiny structures in the skin called Meissner corpuscles. This non-invasive technique allows doctors to detect nerve damage and track its progression, providing a valuable tool for early diagnosis and treatment.
A study led by Ronald Epstein found that doctors voiced empathy in only 15% of office visits, despite repeated prompting from patients. Patients reported high satisfaction when doctors empathized with them, especially in challenging situations.
Researchers at the University of Rochester Medical Center have identified a synthetic RNA-based molecule that eliminates myotonia, a symptom of muscular dystrophy, in mice. The study restored normal muscle function by re-establishing a critical cellular mechanism that controls electrical activity in muscles.
Scientists have found a specific way in which copper contributes to the disease process in Alzheimer's. Copper damages the molecule LRP, which normally escorts out amyloid beta from the brain, leading to increased levels of the toxic substance in the brains of people with Alzheimer's.
Researchers used C. elegans to study sex differences in brain function, finding that hermaphrodites prefer buttery smells while males prefer fresh vegetables. The team's genetic modification revealed that even few neurons can influence behavior, challenging the idea that all sex differences result from neuron-specific differences.
A common medication used to stop preterm labor is associated with increased risk of brain damage and intestinal problems in premature infants. However, use of the medication has not been linked to other serious complications. Obstetricians are now advised to limit its use to cases where babies are at greatest risk.
Researchers found that juvenile mice responded more damagingly to low-dose external radiation than adult mice, indicating potential long-term harm. The study aims to develop biomarkers for treating radiation poisoning and predicting health risks in mass casualty events.
A clinical trial aims to identify individuals at risk of osteoarthritis through the analysis of Smurf2 enzyme expression in cartilage cells. The study seeks to develop a diagnostic test and potential injection to prevent or slow disease progression.
A strain of bacteria resistant to all approved pediatric antibiotics has been discovered, according to researchers at the University of Rochester Medical Center. The 19A strain was found in children with persistent ear infections despite antibiotic treatment, highlighting concerns over potential long-term consequences.
A study reveals a new mechanism controlling how stem cells become either skeletal or smooth muscle cells, with implications for treating heart disease and cancer. The discovery of myocardin suggests new ways to treat diseases driven by stem cell replacement programs.
Researchers aim to modify traditional risk tools to include socioeconomic factors and calculate the impact on prediction. The study, which will use a database of over 30,000 adult patient cases, hopes to identify those with lower economic positions who may be more appropriately treated using an updated risk model.
Researchers found that depression in older people increases the risk of subsequent mental impairment and can act as a predictor of future intellectual decline. The study, which analyzed over 700 patients, showed that depression raises the risk of executive function loss, a key indicator of cognitive decline.
A recent study published in The Journal of Pediatrics has found that administering a combination vaccine to infants does not compromise their immune response or safety. In fact, the study shows that combining three vaccines into one reduces the number of required vaccinations from five to three over six months.
Researchers develop compound that targets leukemia at stem-cell level, where malignancy is born, potentially leading to more effective treatments. DMAPT appears to be unique in its ability to kill both dormant and dividing cancer cells without harming healthy blood cells.
Women with metastatic breast cancer who have endured previous traumatic or stressful events see their cancer recur nearly twice as fast as others, according to a study. The median disease-free interval was 2.5 years for those with traumatic experiences, compared to 5 years for those without.
Scientists have discovered a new approach to treat Huntington's disease using stem-cell therapy, which created thousands of new medium spiny neurons in mice. The treatment resulted in improved health and lifespan for the treated mice.
Effective communication is essential for good cancer care, according to a new report by the National Cancer Institute. The report highlights the need for patients to have access to clear information about their treatment options and outcomes, as well as the importance of patient-centered communication in managing uncertainty and anxiety.
Researchers found a gene named JAK that disrupts DNA activity, leading to cancer in fruit flies and potentially affecting offspring. The study shows epigenetic information can be passed from parent to offspring, even if the mutation itself is not present.
A comprehensive study is underway to examine the impact of prenatal exposure to mercury from dental fillings on neurological development. The researchers will collect hair samples from children in the Seychelles who were exposed to methyl mercury through their mothers' seafood consumption and dental work.
A new study at the University of Rochester Medical Center found that parents' beliefs about their children's asthma medications play a significant role in treatment adherence. The study revealed that parents who perceived a stronger need for their child's medication were more likely to adhere strictly to the prescribed regimen.
A recent study found that only 10% of teens receive annual preventive exams, leading to inadequate vaccination rates. The Centers for Disease Control and Prevention recommends three HPV shots within six months, but many teens are not seeing their doctors often enough.
A study published in the journal Immunity reveals that a toxin released by bacteria causes severe bleeding in the lungs, making infections deadly. The discovery provides a better understanding of what makes major global bacterial infections deadly and may lead to new treatments.
Researchers discovered that increasing the body's ability to absorb amyloid-beta in the blood leads to a decrease in brain levels, halting symptoms. A modified version of the sLRP protein showed promise in mice and humans, promising a new treatment option for Alzheimer's.
Anxious or depressed mothers-to-be are at increased risk of having children who experience sleep problems in infancy and toddlerhood. Babies born to mothers classified as anxious or depressed during pregnancy exhibit more sleep problems, even after controlling for other factors.
A University of Rochester investigation found that physician self-disclosures have no benefits and may disrupt patient information flow. Most physicians believed self-disclosure was a good idea for building relationships, but the study showed it was actually doctor-centered and beneficial to the physician, not the patient.
Random Technologies launched its RPro Statistic Software, providing enterprise-level support for the widely-used open source system R, which is well-suited for biomedical research and data-intensive fields. The company aims to standardize the process of releasing new features and provide professional technology support.
Scientists create a new adenovirus that selectively targets cancer cells with high dNTP concentrations, potentially delivering genetic materials to destroy malignant cells. The approach has shown promise in testing mice and human pancreatic cancer cells.
Researchers found that early palliative care interventions can reduce ICU stay length by over seven days without affecting mortality rates. This proactive approach aims to improve quality of life for seriously ill patients.
A special publication from the University of Rochester Medical Center aims to improve understanding and management of cancer-related fatigue. Studies show that exercise and support groups are effective in helping people cope with this challenging side effect.
A new imaging technique using Indocyanine Green (ICG) dye helps surgeons precisely remove cancerous tumors from the kidney while sparing as much healthy tissue as possible. This innovation allows for more effective treatment and better patient outcomes.
A small group of Rochester breast cancer survivors experienced major improvements in memory, concentration and learning after taking modafinil for eight weeks. The study suggests the drug could provide relief to those suffering from 'chemo-brain', a persistent side effect of chemotherapy.
A recent study found that a key inflammatory regulator in the brain acts as a protector against Alzheimer's disease, helping to remove toxic clumps called plaques. The research used genetically engineered mice with pinpoint control over inflammation levels, revealing that higher IL-1beta activity actually reduced plaque buildup.
A study by the University of Rochester Medical Center found that LeadCheck Swabs are prone to high error rates, detecting 64% of hazardous concentrations of lead in dust as safe. The swab test is not reliable for determining if house dust contains lead above EPA standards.
A new gene therapy has been shown to completely eliminate osteoarthritic pain and significantly reduce long-term joint damage in genetically engineered mice. The therapy works by increasing opioid receptors on nerve cells, making them more responsive to naturally occurring painkillers.
A study found that celecoxib can reduce the production of cells and molecules involved in building new blood vessels in premature infants, which may help prevent germinal matrix hemorrhages. Researchers believe this could lead to improved outcomes for babies born prematurely, reducing the risk of brain damage and related complications.
A study found children with both autism and ADHD are four times more likely to bully than their peers, highlighting the need for additional support services.
Research in mice shows migraines can lead to brain damage, with areas of the brain experiencing oxygen shortage. The study emphasizes the importance of preventing migraines through avoiding triggers and using prescribed medications.
Researchers found that the androgen receptor plays a key role in bladder cancer development, which explains why it affects men more than women. The discovery opens doors to new treatment options and may help doctors predict tumor recurrence.
A new experimental flu vaccine made in insect cells has been shown to be safe and effective in protecting against the flu, with a stronger immune response at higher doses. The use of cell culture systems to grow vaccines is a growing business and could potentially slice off months from the production process.
A University of Rochester study concludes that filtering white cells from donor blood before a transfusion is much safer for patients and long overdue as a national standard. The practice reduces post-surgical infection rates by 30%, saving lives and reducing costs nationwide.
The University of Rochester Medical Center has been awarded a $26 million contract to establish the New York Influenza Center of Excellence, one of six nationwide centers focused on improving flu research. The center aims to develop more effective vaccines against seasonal influenza and future pandemics.
Teens who receive state health insurance through programs like Child Health Plus see improved access to care, reduced racial disparities, and increased preventive services. The program eliminates disparities in care among adolescents, bringing the percentage of all teens seeking care with the same healthcare professionals up to 95%.
A study by the University of Rochester Medical Center found a significant link between high maternal beef consumption and lower sperm counts in sons. The study suggests that prenatal exposure to anabolic hormones from beef may alter sperm production in the male fetus, leading to reduced semen quality.
Cancer researchers have identified a promising compound, ASC-J9, that slows the progression of Kennedy's disease in mice carrying the mutant human gene. The compound breaks up a molecular clog in neurons affected by the disease, improving mobility and muscle function.