Studies found that DNA leakage from cell nuclei triggers an immune response in cancer cells, making them more susceptible to immunotherapy. Delivering radiation before immunotherapy may be an effective way to fight challenging-to-treat cancers.
Scientists have identified a key gene necessary for cells to consume and destroy viruses through a process called autophagy. The study found that a gene called sorting nexin 5 (SNX5) plays a critical role in viral autophagy, suggesting that it could be used to develop broad-spectrum antiviral therapeutics.
A study published in Circulation found that women are significantly less likely to survive out-of-hospital cardiac arrest compared to men. Women received therapeutic hypothermia and coronary angiography at lower rates, leading to a 22.5% survival rate compared to 36.3% for men.
Researchers found a correlation between inflammatory molecules and depression severity, as well as a link between specific symptoms of menopause and depression. The study used data from the Dallas Heart Study to analyze the association between GlycA levels and depressive symptoms in adults.
Researchers at UT Southwestern Medical Center have identified a unique population of cells that record both time and place in the brain, allowing for enhanced memory recall. These findings could provide the basis for new treatments to combat memory loss from conditions such as traumatic brain injury or Alzheimer's disease.
Researchers at UT Southwestern Medical Center have derived a new intermediate embryonic stem cell type that can contribute to chimeras and create precursors to sperm and eggs in culture. This discovery could lead to advances in basic biology, regenerative medicine, and reproductive technology.
A new study from UT Southwestern Medical Center found that 95% of pregnant women who tested positive for COVID-19 had no adverse outcomes, while the virus was transmitted to the fetus in only 3% of cases. The study also found that diabetes may increase the risk of severe or critical maternal illness.
A new study from UT Southwestern finds that being overweight or obese, even in younger patients under age 50, increases the risk of severe COVID-19 complications. The study analyzed data from over 7,600 patients and found that those with severe obesity had a 36% greater risk of dying compared to normal weight individuals.
Research presented at American Heart Association Scientific Sessions 2020 found that Black and Hispanic patients are more likely to be hospitalized with COVID-19 than white patients. Nonwhite men with cardiovascular disease or risk factors also face a higher risk of death from COVID-19.
Researchers found a ubiquitin ligase complex that degrades miR-7 and other miRNAs in cells. This discovery sheds light on how cells dispose of genetic molecules regulating protein production.
A UT Southwestern study found that retired football players with a history of concussions and mild cognitive impairment (MCI) scored similarly to non-athletes on verbal memory and learning tests. However, they showed lower scores on naming tests, which may be related to age-related decline rather than concussion effects.
A study suggests that losing fat mass, but not lean mass, is key for heart health in obese patients with type 2 diabetes. Reducing body fat and waist circumference lowers the risk of heart failure in this population.
A genetic mutation in the cystic fibrosis gene may accelerate heart function decline in DMD patients, suggesting a potential benefit from more aggressive and earlier cardiac interventions. Researchers identified this specific mutation as exacerbating cardiomyopathy in DMD patients.
Researchers at UT Southwestern Medical Center found that patients with acute interstitial nephritis, an autoimmune reaction, respond to immune checkpoint inhibitor drugs. This finding may have broad implications for patients being treated with ICIs.
A new study suggests that aspirin use is most beneficial for individuals with high coronary calcium scores and a low risk of bleeding. The research found that for patients with CAC scores above 100, aspirin's benefits outweigh its risks, but this effect only applies to those with inherent low bleeding risks.
Scientists have discovered a new role for the cancer-fighting gene p53 in preventing retrotransposons from hopping around the human genome, potentially leading to new ways of detecting or treating cancers. The study found that cells without functional p53 had higher rates of retrotransposon movement and multiplication.
Researchers propose adding a new metric to examine how many days patients spend at home after hospitalization, balancing current readmission rates with post-discharge care needs. The proposed '30-day risk-adjusted home time' metric could provide a more comprehensive picture of patient outcomes.
Researchers at UT Southwestern Medical Center found that high sugar diets worsened colitis symptoms and altered the gut microbiota in mice. The study suggests that consuming glucose from high fructose corn syrup may damage the protective mucus layer in the large intestine, increasing the risk of intestinal inflammation.
Two new UT Southwestern studies report that only half of practicing physicians are registered to vote, with time being the most common barrier faced by resident physicians. The researchers say finding ways to increase voter participation among doctors is critical as the nation tackles healthcare issues.
New research led by UT Southwestern shows the effectiveness of a treatment for aplastic anemia and reveals the range of diagnosis and treatment options used by hospitals around the country. The studies highlight how collaborative research can improve outcomes for children with rare blood disorders, including myelodysplastic syndrome.
Researchers discovered that immobilizing extremities alters the way stem cells interact with their extracellular environment, switching their fate from becoming debilitating bone to benign fat. This finding could help doctors optimize healing in patients with extremity injuries.
UT Southwestern Medical Center's COVID-19 adjustments streamlined clinical trials, allowing for remote consents and telehealth visits. A survey of UTSW clinical research professionals found positive experiences with these changes, with over 90% supporting continued use after the pandemic ends.
Research led by UTSW scientists finds that endocannabinoids can shut down genes needed for pathogenic intestinal bacteria to colonize and cause disease. The study suggests that these native chemicals similar to those found in cannabis may eventually lead to new ways to fight gastrointestinal infections.
A machine learning program using neural networks analyzes 1.4 million data points to predict which babies and children are most likely to suffer brain injury after Extracorporeal Membrane Oxygenation (ECMO) treatment, outperforming human clinicians.
A new study led by UT Southwestern researchers found that administering neuropsychology evaluations to children online delivers results comparable to traditional clinic tests. The home-based environment presented unique challenges, but the vast majority of patients and caregivers were satisfied with the videoconference-based test.
Researchers have made significant breakthroughs in understanding the biology of schistosomes, a parasitic flatworm that causes schistosomiasis. By identifying key vulnerabilities, scientists hope to develop new treatments for this deadly disease, which affects up to 250,000 people annually.
Researchers found a sixfold variation in itraconazole levels in tumor samples of lung cancer patients treated with the drug at a fixed dose. The levels correlated with tumor shrinkage and growth inhibition. Higher blood and tumor levels led to greater decreases in tumor volumes and reductions in new blood vessel formation.
Research suggests that conditions related to obesity, such as inflammation and leaky gut, leave lungs more susceptible to COVID-19. Additionally, high levels of ACE2 receptors in obese individuals can lead to a higher viral load, exacerbating disease severity.
A study by UT Southwestern Medical Center found that switching from brand-name to generic cholesterol medications between 2014 and 2018 saved Medicare billions of dollars. The total costs on these drugs went down despite an increase in prescriptions for LDL-lowering drugs, with the number of generic prescriptions rising by 35%.
A program using mail-in stool samples is shown to be an effective and cost-effective alternative to in-person colonoscopies for detecting colon cancer. The study identified nine best practices for implementing such programs, including patient navigation and high-quality testing kits.
Researchers discovered that mutations in ARID1A and ARID1B genes lead to the disassembly of cBAF complexes, causing aggressive liver and skin cancer. This finding challenges a proposed strategy to target these proteins for cancer treatment, highlighting the importance of understanding SWI/SNF biology.
Researchers at UT Southwestern Medical Center have discovered two experimental drugs that can suppress the growth and spread of non-small cell lung cancer (NSCLC) by affecting its blood vessels, oxygen levels, and other environmental factors. The findings highlight the potential of these drugs for NSCLC treatment.
Researchers studied the binding of general anesthetics and benzodiazepines to the GABAA receptor in the brain. They found that both types of drugs can bind to multiple sites on the receptor, with differences between them. This discovery could lead to the development of new, more selective anesthetics with fewer side effects.
A new study published in the Aesthetic Surgery Journal found that UT Southwestern's expanded telehealth services increased patient care in specialties like plastic surgery. The study reported significant benefits for patients, including reduced stress, missed work, and hospital visits, as well as improved access to care.
A new study led by UT Southwestern scientists suggests that breastfeeding changes the body's insulin sensitivity, particularly in highly insulin-sensitive organs like the liver and fat tissue. This increase in insulin sensitivity may provide a buffer against insulin resistance even decades later, lowering the risk of Type 2 diabetes.
UTSW scientists found that STING activates a pathway directly killing tumor-fighting immune cells, revealing a new opportunity for checkpoint inhibition immunotherapy. This finding could lead to longer-lasting immunotherapies and more effective treatments for cancer.
Researchers report a case where a pregnant mother transmitted COVID-19 to her prematurely born baby, highlighting the need to limit exposure for pregnant women. The study adds to evidence that SARS-CoV-2 virus can be transmitted in utero and emphasizes the importance of protecting mothers and newborns.
A new study reveals that melanoma cells that pass through lymph nodes pick up a protective coating, allowing them to survive high levels of oxidative stress in the blood. This coating, composed of oleic acid, protects cancer cells from ferroptosis and enables them to form distant tumors.
A new study published in Circulation: Cardiovascular Imaging found that coronary calcium scores are a better predictor of future heart attacks than strokes, with similar findings across sex and racial groups. The amount of calcified plaque in the heart's arteries was twice as risky for heart attacks as it was for strokes.
Researchers at UT Southwestern Medical Center discovered that Vibrio parahaemolyticus uses a novel pathway to escape human intestinal cells. The bacteria modify cholesterol molecules in the cell membrane, weakening it enough for the bacteria to break through and infect new cells.
Researchers at UT Southwestern Medical Center discovered that depleting the key protein Reelin can protect against multiple sclerosis symptoms and promote recovery. By reducing monocyte adhesion on blood vessel walls, Reelin levels may be a novel way to treat MS.
A new study shows that men treated for testicular cancer at public safety net hospital and academic tertiary care center have the same outcomes, despite differences in demographics. The study eliminated sociodemographic disparities in survival and cancer recurrence rates.
Researchers developed a genetically engineered mouse to visualize fluctuations in circadian clocks of cell types. They found that removing clock genes from AVP neurons disrupted the entire SCN network, while VIP neurons were less affected.
A new study analyzed data on over 15,000 people to better understand the association between HDL cholesterol, heart attacks, and strokes. The researchers found that the number of HDL particles is a more reliable predictor of heart attack and stroke risk than the standard HDL cholesterol metric.
Researchers found that deleting a key gene in mice just their fat tissue made them insulin resistant and had other effects. The findings shed light on Type 2 diabetes and could have implications for human disease.
Researchers at UTSW Medical Center have identified BBOX1 enzyme as a viable target for triple negative breast cancer treatment. Overexpressing BBOX1 causes TNBC cells to proliferate, while eliminating it stops tumor growth.
Researchers at UT Southwestern Medical Center identified a key brain region, the cerebellum's Rcrus1, which regulates repetitive and inflexible behaviors in individuals with autism. Inhibiting activity in this region improved social behaviors, while stimulation restored social functions, offering potential new therapies for ASD.
Researchers used ChIA-PET to map associations between proteins and DNA in prostate cancer cells, discovering hubs of interacting enhancers that regulate gene expression. These findings may lead to novel treatments for the most common type of prostate cancer.
Researchers found that in-person and remote assessments of jugular venous pressure often agreed, correlating with right atrial pressure measurements. The study's results could enable more frequent checks and reduce trips to the doctor's office for heart failure patients.
Two new studies reveal individual cells maintain internal clocks through a combination of genetic and random mechanisms. These findings suggest that cellular periodicity is influenced by epigenetic control and may hold insights into aging and cancer.