Articles tagged with Clinical Trials
A new study led by University of Maryland School of Medicine researchers found that focused ultrasound treatment significantly reduced tremors and improved mobility in Parkinson's patients. Nearly 70% of treated patients showed a successful response after three months, with two-thirds continuing to respond a year later.
Researchers found dapivirine levels in breast milk to be very low, posing no safety concerns. The study supports the inclusion of breastfeeding populations in global guidelines for the use of the dapivirine vaginal ring for HIV prevention.
A fast-dissolving insert containing TAF and EVG was found safe and effective in preventing HIV transmission through anal sex. The study delivered high levels of the drugs to rectal tissue and fluid, with potential protection for up to three days after use.
A new type of digestive endoscopy called Endocytoscopy can diagnose early esophageal cancers without the need for biopsies. Studies have shown that it achieves high accuracy (95%) and specificity (92%) rates, comparable to traditional pathological biopsy methods.
Researchers found that a combination of symptom and high-level viral rebound after untreated COVID-19 infection is rare, occurring in only 3 percent of study participants. This suggests that accounting for underlying rates of symptom relapse is crucial when evaluating antiviral treatment effects.
The DELIVER study found that the vaginal dapivirine ring posed no safety concerns when used in the third trimester of pregnancy. The study enrolled women at different stages of gestation and reported similar pregnancy outcomes between those using the ring and a placebo.
A groundbreaking study found that a new TB treatment strategy can shorten treatment duration while maintaining effectiveness. The TRUNCATE-TB trial showed that an initial 8-week treatment period followed by retreatment for those not cured was as effective as the standard 6-month treatment but halved the average total time on treatment.
Researchers found that an immersive virtual reality (IVR) intervention significantly improved pain and anxiety in pediatric patients undergoing a blood draw. The IVR group showed better outcomes compared to the control group.
Research found PIRI to be an independent predictor of infarct growth rate and 90-day outcomes in large-vessel occlusive stroke. The study suggests PIRI may help identify patients who could benefit from late-window endovascular thrombectomy.
The NIH is conducting a clinical trial to assess the safety and efficacy of S-217622, an investigational antiviral drug, in hospitalized adults with COVID-19. The trial aims to determine if S-217622 can improve recovery times compared to a placebo.
An international survey found that most health and nutrition claims on infant formula products are backed by little to no high-quality scientific evidence. The study identified 757 products with an average of two claims each, including benefits for brain development, immunity, and growth.
The AIDS Clinical Trials Group (ACTG) will present 29 presentations at the Conference on Retroviruses and Opportunistic Infections (CROI) 2023. The studies focus on COVID-19, HIV cure, pathogenesis, treatment, long-term complications, tuberculosis, hepatitis C, and contraception.
A new clinical trial will assess the efficacy of an AI-powered massage robot, EMMA, in managing chronic low back pain. The study aims to explore the effectiveness of robotic Tuina therapy in alleviating pain and improving health outcomes.
A new neuroprotectant medication called ApTOLL has been shown to improve survival and reduce long-term disability among patients with stroke. The study found that ApTOLL, when used in conjunction with standard treatments, reduced death and brain damage, suggesting a promising new approach to treating stroke.
New research supports the role of strawberry consumption in promoting heart health, with potential benefits including decreased cholesterol and inflammation. Studies show that eating strawberries daily may improve insulin resistance and vascular function, supporting a 'food as medicine' approach for preventing type 2 diabetes and cardi...
Researchers from the University of Colorado found that Paxlovid significantly reduced rates of hospitalization and death among non-hospitalized patients infected with recent Omicron subvariants. The study used real-world data from 28,000 patients and suggested a benefit for Paxlovid in preventing severe disease.
A large international clinical study found that patients with large strokes had significantly better recovery after endovascular thrombectomy plus medical management. The SELECT2 study showed almost 20% of patients who received thrombectomy regained functional independence, compared to 7% on medical treatment only.
A phase 2 trial found that talimogene laherparepvec combined with chemotherapy provided strong responses and immune cell activation in 45.9% of patients with early stage triple-negative breast cancer. Tumor samples showed high levels of tumor-fighting T cells, indicating a potential for improved outcomes.
A randomized controlled trial found that calorie restriction slowed the pace of biological aging in healthy adults by 2-3%, measured using the DunedinPACE algorithm, which translates to a 10-15% reduction in mortality risk. The intervention had no effects on other epigenetic clocks.
A single injection of pegylated interferon lambda has been shown to effectively treat early-stage COVID-19, reducing the need for hospitalization and emergency room visits. The treatment has also been found to work on all variants of the virus, making it a potential pan-virus intervention.
Researchers investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. Everolimus treatment significantly inhibited cell growth and reduced tumor angiogenesis and lymphangiogenesis.
Researchers at Aston University have discovered a new approach to process LDF light signals, allowing for more precise measurement of blood flow in specific areas of the vascular bed. This innovation has shown significant improvement in diagnostic accuracy for detecting microvascular changes in patients with type 2 diabetes and age-spe...
A single-dose of the antiviral drug peginterferon lambda reduced the risk of hospitalization or Emergency Department visit due to COVID-19 by half in high-risk patients. The treatment was effective across different variants of concern, including Omicron, and showed minimal side effects.
A phase 3 clinical trial of nearly 700 patients with early-stage lung cancer found that sublobar resection surgery, removing part of the affected lobe, was as effective as traditional lobectomy in terms of disease-free and overall survival. Patients who underwent sublobar resection also showed modestly better lung function.
A Phase 2 clinical trial found that patients with notalgia paresthetica experienced a significant reduction in itch intensity after taking oral difelikefalin. The medication, currently approved for chronic kidney disease, has the potential to become the first FDA-approved treatment specifically for this condition.
The grant aims to eliminate barriers and facilitate access to early phase cancer clinical trials for medically underserved communities. Researchers will develop and implement a multilevel program to improve referrals and enrollment, exploring the impact of remote clinical trials on enhancing diversity in trials.
The American Heart Association is recognizing 10 leading stroke scientists who have made significant contributions to the field of stroke research. Among them, Dr. Cheryl Bushnell will be honored with the Ralph L. Sacco Outstanding Stroke Research Mentor Award for her exceptional mentorship and research in women's issues related to str...
The Alzheimer's Association redefines clinical meaningfulness, finding modest yet significant benefits from approved treatments that expand over time. Combination therapies are expected to provide more substantial benefits moving forward.
The work group reframed what is clinically meaningful to slow Alzheimer's disease progression, including the need for combination therapies and realistic expectations of benefits and risks. Slowing brain deterioration by four to six months in early stages may preserve function, leading to meaningful outcomes for patients and families.
A systematic review found that higher vitamin D intake was associated with a 15% decreased likelihood of developing type 2 diabetes in adults with prediabetes. Inexpensive vitamin D supplementation could delay the development of diabetes in over 10 million people worldwide.
An updated Cochrane review found no effect of vitamin D supplements on reducing the risk of asthma attacks or improving control of asthma symptoms in children and adults. The review analyzed data from 20 randomized controlled trials involving over 2,200 people with mild to moderate asthma.
A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.
Researchers at Kessler Foundation are conducting a double-blind randomized clinical trial to evaluate the impact of their strategy-based cognitive training program on new learning and memory in individuals with multiple sclerosis. The study aims to assess the efficacy of this protocol, which is based on the KF-STEM protocol.
A new study found that women with pre-pregnancy migraine had greater risks of preterm delivery, gestational hypertension, and preeclampsia. Migraine with aura was associated with a higher risk of preeclampsia than without aura.
The SWOG S1416 clinical trial demonstrated the efficacy of PARP inhibitor veliparib in patients with triple-negative breast cancer and a 'BRCA-like' phenotype. Patients treated with veliparib experienced longer progression-free survival times compared to those receiving chemotherapy alone, with median PFS of 5.9 months versus 4.2 months.
Researchers analyzed tumor microenvironment of pancreatic cancer, revealing two major defects that inhibit immune response. The study suggests a new approach using anti-CD137 agonist antibody treatment in combination with anti-PD-1 immunotherapy to activate T cells.
A phase 2 clinical trial combining immunotherapy and targeted therapy showed a 24.3% confirmed response rate and 5-month median progression-free survival among patients with BRAF V600 mutations. The treatment also demonstrated increased durability, with 57% of patients remaining on treatment for more than 6 months.
A personalized brain modeling approach is being tested in a large-scale clinical trial for drug-resistant epilepsy, aiming to improve surgery preparation and patient specificity. The technique uses virtual models of patients' brains to simulate abnormal activity during seizures, helping clinicians identify target areas more effectively.
Researchers developed a translational step forward in treating brain tumors using intraventricular immunovirotherapy, which has shown safety and efficacy in recent clinical trials. This approach uses oncolytic herpes simplex virus type-1 to target high-grade glioma with promising results.
Researchers at the University of Maryland School of Medicine found that monoclonal antibody CIS43LS provided high levels of protection against controlled human malaria infection. The study's findings suggest that this treatment could be a potential game changer for deploying monoclonal antibody therapies in African countries.
Researchers seek to reduce medical errors among patients with limited English proficiency by implementing three different translation approaches. The goal is to compare the effectiveness of telephone interpreter-based and in-person interpreter-assisted communication in reducing errors.
A new COVID-19 vaccine has been tested in humans, showing a good immune response and few side effects. The effectiveness of the vaccine is currently being investigated, but initial results suggest it could provide long-lasting immunity.
A Michigan Medicine study found that hospitals with the highest stroke care designation reported significantly higher rates of stroke detection after TAVR. The study suggests that comprehensive stroke centers are better at detecting smaller strokes, but this does not necessarily mean they are finding more strokes overall.
A new model called 'The Trust Circle' was developed to increase recruitment of AI/AN populations into clinical trials. The model takes into account the trust between trial participants, researchers, and community leaders, with physicians and ministers playing a key role in promoting trust.
A new study shows that Medasense's NOL monitoring during major abdominal surgery can significantly reduce the proportion of patients with severe post-operative pain. The study found that intraoperative opioid dosing based on the NOL index reduced PACU pain scores by a median of 1.5 points at 90 minutes post-surgery. This technology use...
The COVID-19 Prevention Network's coordinated approach to Phase 3 clinical trials has yielded a comprehensive database of trial participants' data. This dataset will help researchers address pressing questions about SARS-CoV-2 and inform future vaccine development.
A phase 3 trial found that adding nab-paclitaxel to a standard gemcitabine plus cisplatin regimen did not significantly extend median overall survival for patients with advanced biliary tract cancers, but provided benefits for subsets of patients. The treatment also showed improved response rates and progression-free survival times.
A controlled clinical trial has shown that the new drug leriglitazone can prevent neurodegeneration and brain inflammation in patients with X-linked adrenoleukodystrophy. The study found improvements in neurological conditions such as balance disorders, which had a positive impact on quality of life.
Researchers found that certain gene signaling pathways, such as interferon γ and beta-catenin, can lead to tumor hyperprogression after immunotherapy. Targeting these pathways may prevent hyperprogression in preclinical models.
A Cancer Research UK-funded clinical trial found that chemotherapy before surgery reduces the chance of colon cancer returning within 2 years by 28%. The study involved 1,053 patients and showed significant benefits in terms of preventing cancer recurrence.
A Phase 3 clinical trial testing an experimental HIV vaccine regimen found the treatment to be safe but ineffective in preventing HIV acquisition. The trial involved over 3,900 volunteers and concluded that the number of HIV infections were equivalent between the vaccine and placebo arms.
A new personalized treatment for bile duct cancer has shown remarkable results, with patients surviving for up to two years when treated with the drug futibatinib. The Phase II clinical trial found that the drug was more effective at reducing tumor size and producing modest side effects compared to chemotherapy.
A new clinical trial of over 12,000 patients found that inexpensive aspirin is just as effective as injectable blood thinners in preventing life-threatening blood clots and other complications. The study suggests that surgeons may change their practice to administer aspirin to patients hospitalized with bone fractures.
Researchers analyzed data from the VITAL trial and found that vitamin D supplementation increased biomarkers associated with vitamin D metabolism in people, regardless of their weight. However, these increases were significantly smaller in people with elevated BMIs, suggesting a blunted response to supplementation.
A new prostate cancer therapy is being tested in clinical trials, targeting the treatment-resistant form of the disease. The therapy uses a drug called Abivertinib to block a specific protein that allows tumors to produce androgens, a goal of using more targeted treatments like TKIs.
A large clinical trial supported by the National Institutes of Health found that two widely used diuretics, furosemide and torsemide, did not differ in improving patient survival when compared. The study suggests a need for better treatments for heart failure patients and highlights the importance of optimizing diuretic doses to improv...
Researchers found that a pro-oxidant mixture of resveratrol and copper can inactivate cell-free chromatin particles, reducing chemotherapy toxicity. The treatment also showed promise in preventing aging and sepsis.
A new study involving Huma's clinical trial platform showed that participants had a positive experience using the app to report measurements and symptoms. The study found sustained levels of engagement over 6 months, with only 2.5% of participants withdrawing.
A randomized clinical trial of 1,288 adults with mild to moderate COVID-19 found that fluvoxamine treatment did not reduce time to sustained recovery compared to placebo. The study suggests that fluvoxamine at a dose and duration tested may not be beneficial in patients with mild to moderate COVID-19.
A new study found that MRI-guided radiotherapy is more effective than CT-guided therapy in reducing side effects and improving quality of life for patients with localized prostate cancer. The trial involved 154 patients, who experienced fewer toxicities and better outcomes when treated with MRI guidance.