Articles tagged with Clinical Trials
Reviparin significantly reduced the composite outcome of death, heart attack, and stroke at 7 and 30 days. Its benefits persisted even when initiated very early after symptom onset, with a 13% lowered risk. Reviparin is considered a moderate but important advance in managing patients with acute myocardial infarction.
A new study by Ohio State University researchers found that calcium supplementation significantly increased bone mass development during a critical childhood growth spurt in pre-adolescent girls. The findings suggest that elevated calcium use during this period may help prevent fractures and osteoporosis later in life.
Researchers at Brenner Children's Hospital will conduct four clinical trials to find the best treatments for children with heart conditions. The hospital hopes to renew its participation in the network after two years, offering patients access to cutting-edge treatment advances and better health outcomes.
Research found that estrogen therapy significantly increases the risk of gallbladder disease and surgery in postmenopausal women, with CEE showing a 67% increased risk. The study also revealed higher risks for cholecystitis and cholelithiasis among estrogen users.
Researchers can submit study information to a new patient website, www.PDtrials.org, designed to improve access to Parkinson's clinical trial information. The site currently lists over 30 studies recruiting patients in the US and aims to educate patient communities on the value of clinical research.
A new device study shows spinal cord injury patients experiencing some degree of functional recovery after six months, with improved sensation and motor function recorded at one year. The oscillating field stimulator device has been shown to promote nerve fiber regeneration, offering a potential treatment option for severe injuries.
The article discusses limitations of trial data generalizability and proposes recommendations to improve reporting and external validity. It emphasizes the need for increased consideration of external validity in guidelines and primary reports of RCTs and systematic reviews.
A multicenter study found women attempting vaginal birth after C-section (VBAC) face increased risk of maternal morbidity and serious obstetric complications. Conversely, elective repeat cesarean delivery shows lower risks for these complications.
The NIAID human clinical vaccine trial tests an experimental vaccine composed of a small circular piece of DNA encoding the viral spike protein. The trial aims to assess the vaccine's safety and immune-stimulating effects in people, with results expected to inform future vaccine development.
A NIAID-sponsored clinical trial is enrolling healthy adults to assess the immune response and safety of the Fluarix vaccine, which has been distributed in over 70 countries. The trial will provide valuable information on the vaccine's efficacy before it can be licensed for use in the US.
A validation study has shown that a 70-gene signature is more effective than current standard criteria in predicting the time to distant metastasis and overall survival in breast cancer patients. The results have the potential to reduce chemotherapy prescriptions by up to 20% and improve quality of life for many women with breast cancer.
A long-term study found that women had a higher risk of death from cardiovascular disease and lung cancer after stopping beta-carotene supplements, while the excess risk in men disappeared. The results suggest careful monitoring is needed to document long-term safety and efficacy.
The study found that raloxifene reduced invasive breast cancer incidence by 59% and ER-positive invasive breast cancer by 66%, leading to a 66% and 76% reduction in these cancers after 8 years. No effect on ER-negative or non-invasive cancers was observed.
The Multicenter UnSustained Tachycardia Trial found significant differences in characteristics, treatment, and outcome between men and women with coronary artery disease. Women were more likely to have experienced angina and had lower rates of atrial fibrillation than men.
Research reveals elderly patients are significantly under-represented in cancer clinical trials, with only 36% of trial participants aged 65 and older compared to 60% of the U.S. cancer population. This underrepresentation may be due to concerns about treatment effectiveness and side effects.
A randomized trial has demonstrated that a HPV vaccine is effective in preventing persistent HPV infections, abnormal Pap tests, and precancerous lesions. The vaccine's efficacy rate is up to 95%, suggesting a substantial reduction in cervical cancer rates globally.
The CorCap Cardiac Support Device has been found to significantly improve heart function and reduce the likelihood of needing a heart transplant in patients with moderate to severe heart failure. The device is an investigational mesh-like 'heart jacket' that prevents further enlargement during chest surgery.
Research suggests that high doses of vitamin E supplements may increase the risk of death from any cause, with no benefit found at doses of 200 IU per day or less. The analysis, which included findings from 14 studies, found that taking greater than 400 IU of vitamin E per day increases mortality risk by about 10 percent.
This study found that different health state value measures produced varying estimates of utilities and QALYs in patients with coronary artery disease (CAD). The use of SF-6D generated lower utilities compared to HUI3, which may impact the conclusions about treatment value.
Research found that African-Americans had higher blood pressure and heart rates, but also better artery response to treatment, leading to worse overall outcomes. The disparity in long-term mortality remains even when adjusting for patient characteristics and cardiovascular risk factors.
Researchers have developed a new device that can repair severe mitral valve regurgitation through a minimally invasive procedure, reducing symptoms and improving heart function. Preliminary results show favorable outcomes, with patients experiencing significant reductions in hospital stay and complications.
The seven-year contract will target non-HIV STIs and include microbicides, vaccines, STI treatments and diagnostic products. Students from international partners can participate in a yearlong program at UCSF for certification and mentoring.
A large UK trial found no significant improvements in survival, hospital admissions, or quality of life from comprehensive assessment and management of elderly patients. However, social functioning showed a small benefit from hospital-based outpatient geriatric care.
Loyola is conducting a clinical trial using a blood substitute in trauma patients to increase oxygen delivery and improve survival rates. The study aims to compare the survival rate of patients receiving the blood substitute to those receiving saline solution.
A study analyzing phase 1 cancer trials from 1991-2002 found a significant decrease in treatment-related deaths and serious toxicity, with adjusted odds of death being less than one-tenth those of patients participating in earlier trials. Targeted therapies and improved supportive care are likely contributing factors.
A new esophageal capsule has been found to be as effective as traditional endoscopy in detecting Barrett's esophagus, a pre-cancerous condition. The study showed a high sensitivity of 97% and specificity of 100% in identifying esophageal abnormalities.
A new radiotherapy regime has been shown to significantly reduce local disease recurrence rates in young women with breast cancer. The treatment involves adding a boost dose of radiation to the tumour bed, resulting in a 5-year local recurrence rate of 8.5% in women under 35 years old.
A randomised clinical trial found that post-operative radiotherapy significantly improved biological and clinical progression-free survival in men with high-risk prostate cancer. The study showed a clear benefit in terms of biological progression-free survival for men who received radiotherapy treatment in addition to surgery.
A new malaria vaccine trial found only 10% vaccine efficacy in Gambian adults, but the DNA/MVA vaccine group showed a significantly stronger immune response than the rabies vaccine group. The researchers are planning further trials to address this issue and develop a more effective malaria vaccine.
The study confirms that patients benefit from two years of treatment with Macugen for wet AMD, demonstrating a statistically significant 45% treatment benefit. Longer-term use may be beneficial for patients suffering from this chronic disease.
Researchers tested electrical stimulation's influence on stroke recovery, showing participants experienced meaningful motor recovery gains. The study aims to validate these findings and potentially reverse paralysis, restoring patients' function and normal lifestyle.
The MRC CRASH* trial found that giving patients corticosteroids after a head injury increased the risk of death within two weeks, with 21% of those treated dying compared to 18% on placebo. The trial involved over 10,000 patients from nearly 50 countries and challenges previous studies' findings.
A study by University of Washington researchers finds that press coverage of lawsuits often portrays plaintiffs winning far more frequently than they do in reality. The distortion is attributed to a combination of factors, including corporate public relations campaigns and the tendency of news media to skim on scientific evidence.
A randomised trial found that doubling the daily dose of imatinib improves progression-free survival by 12% compared to a single daily dose. The study also showed no significant difference in treatment side-effects between the two groups.
A randomized trial found that coronary angioplasty within 24 hours of medical therapy for heart-attack patients can significantly improve outcomes. The study, GRACIA-1, showed a halved rate of death, reinfarction, or revascularisation at 12 months compared to conservative treatment.
The ICMJE editors announce that major medical journals will require registration of clinical trials prior to patient enrollment, aiming for full transparency and accessibility. This policy applies to any clinical trial starting after July 1, 2005, and encourages other biomedical journals to adopt similar policies.
Renal artery intervention procedures have seen a significant increase in cardiologist-performed cases, with the southeast region experiencing the largest surge. The study suggests regional disparities in treatment, highlighting potential over- or under-treatment of patients.
A new analysis of the CHARM* study program shows that Atacand reduces all-cause mortality by 12% and cardiovascular mortality by 16%. The medication is recommended for all patients with heart failure and low LVEF, regardless of background treatment.
A study published in Diabetes shows that six months treatment with Laszarin TM reduces heart size in diabetic patients and reverses heart failure. The research led by Protemix demonstrates that defective copper metabolism is implicated in the development of heart disease.
Thomas Jefferson University is developing a clinical trial using a bone-targeted agent to treat microscopic bony metastasis in high-risk prostate cancer patients. The trial aims to improve death rates from prostate cancer by combining hormones and radiation with the targeted agent, Quadramet.
The UC Davis Cancer Center has a vigorous clinical trials program, with about 16% of new cancer patients participating in trials. This rate is significantly higher than the national average of less than 3%.
The American Society of Clinical Oncology (ASCO) has released a new technology assessment recommending against the use of chemotherapy sensitivity and resistance assays. The assessment found limitations in the literature, including small sample sizes and low yield of assays, cast doubt on their effectiveness in determining treatment.
The European and Developing Countries Clinical Trials Partnership has opened an African office in South Africa, aiming to boost the continent's medical research capacity. The partnership will fund clinical trials for new treatments and vaccines against HIV/AIDS, tuberculosis, and malaria.
Four clinical trials are underway to determine the effectiveness of digital mammography, ultrasound, and MRI in detecting breast cancer and preventing deaths. These non-radiation based techniques could lead to a lower screening age and increased regular screenings for high-risk women.
A study analyzing the Surveillance, Epidemiology, and End Results (SEER) database found that it is reasonably reliable for collecting cancer incidence and mortality data. Researchers compared histologic tumor types from patients reported to the SEER database with those obtained through an independent review, finding no difference in di...
A study found that state-mandated reimbursement policies were associated with an increase in phase II clinical trial enrollment, but not overall or phase III enrollment. The authors suggest that knowledge and attitudes about trials held by physicians and patients play a greater role in participation than state mandates.
The Alzheimer's Association and NIA are expediting prevention trials for Alzheimer's by developing more efficient tools, such as home-based testing. This will reduce costs and burdens on participants while gaining valuable information about the course of cognitive changes in late life.
The CryoCor system, developed by CryoCor of San Diego, has shown a 98% overall treatment success rate in international clinical trials. The technology uses ultracold temperatures to block abnormal electrical signals causing arrhythmia, providing a potential cure for the condition.
Researchers will investigate safety issues and late-stage effectiveness of retinal cell transplantation in animal models before planning human clinical trials. The goal is to preserve vision in patients with RP who retain a small degree of central vision throughout their life.
A Cornell University-Stanford University meta-analysis of 30 clinical trials found that women starting HRT within two years of menopause had a lower total mortality risk. The study also showed significant reductions in hip fractures and recurrent urinary tract infections, but no change in breast cancer deaths.
The NIAID is conducting a clinical trial to test the safety and effectiveness of Omr-IgG-am, an antibody-based product derived from Israeli donors, in treating West Nile virus infection. The study aims to provide preliminary data on the treatment's effectiveness against encephalitis, a brain inflammation caused by WNV infection.
The American Academy of Neurology is expanding its clinical research trial recruitment efforts to improve patient care through education and research. The association has over 80% of clinical trials experiencing recruitment issues, which can delay or even prevent completion.
Studies show that enoxaparin is non-inferior to unfractionated heparin in preventing death or non-fatal myocardial infarction in patients with non-ST elevation acute coronary syndromes. Enoxaparin also shows a lower rate of non-fatal MI with a modest excess of bleeding.
The creation of the UK Clinical Research Collaboration will expand the number and range of clinical trials in the UK, particularly in children
The PROactive study assesses the effect of ACTOS on cardiovascular disease progression in patients with type 2 diabetes. The study examines whether pioglitazone reduces cardiovascular mortality and morbidity in a high-risk population.
The Emory Vaccine Center's Hope Clinic will conduct clinical trials for topical vaginal microbicide gels to prevent HIV transmission, particularly among women in Atlanta and worldwide. The trials aim to test the safety and acceptability of two different gel formulations on healthy and high-risk individuals.
Research suggests that estrogen therapy does not reduce the risk of dementia in older women. The study found a 76% increased risk for probable dementia among those taking estrogen compared to placebo. Hormone therapy also increased the risk of mild cognitive impairment and decline in global cognitive function.
A study found that a compulsory second opinion from another obstetrician reduced the incidence of non-emergency caesarean sections by around 7% in Latin American hospitals. The intervention did not affect maternal and infant outcomes, but is well accepted by pregnant women and attending physicians.
The study found that cancer research participation is low across all patient groups, particularly among the elderly, racial and ethnic minorities, and women. The analysis of data from the National Cancer Institute Clinical Trial Cooperative Group revealed significant disparities in trial enrollment rates by age, sex, and racial/ethnic ...
The study found that minority groups are underrepresented in cancer clinical trials, with Hispanic patients representing only 3.1% of trial participants. Additionally, elderly patients, both minorities and whites, were strikingly underrepresented compared to their younger counterparts.