Articles tagged with Clinical Trials
A randomised trial found that doubling the daily dose of imatinib improves progression-free survival by 12% compared to a single daily dose. The study also showed no significant difference in treatment side-effects between the two groups.
A randomized trial found that coronary angioplasty within 24 hours of medical therapy for heart-attack patients can significantly improve outcomes. The study, GRACIA-1, showed a halved rate of death, reinfarction, or revascularisation at 12 months compared to conservative treatment.
The ICMJE editors announce that major medical journals will require registration of clinical trials prior to patient enrollment, aiming for full transparency and accessibility. This policy applies to any clinical trial starting after July 1, 2005, and encourages other biomedical journals to adopt similar policies.
Renal artery intervention procedures have seen a significant increase in cardiologist-performed cases, with the southeast region experiencing the largest surge. The study suggests regional disparities in treatment, highlighting potential over- or under-treatment of patients.
A new analysis of the CHARM* study program shows that Atacand reduces all-cause mortality by 12% and cardiovascular mortality by 16%. The medication is recommended for all patients with heart failure and low LVEF, regardless of background treatment.
A study published in Diabetes shows that six months treatment with Laszarin TM reduces heart size in diabetic patients and reverses heart failure. The research led by Protemix demonstrates that defective copper metabolism is implicated in the development of heart disease.
Thomas Jefferson University is developing a clinical trial using a bone-targeted agent to treat microscopic bony metastasis in high-risk prostate cancer patients. The trial aims to improve death rates from prostate cancer by combining hormones and radiation with the targeted agent, Quadramet.
The UC Davis Cancer Center has a vigorous clinical trials program, with about 16% of new cancer patients participating in trials. This rate is significantly higher than the national average of less than 3%.
The American Society of Clinical Oncology (ASCO) has released a new technology assessment recommending against the use of chemotherapy sensitivity and resistance assays. The assessment found limitations in the literature, including small sample sizes and low yield of assays, cast doubt on their effectiveness in determining treatment.
The European and Developing Countries Clinical Trials Partnership has opened an African office in South Africa, aiming to boost the continent's medical research capacity. The partnership will fund clinical trials for new treatments and vaccines against HIV/AIDS, tuberculosis, and malaria.
Four clinical trials are underway to determine the effectiveness of digital mammography, ultrasound, and MRI in detecting breast cancer and preventing deaths. These non-radiation based techniques could lead to a lower screening age and increased regular screenings for high-risk women.
A study analyzing the Surveillance, Epidemiology, and End Results (SEER) database found that it is reasonably reliable for collecting cancer incidence and mortality data. Researchers compared histologic tumor types from patients reported to the SEER database with those obtained through an independent review, finding no difference in di...
A study found that state-mandated reimbursement policies were associated with an increase in phase II clinical trial enrollment, but not overall or phase III enrollment. The authors suggest that knowledge and attitudes about trials held by physicians and patients play a greater role in participation than state mandates.
The Alzheimer's Association and NIA are expediting prevention trials for Alzheimer's by developing more efficient tools, such as home-based testing. This will reduce costs and burdens on participants while gaining valuable information about the course of cognitive changes in late life.
The CryoCor system, developed by CryoCor of San Diego, has shown a 98% overall treatment success rate in international clinical trials. The technology uses ultracold temperatures to block abnormal electrical signals causing arrhythmia, providing a potential cure for the condition.
Researchers will investigate safety issues and late-stage effectiveness of retinal cell transplantation in animal models before planning human clinical trials. The goal is to preserve vision in patients with RP who retain a small degree of central vision throughout their life.
A Cornell University-Stanford University meta-analysis of 30 clinical trials found that women starting HRT within two years of menopause had a lower total mortality risk. The study also showed significant reductions in hip fractures and recurrent urinary tract infections, but no change in breast cancer deaths.
The NIAID is conducting a clinical trial to test the safety and effectiveness of Omr-IgG-am, an antibody-based product derived from Israeli donors, in treating West Nile virus infection. The study aims to provide preliminary data on the treatment's effectiveness against encephalitis, a brain inflammation caused by WNV infection.
The American Academy of Neurology is expanding its clinical research trial recruitment efforts to improve patient care through education and research. The association has over 80% of clinical trials experiencing recruitment issues, which can delay or even prevent completion.
Studies show that enoxaparin is non-inferior to unfractionated heparin in preventing death or non-fatal myocardial infarction in patients with non-ST elevation acute coronary syndromes. Enoxaparin also shows a lower rate of non-fatal MI with a modest excess of bleeding.
The creation of the UK Clinical Research Collaboration will expand the number and range of clinical trials in the UK, particularly in children
The PROactive study assesses the effect of ACTOS on cardiovascular disease progression in patients with type 2 diabetes. The study examines whether pioglitazone reduces cardiovascular mortality and morbidity in a high-risk population.
The Emory Vaccine Center's Hope Clinic will conduct clinical trials for topical vaginal microbicide gels to prevent HIV transmission, particularly among women in Atlanta and worldwide. The trials aim to test the safety and acceptability of two different gel formulations on healthy and high-risk individuals.
Research suggests that estrogen therapy does not reduce the risk of dementia in older women. The study found a 76% increased risk for probable dementia among those taking estrogen compared to placebo. Hormone therapy also increased the risk of mild cognitive impairment and decline in global cognitive function.
A study found that a compulsory second opinion from another obstetrician reduced the incidence of non-emergency caesarean sections by around 7% in Latin American hospitals. The intervention did not affect maternal and infant outcomes, but is well accepted by pregnant women and attending physicians.
The study found that cancer research participation is low across all patient groups, particularly among the elderly, racial and ethnic minorities, and women. The analysis of data from the National Cancer Institute Clinical Trial Cooperative Group revealed significant disparities in trial enrollment rates by age, sex, and racial/ethnic ...
The study found that minority groups are underrepresented in cancer clinical trials, with Hispanic patients representing only 3.1% of trial participants. Additionally, elderly patients, both minorities and whites, were strikingly underrepresented compared to their younger counterparts.
Researchers found that clinicians missed about half of symptoms reported by patients, and patients also missed about half of the symptoms recorded by physicians. The study suggests that new patient reporting tools should be developed for use in chemotherapy clinical trials to improve accuracy.
A study of 192 patients with advanced gastrointestinal stromal tumor (GIST) found that Glivec(R) interruption was associated with a high risk of re-progression. In contrast, continuous treatment showed no signs of re-progression within a year. Continuous Glivec(R) treatment is recommended for patients with advanced GIST.
The study confirmed that islet transplantation works for patients with serious and unstable type 1 diabetes, allowing them to be free from daily insulin injections for up to one year. Few treatment-related complications were noted, with minor side effects such as mouth ulcers and diarrhea.
A recent study found that lung cancer patients in Japan had a longer median survival time (12 months) compared to US patients (9 months), despite receiving a lower dose of the same chemotherapy regimen. However, Japanese patients experienced more side effects, such as neutropenia and neuropathy.
Loyola Medicine is conducting a clinical trial testing a new oxygen-carrying blood substitute for trauma patients. The study aims to compare the survival rate of patients receiving the blood substitute with those receiving saline solution. Community outreach efforts have been made to inform the public about the trial.
Researchers have developed a second-generation targeted antibody, 806, which shows potent anti-tumor activity in animal models of human cancers that overexpress EGFR. The antibody binds specifically to activated EGFR on cancer cells, avoiding normal tissues.
A statistical model predicts rapid increase in spinal fractures over time if left untreated, highlighting the importance of intervention before first fracture occurs. The study emphasizes the need for therapy that reduces risk of first fracture within one year to substantially reduce future fracture risk.
A study found that off-pump coronary artery bypass grafting (OPCAB) had similar graft patency and clinical outcomes as conventional CABG with cardiopulmonary bypass. OPCAB also resulted in lower hospitalization costs, with a mean savings of $2,272 at discharge and $1,955 at 1 year.
A new study found that sacral nerve stimulation significantly reduces the number of weekly episodes of incontinence, from 16 to 3-2 per week after one-two years. The technique also shows an improvement in quality-of-life scores and is a safe option for patients with intact or repaired anal sphincters.
Researchers have identified SSX-2, a promising target for cancer vaccines, and found that patients mount their own immunological responses against cancer cells expressing the protein. A new early-phase clinical trial is underway to assess the safety and efficacy of an SSX-2-based vaccine.
A new study will compare patients who receive dialysis six times a week to those on the standard three-times-a-week plan. The researchers aim to determine if more frequent dialysis can prevent urea buildup, improve blood pressure, and enhance quality of life.
Researchers are testing CaHA, a calcium phosphate material, to treat vocal fold disorders such as paralysis and atrophy. The study aims to improve upon existing injection materials with better efficacy and longevity.
A Canadian study found that breast cancer patients who participated in clinical trials had a 60% lower risk of dying, compared to those who did not. Larger treatment centers also showed better survival rates, attributed to participation in research.
A new large-scale trial will test the efficacy of a genetically personalised treatment for breast cancer, using microarrays to identify specific molecular signatures. The MINDACT trial aims to spare patients at low risk of relapse from unnecessary chemotherapy, resulting in reduced side effects and healthcare costs.
A study published in The Lancet found that timely surgery significantly reduces the risk of stroke in individuals with carotid stenosis. Benefit from surgery is greatest when performed within two weeks after a warning stroke, but rapidly declines with increasing delay. Early treatment is crucial due to the high risk of major stroke in ...
Recent breast cancer trials using aromatase inhibitors (AIs) reported results early due to significant advantages over tamoxifen. However, Dr. Martine Piccart argues that this can lead to unanswered questions about long-term efficacy and side effects. She proposes new guidelines for better data collection and risk-benefit analysis.
A new study shows that preoperative anastrozole treatment can downstage tumors and allow more patients to undergo less extensive breast-conserving surgery, reducing the need for mastectomy. The treatment has been shown to be effective in improving outcomes for postmenopausal women with hormone receptor-positive breast cancer.
Older women with breast cancer often lose out on effective treatments, with prognosis not linked to tumour factor. Health policymakers need to develop strategies for elderly patients, while doctors must find suitable treatments tailored to their needs.
A new clip device has shown promising results in repairing faulty heart valves through a less invasive cath lab procedure. The device, developed by Evalve Inc., uses the edge-to-edge technique to repair or replace the mitral valve without open-heart surgery.
A study by Casa Colina Centers for Rehabilitation found that elderly patients experienced decreased pain intensity and improved sleep disturbances with once-daily Kadian dosing. The trial, KRONUS-MSP, showed a lower incidence of side effects compared to other opioids, making it an ideal option for managing chronic pain in older adults.
The Phase I study demonstrated a clear dose-response relationship between the amount of rPA102 administered and the subsequent immune response, with antibody titers continuing to increase after the second and third administration. The vaccine was well-tolerated, with no evidence of dose-limiting toxicity or reactogenicity at any dose.
Researchers at the NIH's National Eye Institute have developed a new therapy, daclizumab, that controls uveitis inflammation in seven of 10 patients over a four-year period. The therapy is well-tolerated and may allow patients to administer it to themselves at home.
A UK MP emphasizes the need to increase teenage participation in cancer clinical trials to improve survival rates. Currently, many teenagers face lengthy travel distances for treatment at specialized units, often exceeding 200 miles from their homes.
A new TB vaccine, rBCG30, is being tested in a human clinical trial to assess its safety and immune response. The vaccine, developed by Dr. Marcus Horwitz and his team at UCLA, has shown promise in preclinical trials and could potentially reduce the TB disease burden worldwide.
A study of over 50,000 patients found consistently low rates of early discharge in Belgium, France, Germany, Spain, and Poland. Despite this, the number of potentially unnecessary hospital days varied greatly between countries, with Germany having the highest rate.
The editorial highlights concerns about government over-regulation of science, highlighting the need for transparency and clarity in research funding. It emphasizes that strong and sustainable research cultures are crucial for addressing global health threats.
Researchers have identified the optimal dosage of a bat-derived clot-buster for acute ischemic stroke treatment, finding a dose of 125 micrograms per kilogram to improve neurological function scores. Carotid artery screenings in seniors may also help prevent strokes and save billions of dollars in healthcare costs.
A four-year study published by Ohio State University researchers found that attempting a vaginal birth after C-section (VBAC) is associated with increased risk of maternal morbidity and serious obstetric complications. Despite this, many women continue to opt for VBAC due to the relatively low level of risk involved.
The HABITS trial was terminated after an unacceptably high risk of recurrent breast cancer was found in women with previous breast cancer who received hormone therapy, compared to those without hormones. Women on active treatment have been advised to discontinue use.
The decline in hormone therapy (HT) use was attributed to the release of data from two long-term studies showing that HT did not protect against heart disease and may even increase the risk. The study found that women who took HT had a higher risk for heart disease and breast cancer compared to those who did not take HT.
Therapy-based rehabilitation services for stroke patients living at home reduced the odds of deteriorating in personal activities of daily living (eg. walking, dressing) by 28% and increased the ability of patients to undertake activities of daily living by 14%. These findings suggest that a therapy-based rehabilitation service could b...
A study found that half of parents did not understand randomization, with minority and less-educated parents being more likely to be confused. However, the presence of a nurse and longer conference duration were associated with improved understanding.
A new recombinant tuberculosis vaccine is being tested in a Phase I clinical trial in the United States, combining two proteins known to stimulate strong immune responses in humans. The vaccine aims to offer protection against pulmonary TB, the most contagious form of the disease.