Research on the tests that detect and monitor disease. Covers blood tests, cancer monitoring, emergency diagnostics, and new patent-pending assays.
Researchers created a blood-based test to detect both diseases, measure viral and bacterial loads, and track treatment progress. The test aims to improve patient outcomes by catching immune reconstitution inflammatory syndrome (IRIS) earlier.
Scientists at Nagoya University have discovered a reliable cancer marker, stromal cell-derived factor 4 (SDF-4), that detects gastric cancer with high accuracy. The protein is found in high levels even in patients with stage I gastric cancer, suggesting its potential for early detection.
Researchers at the University of São Paulo have tested a synthetic molecule called AD-9308, which has shown potential in treating heart failure by activating the enzyme aldehyde dehydrogenase 2. The study found that the molecule improved mitochondrial filtration, eliminating cellular pollutants and boosting heart function by up to 40%.
Researchers at Gwangju Institute of Science and Technology developed metal-enhanced fluorescence probes for rapid and accurate detection of influenza viruses. The probes showed high sensitivity and specificity, detecting the virus even at low concentrations, with a remarkable accuracy of over 99%.
A new rheumatology training program for Native American primary care physicians has expanded its reach to tribes in 15 states. The program, which includes virtual classes and case-based discussions, aims to improve diagnosis and management of rheumatoid arthritis, but faces challenges due to mistrust of accessing private health records.
Researchers introduced a cost-effective solution to correct tilt and curvature errors in two-photon polymerization 3D printing. The method uses Fourier scatterometry, which offers lower uncertainties than traditional methods, resulting in improved image quality and precision.
A study found that physicians who presented treatments for obesity as good news and an opportunity were more successful in helping patients lose weight. Patients who received counseling with a positive and optimistic tone had significantly higher weight loss outcomes compared to those who received neutral or negative advice.
Researchers found that patients with elevated NfL levels had a 91% higher risk of worsening disability with relapse within a year, and a 49% higher risk without relapse nearly two years later. The study suggests that interventions may prevent worsening symptoms by targeting nerve cell death.
A new smartphone app using the APRI+ALBI score increases the safety of liver surgery by providing an individualized risk assessment for patients prior to resection. The score offers a cheaper and less invasive option with comparable predictive power compared to standard preoperative tests.
A recent study published in Nutrients found that daily strawberry consumption can improve cognitive performance and reduce depressive symptoms in middle-aged adults. The research, led by Professor Robert Krikorian, suggests that strawberries contain antioxidants and micronutrients that may help mitigate the risk of dementia.
Researchers developed a PCR test that accurately identifies the causative agent of visceral leishmaniasis, a neglected disease affecting Brazil and Latin America. The test can detect co-infection by both Leishmania infantum and Crithidia, with infection by Crithidia more frequent than previously thought.
University of Alberta researchers have identified taurine as a key player in predicting poor clinical outcomes and treating long COVID. A predictive test and proposed supplement trial aim to minimize symptoms and improve patient outcomes.
A study of 74 children in rural Ethiopian villages found that higher exposure to fluoride was linked to more errors on drawing and memory tests. The results suggest a potential association between high fluoride levels and cognitive impairment, particularly during early brain development and childhood.
Researchers developed the SOMMA Vigor to Frailty Score to rank older adults from 0 (vigorous) to 12 (frail), predicting their resilience to stress. Patients on the high end of the continuum are up to 31 times more likely to have functional limitations.
A clinical trial in Spain found that only 1 in 3 family members of patients with colorectal cancer participate in screening, missing opportunities for early detection. The study used fecal testing and colonoscopy to screen first-degree relatives, but uptake was low.
A new multitarget stool RNA test, ColoSense, has been shown to detect colorectal neoplasia with high sensitivity and comparable specificity to existing molecular diagnostic tests. The test also demonstrated significant improvement in sensitivity relative to the fecal immunochemical test.
A new neighborhood-based care model has been shown to be effective in treating hepatitis C among injection drug users and those experiencing homelessness. The study found that 92% of participants had undetectable levels of the virus after treatment, with 84% achieving sustained virologic response.
The WVU School of Medicine and Benjamin M. Statler College of Engineering and Mineral Resources will support clinical trials and engineering technology development. The project aims to improve care and rehabilitation for people with neurological disorders through novel physician-engineer programs and human research.
A study by UC Riverside researchers found that communities of color in Inland Southern California experienced fear and mistrust of institutions due to historical, cultural, and social traumas. The study highlights the need for culturally sensitive health interventions to address these traumas and promote community-based approaches for ...
Researchers found that longer nights of better sleep correlate with improved mood, motivation, and reduced sleepiness. Irregular sleep patterns had a negative effect on mental well-being, while daytime naps may alleviate inadequate nocturnal sleep's effects.
Researchers at Queen Mary University of London developed a new organ-on-a-chip model of the human synovium to study arthritis mechanisms and develop new treatments. The three-dimensional microfluidic device successfully replicates key features of native synovium biology.
A new blood test has been developed to measure the levels of critical omega-3 fatty acids in the bloodstream, providing a convenient way to assess cardiovascular and cognitive health. The Omega-3 Index (O3I) is derived from two key fatty acids, EPA and DHA, which can be obtained only from certain dietary sources.
Researchers conducted a randomized trial in Canadian ICUs, finding that switching to small-volume blood collection tubes lowered red blood cell transfusion rates. The study suggests this change may improve patient outcomes and reduce the need for transfusions.
A world-first clinical trial published in JAMA found that using small-volume tubes reduced the need for almost one blood transfusion for every 10 patients. The study saved about 1,500 units of blood and may provide an easy way to save tens of thousands of units worldwide.
A systematic review by ISGlobal found that malaria parasite prevalence is highest in migrants from the Sub-Saharan region, particularly those from Central Africa. The study included 23 studies with a total of 4,203 participants tested for malaria parasites.
A multilevel primary care intervention, including electronic health record reminders and patient outreach, improved timely follow-up of overdue abnormal cancer screening test results for breast, cervical, colorectal, and lung cancer. The intervention was found to be effective in reducing missed screenings.
A study of over 850,000 Australian children born between 2009 and 2017 found a small increased risk of birth defects among those conceived through fertility treatment, partly attributed to parental infertility. The use of intracytoplasmic sperm injection (ICSI) was also associated with an increased risk for genitourinary abnormalities.
Researchers found that short-form videos on TikTok can inform and encourage women to get regular pap tests, particularly when created by doctors. The studies also showed that autonomy-supportive messages improved attitude toward the message and engagement intention.
A new generative AI model enhances clinical accuracy and textual quality of chest radiograph reports, surpassing traditional methods like teleradiology. Its implementation could enable timely alerts for life-threatening conditions, aiding imaging interpretation and documentation.
Researchers at the University of Massachusetts Amherst have developed a new method for DNA detection that is 100 times more sensitive than traditional methods. This breakthrough enables fast and accurate disease diagnosis, reducing wait times for lab processing from days to minutes.
Researchers at Northwestern University identified a new evolutionarily conserved RNAi-based form of cell death called Death Induced by Survival gene Elimination (DISE), which targets essential survival genes in cancer cells. This mechanism is ancient and effective against all cancers tested.
Researchers developed a new technology to test new drugs against liver diseases by recreating the real human liver environment. The model consists of live liver cells in an artificial blood vessel system, allowing for controlled testing and monitoring.
Researchers at UVA Health System have developed a powerful new tool to understand how medications affect men and women differently. The model has provided unprecedented insights into biological processes in the liver, helping ensure that new medications will not cause harmful side effects.
A new AI-powered app can detect autism in children with high accuracy, capturing a wide range of behavioral characteristics beyond eye movements. The app provides detailed information on which indicators led to its conclusions and why, enabling healthcare providers to make informed decisions.
A new approach is being developed to identify sepsis in newborn babies, with the potential to transform sepsis testing. The Neosepsis project aims to reduce neonatal deaths in Uganda by providing a quick and reliable test using a small drop of blood.
Researchers developed an integrated microfluidic chip for rapid antimicrobial susceptibility testing from positive blood cultures, reducing diagnosis time to under 3.5 hours. The chip demonstrated high accuracy in diagnosing clinical cases with a 93.3% agreement rate.
A team of researchers at ETH Zurich has developed a suction cup capable of delivering large molecule medications like peptides to the bloodstream through the mucosal lining of the cheek. The device uses an endogenous agent to fluidise cell membranes, allowing the drug to penetrate deeper tissue layers and enter the bloodstream directly.
A new study published in JAMA Network Open suggests that reattribution of pain to mind or brain processes can lead to significant reductions in chronic back pain intensity. Participants who received pain reprocessing therapy reported being pain-free or nearly so after treatment, compared to those receiving placebo controls.
A survey by The BMJ found that patients in deprived areas have limited access to vital diagnostic tests for respiratory conditions. Despite NHS promises, GPs report 'troubling' lack of services, while Asthma + Lung UK warns of acute and long-term deterioration without timely diagnosis.
Researchers found that blueberries infected with Colletotrichum fioriniae emit odors repelling spotted-wing drosophila. By recreating this aroma, farmers can trick flies into perceiving healthy fruit as infected, reducing the need for insecticides.
Over 75% of hospitalized AKI patients lack proper follow-up kidney health testing after discharge. Less than 25% have kidney function monitored with blood and urine tests within 90 days of discharge.
Researchers have developed a new flexible adhesive with improved recovery capabilities and high adhesive strength, enabling applications in foldable displays and medical devices. The adhesive demonstrated remarkable stability under repeated deformation and strain, making it suitable for fields requiring flexibility and optical clarity.
A study at the Technical University of Munich found that people with long Covid experience altered blood vessels in the eye, which could be used to diagnose the condition. Persistent inflammatory responses were also linked to symptom severity and chronic inflammation.
Researchers are creating a frailty instrument that can be used to make health decisions and personalize geriatric veterinary care for dogs. The instrument will consider physical, mental, and emotional changes associated with aging, providing a better indicator of the body's condition than age alone.
A new study using eye-tracking technology found that it can accurately predict autism diagnoses, comparable to expert clinical diagnosis. The research suggests potential for earlier diagnosis and assessment of autism in routine practice.
Scientists have developed a new finger sweat test to detect antipsychotic drugs in patients, providing a quicker and more comfortable alternative to blood draws. The test was tested on 60 patients receiving clozapine, quetiapine, or olanzapine, with promising results.
A large private laboratory is still processing finger prick tests for oestrogen levels despite warnings of unreliability. Experts raise concerns about the validation and regulation of online tests and laboratories, citing a lack of robust assessment and oversight.
A new study found that boys' sleep patterns remain stable until around age 12, suggesting that social and behavioral factors may play a role in sleep problems. After this age, changes in sleep patterns may begin to occur, making it essential for parents to seek help when needed.
This study found a correlation between hospital-onset SARS-CoV-2 infections and community-onset infections, highlighting the importance of ongoing surveillance and prevention measures. The findings suggest that hospitals should be particularly vigilant when community incidence rates are high, in order to reduce in-hospital transmission.
A KAUST researcher has created a highly sensitive glucose detector based on a thin-film transistor that can measure glucose levels in saliva with high accuracy. The device uses an enzyme to oxidize glucose present in the saliva, producing electrons that indicate the glucose concentration.
A systematic review and meta-analysis of 18 clinical trials involving 2.1 million individuals found no significant lifetime gain from common cancer screening tests. However, colorectal cancer screening with sigmoidoscopy may have a potential benefit, according to the study.
Researchers have been awarded $600K each to lead projects improving healthcare access for underserved populations, including Black women and rural/minority communities. These projects will use innovative strategies such as at-home blood pressure monitoring and telemedicine-assisted testing to address health disparities.
A team of KAUST researchers has found a critical protein that regulates cell division and proliferation in breast cancer and leukemia. Their work clears the way for the development of targeted drugs by refuting recent challenges to their approach.
A study found that China suffered an estimated 1.87 million excess deaths among individuals 30 years and older during the first two months after ending its zero COVID policy. The lifted policy led to a significant increase in mortality rates, highlighting the need for continued public health measures.
A new study found that a simple blood test can predict the risk of progressive heart and kidney disease in people with Type 2 diabetes. The test measures levels of four biomarkers, which fell after treatment with canagliflozin, a type 2 diabetes medicine.
A study found low primary care vision testing rates for children and adolescents, with lower rates among those without private insurance. Despite yearly testing recommendations, less than half of those with private insurance received testing.
Researchers at McMaster University developed a new rapid test that can quickly identify eosinophils, key drivers of severe asthma, in complex biological samples. The test uses DNAzymes to track protein signatures and is designed to be simple and adaptable for mass manufacturing.
A new study published in JAMA Ophthalmology found that vision problems are more common in older adults with dementia. The study of nearly 3,000 older adults showed that even mild vision issues were associated with a higher risk of dementia.
A study using wastewater metrics found accurate assessments of county SARS-CoV-2 incidence and may be the best metric for monitoring virus circulation. Home testing increases and vaccination treatment decrease disease acuity, making wastewater surveillance a reliable option.
Researchers develop a new technique to detect circulating tumor cells in blood, overcoming noise issues with existing methods. The dual-ratio approach enhances penetration range and accuracy, paving the way for quicker diagnosis of metastasis.