Articles tagged with Positron Emission Tomography
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Researchers have discovered that the vaccinia virus construct GLV-1h153 can be used to image and treat pancreatic cancer. The study found that hNIS-mediated radiouptake noninvasively imaged with PET provided information into tumor therapeutic response.
The Ohio Third Frontier Commission has awarded $2.5 million to advance two significant imaging research projects at the Philips Healthcare Global Advanced Imaging Innovation Center, a collaboration among University Hospitals Case Medical Center and Case Western Reserve University.
A new study by the Centre for Addiction and Mental Health found that heavy smokers who quit experience an increase in MAO-A levels, a mood-related brain protein. This finding may explain why heavy smokers are at high risk for clinical depression and provides potential targets to prevent sad mood during cigarette withdrawal.
The studies focus on positron emission tomography (PET) to differentiate between types of dementia and identify pharmaceuticals to slow dementia progression. PET scores provide a valid biomarker for monitoring Alzheimer's disease progression.
The investigational amyloid imaging agent [18F]Flutemetamol showed highly consistent image interpretation and comparable in vitro binding to Pittsburgh Compound-B, according to recent clinical research data. Flutemetamol is being studied for the detection of beta amyloid using PET brain scans.
A new PET imaging technique using [11C]erlotinib may help doctors identify lung cancers that respond well to tyrosine kinase inhibitors (TKIs), enabling personalized therapy. The test showed significantly higher tracer uptake in tumors with activating EGFR mutations, indicating a potential non-invasive predictive marker.
Joanna Fowler, a senior chemist at Brookhaven Lab, has been chosen to receive the Distinguished Women in Chemistry/Chemical Engineering Award. Her research focuses on developing radiotracers to measure changes in brain circuits disrupted by drug addiction and other brain diseases.
A study introduced at SNM's 58th Annual Meeting found that 4D PET imaging using state-of-the-art image reconstruction and motion correction significantly improves cancer detection. This method provides clearer images, especially for small lesions, allowing for more accurate diagnosis and better treatment planning.
A new molecular imaging agent has been developed to detect tumor angiogenesis, a process of rapid blood vessel growth associated with malignant cancers. The agent, which targets the CD105 protein biomarker, shows promising results in early studies, including high uptake by tumors in mice.
A new imaging agent called 18F FPPRGD2 targets breast tumor development by detecting angiogenesis, a process that forms new blood vessels in tissues. This allows for better clinical decisions and earlier identification of patients who are ideal candidates for aggressive therapies.
The study presents promising results for the clinical use of a new integrated PET/MRI system, which provides diagnostic information on soft tissues and physiological functions. The technology has been shown to be comparable in detecting cancerous tumors as conventional PET/CT methods.
Researchers combined two molecular imaging agents to create a powerful new tool for acquiring information about the extent of a patient's cancer. The results showed that combined 18F NaF and 18F FDG PET/CT imaging provided good-quality imaging of both skeletal and extra-skeletal malignant lesions from various cancers.
A study found that non-gated PET imaging with 4D computed tomography can produce more accurate tumor imaging for patients with irregular breathing. This approach may improve overall accuracy of tumor detection and inform clinicians about appropriate treatments.
Researchers found that PET/CT imaging with the radiotracer 18F-FDG successfully detected 84% of benign and malignant tumors in patients with adnexal masses. This technology helps predict cancer stage and provide better treatment options for women diagnosed with ovarian cancer.
A recent study published in The Journal of Nuclear Medicine found that PET scans can help determine earlier if treatment for tuberculosis is working or if the disease is multidrug-resistant. This technology has the potential to become a valuable clinical adjunct to genotypic and phenotypic tests, improving patient outcomes.
Researchers found that combining CT and FDG-PET images resulted in a change in tumor delineation in one out of three patients, leading to adjusted treatments in 10% of cases. This improvement was particularly notable in patients with dental inlays, where the primary tumor was not visible on CT scans alone.
A miniature, portable PET scanner has been developed to study brain function and behavior in rats while they are awake and moving freely. This breakthrough technology, dubbed RatCAP, uses a wearable design that counterbalances with springs and motion stabilizers, allowing animals significant freedom of movement.
Researchers found significant improvements in lesion detection with whole-body TOF FDG PET scans, particularly in larger patients and shorter studies. TOF scans yielded better image signal-to-noise due to travel time consideration, reducing scanning time and patient motion.
Researchers have developed methods to store billions of positrons for hours or more and cool them to low temperatures to study their properties. The largest trap for low-energy positrons is being built, capable of storing trillions of antimatter particles.
A new venue for imaging tests has been inaugurated for the PESA study, aiming to improve early detection and prevention of cardiovascular disorders. The research aims to identify risk factors and daily habits influencing atherosclerosis development.
A new study uses PET scans to image metabolic changes in thyroid cancer patients treated with vandetanib, a protein kinase inhibitor. The findings show that PET imaging can help define the therapy response and identify potential markers of treatment efficacy.
Researchers develop molecular imaging procedure to detect beta-amyloid in brains of individuals with Alzheimer's disease, increasing clinical diagnosis accuracy. The study shows a correlation between florbetapir-PET images and presence and quantity of beta-amyloid pathology at autopsy.
Researchers used PET scans to evaluate cognitive dysfunction in children with fever-induced refractory epileptic encephalopathy (FIRES), finding significant brain impairment. The study identified frontotemporal dysfunction as the cause of cognitive deterioration, paving the way for more accurate diagnosis and treatment.
A Swedish case study reveals how Alzheimer's disease progresses, with high amyloid plaque levels at early stages and declining brain energy. The discovery sheds light on the role of nicotinic receptors and neuroinflammation in the disease, offering new insights for diagnosis and treatment.
A study found that using true whole-body field view in PET/CT imaging can lead to more accurate staging and restaging of cancer patients. This increased accuracy can result in changes to treatment plans and the selection of biopsy sites, ultimately reducing unnecessary invasive procedures.
Jacob Hooker, a Brookhaven National Laboratory assistant chemist, received the Presidential Early Career Award for Scientists and Engineers. He was recognized for his research on radiochemistry and biomedical imaging, as well as his efforts to mentor and outreach to the community.
A new study reveals that men are up to twice as likely to develop alcoholism as women, with increased dopamine release in the brain contributing to this difference. The study found that men had greater dopamine release than women after consuming an alcoholic drink, which may contribute to the initial reinforcing properties of alcohol a...
SPADnet aims to create a new generation of smart image sensors for photon-starved biomedical applications, enabling scalable and efficient imaging. The project will develop ring-assembly modules for Positron Emission Tomography (PET) imaging and carry out performance tests in a PET evaluation system.
Two newer breast imaging technologies, BSGI and PEM, have been approved for clinical use despite higher cancer risks. The lifetime risk of radiation-induced cancer from BSGI and PEM exams are significantly higher than digital mammography, with estimated risks ranging from 20 to 30 times higher.
Researchers developed a novel 3D imaging approach that combines CT images with conventional ablation techniques to improve the accuracy of ventricular tachycardia treatment. The new method successfully predicted areas of abnormal electrical activity in 81.7% of heart segments analyzed.
Researchers at Risø National Laboratory are producing radioisotopes for medical diagnostics and therapy, as well as research and development of new technologies. The production has increased significantly due to growing demand from PET-CT scanning, with seven cyclotrons operating in Denmark.
The meeting showcased groundbreaking research and development worldwide in molecular imaging and nuclear medicine, with a focus on using molecular imaging to understand disease mechanisms and improve patient health. Key findings included advances in Alzheimer's disease identification and recurrent prostate cancer detection.
Researchers at the University of Granada have created a new system for early diagnosis of Alzheimer's disease using processed images. The system achieved an impressive 90% success rate in identifying patients with Alzheimer's disease.
Chester A. Mathis receives SNM's 2010 Aebersold Award for his groundbreaking work on early detection in Alzheimer's disease using positron emission tomography (PET) imaging techniques. This recognition acknowledges the significant contributions of Dr. Mathis to advancing molecular imaging and nuclear medicine.
Researchers developed a non-invasive imaging technique combining PET and CT scans without bowel preparation, detecting all significant polyps found by colonoscopy. Patients preferred this method over colonoscopy due to its comfort and lack of sedation.
The VECTor device combines microPET and microSPECT techniques to provide higher resolution and enable simultaneous imaging. This allows for more detailed analysis of cell function and disease mechanisms in experimental animal models.
Researchers at the University of Texas M. D. Anderson Cancer Center have successfully transplanted adult stem cells into injured hearts, improving pumping efficiency for a year in a mouse model. The study used innovative imaging techniques to track the stem cells' location and performance over time.
A study presented at the ARRS 2010 Annual Meeting found that FDG-PET/CT accurately confirmed a suspected colorectal cancer recurrence in 40 out of 71 patients. This early detection enables improved treatment planning and targeted patient care for those with recurrent colorectal cancer.
Researchers used FDG PET scans to identify 'cold spots' in tumors, finding that most were composed of dead cells. By reducing radiation doses to these areas, patients may experience less damage while achieving the same therapeutic effect.
Research published in The Journal of Nuclear Medicine suggests that molecular imaging using 18F-FDG PET/CT can help diagnose acute and chronic aortic dissection. This non-invasive technique can provide images to determine the difference between acute and chronic dissections, helping doctors decide the best course of treatment.
The use and costs of diagnostic imaging for Medicare patients with cancer increased substantially between 1999 and 2006. PET scans saw the largest increase, accompanied by a reduction in conventional nuclear medicine tests and stabilized CT scans.
A study by Duke University Medical Center found that imaging costs rose faster than overall cancer care for Medicare patients. The use of PET scans increased significantly, with a mean annual growth rate of 36-53% across six cancer types.
The Society of Nuclear Medicine and Molecular Imaging (SNM) has received a $48,000 grant from the Agency for Healthcare Research and Quality (AHRQ) to develop research on comparative effectiveness of PET and other molecular imaging techniques. The primary emphasis will be on cancer diagnosis and management, with cardiology and neurolog...
A new imaging technique using FDG PET can help doctors plan cardiac procedures, reducing cost and improving patient outcomes. The study found a trend toward better patient outcomes when FDG PET is used in diagnostic work-up.
A study published in the American Journal of Roentgenology found significant geographic variation in noninvasive diagnostic imaging utilization rates among Medicare beneficiaries. The study revealed that Atlanta had the highest utilization rate, while Seattle had the lowest, with a difference of over 50% between the two regions.
Researchers found that psychopaths have a hyper-reactive dopamine reward system, linked to violent crime, recidivism, and substance abuse. The study suggests that impulsive traits and heightened attraction to rewards overwhelm concerns about risk, contributing to problematic behaviors.
A study published in the Journal of the American College of Radiology found that PET scanner ownership by non-radiologists has significantly increased, outpacing radiologist-owned scans. This trend contributes to unnecessary imaging utilization and increased costs.
A new investigational drug, bapineuzumab, has been shown to reduce amyloid-β deposits in the brain by 25% in patients with mild-to-moderate Alzheimer's disease. This breakthrough finding could help assess the efficacy of other drugs for Alzheimer's treatment.
Researchers at Rice University developed an amplitude gating technique to improve PET/CT scanner efficiency. The method uses a flexible chest band to record breathing cycles during CT scans, creating sharper images with better tumor detection accuracy.
A new study provides clear pediatric PET dose guidelines, allowing clinicians to calculate the optimal radiotracer dose based on a child's weight. The findings suggest that patients can receive high-quality images with reduced scan time or lower doses, minimizing radiation exposure for young children.
A study using positron emission tomography (PET) brain scans identified different forms of Parkinsonism with high accuracy. The research found that image-based classification had excellent specificity and positive predictive value for idiopathic Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
A new imaging test has detected early Alzheimer's disease in older adults, which is likely to progress into symptomatic Alzheimer's disease. The test uses Pittsburgh Compound B (PiB) to bind to beta-amyloid plaques in the brain, identifying individuals who are at risk of developing dementia.
A recent study found that 95% of radiation oncologists utilize advanced imaging modalities like FDG-PET and MRI for target delineation. The most common technologies used were FDG-PET and MRI, with nearly 75% of respondents using one or both.
A study found that combining positron emission tomography and computed tomography (PET-CT) scans six to eight weeks after chemoradiotherapy for advanced head and neck cancer can identify patients who will respond to treatment. The test also showed high sensitivity and specificity in detecting residual disease and distant metastases.
Researchers discuss imaging techniques that may contribute to early diagnosis and advancements in treatment for Alzheimer's disease. The study highlights the potential of biomarkers like MRI and PET to identify underlying structural and functional pathology in AD, MCI, and related diseases.
A rapid decline in PET scan activity is correlated with good local tumor control and better lung cancer outcomes. Higher pre-treatment metabolic activity and tumor size are associated with increased risk of death from lung cancer.
A new study suggests that PET imaging before radiation therapy should not be used to determine areas that may benefit from higher doses of radiation. Researchers found that activity patterns in some patients changed completely after treatment, making it unreliable as a predictor.
Researchers used PET scans to identify neuroinflammation in the brains of schizophrenics and migraine sufferers, shedding light on the underlying causes of these conditions. The findings have the potential to transform diagnosis and treatment options, particularly for schizophrenia.
A new molecular imaging technique using PET imaging shows promising results in evaluating and predicting the course of endometrial carcinoma. The technique combines estrogen receptor expression imaging with 18F-FDG PET to improve diagnostic accuracy, potentially saving women from unnecessary operations and biopsies.
Scientists have developed a potential new material for diagnosing malignant melanoma with greater accuracy than current imaging agents. The substance, called fluoronicotinamides, revealed melanoma cells with high tumor-to-body contrast ratio and rapid renal clearance.