Articles tagged with Side Effects
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The combination of aliskiren and valsartan significantly lowers blood pressure in patients with hypertension, with a mean drop of 12.2mm Hg compared to 9.0mm Hg for monotherapy. However, the treatment is limited by potential life-threatening side effects, including hyperkalemia.
Researchers found that HIV protease inhibitors block an enzyme crucial for generating the structural scaffolding of the cell nucleus. This leads to an accumulation of prelamin A and causes disease phenotypes similar to those associated with genetic defects in ZMPSTE24.
A new study from Stanford Medicine found that magnesium sulfate, commonly used to arrest preterm labor, has more mild to serious side effects than the alternative treatment nifedipine. The research suggests that physicians should consider side effects when choosing which drug to prescribe.
A study of 2,046 women found that misoprostol administration under the tongue or vaginally can be effective, but sublingual administration causes more side effects. The optimal interval for vaginal administration is between three and 12 hours, while sublingual administration requires shorter intervals to minimize side effects.
Recent research confirms statins are well-tolerated and effective in reducing cardiovascular disease risk. The review highlights their impact on LDL cholesterol levels and safety profile, including rare but potential muscle-related side effects.
The study demonstrated that genotyping can optimize Quinamed dosing for improved tolerance and antitumor activity. Patients with slow acetylator genotypes showed evidence of anticancer activity in various tumor types, including prostate, ovarian, and gastrointestinal stromal tumors.
A new system, TAME, assesses toxicity burden of cancer treatments by placing adverse events into three concise risk domains: short-term toxicity, long-term effects, and mortality risk. The method has identified differences of up to 500% in acute toxicity burden between certain cancer treatments.
Most teens do not experience depression after first-time sex, but young girls and early-sex boys/girls in uncommitted relationships are at risk. The study suggests focusing on vulnerable teens rather than promoting a one-size-fits-all approach to sex education.
A team of researchers at the University of Missouri-Columbia has found that carboranes can stabilize transthyretin protein and prevent harmful plaque formation without causing negative side effects. This discovery holds promise for developing new, safer treatments for diseases like heart disease and Alzheimer's.
A recent survey reveals that almost half of US adults have never heard of probiotics, but many show interest in trying them due to intestinal health concerns. The study highlights the growing awareness and potential benefits of probiotic supplements in preventing and managing gastrointestinal issues.
A new report by Breast Cancer Action analyzes 612 women's responses to an online survey, finding nearly all reported side effects and 30% discontinued use due to intolerable side effects. The most common side effects included hot flashes, bone pain, and insomnia.
Patients treated with IMRT had significantly fewer moderate and serious side effects, including urethral stricture and catheterization, compared to those who received I-125 seed brachytherapy. The study found excellent PSA outcomes after treatment in both groups.
A study evaluating extended-field intensity-modulated radiation therapy (IMRT) for cervical cancer found that it resulted in significantly reduced side effects and comparable outcomes to standard radiotherapy. The treatment enabled patients to receive full therapeutic doses with less debilitating side effects.
New research reveals men treated with IMRT experience fewer long-term gastrointestinal side effects, despite higher radiation doses. The study found no significant difference in genitourinary side effects between the two treatments.
A recent study suggests that young breast cancer patients who receive chemotherapy may experience a higher number of serious side effects than previously reported. These side effects result in significantly higher healthcare expenditures for the affected individuals.
Patients with atrial fibrillation have a five times higher stroke risk than those without the condition. Warfarin has been shown to reduce stroke risk by a significant margin, outperforming alternative treatments like aspirin and clopidogrel in reducing stroke rates by nearly two-thirds.
Researchers found that inhibiting an enzyme in the liver, CPT1A, improved feeding behavior and blood sugar levels in obese rats. The study suggests a biochemical pathway involved in nutrient sensing may play a critical role in diet-induced obesity and insulin resistance.
A new study suggests a calcium phosphate-based supplement improves bone strength and thickness in rats with mineral deficiency-induced osteoporosis. The Mg/Zn/F-CaP supplement showed substantial improvement in bone properties without the side effects of current pharmaceutical treatments.
A new study suggests that lower doses of the clot-busting drug tPA can effectively treat intracerebral hemorrhage without increasing bleeding risks, with mortality rates dropping to 13 percent in some cases. The findings are promising for patients who suffer from this type of stroke, which affects over 100,000 Americans annually.
The study found that all 55 percent of plastic surgery patients using herbal supplements took at least two different supplements daily, posing bleeding, respiratory, and immunosuppression risks. Patients should inform doctors about natural supplements to ensure safe discontinuation periods and smooth recoveries.
Researchers found that Viagra's inhibition of PDE6 enzyme causes transient losses in sensitivity to flicker, with severe cases showing almost doubled integration times. This unique effect enables scientists to study the role of PDE6 in vision and light adaptation.
Researchers found that MMF was superior to traditional treatment in inducing complete remission and had fewer severe side effects. The new findings offer hope for improving quality of life for millions of people worldwide suffering from lupus.
A new study published in the New England Journal of Medicine suggests that CellCept, a potential treatment for lupus nephritis, holds promise for improving quality of life for those affected by severe kidney disease. The results offer hope for patients who currently suffer debilitating side effects from traditional treatments.
A nationwide survey found that 54% of NSAID users were unaware of potential side effects, and 18% had previously experienced complications. The study emphasizes the need for patient and physician education to prevent unnecessary complications from painkiller misuse.
A new study by Regino González-Peralta and colleagues found that interferon in combination with ribavirin is an effective treatment for childhood chronic hepatitis C, with sustained virologic response rates higher than those using interferon alone. Common side effects were mild, but severe adverse events occurred in some children.
Researchers have found a dose-response relationship between IMRT volume and oral mucositis severity in head and neck cancer patients. Constricting IMRT dose can lessen toxic effects of treatment, reducing side effects for patients.
Researchers developed a hyper-responsive Stat1 molecule to amplify the body's immune response without side effects. This improvement could lead to treatments for viral infections, cancer, and other conditions with lower doses of interferon.
The Phase II clinical trial of belatacept found that it preserved kidney function and reduced the incidence of acute rejection in transplant patients. Belatacept selectively blocks T-cell activation while allowing the body to fight off infections.
Researchers analyzed AERS reports for rosuvastatin and compared them to other statins, finding a higher rate of muscle and kidney complications. The absolute risk of AERS appears low, with most side effects disappearing upon withdrawal of medication.
Researchers found changes in prefrontal brain function during a placebo lead-in predicted adverse effects in subjects who received an antidepressant. This study's unique design uses quantitative electroencephalography (QEEG) imaging technique cordance to identify individuals at risk of side effects.
A six-year review of DETROL LA data found significant symptom reduction for overactive bladder patients, including improved quality of life measures. The medication was associated with a low frequency of side effects, particularly dry mouth.
Researchers have found that certain antipsychotic drugs can prevent brain cells from becoming infected with the JC virus, which causes PML. The discovery opens up new avenues for therapy and may lead to effective treatments or prevention methods.
Researchers found GVG effective in reducing drug use in heavy users for up to four consecutive weeks. No subjects developed visual field defects despite high doses used.
A review of herbal and nutritional supplements found eight products associated with clinically significant ocular side effects, including ginkgo biloba, Echinacea purpurea, chamomile, licorice, canthaxanthine, Datura, niacin, and vitamin A. The side effects range from dry eye to retinal hemorrhages and transient visual loss.
A study published in Archives of Pediatric Adolescent Medicine found that antipsychotic medication prescriptions for children with attention-deficit/hyperactivity disorder (ADHD) increased dramatically between 1996 and 2001, from 23 per 10,000 to 45 per 10,000. The use of these medications for ASDHD/conduct disorders also rose signific...
Cancer patients anticipate an average of 8.7 symptoms, with fatigue, nausea, and hair loss being the most common expected side effects. The study identifies characteristics of patients who expect more side effects, including age, gender, educational background, and type of cancer.
A study by Yale University researchers found that patients with knee arthritis prefer safer treatment options despite potential reduced efficacy. Older patients rarely opt for anti-inflammatory drugs, indicating the importance of considering individual preferences in treatment decisions.
Researchers found that bicalutamide treatment resulted in increased bone mineral density, reduced body fat, and fewer side effects compared to leuprolide. This study suggests a single-drug treatment plan using bicalutamide may be an attractive alternative for men with non-metastatic prostate cancer.
Researchers at Fox Chase Cancer Center have discovered genetic markers that can predict how well patients with colorectal cancer will respond to certain chemotherapy drugs. The study found that variations in genes involved in metabolizing irinotecan may be useful predictors of response and side effects.
Scientists discovered that the Sirt1 mammalian gene promotes fat mobilization in mice, revealing a potential molecular link between calorie restriction and longevity. The study suggests that mimicking this effect with a drug could lead to health benefits without dieting.
Researchers found that consumer awareness of NSAID side effects has increased over time, but many patients still take excessive doses, putting themselves at risk for serious complications. The study emphasizes the need for education and discussion with physicians to recognize risk factors and prevent adverse reactions.
A study on tablet splitting found that the practice can lead to significant weight variability and uneven drug content, potentially putting patients at risk of experiencing side effects. Researchers recommend taking the prescribed dose as intended to ensure consistent medication amounts.
A randomized study shows rifaximin to be highly effective in preventing all forms of diarrhea and intestinal symptoms in healthy adults traveling to high-risk areas. The medication was also found to prevent chronic diarrhea and irritable bowel syndrome in some individuals, making it a promising treatment for travelers.
The Department of Defense Smallpox Vaccination Program reported over 50 cases of myopericarditis, a heart muscle inflammation, following vaccination. Most soldiers experiencing complications have recovered well with therapy, but researchers stress the need for further study to better understand potential cardiac risks.
A compound found in orange and tangerine peels has shown promise as a natural alternative for lowering LDL cholesterol without side effects. The compound, called polymethoxylated flavones (PMFs), was found to lower cholesterol levels by 32-40% in animal studies.
A University of Michigan study found that most prostate cancer treatment guides overlook key details and favor active treatment over watchful waiting. The researchers recommend complete information on risks and benefits, clear writing styles, and visual elements to engage readers.
Scientists are developing a new anthrax vaccine that requires fewer shots and has fewer side effects. The study aims to improve upon the existing vaccine, which causes numerous side effects and takes 18 months to confer protection.
A study of 42 people found that those taking CoQ10 had significantly fewer migraine attacks than those taking a placebo, with 48% experiencing half as many attacks. The only side effect reported was an allergic skin rash in one patient.
A new study from the Mayo Clinic found that pyridostigmine improves standing blood pressure without increasing blood pressure when lying down, offering a safe treatment option for patients with orthostatic hypotension. The study involved 29 patients who were satisfied with the drug's effects, with 17 taking it as their primary treatment.
A new study published in Urology found that men taking AVODART for four years experienced a significant reduction in urinary symptoms and prostate volume, with an average symptom improvement of 6.1 points on the AUA-SI. Long-term treatment also resulted in low incidence of drug-related side effects.
A recent study by mathematicians and economists found that National League pitchers are more likely to throw inside pitches, increasing the risk of hitting batters. This 'moral hazard' theory suggests that the rule's impact is not due to lower costs for NL pitchers, but rather their fear of retaliation when stepping up to bat.
A new study demonstrates the benefits of Risperdal Consta in young adults with schizophrenia, improving symptoms and reducing side effects. The treatment showed significant satisfaction and improvement in health-related quality of life, making it a promising option for patients.
A recent study found that biological DMARDs significantly increase the risk of serious hepatic events. The study showed no such link with leflunomide or traditional DMARDs, suggesting further investigation is needed.
A study of 1,204 men treated with radiation therapy found that hormone therapy significantly increases the risk of moderate to severe genitorurinary and gastrointestinal side effects. Hormone therapy can extend lives but complicates treatment decision-making.
Researchers found that variations in genes related to serotonin receptors and liver enzyme CYP2D6 impact antidepressant efficacy and side effects. The study suggests personalized treatment approaches based on individual genetic profiles.
A study of 5,016 children with cancer found that five-year survival rates increased from 23% in the 1960s to 70% in the 1990s. However, many survivors experience long-term side effects, such as reduced growth hormone production and cardiac problems.
Combining herbal supplements with regular medication without consulting a doctor can lead to adverse interactions. Patients should discuss their herbal supplement use with their primary physician to ensure safe treatment and prevent unexpected complications.
A study found that applying a non-steroidal anti-inflammatory drug cream to the skin reduced muscle soreness by 37-45% in healthy males after exercise. This method avoids systemic side effects associated with oral NSAID use, which are common among patients.
Researchers have developed a glycosylated enkephalin that appears promising in studies using mice, triggering behavior consistent with reduced addiction and fewer side effects than morphine. The compound interacts with both mu and delta receptors to increase analgesic strength while limiting narcotic side effects.
A recent study published in the New England Journal of Medicine reveals that two types of medications used to treat osteoporosis and certain cancers can cause inflammation in the eyes, leading to vision loss or blindness if left untreated. The research found that almost 100 patients experienced blurred vision, pain, and swelling as a r...