Articles tagged with Side Effects
A new study found that six months of steroid treatment didn't reduce relapse rates or side effects in children with nephrotic syndrome, challenging previous assumptions about optimal treatment strategies. The research highlights the need for new treatment strategies to prevent frequent relapses in this disease.
A new stem cell-derived system can identify cardiotoxic effects in experimental drugs early, potentially saving time and lives. The assay uses fluorescent imaging to monitor calcium ion levels during contractions, revealing beat rate and pattern irregularities.
A recent study published in the Journal of the National Cancer Institute found that proton radiotherapy provides minimal relief from side effects such as incontinence and erectile dysfunction compared to standard radiation treatment IMRT. The study revealed no long-term benefits for proton therapy, despite high costs.
Researchers at Emory University School of Medicine have obtained a detailed molecular picture that shows how glucocorticoid hormones shut off key immune system genes. The finding could help guide drug discovery efforts aimed at finding new anti-inflammatory drugs with fewer side effects.
A new study published in Arthritis Research & Therapy shows lenalidomide to be a safe and effective alternative treatment for refractory cutaneous lupus erythematosus, with significant clinical improvement in most patients. The treatment's efficacy is comparable to thalidomide but with lower toxicity.
A new antidepressant drug called GLYX-13 has shown significant reductions in depression symptoms within hours, with positive effects lasting an average of seven days from a single dose. The novel therapeutic targets brain receptors responsible for learning and memory.
Athletes are vulnerable to extreme heat or cold, which can cause hypothermia, frostbite, heat edema, heat syncope, and even life-threatening conditions. Team physicians play a crucial role in educating coaches and athletes on the risks of exposure and how to prevent these injuries.
Researchers have developed a method to study hepatitis C medication side effects in Petri dishes and test tubes, potentially paving the way for safer treatments. The technique could help identify medications that eliminate all adverse effects and aid in personalized medicine.
Nearly half of patients with chronic conditions don't follow prescribed medication regimens, increasing risk of side effects, hospitalizations, and reduced quality of life. Patients' beliefs about the causes of high blood pressure and treatment alternatives significantly affect their adherence to medications.
Researchers at Texas A&M University have discovered a compound called JQ1 that inhibits sperm production and mobility without any side effects. The finding is promising for the development of a male birth control pill, with potential human trials on the horizon.
A study published in PLoS ONE found that statin potency is a critical determinant of muscle-related side effects. Stronger statins like rosuvastatin were associated with higher rates of reported problems, highlighting the need for greater caution when prescribing these medications.
Researchers have confirmed that normalizing blood vessels by blocking oxygen sensor PHD2 can make chemotherapy more effective. This strategy also reduces the harmful side effects of chemotherapy on healthy organs.
Research finds that men experiencing persistent sexual side effects while on finasteride have a high prevalence of depressive symptoms (11-36%) and suicidal thoughts (44%). Former finasteride users with these side effects are at risk for mental health issues.
A 32-country study found that linagliptin, a DPP-4 inhibitor, is effective in improving glycaemic control without weight gain or increased risk of hypoglycemia. The extended trial demonstrated sustained glucose control for up to 102 weeks treatment duration.
A new study published in Drug Testing and Analysis found that DMAA, a stimulant in many pre-workout supplements, does not originate from natural substances but is comprised of synthetic compounds. The FDA should regulate and/or ban products with significant amounts of synthetic pharmacological compounds added.
A comprehensive review of 24 studies found acetazolamide has limited effectiveness unless baseline AMS risk is high, and some side effects occur at low doses. The authors suggest tailoring treatment to individual risk and acceptability of common side effects.
A device used to prevent incontinence in women after pelvic-floor surgery shows promise, reducing symptoms but increasing side effects. Researchers suggest counseling women on risks and benefits prior to the procedure.
A new computer model has successfully predicted negative side effects in hundreds of current drugs by analyzing their chemical structures and known side-effect molecules. The model identified potential side effects for 151 previously unknown compounds, including a synthetic form of estrogen that causes stomach pain.
An investigational diabetes drug appears to improve insulin sensitivity in mice without the troublesome side effects of current medications, such as weight gain and bone fractures. The drug works through a different pathway, targeting mitochondria instead of PPARγ receptors.
Researchers have identified methylglyoxal as the culprit behind increased pain sensitivity in diabetics. The team proposes using small peptides to target and reduce MG activity, leading to a reduction in pain.
A Kaiser Permanente study found that younger girls are more likely to report side effects after receiving the HPV vaccine, but these side effects are generally non-serious. The study suggests that educating young girls and their parents about what to expect from the vaccine can help alleviate fears and improve vaccination rates.
Researchers aim to create targeted compounds that selectively attack cancerous cells by zeroing-in on pollutants produced by tumors' characteristic metabolism. This approach seeks to minimize side effects associated with conventional chemotherapy.
Researchers found a strong correlation between genetic variation and chemotherapy side effects, enabling personalized treatment approaches. This study aims to tailor chemotherapy regimens to individual patients' genetic profiles.
Researchers have developed a mutated version of the IL-2 protein that enhances its anti-cancer efficacy while reducing severe side effects. The new molecule, dubbed Super-2, has been shown to outperform natural IL-2 in slowing tumor growth and minimizing pulmonary edema.
A large cross-sectional survey of 2325 Canadian men aged 55-97 years old found that mobility impairments, memory loss, and medication side effects were top health concerns. However, only a minority reported receiving adequate counseling on these issues, highlighting important gaps in healthcare.
Researchers found that mild hypothermia (34C) can offset the damage caused by tPA treatment in rats, reducing swelling and damaged tissue after a stroke. The therapy may also increase the time window for tPA treatment, potentially benefiting patients who experience significant brain function loss.
Researchers aim to create potent pain relievers with reduced side effects by studying four new compounds that avoid recruiting the protein beta arrestin 2. Genetic studies have shown animal models lacking beta-arrestins experience robust pain relief with diminished side effects.
A team at Karolinska Institutet has generated a map of the effects of small molecules on PARP1 and other proteins, which may explain putative side effects and contribute to new cancer therapies. The study's results provide unique insights into specificity and cross-reactivity of PARP inhibitors.
A study with mice suggests Alzheimer's drugs could miswire neurons, interfering with brain communication. The findings imply that these drugs might impair memory, even at doses intended to reduce amyloid plaques.
A new study by the University of Leicester found that combining anti-obesity drugs with a modified lifestyle is effective in reducing weight and body mass index. Lifestyle advice alone was also shown to lead to weight loss at 6 and 12 months, highlighting the importance of balanced diet and exercise for weight management.
Researchers recommend a stop-and-go approach to balance oxaliplatin dose with neurological side effects, maximizing effectiveness while minimizing harm. Supplements such as calcium and magnesium may mitigate drug damage, improving patient outcomes.
Researchers found that antipsychotics activate the TGFbeta pathway, leading to metabolic side effects, while drugs without these effects do not. The study suggests a new approach to developing safer therapeutics for bipolar disorder and schizophrenia patients.
Researchers treated 17 patients with trigeminal neuralgia using Cyberknife radiosurgery, resulting in partial or complete relief from symptoms for 14 patients. The procedure offered a viable alternative to invasive approaches, with no major complications reported.
A new study found that patients who quickly stop taking immunosuppressive prednisone after receiving a kidney transplant avoid experiencing serious prednisone-related side effects. The study also showed that rapid discontinuation of prednisone does not jeopardize the long-term survival of patients and their new organs.
A new study by Northwestern University finds that joint pain is the most common reason for women to stop taking aromatase inhibitors, a common breast cancer medication. The research also highlights a gap between clinicians' reported side effects and women's actual experiences.
Researchers at the University of Warwick have developed synthetic helix-shaped molecules that target MRSA and E-coli with low toxicity. The 'flexicates' harness chirality to create targeted treatments.
A study published in Annals of Oncology found that nearly half of male breast cancer patients on tamoxifen experience significant side effects, including weight gain and sexual dysfunction. The research highlights the need for better understanding and awareness of treatment risks and benefits.
A large study found that 53% of male breast cancer patients experience tamoxifen-related side effects, leading to early discontinuation. The study suggests that these patients may be at increased risk of cancer recurrence.
Researchers at UCLA have developed a promising new treatment for iron overload disorders using minihepcidin peptides, which mimic the natural protein hepcidin to lower iron levels in the blood. The study provides hope for individuals affected by hereditary hemochromatosis and beta-thalassemia.
Researchers at Oregon Health & Science University discovered that calcineurin inhibitors spurs the production of a natural protein in the kidney, leading to hypertension. A thiazide diuretic drug blocks this protein, reducing hypertension in mice and showing promise for transplant patients with similar issues.
A new study found that humor therapy reduces agitation in dementia patients by 20%, comparable to widely used antipsychotic drugs. This approach also improves happiness and positive behaviors, but effects are short-lived once the program ends.
A new study has shown that a 24-week treatment course for hepatitis C is just as effective as a 48-week regimen for many patients. The study included 540 patients with chronic genotype 1 hepatitis C who had not previously been treated or could not be successfully treated with current standard of care.
Researchers have discovered a new class of anti-diabetic compounds that target a unique molecular switch, potentially offering fewer side effects than existing drugs. The new compound, SR1664, blocks Cdk5's action on PPARG and shows improved blood sugar levels without weight gain or fluid retention.
A new study found that fast disclaimers can harm purchase intentions for unknown or distrusted brands, while trusted brands can use them without issue. Advertisers promoting trusted brands may save time by using fast disclaimers, but regulators need to consider the impact on consumer trust and advertising policies.
The THRIVE and ECHO phase 3 trials showed that rilpivirine is non-inferior to efavirenz with a better side-effect profile, but had a higher incidence of virological failures. Rilpivirine was found to be effective in suppressing HIV virus levels in patients starting treatment for the first time.
A large cohort study of over 13,000 people aged 65 and over found that those taking medications with anticholinergic properties had a higher risk of dying and experiencing cognitive impairment. The study suggests that clinicians should review medication regimens regularly to minimize harm.
A meta-analysis of 10 randomized clinical trials found that topiramate-treated patients lost 11.8 pounds more on average than placebo group members, with a higher success rate for weight loss over 28 weeks.
Researchers found that complex drug labels contain an average of 70 side effects, with antidepressants and newer treatments having the most reactions. The study aims to improve patient safety by presenting information efficiently to healthcare providers.
A new study suggests that damage to surrounding tissue during chemoradiation for high-grade glioma may play a role in determining long-term outcome and overall survival. Patients who experienced fewer side effects lived 4 months longer compared to those who did not.
Dr. Bryan Roth has received the PhRMA Foundation Award in Excellence in Pharmacology/Toxicology for his groundbreaking research on drug discovery and development. His work aims to understand how central nervous system drugs affect brain neurons and mitigate side effects, particularly for conditions like schizophrenia and depression.
Patients with CML taking imatinib in remission after two years have a mortality rate similar to the general population. Despite side effects, survival rates remain high even after eight years of treatment.
Research on Prozac reveals it can reorganize brain plasticity by altering neuronal cell activity and connections in the hippocampus. This changes may contribute to anxiety symptoms experienced by some patients.
A Yale University study found that older adults are unwilling to take medications for heart disease prevention if they have potential side effects, such as fatigue or nausea. In contrast, most participants would take the medication if it had no adverse effects and offered an average risk reduction.
Researchers identify two distinct neuronal signaling pathways activated by Imiquimod, a topical cream that treats skin diseases while inducing severe itching as a side effect. The study may lead to designing future drugs that effectively treat targeted conditions while blocking problematic itching and scratching.
Researchers found that 5a-reductase inhibitors, used to treat BPH and hair loss, can cause significant adverse effects in some individuals, including loss of libido, erectile dysfunction, and depression. The study suggests that caution should be exercised before prescribing these medications to patients.
A new study published in CMAJ found that people over 65 undergoing latent tuberculosis infection therapy are at a higher risk of severe adverse reactions requiring hospitalization. The study provides age-stratified estimates of the risk of these events, accounting for comorbidities and similar health events in the general population.
A team of researchers has discovered a way to target and block the enzyme beta glucuronidase, which causes severe diarrhea in patients taking CPT-11, a widely used colon cancer treatment. The breakthrough approach could improve anticancer drug efficacy and tolerance without harming beneficial gut bacteria.
Researchers at Fox Chase Cancer Center found that precisely targeted radiation therapy is a safe and effective treatment for paranasal sinus cancer, controlling the disease with fewer serious side effects. The study used intensity-modulated radiation therapy (IMRT) to minimize damage to surrounding healthy tissues.
Researchers at Fox Chase Cancer Center found that hypofractionated radiation therapy does not increase urinary or gastrointestinal problems. This new treatment approach delivers a higher total dose of radiation in fewer sessions, without compromising quality of life.
A new study from the University of Pennsylvania School of Medicine found that intensity modulated radiation therapy (IMRT) minimizes gastrointestinal complications in prostate cancer patients. The study compared IMRT to three-dimensional conformal radiotherapy and found that men treated with IMRT had fewer serious bowel complications.