Articles tagged with Side Effects
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study published in PLoS ONE found that statin potency is a critical determinant of muscle-related side effects. Stronger statins like rosuvastatin were associated with higher rates of reported problems, highlighting the need for greater caution when prescribing these medications.
Researchers have confirmed that normalizing blood vessels by blocking oxygen sensor PHD2 can make chemotherapy more effective. This strategy also reduces the harmful side effects of chemotherapy on healthy organs.
Research finds that men experiencing persistent sexual side effects while on finasteride have a high prevalence of depressive symptoms (11-36%) and suicidal thoughts (44%). Former finasteride users with these side effects are at risk for mental health issues.
A 32-country study found that linagliptin, a DPP-4 inhibitor, is effective in improving glycaemic control without weight gain or increased risk of hypoglycemia. The extended trial demonstrated sustained glucose control for up to 102 weeks treatment duration.
A new study published in Drug Testing and Analysis found that DMAA, a stimulant in many pre-workout supplements, does not originate from natural substances but is comprised of synthetic compounds. The FDA should regulate and/or ban products with significant amounts of synthetic pharmacological compounds added.
A comprehensive review of 24 studies found acetazolamide has limited effectiveness unless baseline AMS risk is high, and some side effects occur at low doses. The authors suggest tailoring treatment to individual risk and acceptability of common side effects.
A device used to prevent incontinence in women after pelvic-floor surgery shows promise, reducing symptoms but increasing side effects. Researchers suggest counseling women on risks and benefits prior to the procedure.
A new computer model has successfully predicted negative side effects in hundreds of current drugs by analyzing their chemical structures and known side-effect molecules. The model identified potential side effects for 151 previously unknown compounds, including a synthetic form of estrogen that causes stomach pain.
An investigational diabetes drug appears to improve insulin sensitivity in mice without the troublesome side effects of current medications, such as weight gain and bone fractures. The drug works through a different pathway, targeting mitochondria instead of PPARγ receptors.
Researchers have identified methylglyoxal as the culprit behind increased pain sensitivity in diabetics. The team proposes using small peptides to target and reduce MG activity, leading to a reduction in pain.
A Kaiser Permanente study found that younger girls are more likely to report side effects after receiving the HPV vaccine, but these side effects are generally non-serious. The study suggests that educating young girls and their parents about what to expect from the vaccine can help alleviate fears and improve vaccination rates.
Researchers aim to create targeted compounds that selectively attack cancerous cells by zeroing-in on pollutants produced by tumors' characteristic metabolism. This approach seeks to minimize side effects associated with conventional chemotherapy.
Researchers found a strong correlation between genetic variation and chemotherapy side effects, enabling personalized treatment approaches. This study aims to tailor chemotherapy regimens to individual patients' genetic profiles.
Researchers have developed a mutated version of the IL-2 protein that enhances its anti-cancer efficacy while reducing severe side effects. The new molecule, dubbed Super-2, has been shown to outperform natural IL-2 in slowing tumor growth and minimizing pulmonary edema.
A large cross-sectional survey of 2325 Canadian men aged 55-97 years old found that mobility impairments, memory loss, and medication side effects were top health concerns. However, only a minority reported receiving adequate counseling on these issues, highlighting important gaps in healthcare.
Researchers found that mild hypothermia (34C) can offset the damage caused by tPA treatment in rats, reducing swelling and damaged tissue after a stroke. The therapy may also increase the time window for tPA treatment, potentially benefiting patients who experience significant brain function loss.
Researchers aim to create potent pain relievers with reduced side effects by studying four new compounds that avoid recruiting the protein beta arrestin 2. Genetic studies have shown animal models lacking beta-arrestins experience robust pain relief with diminished side effects.
A team at Karolinska Institutet has generated a map of the effects of small molecules on PARP1 and other proteins, which may explain putative side effects and contribute to new cancer therapies. The study's results provide unique insights into specificity and cross-reactivity of PARP inhibitors.
A study with mice suggests Alzheimer's drugs could miswire neurons, interfering with brain communication. The findings imply that these drugs might impair memory, even at doses intended to reduce amyloid plaques.
A new study by the University of Leicester found that combining anti-obesity drugs with a modified lifestyle is effective in reducing weight and body mass index. Lifestyle advice alone was also shown to lead to weight loss at 6 and 12 months, highlighting the importance of balanced diet and exercise for weight management.
Researchers recommend a stop-and-go approach to balance oxaliplatin dose with neurological side effects, maximizing effectiveness while minimizing harm. Supplements such as calcium and magnesium may mitigate drug damage, improving patient outcomes.
Researchers found that antipsychotics activate the TGFbeta pathway, leading to metabolic side effects, while drugs without these effects do not. The study suggests a new approach to developing safer therapeutics for bipolar disorder and schizophrenia patients.
A new study found that patients who quickly stop taking immunosuppressive prednisone after receiving a kidney transplant avoid experiencing serious prednisone-related side effects. The study also showed that rapid discontinuation of prednisone does not jeopardize the long-term survival of patients and their new organs.
Researchers treated 17 patients with trigeminal neuralgia using Cyberknife radiosurgery, resulting in partial or complete relief from symptoms for 14 patients. The procedure offered a viable alternative to invasive approaches, with no major complications reported.
A new study by Northwestern University finds that joint pain is the most common reason for women to stop taking aromatase inhibitors, a common breast cancer medication. The research also highlights a gap between clinicians' reported side effects and women's actual experiences.
Researchers at the University of Warwick have developed synthetic helix-shaped molecules that target MRSA and E-coli with low toxicity. The 'flexicates' harness chirality to create targeted treatments.
A study published in Annals of Oncology found that nearly half of male breast cancer patients on tamoxifen experience significant side effects, including weight gain and sexual dysfunction. The research highlights the need for better understanding and awareness of treatment risks and benefits.
A large study found that 53% of male breast cancer patients experience tamoxifen-related side effects, leading to early discontinuation. The study suggests that these patients may be at increased risk of cancer recurrence.
Researchers at UCLA have developed a promising new treatment for iron overload disorders using minihepcidin peptides, which mimic the natural protein hepcidin to lower iron levels in the blood. The study provides hope for individuals affected by hereditary hemochromatosis and beta-thalassemia.
Researchers at Oregon Health & Science University discovered that calcineurin inhibitors spurs the production of a natural protein in the kidney, leading to hypertension. A thiazide diuretic drug blocks this protein, reducing hypertension in mice and showing promise for transplant patients with similar issues.
A new study found that humor therapy reduces agitation in dementia patients by 20%, comparable to widely used antipsychotic drugs. This approach also improves happiness and positive behaviors, but effects are short-lived once the program ends.
A new study has shown that a 24-week treatment course for hepatitis C is just as effective as a 48-week regimen for many patients. The study included 540 patients with chronic genotype 1 hepatitis C who had not previously been treated or could not be successfully treated with current standard of care.
Researchers have discovered a new class of anti-diabetic compounds that target a unique molecular switch, potentially offering fewer side effects than existing drugs. The new compound, SR1664, blocks Cdk5's action on PPARG and shows improved blood sugar levels without weight gain or fluid retention.
A new study found that fast disclaimers can harm purchase intentions for unknown or distrusted brands, while trusted brands can use them without issue. Advertisers promoting trusted brands may save time by using fast disclaimers, but regulators need to consider the impact on consumer trust and advertising policies.
The THRIVE and ECHO phase 3 trials showed that rilpivirine is non-inferior to efavirenz with a better side-effect profile, but had a higher incidence of virological failures. Rilpivirine was found to be effective in suppressing HIV virus levels in patients starting treatment for the first time.
A large cohort study of over 13,000 people aged 65 and over found that those taking medications with anticholinergic properties had a higher risk of dying and experiencing cognitive impairment. The study suggests that clinicians should review medication regimens regularly to minimize harm.
A meta-analysis of 10 randomized clinical trials found that topiramate-treated patients lost 11.8 pounds more on average than placebo group members, with a higher success rate for weight loss over 28 weeks.
Researchers found that complex drug labels contain an average of 70 side effects, with antidepressants and newer treatments having the most reactions. The study aims to improve patient safety by presenting information efficiently to healthcare providers.
A new study suggests that damage to surrounding tissue during chemoradiation for high-grade glioma may play a role in determining long-term outcome and overall survival. Patients who experienced fewer side effects lived 4 months longer compared to those who did not.
Dr. Bryan Roth has received the PhRMA Foundation Award in Excellence in Pharmacology/Toxicology for his groundbreaking research on drug discovery and development. His work aims to understand how central nervous system drugs affect brain neurons and mitigate side effects, particularly for conditions like schizophrenia and depression.
Patients with CML taking imatinib in remission after two years have a mortality rate similar to the general population. Despite side effects, survival rates remain high even after eight years of treatment.
Research on Prozac reveals it can reorganize brain plasticity by altering neuronal cell activity and connections in the hippocampus. This changes may contribute to anxiety symptoms experienced by some patients.
A Yale University study found that older adults are unwilling to take medications for heart disease prevention if they have potential side effects, such as fatigue or nausea. In contrast, most participants would take the medication if it had no adverse effects and offered an average risk reduction.
Researchers identify two distinct neuronal signaling pathways activated by Imiquimod, a topical cream that treats skin diseases while inducing severe itching as a side effect. The study may lead to designing future drugs that effectively treat targeted conditions while blocking problematic itching and scratching.
Researchers found that 5a-reductase inhibitors, used to treat BPH and hair loss, can cause significant adverse effects in some individuals, including loss of libido, erectile dysfunction, and depression. The study suggests that caution should be exercised before prescribing these medications to patients.
A new study published in CMAJ found that people over 65 undergoing latent tuberculosis infection therapy are at a higher risk of severe adverse reactions requiring hospitalization. The study provides age-stratified estimates of the risk of these events, accounting for comorbidities and similar health events in the general population.
A team of researchers has discovered a way to target and block the enzyme beta glucuronidase, which causes severe diarrhea in patients taking CPT-11, a widely used colon cancer treatment. The breakthrough approach could improve anticancer drug efficacy and tolerance without harming beneficial gut bacteria.
Researchers at Fox Chase Cancer Center found that precisely targeted radiation therapy is a safe and effective treatment for paranasal sinus cancer, controlling the disease with fewer serious side effects. The study used intensity-modulated radiation therapy (IMRT) to minimize damage to surrounding healthy tissues.
Researchers at Fox Chase Cancer Center found that hypofractionated radiation therapy does not increase urinary or gastrointestinal problems. This new treatment approach delivers a higher total dose of radiation in fewer sessions, without compromising quality of life.
A new study from the University of Pennsylvania School of Medicine found that intensity modulated radiation therapy (IMRT) minimizes gastrointestinal complications in prostate cancer patients. The study compared IMRT to three-dimensional conformal radiotherapy and found that men treated with IMRT had fewer serious bowel complications.
A study found that intensity modulated radiation therapy (IMRT) minimizes side effects of prostate cancer treatment, particularly gastrointestinal complications. In contrast, urinary side effects did not differ significantly between the two treatments.
Research finds that patients receiving a combination of ketamine and propofol have a faster recovery time and less severe side effects compared to using ketamine alone. The study, conducted by Drs. Amit Shah et al., included 136 children treated in the Paediatric Emergency Department.
A new study found that intravenous aspirin was associated with a 25% reduction in pain scores and moderate effectiveness in treating severe headaches. The treatment had six percent side effects, mostly nausea and vomiting.
The study aims to determine the best balance between effective treatment and side effects for children with Duchenne muscular dystrophy. The researchers will assess the breathing capacity, satisfaction levels, and muscle function of patients, using three steroid treatments: prednisone, deflazacort, and a combination of both.
A study by Yale University researchers found that a combination of four herbs reduced gastrointestinal side effects of chemotherapy in mice while increasing the effectiveness of cancer treatment. The herbal formula PHY906 enhanced anti-tumor activity and promoted intestinal cell regeneration.
A new study published in Neurology found that lithium is not effective in treating amyotrophic lateral sclerosis (ALS) due to a high dropout rate and serious side effects. The research involved 171 people with ALS, but showed no difference between those receiving therapeutic or subtherapeutic doses of lithium.
Researchers have developed a new drug that targets peripheral CB1R, reducing glucose and fat levels in the blood without causing weight loss or neurological side effects. This approach aims to reduce health risks associated with obesity, but caution is needed to ensure the drug does not access the brain.
A study found that patients report 20 times more side effects from depression medication than psychiatrists record in charts. The researchers suggest using a self-administered patient questionnaire to improve recognition of side effects.
A new graphical tool called RXplore allows physicians to instantly track down the cause of drug side effects by retrieving adverse reaction data for multiple medications simultaneously. The study found that physicians can retrieve accurate information 65% faster using Rxplore than traditional resources.
A study found that increasing the radiation dose for prostate cancer treatment did not lead to increased long-term side effects. Patients reported minimal distress from chronic symptoms, with many considering their quality of life 'normal' despite experiencing symptoms. The results suggest that patients may adapt to treatment and exper...