Articles tagged with Side Effects
The HPS2-THRIVE study found that niacin therapy provides no benefit and may even be harmful for patients with vascular disease. The study showed a higher incidence of bleeding, infections, new onset diabetes, and gastrointestinal problems among those receiving the drug.
A pilot study may lead clinicians to more accurately predict which patients will suffer from gastrointestinal side effects of radiotherapy. The technology uses an electronic nose and FAIMS to analyze stool samples and identify patterns in toxicity levels.
A new device encircles the esophagus valve to control chronic acid reflux, easing symptoms in 92% of patients and allowing 87% to stop using acid-suppressing drugs. Installation is minimally invasive, taking one to two hours, and patients experience significant improvement with 94% satisfaction.
Researchers dispute evolutionary psychology's 'adaptive' explanation for males' superior spatial navigation, suggesting it may be a result of testosterone levels. The study analyzed 35 species and found no consistent support for the hypothesis that male superiority is an adaptation.
Researchers at Ruhr-University Bochum found that loyal customers play out their loyalty in price negotiations, gaining an extra 5% discount without issue. This study turned the perception of customer loyalty on its head, highlighting its negotiating power in stores across various sectors.
A new study published in Neurology suggests that wearing a nerve stimulator for 20 minutes a day can reduce the frequency of migraine attacks. The device delivers electrical stimulation to the supraorbital nerve, resulting in fewer days with migraine and a significant reduction in attack frequency compared to sham treatment.
A study analyzing over 25,000 message board posts found that breast cancer survivors frequently discuss troublesome side effects from aromatase inhibitors, leading some to discontinue or switch therapies. The findings have broad implications for promoting proper adherence and informing patient-to-patient discussion online.
Scientists have developed a new computer-based approach to predicting possible side effects of medications. The method is based on knowledge about chemical and biological information about ingredients in these medications and has been shown to be useful in identifying potential side effects for both known and uncharacterized molecules....
A new study found that six months of steroid treatment didn't reduce relapse rates or side effects in children with nephrotic syndrome, challenging previous assumptions about optimal treatment strategies. The research highlights the need for new treatment strategies to prevent frequent relapses in this disease.
A new stem cell-derived system can identify cardiotoxic effects in experimental drugs early, potentially saving time and lives. The assay uses fluorescent imaging to monitor calcium ion levels during contractions, revealing beat rate and pattern irregularities.
A recent study published in the Journal of the National Cancer Institute found that proton radiotherapy provides minimal relief from side effects such as incontinence and erectile dysfunction compared to standard radiation treatment IMRT. The study revealed no long-term benefits for proton therapy, despite high costs.
Researchers at Emory University School of Medicine have obtained a detailed molecular picture that shows how glucocorticoid hormones shut off key immune system genes. The finding could help guide drug discovery efforts aimed at finding new anti-inflammatory drugs with fewer side effects.
A new study published in Arthritis Research & Therapy shows lenalidomide to be a safe and effective alternative treatment for refractory cutaneous lupus erythematosus, with significant clinical improvement in most patients. The treatment's efficacy is comparable to thalidomide but with lower toxicity.
A new antidepressant drug called GLYX-13 has shown significant reductions in depression symptoms within hours, with positive effects lasting an average of seven days from a single dose. The novel therapeutic targets brain receptors responsible for learning and memory.
Athletes are vulnerable to extreme heat or cold, which can cause hypothermia, frostbite, heat edema, heat syncope, and even life-threatening conditions. Team physicians play a crucial role in educating coaches and athletes on the risks of exposure and how to prevent these injuries.
Researchers have developed a method to study hepatitis C medication side effects in Petri dishes and test tubes, potentially paving the way for safer treatments. The technique could help identify medications that eliminate all adverse effects and aid in personalized medicine.
Nearly half of patients with chronic conditions don't follow prescribed medication regimens, increasing risk of side effects, hospitalizations, and reduced quality of life. Patients' beliefs about the causes of high blood pressure and treatment alternatives significantly affect their adherence to medications.
Researchers at Texas A&M University have discovered a compound called JQ1 that inhibits sperm production and mobility without any side effects. The finding is promising for the development of a male birth control pill, with potential human trials on the horizon.
A study published in PLoS ONE found that statin potency is a critical determinant of muscle-related side effects. Stronger statins like rosuvastatin were associated with higher rates of reported problems, highlighting the need for greater caution when prescribing these medications.
Researchers have confirmed that normalizing blood vessels by blocking oxygen sensor PHD2 can make chemotherapy more effective. This strategy also reduces the harmful side effects of chemotherapy on healthy organs.
Research finds that men experiencing persistent sexual side effects while on finasteride have a high prevalence of depressive symptoms (11-36%) and suicidal thoughts (44%). Former finasteride users with these side effects are at risk for mental health issues.
A 32-country study found that linagliptin, a DPP-4 inhibitor, is effective in improving glycaemic control without weight gain or increased risk of hypoglycemia. The extended trial demonstrated sustained glucose control for up to 102 weeks treatment duration.
A new study published in Drug Testing and Analysis found that DMAA, a stimulant in many pre-workout supplements, does not originate from natural substances but is comprised of synthetic compounds. The FDA should regulate and/or ban products with significant amounts of synthetic pharmacological compounds added.
A comprehensive review of 24 studies found acetazolamide has limited effectiveness unless baseline AMS risk is high, and some side effects occur at low doses. The authors suggest tailoring treatment to individual risk and acceptability of common side effects.
A device used to prevent incontinence in women after pelvic-floor surgery shows promise, reducing symptoms but increasing side effects. Researchers suggest counseling women on risks and benefits prior to the procedure.
A new computer model has successfully predicted negative side effects in hundreds of current drugs by analyzing their chemical structures and known side-effect molecules. The model identified potential side effects for 151 previously unknown compounds, including a synthetic form of estrogen that causes stomach pain.
An investigational diabetes drug appears to improve insulin sensitivity in mice without the troublesome side effects of current medications, such as weight gain and bone fractures. The drug works through a different pathway, targeting mitochondria instead of PPARγ receptors.
Researchers have identified methylglyoxal as the culprit behind increased pain sensitivity in diabetics. The team proposes using small peptides to target and reduce MG activity, leading to a reduction in pain.
A Kaiser Permanente study found that younger girls are more likely to report side effects after receiving the HPV vaccine, but these side effects are generally non-serious. The study suggests that educating young girls and their parents about what to expect from the vaccine can help alleviate fears and improve vaccination rates.
Researchers aim to create targeted compounds that selectively attack cancerous cells by zeroing-in on pollutants produced by tumors' characteristic metabolism. This approach seeks to minimize side effects associated with conventional chemotherapy.
Researchers found a strong correlation between genetic variation and chemotherapy side effects, enabling personalized treatment approaches. This study aims to tailor chemotherapy regimens to individual patients' genetic profiles.
Researchers have developed a mutated version of the IL-2 protein that enhances its anti-cancer efficacy while reducing severe side effects. The new molecule, dubbed Super-2, has been shown to outperform natural IL-2 in slowing tumor growth and minimizing pulmonary edema.
A large cross-sectional survey of 2325 Canadian men aged 55-97 years old found that mobility impairments, memory loss, and medication side effects were top health concerns. However, only a minority reported receiving adequate counseling on these issues, highlighting important gaps in healthcare.
Researchers found that mild hypothermia (34C) can offset the damage caused by tPA treatment in rats, reducing swelling and damaged tissue after a stroke. The therapy may also increase the time window for tPA treatment, potentially benefiting patients who experience significant brain function loss.
Researchers aim to create potent pain relievers with reduced side effects by studying four new compounds that avoid recruiting the protein beta arrestin 2. Genetic studies have shown animal models lacking beta-arrestins experience robust pain relief with diminished side effects.
A team at Karolinska Institutet has generated a map of the effects of small molecules on PARP1 and other proteins, which may explain putative side effects and contribute to new cancer therapies. The study's results provide unique insights into specificity and cross-reactivity of PARP inhibitors.
A study with mice suggests Alzheimer's drugs could miswire neurons, interfering with brain communication. The findings imply that these drugs might impair memory, even at doses intended to reduce amyloid plaques.
A new study by the University of Leicester found that combining anti-obesity drugs with a modified lifestyle is effective in reducing weight and body mass index. Lifestyle advice alone was also shown to lead to weight loss at 6 and 12 months, highlighting the importance of balanced diet and exercise for weight management.
Researchers recommend a stop-and-go approach to balance oxaliplatin dose with neurological side effects, maximizing effectiveness while minimizing harm. Supplements such as calcium and magnesium may mitigate drug damage, improving patient outcomes.
Researchers found that antipsychotics activate the TGFbeta pathway, leading to metabolic side effects, while drugs without these effects do not. The study suggests a new approach to developing safer therapeutics for bipolar disorder and schizophrenia patients.
Researchers treated 17 patients with trigeminal neuralgia using Cyberknife radiosurgery, resulting in partial or complete relief from symptoms for 14 patients. The procedure offered a viable alternative to invasive approaches, with no major complications reported.
A new study found that patients who quickly stop taking immunosuppressive prednisone after receiving a kidney transplant avoid experiencing serious prednisone-related side effects. The study also showed that rapid discontinuation of prednisone does not jeopardize the long-term survival of patients and their new organs.
A new study by Northwestern University finds that joint pain is the most common reason for women to stop taking aromatase inhibitors, a common breast cancer medication. The research also highlights a gap between clinicians' reported side effects and women's actual experiences.
Researchers at the University of Warwick have developed synthetic helix-shaped molecules that target MRSA and E-coli with low toxicity. The 'flexicates' harness chirality to create targeted treatments.
A study published in Annals of Oncology found that nearly half of male breast cancer patients on tamoxifen experience significant side effects, including weight gain and sexual dysfunction. The research highlights the need for better understanding and awareness of treatment risks and benefits.
A large study found that 53% of male breast cancer patients experience tamoxifen-related side effects, leading to early discontinuation. The study suggests that these patients may be at increased risk of cancer recurrence.
Researchers at UCLA have developed a promising new treatment for iron overload disorders using minihepcidin peptides, which mimic the natural protein hepcidin to lower iron levels in the blood. The study provides hope for individuals affected by hereditary hemochromatosis and beta-thalassemia.
Researchers at Oregon Health & Science University discovered that calcineurin inhibitors spurs the production of a natural protein in the kidney, leading to hypertension. A thiazide diuretic drug blocks this protein, reducing hypertension in mice and showing promise for transplant patients with similar issues.
A new study found that humor therapy reduces agitation in dementia patients by 20%, comparable to widely used antipsychotic drugs. This approach also improves happiness and positive behaviors, but effects are short-lived once the program ends.
A new study has shown that a 24-week treatment course for hepatitis C is just as effective as a 48-week regimen for many patients. The study included 540 patients with chronic genotype 1 hepatitis C who had not previously been treated or could not be successfully treated with current standard of care.
Researchers have discovered a new class of anti-diabetic compounds that target a unique molecular switch, potentially offering fewer side effects than existing drugs. The new compound, SR1664, blocks Cdk5's action on PPARG and shows improved blood sugar levels without weight gain or fluid retention.
A new study found that fast disclaimers can harm purchase intentions for unknown or distrusted brands, while trusted brands can use them without issue. Advertisers promoting trusted brands may save time by using fast disclaimers, but regulators need to consider the impact on consumer trust and advertising policies.
The THRIVE and ECHO phase 3 trials showed that rilpivirine is non-inferior to efavirenz with a better side-effect profile, but had a higher incidence of virological failures. Rilpivirine was found to be effective in suppressing HIV virus levels in patients starting treatment for the first time.
A large cohort study of over 13,000 people aged 65 and over found that those taking medications with anticholinergic properties had a higher risk of dying and experiencing cognitive impairment. The study suggests that clinicians should review medication regimens regularly to minimize harm.
A meta-analysis of 10 randomized clinical trials found that topiramate-treated patients lost 11.8 pounds more on average than placebo group members, with a higher success rate for weight loss over 28 weeks.
Researchers found that complex drug labels contain an average of 70 side effects, with antidepressants and newer treatments having the most reactions. The study aims to improve patient safety by presenting information efficiently to healthcare providers.
A new study suggests that damage to surrounding tissue during chemoradiation for high-grade glioma may play a role in determining long-term outcome and overall survival. Patients who experienced fewer side effects lived 4 months longer compared to those who did not.
Dr. Bryan Roth has received the PhRMA Foundation Award in Excellence in Pharmacology/Toxicology for his groundbreaking research on drug discovery and development. His work aims to understand how central nervous system drugs affect brain neurons and mitigate side effects, particularly for conditions like schizophrenia and depression.
Patients with CML taking imatinib in remission after two years have a mortality rate similar to the general population. Despite side effects, survival rates remain high even after eight years of treatment.
Research on Prozac reveals it can reorganize brain plasticity by altering neuronal cell activity and connections in the hippocampus. This changes may contribute to anxiety symptoms experienced by some patients.