Articles tagged with Side Effects
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study found that women with overactive bladder who received antimuscarinics were 38% more likely to develop depressive disorder within three years. The use of these drugs was associated with an increased risk of depression, highlighting the need for careful monitoring and consideration of alternative treatment options.
A recent study found that women with overactive bladder who received antimuscarinics were 38% more likely to develop depressive disorder within three years. The use of these drugs was associated with a higher risk of depression despite their ability to improve bladder symptoms by blocking muscarinic receptors.
A new imaging device developed by Modulated Imaging Inc. uses low-power LEDs to project light onto the breast, measuring absorption and scattering properties to quantify skin health. The device aims to predict acute and late skin damage effects from radiation therapy in breast cancer patients.
A new study has identified distinct patterns of side effects in prostate cancer treatment choices, providing insights for patients to make informed decisions. The research found that surgery was linked to higher sexual dysfunction and urinary leakage than other options.
A recent study by Radhika Joshi at NCBS Bangalore has shown that environmental factors can modulate the sedative side effects of antipsychotics. Mice without the 5-HT2A receptor were less affected when given Clozapine in novel cages or with new objects, suggesting a potential strategy for managing these side effects.
Research shows that people who are less numerate experience worse health outcomes, including for cancer patients. To cope, patients can ask for numbers, understand what the numbers mean, consider absolute risk, and narrow down treatment options.
Researchers have discovered a novel substance that may effectively treat trigeminal neuralgia, a chronic nerve pain condition. The substance, BIIB074, inhibits the sodium channel 1.7, reducing pain intensity without burdening side effects.
Researchers found that statin specific side effects were the main reason patients failed to meet LDL cholesterol targets. Patients prescribed low-intensity statins were more likely to miss the target than those on high-intensity statins.
A Pew Research Center survey found that 88% of Americans believe the benefits of the MMR vaccine outweigh its risks. However, parents of young children are more likely to see a higher risk and lower benefits from the vaccine. Those with high science knowledge and higher incomes tend to support school-based MMR vaccine requirements.
Researchers at Tohoku University identified a new mechanism producing low-energy free electrons from X-ray absorption in matter. The process, known as Electron Transfer Mediated Decay, involves rapid charge redistribution over multiple atomic sites.
A study found that nearly half of women treated for early stage breast cancer experienced at least one severe or very severe side effect from their treatment. The most common side effects were pain, skin irritation, and constipation, with Latina women being 30% more likely to report a severe side effect.
A team led by Prof Dr Aiden Haghikia and Prof Dr Ralf Gold report two patients who developed severe symptoms under alemtuzumab, a common MS treatment. The researchers successfully treated the side effects with a new algorithm that could benefit other patients worldwide.
Patients taking antidepressants for depression are more likely to report gastrointestinal and cardiovascular side effects if they also have panic disorder, according to a new study. Co-occurring panic disorder is associated with an increased risk of worsening depressive symptoms.
Researchers at KIT and Jacobs University Bremen have discovered a new class of host molecules, namely, barrel-shaped cucurbiturils, which can transport medical substances and hormones more efficiently. This breakthrough may lead to improved medicine formulations with reduced side effects.
A Drexel study analyzed nearly 200,000 English-language tweets about the HPV vaccine between 2014 and 2015. The results show that 39% of tweets were positive, while negative sentiments accounted for only 25%. Prevention and protection were popular topics in positive tweets, while side effects dominated negative ones.
A University of Liverpool study found that reducing the dose of leukemia drug tyrosine kinase inhibitors (TKI) can safely reduce side effects in patients with chronic myeloid leukemia. Patients who achieved stable molecular remission levels showed no evidence of leukaemia rebound after cutting their TKI dose, with some reporting signif...
A study published in The New England Journal of Medicine details two cases of acute and unexpected fatal myocarditis that occurred in melanoma patients following treatment with a combination of ipilimumab and nivolumab. High-dose corticosteroids were initially administered, but both patients died due to the severe immune reaction.
Research suggests that many people with chronic low back pain experience limited relief from opioids, with only 13% finding them 'very successful'. Additionally, patients often report side effects such as constipation, sleepiness, and cognitive issues.
The use of glutathione for skin bleaching is on the rise in the UK despite potential risks and lack of regulation. The practice has been linked to serious side effects such as Stevens Johnson syndrome and toxic epidermal necrolysis, as well as transmission of infectious diseases like HIV and hepatitis.
Pokémon Go has been linked to increased physical activity and social connections, with players walking longer distances and interacting with strangers in public spaces. However, the game also carries risks, such as accidents and thefts, that have sparked concerns about its impact on mental health.
Researchers at Penn Medicine discovered that breast cancer drug trastuzumab affects the development of blood vessels in the heart, leading to potential cardiovascular side effects. The study highlights a new role for ErbB2 protein in blood vessel formation and provides insights into the molecular mechanisms underlying these side effects.
A new study by Ben-Gurion University of the Negev found that medical marijuana users report improved pain, nausea, anxiety, appetite, and mood, with only minor side effects. The study involved over 2,000 patients using medical marijuana for cancer and non-cancer treatment.
Scientists created a way to make tissues and organs clearer by linking molecules together, leaving lipids that cause opacity intact. This breakthrough allows tracking of nanoparticles at depths of over 1 millimeter, enabling better understanding of interactions with tumors and organs.
A team of researchers has identified a ketamine metabolite that quickly reverses depression in mice without ketamine's major side effects. The study suggests that this compound may work by activating AMPA receptors, potentially opening up new vistas for the development of safer antidepressant treatments.
Researchers modified an obesity drug to block brain penetration, reducing psychiatric side effects. The new version of the drug can work on cannabinoid receptors outside the brain.
A team at the Wyss Institute for Biologically Inspired Engineering developed a novel strategy for engineering protein fusions to improve in vivo efficacy and safety. The approach enabled the creation of cell-targeted drugs that reduce potential side effects and accelerate new drug development.
A significant association has been found between HLA-B*59:01 and Clozapine-induced agranulocytosis and granulocytopenia, suggesting the allele may serve as a marker for prioritizing patients at low risk of developing these severe side effects. Further analysis is needed to clarify the mechanism behind this association.
Australian scientists have developed a new method for harvesting stem cells that eliminates the need for growth factor injections, reducing side effects for donors. The new method combines two molecules to mobilize stem cells into the bloodstream within an hour of administration.
Researchers at the University of Vermont have discovered a molecule that rescues damaged blood vessels without harming healthy ones. This finding could lead to the development of new pharmaceutical therapies with fewer side effects for hypertension, a major risk factor for cardiovascular and kidney disease.
Researchers have developed a computer program that predicts pharmaceutical side effects, outperforming earlier software in accuracy. The system assesses drug molecules and identifies potential side effects using an ensemble approach, demonstrating its effectiveness in flagging adverse reactions.
Research from University at Buffalo finds that antidepressant use increases the odds of dental implant failure by four times. The study highlights the importance of weighing benefits against side effects for patients using these medications.
A new study from Trinity College Dublin reveals that modifying ECT can minimize cognitive side effects while maintaining its effectiveness in treating severe depression. The 'unilateral' approach, involving unilateral electrode placement, shows promising results.
A new approach has been discovered to reduce uncontrolled movements caused by levodopa, a common Parkinson's disease medication. By boosting the functioning of a specific brain receptor, scientists have found that side effects such as dyskinesia can be dramatically reduced.
A possible solution to the inflammatory side effects of Alzheimer's immunotherapy has been discovered by researchers from the University of Southampton. They engineered three new antibodies that preserved immunotherapeutic activity while reducing inflammation.
A team of researchers at the University of California, San Diego has developed a predictive model that can forecast how different individuals will respond to a particular drug. The model, which uses genomic and metabolomics data, aims to provide insights into why some patients experience side effects while others do not.
Researchers at Scripps Research Institute have discovered a class of compounds that can effectively treat chronic itch without inducing sedation. The new compounds target the kappa opioid receptor, which is associated with pain perception and stress responses.
Researchers have developed a molecular 'on switch' to control T cell actions in cancer therapy, allowing for sharper reduction of severe side effects. The innovation enables doctors to precisely manage immune responses using a controller drug that flips cells into an active status.
Researchers developed nanoparticles that deliver allergens to specific cells, reducing side effects. The new approach could lead to safer and more effective treatments for allergies and other conditions.
A chemist at San Diego State University developed a new technique to improve the selectivity of protein kinase inhibitors, which can lead to fewer side effects. By locking in either the right- or left-handed version of an atropisomeric compound, researchers found more selective inhibition of specific kinases.
A NIHR-funded study has found that repositioning patients after the Valsalva manoeuvre significantly increases its success rate in treating supraventricular tachycardia. The modified technique improved heart rhythm return rates from 17.5% to 43.5%, offering a cost-free and comfortable option for patients.
A study of 515 premenopausal patients found that younger women with stage 0-III hormone receptor-positive breast cancer are less likely to initiate or continue tamoxifen treatment due to concerns about side effects and fertility, highlighting the need for targeted interventions.
A new study suggests that ultra-brief pulse stimulation is almost as effective as standard ECT in treating severe depression, but with significantly fewer cognitive side effects. The treatment has the potential to benefit up to 10,000 Australians who have not responded to first-line treatments.
Scientists have identified promising compounds that could treat depression in less than 24 hours while minimizing side effects. The compounds, called GABA-NAMs, target the brain's excitatory and inhibitory communication, restoring balance and relieving symptoms.
Researchers have found a way to separate cannabis' medical benefits from its negative effects by blocking a specific pathway. This breakthrough could lead to safe cannabis-based therapies that preserve pain relief and memory function.
Researchers found that blocking a specific pathway involving cannabinoid and serotonin receptors can reduce detrimental cognitive effects while preserving pain relief. The breakthrough aims to create safe cannabis-based therapies without memory impairment or other adverse effects.
A pharmacy professor argues that a two-tier system of prescription or non-prescription drugs would be simpler and less confusing for consumers. The current pharmacy medicine category has limited benefits and lacks evidence to support its value.
Researchers at the University of Missouri have discovered a new compound called boronicaine that offers longer-lasting painkilling effects compared to lidocaine. The compound provides about five times longer relief, making it a potential alternative for treating sports injuries and joint replacement procedures.
Scientists at Scripps Research Institute have been awarded a $2.4 million grant to expand development of new pain medications that utilize the same biological target as morphine but with fewer side effects. These new compounds aim to reduce respiratory suppression and persistent constipation associated with current opioid drugs.
Women with breast cancer who follow a physical exercise program during chemotherapy experience less fatigue, nausea, and pain. The study found that both moderate and low-intensity exercise programs significantly reduced the need for dose adjustments in chemotherapy treatment.
A study of 1,964 patients found extending natalizumab dosing up to 8 weeks is well-tolerated and effective in treating MS disease activity. No cases of progressive multifocal leukoencephalopathy were reported in the extended dosing group.
A new study suggests statins could be a cost-effective tool for preventing heart attacks and other cardiovascular incidents in adults over age 75. However, potential side effects such as muscle weakness and cognitive impairment need to be considered.
A new study found that statins can help prevent heart disease in older adults but may cause muscle pain, weakness, and mild cognitive impairment. The study suggests that the benefits of statin use may be offset by these side effects, particularly in geriatric populations.
A study led by the University of Pennsylvania found that roseroot extract may be an effective treatment for mild to moderate major depressive disorder, with fewer side effects than conventional antidepressants. The herbal remedy showed a more favorable risk-to-benefit ratio, suggesting its potential as an alternative therapy option.
A new Northwestern Medicine study found that low-dose VM202 gene therapy significantly improves pain symptoms and perception of light touch in patients with painful diabetic neuropathy. The treatment has virtually no side effects, offering hope for a potential new treatment for this debilitating condition.
Researchers at the Buck Institute discovered how rapamycin inhibits mTORC2, a complex linked to metabolic side effects. The study suggests that manipulating FK506 binding proteins could selectively target mTORC1, reducing side effects and improving longevity outcomes.
A recent study found that delays in the withdrawal of drugs from the market due to reported deaths could have been reduced if there were more efficient reporting and regulatory processes. The researchers identified 95 drugs that were withdrawn due to deaths, with most being used to treat neurological or psychiatric disorders.
Researchers have developed a novel, drug-releasing wafer that patients can apply directly to their affected eyes once daily, showing twice the effectiveness of traditional eye drops in mice without causing inflammation. This innovative treatment could help patients recover faster and reduce side effects associated with current therapies.
Patients with a history of smoking have increased risks of cancer relapse, side effects, and death from prostate cancer, according to a study published in BJU International. Smoking negatively affects prostate cancer health outcomes, particularly when treated with radiotherapy.
Joining a walking group improves lung power, physical functioning, and general fitness, with few side effects, according to an analysis of available evidence published in the British Journal of Sports Medicine. The study found wide-ranging benefits for adults with various long-term conditions.
Glucocorticoids suppress inflammation by targeting nuclear factor-κB and upregulating IRAK-M, a key negative regulator of inflammatory pathways. The discovery provides new insights into the mechanism of glucocorticoid action and could lead to the development of new therapeutic strategies for controlling overactive inflammation.