Articles tagged with Side Effects
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a nanofluidic seed that can deliver sustained-release doses of immunotherapy directly to tumors, reducing the need for multiple IV treatments and eliminating side effects. The device has shown promising results in mice models, with equal effectiveness compared to systemic immunotherapy while minimizing toxicities.
SLU scientist Daniela Salvemini is studying chemotherapy-induced cognitive impairment and opioid addiction to develop new treatments. Her research aims to identify novel therapeutic approaches to mitigate chemo-brain and improve quality of life for cancer patients.
A new investigational steroid called vamorolone has been found to replicate the benefits of prednisone while reducing its side effects, offering hope for patients with chronic inflammatory diseases. The study identifies nine potential biomarkers for inflammatory diseases that could serve as a fingerprint for chronic inflammation.
Researchers found that medical cannabis provides immediate symptom relief across various health conditions, including chronic pain and insomnia. Patients reported an average symptom reduction of nearly 4 points on a 1-10 scale following cannabis consumption.
A recent study published in Health & Social Care in the Community found that over a quarter of patients want more information about their medicines, while nearly half are concerned about long-term adverse effects. The research also revealed that older patients feel using regular medicines is less burdensome than younger patients.
Researchers have developed a new drug, GC4419, that appears to prevent severe oral mucositis (SOM), a painful side effect of radiation therapy for head and neck cancers. The drug has already been designated as a breakthrough therapy by the FDA and shows safety and efficacy in clinical trials.
A new international collaborative research study has found that a four-month daily regimen of antibiotic rifampicin is as effective as a nine-month daily regimen of another antibiotic, isoniazid, in preventing people with latent tuberculosis infection from developing the full-blown disease. The study, published in the New England Journ...
Researchers have made significant breakthroughs in treating hereditary angioedema with the new drug BCX7353. The medication has been shown to significantly reduce attack frequency and improve quality of life by up to 75% compared to placebo, offering a convenient oral administration without severe side effects.
A team of researchers developed an AI system called Decagon to predict potential side effects from drug combinations. By analyzing cellular machinery interactions and known associations between drugs and side effects, the system identified patterns and predicted previously unseen consequences.
Researchers at UVA School of Medicine have developed a technique to manipulate molecules within cells, enabling precise targeting and minimizing side effects. This breakthrough has significant potential for treating diseases such as cancer, autism, and Alzheimer's.
Researchers developed a DNA sequencing kit that identifies variations in the NUDT15 gene, allowing for accurate predictions of adverse reactions. The test has been approved for clinical use in Japan and holds promise for reducing severe side effects in East Asian patients.
Researchers have developed a tool that analyzes protein phosphorylation patterns in the brain, revealing changes associated with desired and undesired opioid effects. This study aims to identify potential non-addictive opioids and reduce side effects by interfering with signal cascades.
A population-based survey study found that nearly 37% of adults used prescription medications associated with depression as a potential side effect. The study also revealed that patients taking multiple such medications were more likely to experience depressive symptoms.
A new report calls for better evaluation of side effects from modern blood cancer treatments, which have dramatically improved survival rates. The Commission proposes new approaches to reporting adverse events, including capturing chronic and cumulative effects.
A new study found that men with prostate cancer who experience urinary, bowel, or sexual dysfunction after treatment are more likely to experience emotional distress, which can lead to worsening function. The researchers emphasize the need for greater investment in psychosocial care to mitigate treatment side effects and improve qualit...
Researchers found that Galectin-1 can lower blood pressure by reducing activity of L-type calcium channels in arteries. This discovery offers a novel approach to treating hypertension, potentially with minimal side effects.
Researchers found that nitric oxide deficiencies can underlie heart failure, while low levels may cause GPCRs to activate harmful pathways. Managing nitric oxide could help improve heart function and reduce side effects of existing medications.
Researchers have developed a refined CAR-T therapy called SUPRA-CART that addresses the three major flaws of traditional CAR-T: target specificity, response strength, and adaptive capability. This new system allows for continuous alteration to target different types of cancer cells and can be deactivated in case of severe side effects.
Two randomized controlled studies show a 65% improvement in treatment group and a 27% improvement in patient-rated measures compared to sham stimulation. The therapy has few side effects, with most participants reporting improvement after receiving treatment.
Medical marijuana shows promise in managing pain and chemotherapy-induced nausea and vomiting in older adults. However, its use requires a thorough assessment of side effects to ensure lower doses have a greater impact.
The study reveals that the glucocorticoid receptor (GR) can directly bind to DNA at NF-kappaB sites, one at a time, turning down inflammation genes. This finding could lead to reinterpretation of previous studies and potential development of targeted drugs.
A recent NRG Oncology study found that high-dose radiotherapy improves biochemical control and reduces distant metastases in men with intermediate-risk prostate cancer, but does not enhance overall survival. The treatment also resulted in more side effects compared to standard radiotherapy.
A new study by Boston Medical Center found chemical peels to be a relatively safe treatment option for people with darker skin. The research revealed that less than four percent of participants experienced unwanted side effects.
A new study casts doubt on the use of ketamine nasal sprays for treating severe depression. The pilot trial found that the dosage of ketamine through an intranasal device can vary greatly between individuals and within a day, leading to unpredictable side effects such as high blood pressure and psychotic-like symptoms.
A new study by researchers at The Ohio State University Wexner Medical Center found no evidence of a link between hormonal birth control and depression. Dr. Brett Worly notes that while some groups may be at higher risk of depression, including adolescents and postpartum women, this is not due to the birth control itself.
Researchers discovered that inhibiting HDAC6 improves the structural stability of cells, protecting against neuronal damage. This finding has therapeutic potential for treating peripheral neuropathies caused by Charcot-Marie-Tooth disease and chemotherapy side effects.
A new study reveals that fentanyl can increase pain sensitivity in animals by lowering their pain threshold. The researchers found that blocking calcium signaling inside sensory neurons prevents this effect, suggesting a possible mechanism for hyperalgesia.
Researchers have deciphered the molecular structure of an antipsychotic docked in its key receptor, revealing a deep pocket that could be targeted to design more selective drugs with fewer side effects. This discovery may hold secrets to designing better treatments for schizophrenia and bipolar disorder.
A study published in British Journal of Clinical Pharmacology analyzed herbal product interactions with prescription medications. The analysis revealed significant adverse drug reactions, particularly among patients taking warfarin and statins for cardiovascular complications.
A national survey of over 700 adults who helped manage common chronic illnesses found that many wish they could understand their loved one's condition better or get more involved in their care. However, health providers often fail to inform them or involve them in decisions, despite the potential benefits for patient success.
Researchers at North Carolina State University have developed a mathematical model for computing radiation therapy treatments that could substantially reduce patient side effects while delivering the same results as conventional radiation therapy. The new approach, known as spatiotemporal fractionation, delivers different doses to part...
A phase II trial shows that combining olaparib, a PARP inhibitor, with durvalumab, an immunotherapy drug, achieves 80% disease control at 12 weeks. The treatment is well-tolerated and produces fewer serious side effects compared to chemotherapy.
Researchers found that combining targeted drugs with hormone therapy results in a significant increase in the risk of severe or life-threatening adverse events. Most of these side effects are treatable and potentially preventable.
A Cochrane review found that mefloquine is at least as effective as other options for preventing malaria, but its psychological side effects outpace those of alternatives. Common symptoms include sleeplessness, abnormal dreams, anxiety, and depression.
Scientists used fMRI to study the neurological causes of the nocebo effect, finding that brain regions can influence primal pain sensing. People who believed they were receiving an expensive cream reported greater sensitivity on a heat-tolerance test and experienced more pronounced nocebo effects over time.
Mayo Clinic researchers found that reducing radiation therapy intensity by 50% resulted in fewer side effects without compromising survival or cure rates. The study followed 80 patients with HPV-related throat cancer and reported a 95% tumor control rate at two years, with only one regional recurrence.
A study presented at ESMO 2017 found that socio-psychological factors, such as anxiety and family concerns, are now more significant for cancer patients than previously thought. The study suggests that doctors should consider improving supportive therapies and providing stronger psychological support to address these issues.
A recent study found that almost all antidepressants present significant side effects, but some individuals may better tolerate certain side effects. Personalized medicine is recommended to match chronic pain patients with suitable antidepressant medication, taking into account their individual health profiles and existing health issues.
Researchers from Kumamoto University found that different anticoagulants can form thrombi at varying rates, with some having faster clotting times than others. This study used a Total Thrombus-Formation Analysis System to analyze blood samples from patients taking warfarin or direct oral anticoagulants.
A research team led by Professor Hyoungsoo Kim quantified the Marangoni effect in miscible liquids, revealing a new mechanism for driving transport without surface contamination. The findings have potential applications in removing impurities from surfaces and developing alternative materials to surfactants.
A study published in the Journal of Clinical Investigation reveals that genetic abnormalities contribute to thiazide-induced hyponatremia, a condition causing low sodium levels. Researchers identified patients with this side effect who exhibited persistent subtle differences in blood and urine tests even after medication was stopped.
A systematic review of ketamine treatment for depression found few studies reporting on the safety of repeated doses or sustained use. The review highlights the need for more research into the long-term effects of ketamine treatment to ensure its safe adoption as a clinical treatment.
Researchers have conducted the world's first randomised control trial assessing ketamine's effectiveness as an antidepressant in elderly patients. The trial found that repeated intravenous doses of ketamine resulted in a 68.8% response and remission rate among patients, with no severe side effects reported.
A recent study published in BMJ Open found that negative media coverage and personal experiences of statin side effects are significant barriers to adherence among stroke survivors. The research highlights the need for open dialogue between patients and healthcare professionals to address concerns and improve medication adherence.
Researchers at the University of Liverpool have developed a novel approach to treating chronic myeloid leukemia (CML), which safely increases treatment success and reduces negative side effects. The study, led by Professor Richard Clark, shows that CML patients with stable responses to treatment can reduce their medication dosage befor...
Researchers found a 25% increased risk of death from all causes among PPI users compared to H2 blocker users. The study also suggested that PPIs may boost oxidative stress and shorten telomeres, potentially leading to tissue damage.
A study of 1488 adult patients found that 20% experienced adverse reactions to antibiotics, with gastrointestinal and kidney issues being the most common. Nearly a fifth of these adverse effects were unnecessary and occurred in patients who didn't need antibiotics.
A new study found that SGLT2 inhibitors increase the risk of diabetic ketoacidosis by twice as much as another class of diabetes medications. Despite being rare, this complication can be fatal if left untreated.
A phase III clinical trial suggests a potential new treatment for patients with advanced EGFR-positive non-small cell lung cancer. Dacomitinib delayed cancer growth by 5.5 months compared to gefitinib, but also caused more side effects.
The immunotherapy drug pembrolizumab has been shown to shrink tumors in patients with metastatic triple negative breast cancer, regardless of prior treatment. In a Phase II clinical trial, the drug demonstrated activity in both PD-L1-positive and -negative tumors.
Researchers have developed a potential new diabetes treatment that uses a 'sugar sponge' to regulate glucose levels. The system, which consists of a lectin-coated polymer vesicle, can absorb glucose when levels are high and release it when levels are low. In laboratory tests and mouse studies, the treatment showed antidiabetic effects.
Researchers at the University of Cincinnati have engineered a cancer stem cell vaccine that expresses pro-inflammatory protein IL-15 and its receptor to stimulate T cell production. This results in enhanced immune responses against tumors with reduced side effects, offering potential new immunotherapy treatments.
The clinical trial found that systemic therapy preserved visual acuity and had fewer side effects compared to the intraocular implant. The researchers concluded that systemic therapy would be the first choice of treatment for average patients with uveitis.
A new study in The Lancet found that muscle-related symptoms are less commonly reported when patients and doctors are unaware of statin therapy. However, when patients know they're taking a statin, they were more likely to report symptoms, suggesting the nocebo effect may be at play.
A systematic review by Aarhus University researchers documents that ECT-related deaths are extremely rare, with only one reported death out of 414,747 treatments. The study highlights the procedure's highly beneficial effects on mental disorders, outweighing potential side effects like memory impairment.
Researchers warn that hospital policies to restrict patient mobility may worsen health outcomes, citing increased risk of falls and medical adverse events. Promoting mobility with supervised walks and trained staff could help prevent these issues.
A preliminary study suggests that removing Epstein-Barr virus-infected B cells and boosting the immune system may improve symptoms of multiple sclerosis. Three participants showed significant improvements, including one person with secondary progressive MS who was able to walk without assistance for the first time in 20 years.
People taking oral corticosteroids for less than 30 days are at higher risk of broken bones, dangerous blood clots, and sepsis. Researchers call for better education on the potential risks and most appropriate uses of steroids.
A small study found that the new chemical composition of poppers is linked to retinal damage, with symptoms starting within hours or days of inhaling the substance. Most patients fully recovered after stopping drug use, but some experienced prolonged visual effects.
A recent study found that women with overactive bladder who received antimuscarinics were 38% more likely to develop depressive disorder within three years. The use of these drugs was associated with an increased risk of depression, highlighting the need for careful monitoring and consideration of alternative treatment options.