Articles tagged with Side Effects
Researchers develop a method called Cell Painting that uses morphological profiling to detect side effects of substances on cells, enabling the identification of tubulin-modulating compounds. The study reveals over 1% of tested substances have this effect, including previously unknown reference substances.
Patients with skin-related side effects from immune checkpoint inhibitors tend to live longer, with a 22-50% decrease in mortality. These findings suggest that skin toxicities can be an indicator of treatment efficacy and may help identify patients who are more likely to benefit from their current immunotherapy regimen.
A new combination immune therapy treatment extends cancer patients' lives while reducing toxic side effects and improving their overall health. This study found that the treatment was less toxic than other drugs on the market, providing an added benefit for patients' quality of life.
Researchers at RIKEN successfully treated cancer in mice using metal catalysts that assemble anticancer drugs inside the body. The technique avoids indiscriminate tissue damage and increases cancer-inhibiting activity by 1000 times.
Scientists develop hairy cellulose nanocrystals to capture and remove excess chemotherapy drugs from the blood. The nanocrystals effectively removed over 6,000 milligrams of doxorubicin per gram, increasing DOX capture by two to three orders of magnitude compared to existing methods.
A registry study found that people with inflammatory RMDs, such as rheumatoid arthritis and psoriatic arthritis, tolerate their COVID vaccine well, with short-lived reactions being the most common side effect. The majority of participants were able to continue on their normal medication with no changes.
A study found that cholinesterase inhibitors like donepezil increase the risk of overactive bladder in people with dementia. Galantamine and rivastigmine were not associated with this increased risk.
A new study suggests that combining two drugs can reduce postoperative opioid use and side effects in adolescents with scoliosis. The combination of intrathecal morphine and oral gabapentin provides more effective pain control, resulting in fewer side effects and lower narcotic consumption.
A clinical trial found that remote monitoring of medication's potential arrhythmic side effects is feasible and safe for patients with mild COVID-19. The study used handheld devices to transmit digital ECGs, suggesting a potential expansion of clinical research to broader populations and reducing participants' burdens.
A review suggests that doctors should prescribe fewer antidepressants and for shorter periods due to the potential severity and duration of withdrawal symptoms. The use of antidepressants is also associated with a range of side effects, but clinical trial data often don't assess outcomes that matter most to patients.
Researchers at PSI have developed a platform to measure biased signalling in G protein-coupled receptors (GPCRs), enabling selective therapeutic effects and fewer side effects. By testing specially designed bivalent ligands, they can bias signalling towards desired pathways.
A new NRG Oncology clinical trial found that bupropion did not improve sexual desire in female cancer survivors. The trial evaluated the effects of extended-release bupropion on postmenopausal women with low baseline sexual desire scores.
A case study published in Nature Medicine reports a patient experiencing progressive neurological features resembling Parkinson's disease after CAR-T cell therapy, suggesting potential neurotoxicity. The study highlights the importance of monitoring for neurotoxicity in patients receiving BCMA-targeted CAR-T therapies.
Researchers found that most cases of suspected COVID-19 vaccine-related myocarditis in people younger than 21 are mild and resolve quickly. The study suggests that the benefits of COVID-19 vaccination far exceed the rare risks of adverse events, including myocarditis.
A new study has identified a promising drug candidate to minimize uncontrolled muscle movements associated with Parkinson’s disease. PD13R reduced dyskinesia by more than 85% in animal studies, also improving sleep quality compared to other treatments.
A new programme is seeking to understand the rare condition of blood clotting with low platelets in COVID-19 infection and vaccination. The vast majority of people experience mild reactions, but some develop severe side effects, including blood clots and low platelet levels.
Researchers discovered a correlation between simultaneous vaccination with the flu and shingles vaccines, resulting in reduced likelihood of administering a flu shot the next year. The study suggests that side effects from the shingles vaccine may be misattributed to the flu vaccine, contributing to this phenomenon.
A new study found that a simple surgical technique called posterior left pericardiotomy significantly reduces the risk of atrial fibrillation in patients undergoing cardiac surgery. The procedure, which involves draining excess fluid and small clots from the heart sac, was associated with a 56% lower incidence of irregular heart rhythm...
Researchers found a clear link between people's expectations and actual vaccine side effects, suggesting that psychological factors can predict which individuals will experience more symptoms. The study aims to help overcome lingering vaccine hesitancy by reframing the way we think about side effects.
A multi-center study demonstrated improved overall survival and quality of life for inoperable pancreatic cancer patients treated with MRIdian SMART, with a median survival of 26 months. The treatment showed low rates of major adverse events and was more effective than standard radiation therapy.
A study published in International Journal of Molecular Sciences found that the Sputnik-V COVID vaccine elicits both robust antibody and T-cell responses. The research suggests that long-term immunity is possible, supporting the effectiveness of the vaccine against local virus variants.
A recent clinical trial found that a shortened course of radiation therapy after prostate removal surgery does not increase long-term side effects or lower quality of life compared to conventional treatment. Patients who underwent hypofractionated, post-operative radiation therapy experienced comparable genitourinary and gastrointestin...
A study of 702 Swedish adolescents aged 15–19 found that 54.3% were willing to receive the COVID-19 vaccine, with many citing a desire to protect others. Anxiety about vaccination and misinformation from parents contributed to reluctance.
A new AI tool pairs protein pathways with clinical side effects and patient comorbidities to suggest targeted Covid-19 treatments. The tool, MOATAI-VIR, predicts 24 out of 26 major clinical manifestations of Covid-19 and their underlying disease-protein-pathway relationships.
Researchers at Karolinska Institutet studied long-term outcomes of patients with pacemakers after transcatheter aortic valve replacement and found no significant difference in mortality. The study included over 3,400 patients, with 481 receiving permanent pacemakers within 30 days of surgery.
A City of Hope clinical trial showed that patients over 65 experiencing significantly fewer treatment-related side effects when a multidisciplinary team analyzed each case and introduced personalized interventions. The completion of advance directives was also higher in the experimental group.
Patients treated with immune checkpoint inhibitors show better quality of life and reduced symptoms compared to those without immunotherapy. The study analyzed self-reported outcomes of 26 published studies and found that patients' global quality of life was stable or improved, but breathing difficulties increased
A recent study found that breastfeeding mothers who received Pfizer-BioNTech or Moderna COVID-19 vaccines experienced temporary symptoms such as pain and swelling at the injection site, chills, muscle/body aches, fever, and vomiting. The study also reported no serious side effects in breastfed infants.
Researchers at the University of Gothenburg have developed a simple blood test to detect treatment-triggered encephalitis in patients undergoing immunotherapy. The study found that markers such as S-100B and NFL can act as early warnings for encephalitis, allowing for timely administration of anti-inflammatory drugs.
A small study of 27 children aged 12-15 with neurological conditions found the Pfizer jab's side effects were mild to moderate and cleared up within a week. The vaccination was taken by parents who believed their children were at high risk of COVID-19 disease, highlighting its benefits in vulnerable groups.
The study found that patients with low risk of exacerbations do not benefit from low to moderate dose inhaled corticosteroids, while high doses are associated with severe side effects. Tailoring treatment according to patient characteristics, such as age and blood cell count, can minimize over- and underuse of inhaled corticosteroids.
A large-scale analysis of Israel's COVID-19 vaccination data found that the Pfizer/BioNTech BNT162B2 vaccine is very safe, with only a few potential side effects. The study also revealed that coronavirus infection poses a much higher risk of serious adverse events compared to vaccination.
Researchers found Prozac reduces lipid concentrations in monkey brains, linked to potential side effects in young patients. The study suggests dietary changes may alleviate adverse effects by influencing lipid synthesis.
Researchers identified DSS1 as a critical protein in breast cancer progression and found that depleting it makes cancer cells more responsive to lower doses of anti-cancer drugs. This technique may reduce drug-induced side effects in breast cancer patients, providing a safer treatment option.
A large-scale population-based study confirms that COVID-19 vaccines far outweigh the risk of Bell's palsy. The study found a small increased risk of Bell's palsy associated with CoronaVac vaccination, but not with BNT162b2.
Analysis of real-world data found that ACE inhibitors and ARBs prevent heart events with equal effectiveness, but ARBs may cause fewer side effects. Patients taking ARBs were 3.3 times more likely to develop angioedema, while those taking ACE inhibitors were 32% more likely to experience a cough.
Researchers identified bioactive substances that modulate cholesterol homeostasis, a common feature among many compounds. These findings suggest potential side effects of active substances and provide new insights into targeting cholesterol homeostasis, which may also impact SARS-CoV-2 infections.
New research shows that open communication about vaccine effectiveness and side effects boosts trust in health authorities, reducing hesitancy and conspiracy theories. Vague or reassuring communication, on the other hand, lowers acceptance of vaccines.
A meta-analysis of pediatric patients treated with medical cannabis found the treatment to be successful in reducing seizures and nausea in children undergoing chemotherapy, while also noting potential negative effects on mental health, including fatigue and lethargy.
Research found that COVID-19 vaccines are safe for patients with inflammatory bowel disease (IBD), who experience chronic digestive symptoms. Most side effects were mild and short-lived, with gastrointestinal issues being the most common. IBD patients on biologic therapies reported even fewer side effects due to the modulating effect o...
A new study found that a one-hour inhalation session with 25% nitrous oxide gas improved depression symptoms for over two weeks, with fewer adverse side effects compared to higher concentrations. The effects were nearly as effective as 50% nitrous oxide at rapidly relieving symptoms of treatment-resistant depression.
Researchers at Imperial College London have developed nanocapsules that target specific blood clots, potentially reducing the risk of life-threatening bleeding and increasing the effectiveness of a clot-dissolving drug. The new nanocapsules are designed to attach to activated platelets and release tPA, which dissolves clots.
Researchers have developed a peptide that enables THC to fight pain without the cognitive side effects associated with cannabis. In mice, the optimized peptide showed improved memory and reduced immune response, making it an ideal drug candidate for reducing cognitive side effects from cannabis-based pain management.
Researchers develop microneedles for immunotherapy, allowing for high efficiency and minimal invasiveness. The devices can improve the efficacy of immune checkpoint inhibitors and represent an alternative to conventional cancer vaccine designs.
The study found that 25.4% of vaccinated people experienced systemic side effects, with headache being the most common, while local side effects were reported by 66.2%.
A study in cells and mice finds a positive allosteric modulator can boost endorphins' ability to activate the mu-opioid receptor, producing analgesia with reduced side effects. The compound shows promise as an alternative to traditional opioid drugs for pain relief.
A new analysis found that younger age and specific types of cancer, such as melanoma and kidney cancer, increase the risk of severe side effects. Patients receiving multiple immune checkpoint inhibitors also faced a higher risk.
A large-scale study found that 25.1% of patients on immune checkpoint inhibitors developed skin-related side effects, including itching, inflammation, and rash. The study identified 10 specific conditions at higher risk among melanoma or kidney cancer patients.
L-DOPA-induced dyskinesia is a major side effect of long-term medication, affecting millions worldwide. Researchers revealed the link between neuronal activity changes and dyskinesia, suggesting suppressing or restoring neurotransmission through key pathways may improve symptoms.
A comprehensive analysis of 24 studies found limited evidence on risk factors for steroid-induced psychological reactions in children with acute lymphoblastic leukemia. Younger patients were at risk for behavioral problems, while older patients were more susceptible to sleep issues.
A targeted opioid called NFEPP selectively activates opioid receptors in acidic tissues, relieving pain from colitis without causing severe side effects. Researchers are now collecting tissue samples to test NFEPP's ability to inhibit pain in the human gut and plan clinical trials.
Chronic side effects among melanoma survivors after anti-PD-1 immunotherapy treatment are more common than previously recognized, affecting 43% of patients. The most frequently affected organs were joints and the endocrine system.
A study by researchers at the Annenberg Public Policy Center found that news coverage of expert scientific evidence on vaccine safety increases public acceptance of vaccines. In contrast, personal narratives about real side effects diminish the positive effect of such messages. The experiment tested six video clips featuring experts an...
Researchers used an experimental safety switch to curb treatment side effects in a patient with refractory acute B-cell leukemia, achieving a significant reduction in toxicities. The study demonstrates potential for expanded use of CAR-T immunotherapy paired with the safety switch.
A team of researchers has developed a new method to combat periodontitis by targeting only the bacteria that cause the disease. The approach uses a test substance that attacks glutaminyl cyclase, an enzyme in the bacteria that plays a special role in metabolism.
Researchers found that older people correctly understood basic medication information in over 70% of cases. However, when physicians failed to discuss potential side effects, patients incorrectly assumed there were none for nearly half of their prescribed medications.
A new nasal spray delivery method promises relief from antipsychotic medication's adverse side effects by delivering medication directly to the brain. This approach could reduce required doses by as much as three quarters, sparing patients from debilitating side effects and improving treatment efficacy.
Researchers developed a peptide-based photosensitizer that activates in cancer tissues only and destroys cancer cells without affecting surrounding normal cells. The new technology allows for repeated treatment with long-term release of the agent, reducing side effects associated with traditional phototherapy methods.
Researchers at Uppsala University have discovered a link between faulty L-Dopa metabolism and severe side effects in Parkinson's patients. Abnormally elevated levels of L-Dopa and its metabolite were detected in brain regions outside the striatum, suggesting alternative mechanisms underlying motor disorders.
A new study found that physicians did not recognize significant symptoms in over half of breast cancer patients who reported pain, itchy skin, swelling, or fatigue during radiation therapy. The under-recognition was more common among younger patients and those from Black backgrounds, suggesting the need for better symptom detection met...