Articles tagged with Side Effects
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at UNIGE have found that the S100A9 protein can significantly improve insulin metabolism in diabetic patients, reducing the risk of severe side effects associated with insulin therapy. The protein's anti-inflammatory effect may also help to normalize ketone production and prevent life-threatening conditions.
Bone marrow donors can now receive significantly reduced opioid medication during and after the donation procedure, resulting in a more comfortable experience. The new pain control method, using regional anesthesia, drastically decreased opioid usage from 84% to 23% among patients.
Researchers at Edith Cowan University have found a genetic link between human leukocyte antigens and immunotherapy side effects in non-small cell lung cancer patients. The discovery enables doctors to tailor treatment to individual patients, reducing the risk of toxicities and improving overall outcomes.
A new study found that opioids like morphine can cause gastric inflammation due to increased acid secretion and delayed gastric emptying. Treatment with naloxone or proton pump inhibitors like omeprazole may provide gastroprotection, improving pain management and reducing side effects.
A population-based study found that patients with estrogen receptor-positive breast cancer who experienced hot flashes while on adjuvant hormone therapy had worse outcomes and a higher risk of early treatment discontinuation. The study suggests that managing side effects may not be enough to prevent treatment discontinuation, highlight...
A new study from Mount Sinai Heart found that heart failure patients unvaccinated against COVID-19 are three times more likely to die from it than those who are fully vaccinated and boosted. The research also shows that these unvaccinated patients face higher risks of hospitalization and ICU admission if infected with the virus.
A systematic review of cannabis-related products found short-term benefits for neuropathic pain, particularly with dronabinol and nabilone. However, the evidence is limited, with many products not well-studied, and patients should consult their primary care physician before using cannabis-based treatments.
A review of 25 trials found that synthetic cannabis products with high THC-to-CBD ratios improved chronic pain, but were associated with higher risks of adverse events. In contrast, products with comparable THC-to-CBD ratios showed few benefits in overall functioning.
A new Northwestern University study reveals ketamine's fast-acting antidepressant effects by increasing activity in existing newborn neurons, offering hope for a faster-working treatment with fewer side effects.
Leading ethicists argue that mandatory flu vaccination for healthcare staff is ethically justified due to the risks of nosocomial infections and staff shortages. In contrast, a COVID-19 vaccine mandate is considered unethical due to the low risk of serious illness among younger staff and concerns over coercion.
Pharmaceutical scientist Hans Lennernäs will collaborate with JGU's Peter Langguth to investigate ways to mitigate chemotherapy side effects. The goal is to identify active substances that can counteract adverse reactions and develop effective drugs.
A new study has found that a one-off treatment with senolytics can prevent premature ageing and frailty caused by cancer radiotherapies. The treatment was tested in mice and showed improved health conditions, providing new hope for cancer survivors.
A large randomized controlled trial found that treatment with methylprednisolone reduces the risk of kidney function loss and failure in patients with IgA nephropathy. The study's results suggest a lower dose regimen may be effective while minimizing side effects.
A new case report highlights the risks of herbal supplements containing CBD and berberine, which can cause cardiac arrhythmias. The study involves a patient who experienced dizziness and fainting after taking high doses of hemp oil and berberine supplements, leading to a life-threatening condition.
Research by University of Texas M.D. Anderson Cancer Center reveals adolescent and young adult leukemia survivors have shorter life spans than those without cancer. The study found inferior long-term mortality outcomes persist even decades after treatment, impacting quality of life and overall survival.
Researchers at University of Texas M.D. Anderson Cancer Center identify IL-6 as a key player in immunotherapy toxicity. A novel strategy combining IL-6 blockade with immune checkpoint blockade shows promise in reducing autoimmune side effects while preserving antitumor efficacy.
Researchers at Ochsner Health and MD Anderson have discovered that blocking interleukin-6 (IL-6) in lab models improves cancer responses while minimizing inflammation in healthy tissue. By targeting this cytokine, immune checkpoint inhibitors may become more targeted on tumors with fewer side effects.
Researchers from Osaka University have discovered that mesenchymal stem cells can prevent the onset of type 1 diabetes associated with immune checkpoint cancer therapy. MSCs secrete factors that protect pancreatic cells against immune attack, suggesting a new approach to preventing this debilitating side effect.
Scientists discovered that intermittent dosing of PI3Kδ inhibitors can reduce toxicity while maintaining anti-tumor immunity in patients with head and neck cancers. This finding holds promise for improving treatment outcomes and saving lives.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
A study involving hypothetical COVID-19 vaccines found that effectiveness and risk of side effects significantly influence people's vaccine preferences. The attributes of actual vaccines may not be as crucial for those already open to vaccinations.
A third of healthcare workers took sick leave after receiving the COVID-19 vaccine, with average length of sick leave being two days. The study found that those given mRNA jabs were most likely to take sick leave after their second or third dose.
A new international study confirms the low risk of myopericarditis following COVID-19 vaccination, with a rate of 18 cases per million doses. The study found no statistically significant difference between the incidence of myopericarditis after COVID-19 vaccination and other vaccinations.
Researchers developed innovative smart sensors to test new vaccines, revealing significant discrepancies between subjective self-reports and objective measurements. The study found that side effects escalate over the first 48 hours and then stabilize, with parameters returning to pre-vaccination levels.
A study found that childhood cancer survivors who received combined chemotherapy and radiotherapy have a higher risk of dental developmental anomalies. The first signs of dental disturbances can appear within one or two years after treatment. Researchers identified specific treatments and age factors associated with increased DDA risk.
A study in rats suggests that vitamin C supplementation can help preserve skeletal muscle after doxorubicin therapy, reducing oxidative stress and inflammation. The findings suggest vitamin C may represent a promising opportunity to reduce some of the drug's most debilitating side effects.
Researchers at Rensselaer Polytechnic Institute found that alternative delivery locations can help offset the negative impacts of increased home deliveries. The study suggests that these locations may be more appealing to underrepresented groups who don't receive many packages, increasing their willingness to use them.
A recent study found that cancer treatment side effects significantly affect patients' and caregivers' eating habits, food preferences, and overall well-being. The research team identified six themes, including managing symptoms, losing taste, and caregiver burden.
Scientists have developed a non-hormonal male contraceptive that effectively prevents pregnancy in mice, targeting the retinoic acid receptor alpha protein. The compound YCT529 was found to be 99% effective in preventing pregnancy without observable side effects, paving the way for human clinical trials.
A retrospective cohort study found that shoulder injuries occurred in fewer than 1 in 10,000 patients who received intramuscular vaccinations administered in the deltoid muscle. Researchers also identified risk factors for developing shoulder conditions, including advanced age, female sex, and receiving pneumococcal conjugate vaccine.
A new discovery could lead to modified thiazolidinediones with fewer side effects, benefiting more patients with diabetes. Activating only PPARγ2 eliminates the risk of weight gain while maintaining anti-diabetic effects.
The International Lipid Expert Panel recommends a step-by-step approach to diagnosing and managing muscle symptoms caused by statins. The 'nocebo/drucebo' effect, where patients experience side effects due to expectation, affects up to 70% of diagnosed statin intolerance cases.
Researchers at the University of South Australia have developed a new way to deliver chemotherapy drugs, using liposomal formulations that target tumors more effectively. This breakthrough could improve treatment outcomes for thousands of cancer patients, reducing side effects and improving quality of life.
A new study found that nearly one-third of older adult female survivors of colorectal, endometrial, and ovarian cancer experience quality-of-life-impacting challenges with physical activity due to chronic lower extremity lymphedema. The researchers urge the medical community to include regular lymphedema assessments in survivorship care.
A large US study found that 92% of reported adverse events following mRNA COVID-19 vaccination were non-serious, with most side effects being mild and decreasing substantially after one day. The study also found that less than 1% of participants reported seeking medical care after vaccination.
The article suggests a potential treatment option for COVID-19 by targeting SARS-CoV-2's interaction with ACE2 receptors. Combining DPP4 inhibitors and spironolactone may mitigate COVID-19 complications and infections without adverse side effects.
Researchers discovered that a specific osmolyte causes kidney cells to undergo an EMT transformation, leading to renal failure. The team found a way to prevent this change by arresting focal adhesion rearrangement, suggesting a new approach to enhance therapeutic value of common osmolytes.
A new phase II trial found that mid-treatment PET scans can help determine if patients with p16-positive oropharynx cancer can receive a lower dose of radiation therapy without compromising cancer control. The study reported fewer short-term side effects in patients who received de-escalated therapy.
A new study highlights alternative treatment options that consider a patient's likelihood of recovery and quality of life. Total Definitive Treatment (TDT) is an approach that combines chemotherapy, radiation therapy, and close monitoring to potentially cure patients without surgery.
A new study found that statin intolerance is over-estimated, affecting only 6-10% of patients worldwide. Researchers identified risk factors for statin intolerance, including age, sex, ethnicity, and medical conditions.
A recent study found that women have a 34% higher risk of severe toxicity than men in cancer treatment, with higher risks for immunotherapy and targeted therapies. The analysis of over 20,000 patients from more than 200 clinical trials supports the idea that sex may independently modulate drug toxicity.
Ammonium toxicity triggers reactive oxygen species formation in plant roots, causing inhibited root elongation. A newly identified gene, PDX1.1, plays a crucial role in vitamin B6 biosynthesis, which neutralizes oxidative stress and protects roots from ammonium-induced damage.
Researchers develop a method called Cell Painting that uses morphological profiling to detect side effects of substances on cells, enabling the identification of tubulin-modulating compounds. The study reveals over 1% of tested substances have this effect, including previously unknown reference substances.
A new combination immune therapy treatment extends cancer patients' lives while reducing toxic side effects and improving their overall health. This study found that the treatment was less toxic than other drugs on the market, providing an added benefit for patients' quality of life.
Patients with skin-related side effects from immune checkpoint inhibitors tend to live longer, with a 22-50% decrease in mortality. These findings suggest that skin toxicities can be an indicator of treatment efficacy and may help identify patients who are more likely to benefit from their current immunotherapy regimen.
Researchers at RIKEN successfully treated cancer in mice using metal catalysts that assemble anticancer drugs inside the body. The technique avoids indiscriminate tissue damage and increases cancer-inhibiting activity by 1000 times.
A registry study found that people with inflammatory RMDs, such as rheumatoid arthritis and psoriatic arthritis, tolerate their COVID vaccine well, with short-lived reactions being the most common side effect. The majority of participants were able to continue on their normal medication with no changes.
Scientists develop hairy cellulose nanocrystals to capture and remove excess chemotherapy drugs from the blood. The nanocrystals effectively removed over 6,000 milligrams of doxorubicin per gram, increasing DOX capture by two to three orders of magnitude compared to existing methods.
A study found that cholinesterase inhibitors like donepezil increase the risk of overactive bladder in people with dementia. Galantamine and rivastigmine were not associated with this increased risk.
A new study suggests that combining two drugs can reduce postoperative opioid use and side effects in adolescents with scoliosis. The combination of intrathecal morphine and oral gabapentin provides more effective pain control, resulting in fewer side effects and lower narcotic consumption.
A review suggests that doctors should prescribe fewer antidepressants and for shorter periods due to the potential severity and duration of withdrawal symptoms. The use of antidepressants is also associated with a range of side effects, but clinical trial data often don't assess outcomes that matter most to patients.
A clinical trial found that remote monitoring of medication's potential arrhythmic side effects is feasible and safe for patients with mild COVID-19. The study used handheld devices to transmit digital ECGs, suggesting a potential expansion of clinical research to broader populations and reducing participants' burdens.
Researchers at PSI have developed a platform to measure biased signalling in G protein-coupled receptors (GPCRs), enabling selective therapeutic effects and fewer side effects. By testing specially designed bivalent ligands, they can bias signalling towards desired pathways.
A case study published in Nature Medicine reports a patient experiencing progressive neurological features resembling Parkinson's disease after CAR-T cell therapy, suggesting potential neurotoxicity. The study highlights the importance of monitoring for neurotoxicity in patients receiving BCMA-targeted CAR-T therapies.
A new NRG Oncology clinical trial found that bupropion did not improve sexual desire in female cancer survivors. The trial evaluated the effects of extended-release bupropion on postmenopausal women with low baseline sexual desire scores.
Researchers found that most cases of suspected COVID-19 vaccine-related myocarditis in people younger than 21 are mild and resolve quickly. The study suggests that the benefits of COVID-19 vaccination far exceed the rare risks of adverse events, including myocarditis.
A new study has identified a promising drug candidate to minimize uncontrolled muscle movements associated with Parkinson’s disease. PD13R reduced dyskinesia by more than 85% in animal studies, also improving sleep quality compared to other treatments.
A new programme is seeking to understand the rare condition of blood clotting with low platelets in COVID-19 infection and vaccination. The vast majority of people experience mild reactions, but some develop severe side effects, including blood clots and low platelet levels.
Researchers discovered a correlation between simultaneous vaccination with the flu and shingles vaccines, resulting in reduced likelihood of administering a flu shot the next year. The study suggests that side effects from the shingles vaccine may be misattributed to the flu vaccine, contributing to this phenomenon.
A new study found that a simple surgical technique called posterior left pericardiotomy significantly reduces the risk of atrial fibrillation in patients undergoing cardiac surgery. The procedure, which involves draining excess fluid and small clots from the heart sac, was associated with a 56% lower incidence of irregular heart rhythm...