Articles tagged with Side Effects
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A novel chemotherapy approach uses patient's own cells as Trojan horses to deliver targeted cancer-killing drugs to lung cancer cells. The method has shown promise in reducing tumor size and improving treatment efficacy with minimal collateral damage to healthy tissues.
Researchers identified mechanisms that cause ponatinib to harm the heart and found a promising treatment that could reverse this process. The treatment protects heart cells without diminishing the tumor-fighting efficacy of the drug.
A team led by UCF College of Nursing Professor Victoria Loerzel developed an innovative educational game for older adults with cancer, simulating symptoms and self-management. The game was successful in increasing the use of preventative strategies among participants, reducing symptom severity and hospital admissions.
Cancer immunotherapy can cause severe colitis due to hyper-activated immune T cells and deleted regulatory T cells. Researchers at Michigan Medicine have identified a new mouse model that develops colitis after treatment with antibodies used for tumor immunotherapy, revealing the mechanism behind this side effect.
Researchers have developed nanodrones that target and eliminate cancer cells by recruiting natural killer cells to tumor sites. The study offers a potential solution for intractable types of cancers, with promising results in suppressing tumor growth without causing side effects.
The use of 'trip-killers' to shorten psychedelic drug trips is a growing concern among doctors, with benzodiazepines and antipsychotics being the most frequently recommended options. However, warnings about their potential side effects are rarely included, highlighting a need for greater awareness.
A recent review of opioid medicines for cancer pain found surprisingly large gaps in evidence regarding their true benefits. Non-steroidal anti-inflammatory drugs (NSAIDs) may be at least as effective as some opioids for background cancer pain, offering potential alternatives to reduce dependence and waning analgesia over time.
A Northwestern University study found that nearly two-thirds of patients discontinue or change their medication within a year, highlighting the need for better understanding of barriers to treatment adherence. The high discontinuation rate for GLP-1 RAs may be due to gastrointestinal side effects.
Researchers found that BCMA-positive extracellular vesicles (EVs) in plasma levels correlated with myeloma patient responses to belantamab-mafodotin therapy. High EV levels preceded FLC progression and were associated with mafodotin-induced eryptosis.
A recent study from Drexel University's College of Nursing and Health Professions aimed to understand the challenges and supports affecting individuals with GI cancer and their caregivers when it comes to maintaining a healthy diet and avoiding malnutrition. The research highlighted the importance of creating dietary interventions that...
A Phase II clinical trial has shown a clear clinical benefit of combining Dabrafenib and Trametinib in treating BRAF mutated low-grade paediatric gliomas. The combination therapy improved overall response rate by over four-fold and increased median progression-free survival.
Researchers investigate nanoparticles for cancer treatment, hoping to reduce side effects and improve efficacy. La-Beck's lab aims to understand the body's interaction with nanoparticles and their impact on tumor growth and immune responses.
A new study by Harvard researchers proposes that social factors, such as gendered variables, may better explain observed sex disparities in adverse drug events. The study highlights the need to consider social and structural differences in individuals' experiences and health outcomes.
A simple MRI scan and a new metric for prostatic urethra length may help identify men at risk of chronic urinary side effects after radiation therapy. The study found that longer prostatic urethras are associated with a higher likelihood of these symptoms, which can impact quality of life.
Researchers will study the impact of exercise, intermittent fasting, and their combination on fatigue, biomarkers of inflammation, and quality of life in women with advanced breast cancer. The trial aims to improve treatment tolerability and possibly life duration for these patients.
Researchers developed a promising strategy to reduce adverse reactions to nanoparticles by using complement inhibitors. The study showed that regulators being studied effectively inhibited complement activation by nanoparticles in human serum in vitro and animal models.
Patients who engage in regular sexual activity or vaginal dilation have a lower risk of long-term side effects, including vaginal stenosis. Regular dilation and/or sex were associated with lower risk of moderate-grade vaginal shortening and narrowing five years after treatment.
Researchers found persistent inflammation in intestines of patients 20 years post-radiotherapy, even with targeted treatments. This could lead to chronic symptoms like tenesmus and frequent diarrhea.
Researchers found that etripamil nasal spray restored normal heart rhythms within 30 minutes in 54% of patients, making it a potential new option for self-treating paroxysmal supraventricular tachycardia. The study showed the medication to be safe and well-tolerated.
A study found that 80.3% of patients with metastatic breast cancer who received standard care treatment with alpelisib developed hyperglycemia, with 40.2% experiencing serious hyperglycemia. Lifestyle interventions and medication may help improve blood sugar levels and reduce the risk of needing to discontinue the drug.
Researchers found that patients prescribed amoxicillin-clavulanate had higher rates of gastrointestinal symptoms and yeast infections than those prescribed amoxicillin. The study showed no difference in treatment failure rates between the two antibiotics, with treatment failure occurring in less than 2% of cases.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
A comprehensive review of over 70 years of menopause science emphasizes the need for more research into symptom timeline and treatment effectiveness. The authors advocate for holistic, individualized approaches addressing physical and mental health impacts of menopause.
Breast cancer survivors often struggle to take their life-extending medication due to side effects and high costs. A new study found that interventions such as cost-cutting policies, mobile apps, and psychological counseling can increase medication adherence by nearly 1.5 times. Addressing mental health issues, particularly depression,...
Two studies published by Aarhus University found that common side effects like malaise, fever, and fatigue occur frequently after COVID-19 vaccination. Menstruating women reported a 30% increase in menstrual cycle changes, with stress, age, and smoking contributing to the correlation.
Researchers identified a specific type of CD8 T cell that characterizes inflammatory arthritis induced by ICI therapies. A unique population of CD8 T cells was found to promote joint inflammation and persist in the bloodstream, explaining why ICI-arthritis continues after therapy is discontinued.
A muscle-building supplement called beta-hydroxy beta-methylbutyrate (HMB) has been shown to reduce plaques and increase factors for neuronal growth in mice with Alzheimer's-like pathology. The study found that HMB stimulates a nuclear hormone receptor to improve memory and learning in mice with Alzheimer's disease.
A new study found that 21.3% of respondents used skin lightening agents, often for conditions like acne or hyperpigmentation, but most users were unaware of potential toxic ingredients and risks. The study highlights the need for cultural mindfulness in dermatology care to ensure safe and effective treatment across all communities.
Researchers have developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA. This 'Purecap' technique extracted up to 100% pure Cap2-type mRNA, which showed improved protein production and lower immunostimulatory activity.
A clinical trial has shown that desmopressin may reduce the risk of death or disability in stroke patients taking antiplatelet drugs. The results support the need for a large-scale trial to determine its effectiveness.
The University of Sydney-led guidelines recommend personalized deprescribing plans and gradual dose reduction to minimize withdrawal symptoms. Clinicians should avoid abruptly stopping opioids without support or pain management plans, especially for patients with severe opioid use disorder.
A new study by UNM researchers found that patients who reported feeling 'high' experienced 7.7% greater symptom relief, but also a more than 20% increase in negative side effects. The study suggests that feeling 'high' may be an unavoidable component of using cannabis medicinally.
Scientists discovered a novel method to activate G protein-coupled receptors from inside cells, which can help develop drugs with fewer or no side effects. This new process uses a non-peptide message molecule called PCO371 that binds to the intracellular region of the receptor and interacts directly with G protein subunits.
A large study tracked CIPN in over 1,100 breast cancer patients treated with taxanes, showing persistent sensory and motor symptoms with more severe symptoms with paclitaxel than docetaxel. The study defines a risk prediction model to help doctors individualize patient care.
A case study published in the Journal of Alzheimer's Disease reveals that lecanemab can lead to therapy-induced Aβ phagocytosis and multifocal intracerebral hemorrhage, highlighting a potential risk of brain damage and death. The study suggests that better biomarkers are needed to assess the extent of cerebral amyloid angiopathy.
Researchers at the University of Tsukuba found an association between evaporated alcohol from incubator disinfectants and alcohol absorption in premature infants. They introduced a new practice to reduce alcohol exposure, which was associated with decreased alcohol levels in infants' blood and air.
The Vaccine Adverse Event Reporting System (VAERS) collects reports of adverse events after vaccination, but public confusion about its nature and reports has increased. A new report recommends renaming the system to a clearer alternative and making additional changes to reduce misinterpretation.
A study led by Brown University researchers found that qigong practice significantly improved cancer-related fatigue in participants. The program was as effective as a more standard exercise program in reducing fatigue levels.
A significant increase in illicit ketamine seizures in the US has raised concerns about the risks of non-medical and recreational use, as well as the presence of fentanyl. The study found a 349% rise in seizures from 2017 to 2022, with the highest numbers reported in Tennessee, Florida, and California.
Researchers have found a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment. The aromatic ketone 2',4',6'-trihydroxyacetophenone (THA) inhibits the CCBL1-mediated metabolism of cisplatin, reducing its toxic effects without affecting its potency.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
Researchers at UCLA Jonsson Comprehensive Cancer Center have found a potential therapeutic target, IL-21, to reduce endocrine autoimmune side effects from checkpoint immunotherapy. A specific group of immune cells play a central role in this autoimmune attack and blocking IL-21 prevents thyroid autoimmunity.
A recent clinical trial, PLATO, demonstrated that lowering the dose and duration of radiotherapy treatments for anal cancer reduces side effects without compromising cancer cure rates. The treatment involves intensity modulated radiotherapy (IMRT), which allows for personalized doses to be applied to visible tumors.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
KNT-127 exhibits anti-stressing and anti-depressant effects in mice, improving social interaction and reducing stress-induced hormone levels. The agent suppresses neuronal inflammation and newborn death without affecting neurogenesis.
A pilot study found that high-dose tadalafil improved metabolic control and reduced hemoglobin A1c levels by 2.50 mmol/mol in patients with well-controlled type 2 diabetes. The treatment also showed increased blood flow, liver values, and metabolism.
A study found that psychological factors, such as beliefs and attitude towards the COVID-19 vaccine, significantly contribute to the onset and severity of adverse effects. The researchers investigated how fear, trust, and expectations affect side effects and explained 30% of the intensity of symptoms.
Researchers discuss the importance of biomarkers in breast lump management, enabling patients to make informed decisions between proactive treatment and watchful waiting. The development of biomarkers could provide personalized risk assessments and guide treatment strategies for women with breast lumps.
Researchers have identified ATAD3A as a molecular determinant that favors the development of head and neck cancer. The protein is involved in various cellular processes, including energy metabolism and apoptosis. Targeting ATAD3A could offer a novel approach to developing effective anti-cancer therapeutics.
A new meta-analysis found that clozapine is associated with decreased insomnia and a lower risk of suicide in patients with schizophrenia. The study suggests that clozapine's ability to improve sleep quality may be linked to its reduced suicide risk, and highlights the importance of assessing and treating insomnia in these patients.
Research finds diclofenac's high variability in metabolism due to UGT2B17, a little-studied enzyme. The study suggests genetic testing and dose adjustments for specific populations can help minimize side effects.
A new study by Ohio State University researchers has made significant strides in ensuring the safe and effective transfusion of artificial blood substitutes. The key to improved safety lies in the size of the artificial blood molecule, with larger sizes reducing cardiovascular side effects.
A nurse has shared her experience of developing sudden sensorineural hearing loss (SSNHL) after a mild COVID-19 infection. She highlights the importance of clinicians including SSNHL as a potential side effect of COVID-19 and recommends high-dose corticosteroids as treatment.
Researchers developed a simple sensor to monitor paracetamol levels in saliva in real-time, enabling personalized treatment and reducing toxic side effects. The device is low-cost, portable, and uses non-invasive collection methods, making it an attractive alternative for therapeutic drug monitoring.
Researchers developed a complex that accumulates in tumour tissue and is activated by ultrasound waves, triggering the release of a toxic compound and eradicating tumours. This method could make cancer treatment less invasive and more effective for large and deep-seated tumours.
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
A new class of compounds reduces weight dramatically and lowers blood glucose in lab animals, boosting calorie burn and avoiding nausea. The injectable treatments activate multiple gut hormone receptors, including GLP-1 and PYY, to signal fullness and curb appetite.
Researchers debunk rock'n'roll myth, finding narcotics have no effect on inspiration. Instead, complex training programs, meditation, and cultural exposure boost creativity. Training that highlights mental techniques has long-term impacts, while mindfulness activities like meditation also improve imagination in the short term.
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
A recent study found that the side effects of treating brain diseases with antisense oligonucleotides are related to altered calcium balance. By modulating calcium levels, researchers hope to reduce neurotoxicity and improve treatment outcomes for various neurological diseases.