Articles tagged with Side Effects
Researchers at the University of Missouri have discovered a new compound called boronicaine that offers longer-lasting painkilling effects compared to lidocaine. The compound provides about five times longer relief, making it a potential alternative for treating sports injuries and joint replacement procedures.
Scientists at Scripps Research Institute have been awarded a $2.4 million grant to expand development of new pain medications that utilize the same biological target as morphine but with fewer side effects. These new compounds aim to reduce respiratory suppression and persistent constipation associated with current opioid drugs.
Women with breast cancer who follow a physical exercise program during chemotherapy experience less fatigue, nausea, and pain. The study found that both moderate and low-intensity exercise programs significantly reduced the need for dose adjustments in chemotherapy treatment.
A new study found that statins can help prevent heart disease in older adults but may cause muscle pain, weakness, and mild cognitive impairment. The study suggests that the benefits of statin use may be offset by these side effects, particularly in geriatric populations.
A study of 1,964 patients found extending natalizumab dosing up to 8 weeks is well-tolerated and effective in treating MS disease activity. No cases of progressive multifocal leukoencephalopathy were reported in the extended dosing group.
A new study suggests statins could be a cost-effective tool for preventing heart attacks and other cardiovascular incidents in adults over age 75. However, potential side effects such as muscle weakness and cognitive impairment need to be considered.
A study led by the University of Pennsylvania found that roseroot extract may be an effective treatment for mild to moderate major depressive disorder, with fewer side effects than conventional antidepressants. The herbal remedy showed a more favorable risk-to-benefit ratio, suggesting its potential as an alternative therapy option.
A new Northwestern Medicine study found that low-dose VM202 gene therapy significantly improves pain symptoms and perception of light touch in patients with painful diabetic neuropathy. The treatment has virtually no side effects, offering hope for a potential new treatment for this debilitating condition.
Researchers at the Buck Institute discovered how rapamycin inhibits mTORC2, a complex linked to metabolic side effects. The study suggests that manipulating FK506 binding proteins could selectively target mTORC1, reducing side effects and improving longevity outcomes.
Researchers have developed a novel, drug-releasing wafer that patients can apply directly to their affected eyes once daily, showing twice the effectiveness of traditional eye drops in mice without causing inflammation. This innovative treatment could help patients recover faster and reduce side effects associated with current therapies.
A recent study found that delays in the withdrawal of drugs from the market due to reported deaths could have been reduced if there were more efficient reporting and regulatory processes. The researchers identified 95 drugs that were withdrawn due to deaths, with most being used to treat neurological or psychiatric disorders.
Patients with a history of smoking have increased risks of cancer relapse, side effects, and death from prostate cancer, according to a study published in BJU International. Smoking negatively affects prostate cancer health outcomes, particularly when treated with radiotherapy.
Joining a walking group improves lung power, physical functioning, and general fitness, with few side effects, according to an analysis of available evidence published in the British Journal of Sports Medicine. The study found wide-ranging benefits for adults with various long-term conditions.
Glucocorticoids suppress inflammation by targeting nuclear factor-κB and upregulating IRAK-M, a key negative regulator of inflammatory pathways. The discovery provides new insights into the mechanism of glucocorticoid action and could lead to the development of new therapeutic strategies for controlling overactive inflammation.
A new tool assesses radiotherapy-related toxicities in lung cancer patients using patient-reported outcomes, revealing strongest agreement with quality-of-life measures. The study found that clinicians' recorded toxicities underestimated their severity, highlighting the potential for early detection and improved treatment.
A new model for measuring acceptability of a long-acting contraceptive vaginal ring was tested among 1,036 women in a Phase 3 clinical trial. The study found that 89% of women were satisfied with the ring and had easy insertion and removal. Continued research is recommended to broaden the evidence supporting its use.
A Dartmouth/Univ. of Exeter study found that correcting myths about the flu vaccine did not effectively promote immunization among vaccine skeptics, and in some cases even reduced intention to vaccinate among those with high concerns about side effects.
A phase three study has demonstrated increased survival rates among AML patients who relapse, with combination therapy employing cytarabine and vosaroxin showing significant benefits. Patients over 60 years old experienced the greatest overall survival benefit from the treatment.
Lawrence Livermore National Laboratory researchers used supercomputers and molecular docking to predict adverse drug reactions (ADRs) from off-target proteins. The computational model outperformed current statistical methods in predicting side effects, particularly in vascular disorders and neoplasms.
A new study by Dana-Farber Cancer Institute reveals that a half-day educational program can help women manage side effects of ovary-removing surgery, including vaginal dryness, decreased libido, and anxiety. Participants reported significant improvement in sexual health, self-image, and emotional well-being after the program.
Researchers developed a novel strategy to restrict tyrosine kinase inhibitors' activity to malignant tumour cells, minimizing damage to healthy tissue. The approach uses cobalt(III) compounds that are activated selectively in tumours under low-oxygen conditions.
Researchers have found a promising plant-derived compound, CDDO, that may block both steps of lupus development and has no known side effects. The compound, originally derived from plants, could potentially eliminate the risks associated with current lupus treatments.
A new treatment, anti-LINGO-1, has been found to be safe and tolerable in phase I clinical trials for multiple sclerosis. The treatment blocks a protein that prevents myelination, potentially repairing damaged nerves.
A nationwide survey of Swedish anesthesiologists and nurse anesthetists found low awareness of cognitive side effects following surgery. Postoperative cognitive impairments can have major implications for patient care. Investigators called for improved knowledge on risk factors, prevention, and management.
The number of enquiries made to the National Poisons Information Service about 2,4-Dinitrophenol's harmful effects has sharply risen in the past three years. The most commonly reported symptoms include fever, rapid heart rate and sweating.
Researchers found that combining two smoking cessation therapies is more effective than using just one for male and highly nicotine-dependent smokers who weren't initially helped by the nicotine patch. The treatment combination resulted in a higher abstinence rate among male smokers, with an increase of 61% compared to varenicline alone.
Researchers discovered a specific immune response triggered by statins that impairs insulin function, increasing the risk of diabetes. Combining statins with another medication may suppress this side effect, offering potential new targets for minimizing adverse effects.
Pharmacists at Jena University have developed three potential therapeutic agents that may improve the healing of inflammatory illnesses. The agents suppress a key enzyme in the body's own cascade of inflammation, specifically targeting 5-LOX, which plays a pivotal role in synthesizing leukotrienes. This breakthrough could lead to more ...
A pre-treatment snack improved treatment uptake for schistosomiasis in Ugandan schoolchildren, with higher rates of drug adherence and lower infection rates. The study found that providing a snack before mass treatment increased uptake by 15.2% compared to schools without snacks.
A new study found that Orlistat patients attribute weight loss failure to side effects or ineffective medication. Patients described barriers such as psychological and physical health issues, relationships, and alternative methods of weight loss, emphasizing the need for better patient support and dietary education.
A pilot study found that a vibrating capsule increased spontaneous bowel movements and decreased constipation symptoms in patients with chronic idiopathic constipation (CIC) and C-IBS. The capsule uses mechanical stimulation to mimic the body's natural physiology, avoiding common side effects of medication.
Atrasentan has been shown to lower albuminuria by 36% without major side effects in patients with type 2 diabetes and kidney disease. The drug also lowers blood pressure and cholesterol levels, suggesting a potential benefit for patients at high risk of serious medical problems.
Scientists at Scripps Research Institute have discovered a new binding site on peroxisome proliferator-activated receptor-gamma (PPARG) that could lead to improved insulin-sensitizing drugs. This alternative site may provide clues to the adverse effects of existing anti-diabetic medications, such as bone loss and congestive heart failure.
In a phase III study, evolocumab was shown to effectively lower LDL-C levels, with fewer side effects compared to ezetimibe. The results suggest that evolocumab may be a promising alternative for patients who cannot tolerate statins due to intolerable side effects.
A recent study analyzing over 80,000 patients found that only a small minority of reported side effects from statin use were actually caused by the medication. In contrast, many common side effects like muscle pain and fatigue were equally common in both treatment and placebo arms.
Research at the University of Copenhagen reveals that cosmetic fillers can act as incubators for bacterial infection, causing lesions and tough film-like material resistant to antibiotics. Prophylactic antibiotic treatment during procedures can prevent these complications.
Researchers at CNIO have identified two novel treatments for psoriasis, one targeting S100A9 and the other inhibiting miR-21, which show promise in reducing side effects. These discoveries offer new hope for patients suffering from this chronic disease.
Researchers at GEOMAR found that large-scale climate intervention methods have limited benefits and significant side effects, such as accelerated global warming. The study's results highlight the need for careful consideration of the potential social, political, legal, and ethical implications of proposed climate engineering methods.
A newly-developed dietary fiber with a slow release mechanism may alleviate IBS symptoms and improve gut health, targeting the distal colon where colon cancer and other diseases occur.
A recent study by Tel Aviv University researchers found that warning labels can paradoxically promote trust in products over time, leading to increased sales. The study suggests that regulators and managers should consider the timing of when warnings are presented to consumers to maximize their effectiveness.
A study published in Depression and Anxiety found that exercise can improve orgasm function and overall sexual functioning in women taking antidepressants. Regular exercise, especially immediately before sex, was shown to boost libido and alleviate side effects of antidepressant medications.
Researchers discovered that Δ9-THC causes an increase in COX-2 levels, leading to memory impairments. Taking an over-the-counter painkiller like ibuprofen can prevent these side effects by inhibiting COX-2 levels.
A new Penn Medicine study shows that proton therapy significantly reduces side effects in pediatric head and neck cancer patients. The results, which followed 25 patients aged 1-21, found no evidence of disease in 76% after 13 months, with only mild side effects such as fatigue and dermatitis.
A new study suggests that warning consumers about potentially harmful side effects can improve their opinions and increase product sales. Researchers found that when warnings are delayed, they can actually make products seem more trustworthy to consumers.
Researchers have developed substrate-selective COX-2 inhibitors that relieve anxiety behaviors in mice by activating natural endocannabinoids without gastrointestinal side effects. The findings suggest a new approach to treating mood and anxiety disorders, potentially paving the way for clinical trials and new treatments.
Researchers have identified a new chemical compound, CYM51010, that targets the opioid receptor complex and shows promise as an alternative to morphine. The compound is potent and less likely to result in tolerance and negative side effects.
Research suggests that simultaneous boosting of these hormones can reduce appetite, fat gain, and insulin-resistance in mice. The double-barreled approach stimulates complementary brain regions and nerve pathways, leading to a powerful combined effect.
In a Phase 2 study, ibrutinib demonstrated an overall response rate of 68% and complete response rate of 21% in patients with relapsed or refractory mantle cell lymphoma. The treatment showed promise with fewer side effects than traditional chemotherapy approaches.
A new compound, GLYX-13, has been shown to rapidly lift depression without the severe side effects associated with ketamine. The molecule activates NMDA receptors, leading to increased memory and learning, and has been found effective in patients who failed treatment with conventional antidepressants.
A recent study has found that physicians are often poorly informed about the side effects of prescription drugs, with medical sales reps dominating discussions and rarely disclosing serious risks. The research highlights a concerning trend in the pharmaceutical industry's information practices.
EPFL scientists have identified the molecular basis behind sulfonamide antibiotics' neurological side effects, which can include nausea, hallucinations, and psychosis. By understanding how sulfonamides interact with a patient's nervous system, doctors may be able to customize therapeutic regimes to minimize these side effects.
A recent study published in Cell Reports reveals how certain genes control the ratio of proteins p21 and PUMA, which determines whether tumors adapt or die when faced with p53-activating drugs. The researchers found a handful of genes that fine-tune this balance.
A University of Arizona research team has identified unusual swellings within neurons caused by statin drugs, which may lead to cognitive declines. Removing statins results in the disappearance of these 'beads-on-a-string' effects, offering promise for personalized medication and therapy.
Researchers investigated the recreational use of HIV antiretroviral drug efavirenz, which is commonly used to treat HIV. Studies found that its diversion for psychoactive effects can lead to adverse neuropsychiatric complications and potentially create resistant strains of the virus.
Researchers found that blocking phosphodiesterase 4B suppresses inflammation by affecting the CLYD gene, which acts as a brake on inflammation. This new strategy offers a safer alternative to current treatments that come with serious side effects.
Researchers are exploring how lithium works in the body to develop a safer medication for treating bipolar disorder. They aim to create a second-generation successor without lithium's drawbacks, such as thyroid problems and kidney failure.
The HPS2-THRIVE study found that niacin therapy provides no benefit and may even be harmful for patients with vascular disease. The study showed a higher incidence of bleeding, infections, new onset diabetes, and gastrointestinal problems among those receiving the drug.
A pilot study may lead clinicians to more accurately predict which patients will suffer from gastrointestinal side effects of radiotherapy. The technology uses an electronic nose and FAIMS to analyze stool samples and identify patterns in toxicity levels.
A new device encircles the esophagus valve to control chronic acid reflux, easing symptoms in 92% of patients and allowing 87% to stop using acid-suppressing drugs. Installation is minimally invasive, taking one to two hours, and patients experience significant improvement with 94% satisfaction.
Researchers dispute evolutionary psychology's 'adaptive' explanation for males' superior spatial navigation, suggesting it may be a result of testosterone levels. The study analyzed 35 species and found no consistent support for the hypothesis that male superiority is an adaptation.