Articles tagged with Statins
A UK multi-centre randomised trial found that statins reduce the risk of heart attacks, strokes or revascularisation operations by about a third in diabetic patients, irrespective of their cholesterol levels. This could prevent at least 10,000 heart attacks, strokes and revascularisation operations each year worldwide.
A study found that statin therapy combined with aggressive lifestyle modifications can significantly reduce coronary calcium scores and prevent disease progression. In the 12-year follow-up, nearly one-third of patients on statins and lifestyle changes showed reduced calcification scores, avoiding revascularization procedures.
A large international study has found that kidney-transplant patients who receive statin therapy experience reduced cardiovascular risk and mortality. The study's findings support the use of statins as a preventive measure for these high-risk patients, particularly those with mild renal failure.
A Northwestern Memorial HealthCare-led study presents data demonstrating calcification in human tissue as the primary cause of aortic valve blockages. Statin therapy may delay progression and reduce need for surgical replacement.
A study of 589 postmenopausal women found a significant association between menopause and sleep-disordered breathing. Additionally, researchers discovered that statin use can significantly reduce tissue rejection and improve pulmonary function in lung transplant patients. These findings highlight the importance of evaluating sleep-diso...
Researchers found that simvastatin, a cholesterol-lowering statin, prevents diet-induced arterial hypertension and metabolic insulin resistance in mice by stimulating nitric oxide bioavailability. This effect appears to be related to stimulation of vascular NO availability.
A new study found that statins can significantly reduce the risk of cardiovascular disease in people with high blood pressure and normal or low cholesterol levels. The treatment resulted in a 36% lower risk of primary events such as death from CHD and non-fatal heart attacks, primarily within the first year of treatment.
Roth's discovery led to the development of Lipitor, which has logged more than 36-million patient years of experience and involved over 400 clinical trials. His innovative approach to statin structure resulted in a simpler molecule with equal efficacy.
Recent studies suggest apolipoprotein B is a superior marker for predicting cardiovascular disease risk compared to total cholesterol or LDL cholesterol. The ratio of apolipoprotein B to apolipoprotein A-1 is also more effective in assessing cardiovascular risk than the traditional LDL/HDL ratio.
Researchers explore the role of statins in preventing CNS leucocyte accumulation in multiple sclerosis, a condition that increases dementia risk. A review on mild cognitive impairment highlights the urgency to address these disorders.
A recent study found that pravastatin treatment reduced coronary death, non-fatal heart attack, and fatal or non-fatal stroke by 15% in adults aged 70-82. The benefits were most pronounced for reducing death from heart disease, with a nearly 25% relative risk reduction.
A new study suggests statin therapy may slow the progression of aortic stenosis in patients with heart valve disease. By reducing cholesterol and inflammation, statins could potentially eliminate the need for valve replacement surgery in some patients.
Researchers found that a cholesterol drug, atorvastatin, reduced paralysis and suppressed attacks in mice with multiple sclerosis. The study suggests that the drug could prevent progression to definite multiple sclerosis in individuals who have had a first attack.
Researchers found that statins modify immune system molecules involved in MS progression, exhibiting potent anti-inflammatory effects. Statin therapy may serve as a useful standalone or add-on treatment for patients with MS.
A recent study found that simvastatin significantly reduced hsCRP levels in patients with high LDL cholesterol after just two weeks of treatment. The results suggest that statins may work through multiple mechanisms to reduce inflammation and prevent heart disease events.
A new study reveals that statins can cut the risks of heart attacks and strokes in people with diabetes, narrowed arteries, or a history of stroke. The findings recommend changing guidelines to consider statin use for anyone at increased risk of heart disease, regardless of cholesterol levels.
New findings from the Heart Protection Study (HPS) reveal substantial benefits of statins among high-risk patients, including those with normal or low blood cholesterol levels. The study found a significant reduction in death rates from heart attack and stroke, with simvastatin also showing well-tolerated benefits.
A new analysis suggests that early statin use after a heart attack is only effective in patients with high cholesterol levels above the recommended guidelines. The study found no difference in mortality rates between those who received early statins and those who did not.
People taking statins were 14 times more likely to develop peripheral neuropathy than those not taking statins, according to a Danish study. The risk increased with longer statin use and higher doses.
Researchers found that statin use was associated with a 79% reduced risk of developing Alzheimer's disease, regardless of ethnicity or apoE gene variant. The study also showed no difference between natural and synthetic statins in reducing the risk.
Researchers found that statins block the vasoconstrictive effects of A-beta protein and have anti-inflammatory properties that may protect against dementia. Statin treatment has been linked to a reduced risk of developing Alzheimer's disease in populations studied.
A recent study suggests that statins may inhibit calcium growth on aortic valves in elderly people, potentially reducing the risk of cardiovascular events. Researchers found that those taking statins had a 62% lower median rate of calcium accumulation compared to non-statins group.
A UCSF study found that high cholesterol levels are associated with poorer cognitive performance in elderly women. Using statins to lower cholesterol levels was linked to improved cognitive skills, suggesting a potential benefit for preventing Alzheimer's disease.
Researchers found that two statins, atorvastatin and simvastatin, significantly reduced remnant lipoprotein (RLP) cholesterol levels, while pravastatin had no effect. This suggests that these drugs may have additional mechanisms for reducing cardiovascular risk beyond just lowering LDL cholesterol.
A combination treatment of statin and niacin reduced cardiovascular events by 60-90%, reversing plaque buildup in the arteries. Antioxidant vitamins had no significant benefit on cardiovascular outcomes, contrary to previous assumptions.
Researchers have discovered that statins can help alleviate symptoms of cardiac hypertrophy without affecting cholesterol levels. The findings suggest that statins may modulate signaling pathways involved in hypertrophic growth, leading to improved cardiovascular outcomes.
The LIFE-SAVER trial found significant reductions in heart attacks and strokes among high-risk patients, including those with diabetes and low cholesterol levels. Statin treatment can prevent major vascular events in over 70% of patients.
The International Lipid Information Bureau (ILIB) emphasizes the importance of statins in lowering cholesterol and preventing coronary heart disease. Landmark clinical trials have shown that statins prevent CHD, heart attacks, revascularization, and strokes.
A study found that a combination of statin and niacin can reduce the risk of hospitalization for chest pain or heart attacks by 70% among patients at high risk. The treatment also showed promise in reversing arterial buildup in these patients, with angiograms revealing decreased plaque buildup in most participants.
A multicenter study published in the American Journal of Cardiology found that adding Benecol spread to a patient's diet can lower LDL-C and total cholesterol levels by 17% and 12%, respectively. The study also showed that the cholesterol-lowering effect of Benecol was evident as early as the second week of treatment.
Two studies in Annals of Internal Medicine explore cost-effectiveness of statins on specific populations. Statin therapy was found to be reasonably cost-effective for patients aged 75-84 years old with a history of heart attack, increasing life expectancy by four months while costing $18,800 per quality-adjusted life year. Cost-effecti...
Researchers discovered statins, commonly used to lower cholesterol, can build new bone and potentially treat osteoporosis. Statin drugs stimulate the production of osteoblasts, specialized cells that create new bone.
The American Heart Association recommends statin drugs as a second step after lifestyle modifications for cholesterol-lowering. Red yeast rice, found in Cholestin, may be less safe and effective than prescription medications.
A recent international study involving 842 patients found that statins significantly raised high-density lipoprotein (HDL) cholesterol levels, particularly in those with low HDL. The study's results challenge the long-held emphasis on low-density lipoprotein (LDL) and triglycerides, suggesting that increasing HDL may be a crucial facto...