Articles tagged with Asthma
The ACRN, a partnership of NHLBI and eight clinical centers across the US, conducts well-designed clinical trials for asthma treatments. Penn State's Data Coordinating Center leads expertise in biostatistical design and analysis.
Researchers found that children with mild asthma already show pathologic features of adult disease, including basement membrane thickening and airway eosinophilia. New AAT deficiency guidelines also aim to improve diagnosis and management by identifying specific risk factors for this hereditary disorder.
A recent study by Henry Ford Health found a significant link between early antibiotic use in children and an increased risk of developing allergies and asthma. The study followed 448 children from birth to seven years and found that those who received antibiotics in the first six months were more likely to develop these conditions.
The award recognizes journalists who raise public awareness about allergic diseases, recognize allergists as experts, and provide medically accurate information. Eligible entries must have been published or broadcast between September 1, 2002, and August 31, 2003.
Researchers will use gene expression profiling and other techniques to identify genes involved in asthma. The program aims to understand how environmental factors interact with genetic causes to affect the disease's progression.
Research identifies critical role of innate immunity in lung transplant rejection, suggesting novel therapies may prevent acute rejection. Preschool children with asthma also exhibit abnormal pulmonary function, while patients with sleep apnea show periods of stable breathing.
Researchers found that higher melatonin levels in asthma patients at night lead to impaired lung function, suggesting all patients with asthma should avoid melatonin supplements until more is known about their safety. This study's findings support previous research linking melatonin to inflammation in asthma.
Regularly scheduled use of inhaled beta-agonists can result in airway hyperresponsiveness and prolonged asthmatic attacks, according to recent studies. Researchers suggest that targeting phospholipase C-beta may offer a new treatment approach for asthma patients.
A UCI biomedical engineer has received a $1.8 million grant to create viable lung tissue similar to that found in bronchial tubes, which will be injured to simulate asthma injuries. The goal is to better understand what causes scarring in the lungs of people with asthma and develop more effective treatments.
Children with severe asthma defy conventional understanding of inflammation-driven disease, showing little to no evidence of ongoing inflammation and permanent changes in lung tissue despite long-term therapy. Despite aggressive treatment, many patients experience uncontrolled symptoms, frequent hospitalizations, and even death.
Research found that daily consumption of full cream milk and butter was associated with lower rates of asthma and wheeze in pre-school children. Antioxidants and other micronutrients in these products may play a role in this beneficial effect.
Researchers found that a humanized anti-human interleuken antibody reduced eosinophils in severe asthma patients, improving pulmonary function. In another study, poor oral hygiene was linked to an increased risk of aspiration pneumonia, with Gram-negative bacteria being the main culprits.
Sandra McLachlan and her team reveal that cleavage of the TSHR A subunit can induce or amplify the immune response to the TSHR, resulting in autoantibodies that stimulate thyroid hormones. This finding increases understanding of why autoantibodies arise specifically to the TSHR, leading to Graves hyperthyroidism.
Research breakthrough identifies 291 genes associated with asthma, opening up new avenues for treatment and diagnostic development. The study focused on the arginase pathway, which regulates critical processes involved in allergic reactions.
Researchers identified nearly 300 asthma signature genes involved in pathogenesis, including arginase, which triggers asthmatic symptoms. The discovery could lead to targeted treatments for individual patients.
The XPERT TM study shows Xyzal significantly improved symptoms and quality of life for patients with persistent allergic rhinitis. Long-term treatment reduced co-morbidity, lost productivity, and economic savings.
A recent study found that nearly 20% of North Carolina children experience un-diagnosed asthma symptoms, leading to missed school days and limited activities. The condition affects not only physical health but also sleep patterns, cognitive function, and learning ability.
A study of 114 asthmatic children found that higher exposure to nitrogen dioxide before a viral infection led to more severe asthma symptoms and exacerbations. This suggests that controlling air pollution could reduce healthcare costs associated with treating acute asthma attacks.
A study found that regular indoor swimming pool attendance is associated with increased lung damage and a higher risk of childhood asthma. The researchers measured lung proteins in children who swam regularly at indoor pools, finding significant associations with cellular damage and respiratory issues.
A new study reveals that dogs cause a stronger reaction in asthmatics than cats, even though more people are allergic to cats. The study found that dogs triggered a combination of reactions that included reduced air exhalation and increased nitric oxide release due to inflammation.
A new study by USC researchers found that exposure to cockroaches, weed killers, pesticides, and other environmental pollutants in the first year of life are linked to an increased risk of early asthma. Daycare attendance before 4 months also contributed to this risk.
Exposure to environmental toxins during the first year of life significantly increases asthma risk, with cockroach infestations doubling the likelihood, according to a study led by Dr. Frank Gilliland.
A study found that one-third of young adults who outgrow asthma may experience a relapse by age 26. Those highly allergic or with bronchial hyper-responsiveness are at greatest risk. The study followed 1,037 New Zealanders to age 26, with detailed respiratory histories every two years.
A study of 15 African American adults with persistent asthma found five primary themes hindering inhaled corticosteroid (IC) use, including reluctance, social distractions and misconceptions about side effects. Improving communication between healthcare providers and patients is crucial to overcoming these barriers.
Children prescribed asthma medications have lower rates of emergency room visits compared to those without prescriptions. However, asthmatic African-American and urban children experience more frequent ER visits due to asthma attacks.
A new imaging technique using hyperpolarized helium MRI offers a noninvasive method to study the airways of people with asthma. The technique provides information on ventilation and depicts structure and function of the airways, which can help correlate symptoms with treatment.
A study of 589 postmenopausal women found a significant association between menopause and sleep-disordered breathing. Additionally, researchers discovered that statin use can significantly reduce tissue rejection and improve pulmonary function in lung transplant patients. These findings highlight the importance of evaluating sleep-diso...
A study published in the April 2003 Journal of Allergy and Clinical Immunology found that asthma hospital visits doubled between 1978 and 1990, but stabilized afterwards. Controller medication use increased, particularly inhaled corticosteroids, while reliever medication use decreased. The data suggests that asthma treatment is becomin...
Researchers found that mice lacking NKT cells remained resistant to asthma-inducing stimuli, while those with NKT cells developed airway hyper-reactivity and symptoms. The study suggests NKT cells play a key role in asthma development and may be targeted for treatment.
A study published in the Journal of Allergy and Clinical Immunology found that allergy specialist care can significantly reduce emergency room visits for asthma. Patients receiving adequate inhaled corticosteroid therapy (at least four canisters per year) and/or allergy specialty care had a lower risk of hospitalization, with 27% showi...
A study of over 7200 patients found that budesonide decreased the risk of severe asthma attacks by 44% and reduced the need for systemic steroids. The drug also improved lung function and was well-tolerated, but had a negative effect on growth in children under 11.
Two new studies report associations between prenatal exposure to maternal smoking and early-onset asthma with deficits in children's lung function. In the first study, a two-month rifampin/pyrazinamide regimen was found to be effective in treating latent TB in high-risk, non-adherent groups, but with potential liver toxicity risks.
Birks, a renowned Boulder chemist, has won the ACS Award for Creative Advances in Environmental Science and Technology. He is developing smaller instruments to measure atmospheric gases using balloons, which may have medical benefits, such as tracking nitric oxide levels for asthma treatment.
A recent study suggests that bacterial infections can modify the allergic response, potentially preventing asthma and allergies in children. The research found that mice infected with M. pneumoniae showed a milder reaction to allergens than control mice.
A family history of asthma is a consistent risk factor for childhood asthma, but only partially identifies children at increased risk. Despite this, knowledge of the risk can motivate parents and healthcare providers to take proactive steps in prevention.
Researchers found that normalizing induced sputum eosinophil count reduces asthma exacerbations by 63% and severe asthma attacks by 67%. The strategy has implications for regular monitoring of airway inflammation to treat moderate to severe asthma.
Researchers found that asthma patients frequently move between severity categories, with no single parameter reliably predicting overall severity. This variability may lead to underestimation or overestimation of asthma severity, emphasizing the importance of proper management and daily maintenance treatments.
A study found that Advair Diskus can reduce inhaled corticosteroid doses by 60% without compromising asthma control. The treatment, which combines an inhaled long-acting bronchodilator and corticosteroid, was shown to improve pulmonary function, symptom-free days, and albuterol use in patients requiring higher doses of corticosteroids.
Exposure to inhaled corticosteroids was associated with a decreased risk of death and longer survival in patients with chronic obstructive pulmonary disease (COPD). ICS plus salmeterol combination showed significant reduction in mortality risk.
The NHLBI initiative establishes partnerships between research-intensive and minority-serving institutions to investigate factors contributing to asthma disparities. The project focuses on psychosocial factors, ethnic variations in sensitivity to environmental allergens, and the interrelationship between genetic susceptibility and stress.
The University of Wisconsin will lead a research network to develop and test immune-based treatments for asthma in inner-city children, building on successful NCICAS interventions that have reduced asthma severity.
A study found that treating acid reflux significantly improved quality of life and reduced asthma symptoms in patients with moderate to severe persistent asthma. The use of a proton pump inhibitor, such as lansoprazole, was shown to offer significant benefits for these patients.
A recent study reveals that asthma affects over 42,000 US households, with moderate to severe persistent disease prevalent among individuals. Additionally, the research highlights the significant impact of asthma on daily activities, affecting two-thirds of respondents.
A German study found exposure to house dust endotoxin is associated with lower allergic sensitization in school children. Researchers also discovered that females are more sensitive to coughing agents than males. Occupational exposure to dust and fumes is linked to increased respiratory symptoms and asthma risk.
A JAMA study found that pharmacist interventions significantly improved peak flow rates for patients with asthma, but not those who received standard care. The study also showed a notable decrease in breathing-related emergency department or hospital visits among the intervention group.
A recent study found that breastfeeding had no significant effect on the risk of developing asthma or allergies in childhood. In fact, children who were breastfed for more than four weeks were twice as likely to develop allergic disease or asthma compared to those who were not breastfed.
A study of 24,690 British children found a dose-related association between maternal antibiotic exposure during pregnancy and increased risk of asthma, eczema, and hay fever. Another study on Alaskan sled dogs suggests that 'ski asthma' may be a model for exercise-induced airway injury in humans.
A new study confirms that cat exposure increases the risk of persistent wheezing and asthma in children whose mothers have asthma. In contrast, exposure to cats is protective for children without a family history of asthma, reducing the risk of wheezing by 40%.
A Swedish study of over 3,000 children found that living with a cat significantly reduced the risk of developing asthma. Conversely, continuing smokers showed substantially lower lung function levels, indicating severe to moderate chronic obstructive pulmonary disease (COPD).
A study found that children exposed to dogs and cats in the home have a significantly reduced risk of developing common allergies, with exposure levels reducing allergy rates by up to 45%. The research suggests that early exposure to endotoxins from pets may help the immune system develop a different response, making it less likely for...
A study of 2,950 children found that in utero exposure to maternal smoking was linked to asthma and wheezing, with genetic susceptibility playing a significant role. Low body weight in COPD patients is also associated with greater muscle atrophy and poorer exercise capacity.
Researchers found that humming increased nitric oxide levels in the sinuses, boosting ventilation. Smoking by family members was linked to an increased likelihood of children being diagnosed with asthma before age 6. Obstructive sleep apnea was also associated with a significant increase in heart disease.
Researchers will quantify the long-term effects of PM2.5 particles on lung function and asthma exacerbations in children with moderate to severe asthma. The study aims to determine if environmental interventions can reduce asthma severity and improve lung function.
The study discovered a novel gene, ADAM33, linked to asthma susceptibility and airway changes in asthmatic patients. This gene is involved in generating bronchial hyperresponsiveness and may underlie abnormalities in asthmatic airway function.
Researchers found that viral infections in infancy can cause long-term changes in the body's anti-viral system, leading to chronic respiratory inflammation and distress. Mice infected with paramyxoviral virus developed airway hyperreactivity and mucus-producing cells, symptoms similar to asthma.
A new study by National Jewish Health reveals that smoking and pet ownership are common triggers of asthma attacks in children. Households with smokers differ from those with pets in terms of socioeconomic and psychosocial profiles, suggesting that addressing these triggers requires individualized approaches.
Researchers found significant effects of air pollution on children's lung function growth rates, with acid vapor showing the most consistent effect. A separate study found no association between antibiotic use in early life and asthma development at age 5.
A collaboration between students and scientists from NASA's Goddard Space Flight Center aims to identify environmental triggers of pediatric asthma in Baltimore. The Baltimore Student Sun photometer Network (BSSN) will collect daily aerosol data, enhancing science, math, and technology skills for the students involved.
The article highlights the significant impact of behavioral factors on various diseases, including coronary heart disease, diabetes, obesity, and asthma. Research shows that negative emotions can lower immunity, while stress and depression can provoke the release of hormones that affect immune function.
Researchers found that antibiotic treatment improved lung function in 56% of mild to moderate asthmatics with evidence of Mycoplasma pneumoniae or Chlamydia pneumoniae infections. Lung function also showed improvement after treatment, with an average increase of 200 milliliters.