Articles tagged with Inflammatory Bowel Diseases
Researchers have discovered a cellular pathway that promotes inflammation in diseases like asthma, rheumatoid arthritis, and psoriasis. Understanding this pathway may provide opportunities for tailored treatments of inflammatory and autoimmune diseases.
A study found that many gastroenterologists are not knowledgeable about the appropriate immunizations to recommend to IBD patients. In fact, over half of gastroenterologists did not regularly ask their patients about immunization history. This lack of knowledge can lead to IBD patients being vulnerable to vaccine-preventable illnesses.
A systematic review found that biologic drugs used to treat arthritis may have rare but serious side effects, including increased risk of infections and cancer. The study analyzed data from 163 studies involving over 50,000 patients, highlighting the importance of comparative safety research.
Scientists at Virginia Tech have discovered key molecular events in the immune system that contribute to inflammatory bowel disease. The study identifies peroxisome proliferator-activated receptor-gamma as a crucial regulator of inflammation and offers potential targets for repurposed drugs and naturally occurring compounds.
Researchers at Virginia Tech have created a mathematical model of colon inflammation that identifies pro-inflammatory macrophages as key culprits for unregulated inflammation in inflammatory bowel disease. The model allows scientists to explore cellular and molecular changes underlying chronic inflammation, identify intervention points...
A study found that standard CRP tests are not informative enough for pediatric IBD patients, while hs-CRP detects low levels of CRP and correlates with ileal inflammation. However, hs-CRP did not help distinguish between active intestinal inflammation and quiescent disease or response to treatment.
A study published in the World Journal of Gastroenterology found that colonoscopy in Hong Kong Chinese children has a high safety yield and can effectively diagnose inflammatory bowel disease. The procedure also provided therapeutic value by successfully removing colonic polyps, with no complications reported.
Patients with active inflammatory bowel disease are at a significantly increased risk of developing venous thromboembolism, especially when ambulatory. The study found that non-hospitalized patients with active IBD have a relative risk of 16 times higher than the general population, highlighting the need for prophylaxis strategies.
Dr. Daniel K. Podolsky, UT Southwestern president, has been elected to the Institute of Medicine for his scientific and medical achievements. He joins 19 current UT Southwestern faculty members as a national member.
Dr. Daniel K. Podolsky receives the 2009 Julius Friedenwald Medal for his lifelong contributions to gastroenterology and groundbreaking scientific achievements. He credits his colleagues and mentors for his success, highlighting UT Southwestern's role in his career.
Dr. Casey Weaver receives the HudsonAlpha Prize for his groundbreaking work on T cell studies and immune disease. His research has identified a new class of T cells, called Th17 cells, linked to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Researchers have developed biodegradable polymers called polyketals that can deliver drugs, proteins, and snippets of ribonucleic acid to specific areas in the body. The microparticles degrade quickly into biocompatible compounds, reducing inflammation.
Research suggests tricyclic antidepressant desmethylimipramine can restore vagal function and reduce intestinal inflammation in individuals with inflammatory bowel disease and depression. Decreased vagal signaling and increased macrophage presence in the intestine are key factors in increasing susceptibility to intestinal inflammation.
T cells activated during IBD found in PSC livers, re-routed by aberrant attractant protein. Long-lived memory cells may explain delayed liver disease onset after IBD resolution.
A study by Ohio State University researchers found that children with mild inflammatory bowel disease (IBD) are more likely to experience behavioral and emotional problems, including being withdrawn or anxious. The study also showed a link between the severity of IBD and social functioning.
Researchers have discovered a key molecule involved in regulating the immune system that may contribute to stomach cancer. Mutations to this molecule, gp130, induced cellular changes reminiscent of early gastric cancer in mice, highlighting a potential new target for treatment.