Articles tagged with Inflammatory Bowel Diseases
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that a vegan-based fasting diet reduced inflammatory bowel disease (IBD) pathology in mice by changing their gut microbiota. The diet, known as the fasting-mimicking diet (FMD), increased stem cell numbers and stimulated protective gut microbiota, leading to reduced intestinal inflammation.
A new study found patients with inflammatory bowel disease are more likely to develop Parkinson's disease. Anti-tumor necrosis factor therapy for IBD was associated with a reduced incidence of Parkinson's in over 170 million patient records analyzed.
A recent study published in The BMJ found that dipeptidyl peptidase-4 inhibitors, a type of diabetes drug, are associated with an increased risk of inflammatory bowel disease. The study analyzed data from over 141,000 patients and found a 75% higher incidence rate compared to other antidiabetic drugs.
A new analysis found a link between weight loss surgery and an increased risk of inflammatory bowel disease (IBD), with patients having a nearly 2-times higher likelihood of developing IBD. The mechanism behind this association is unclear, but alterations in gut microbes and vitamin D/bile salt deficiencies may play a role.
Researchers have identified a key gene, Ufbp1, that helps maintain healthy Paneth cells in the small intestine, which are essential for a balanced gut microbiome. The study found that when this gene is knocked out, Paneth cells die and good bacteria levels decrease, leading to inflammatory bowel disease.
A new study found that an infliximab biosimilar is safe and effective for treating inflammatory bowel disease, with comparable drug levels to the original medication. However, a high rate of discontinuation was observed due to subjective disease worsening or elective withdrawal after switching to the biosimilar.
Research predicts increased inflammatory bowel disease (IBD) rates in developing countries as they adopt Western lifestyles and become more industrialized. IBD incidence is expected to rise dramatically, posing a global health challenge.
Researchers from the Wellcome Trust Sanger Institute and their collaborators have created a high-resolution map of the disease, pinpointing 18 genetic variants with over 95% certainty. This breakthrough has significant implications for the development of new treatments and personalized medicine for IBD.
A new report links early life antibiotic use to inflammatory gut diseases in adulthood, finding that altered gut bacteria may increase the likelihood of conditions like IBD, asthma, and multiple sclerosis. The study adds evidence to suggest that modifying gut flora could be a treatment approach for some inflammatory diseases.
New research from the University of Exeter and University of Zaragoza found that gut microorganisms regulate serotonin levels through a protein called TLR2. This discovery may shed light on inflammatory bowel disease and other neurological conditions.
A new study suggests that generic biologic drugs are as safe and effective as their brand-name counterparts, offering a cheaper alternative for consumers and the healthcare system. The findings have significant implications for the pharmaceutical market, with wide adoption of biosimilars expected to save billions of dollars.
A new tool called MDSINE predicts the behavior of the human microbiome, which could lead to the development of new treatments for serious diseases. The algorithm is applied to predict the dynamics of C. difficile infections and analyze the effects of probiotic cocktails on bacterial communities.
Scientists at the University of Manchester have identified crucial molecules that allow regulatory T cells to function and cure active inflammation. This discovery could lead to improved therapies for autoimmune diseases such as type I diabetes, rheumatoid arthritis, and inflammatory bowel disease.
Researchers analyzed Beethoven's compositions for clues of a heart condition and found striking rhythms that reflect the irregular patterns of his cardiac arrhythmia. The study suggests that Beethoven's music could be 'musical electrocardiograms,' a readout of modern heart rhythm testing equipment.
Researchers have developed a novel method to distinguish between different types of bowel disease using stool samples, with an overall accuracy of 76%. The technique uses volatile organic compounds emitted from the samples to provide a unique profile for each condition, offering a cheaper and quicker alternative to current methods.
A new study found that smoking boosts the risk of infection, pneumonia, and death after elective colorectal procedures. Smokers are more likely to experience complications and have longer hospital stays compared to non-smokers.
A comparative study of 80 patients found that coffee consumption reduced recovery time for bowel movements and tolerance of solid food after colon surgery. Coffee also helped patients pass stool sooner, with an average time of just over 60 hours.
A recent study found that most celiac disease patients do not receive adequate medical follow-up, which can lead to non-compliance with a gluten-free diet. The study suggests that gastroenterologists need to improve communication with patients to ensure timely follow-up care and improve outcomes in celiac disease.
A study found that inactivating the epidermal growth factor receptor increases colorectal tumors, while promoting its activity reduces inflammation and tumor development. This suggests that increasing epidermal growth factor activity in IBD patients may lower their long-term cancer risk.
A new study published in Clinical Gastroenterology and Hepatology found that IBD travelers are not at a higher risk of contracting intestinal infections when visiting developing or tropical countries. Traveling during clinical remission can significantly reduce the risk of illness, according to lead author Shomron Ben-Horin.
A study analyzing data from over 268,000 patients reveals that those with IBD undergoing surgery have a two-fold increased risk of developing DVT or PE. The findings suggest standard DVT and PE prophylaxis should be reconsidered for this patient group
Researchers have discovered a cellular pathway that promotes inflammation in diseases like asthma, rheumatoid arthritis, and psoriasis. Understanding this pathway may provide opportunities for tailored treatments of inflammatory and autoimmune diseases.
A study found that many gastroenterologists are not knowledgeable about the appropriate immunizations to recommend to IBD patients. In fact, over half of gastroenterologists did not regularly ask their patients about immunization history. This lack of knowledge can lead to IBD patients being vulnerable to vaccine-preventable illnesses.
A systematic review found that biologic drugs used to treat arthritis may have rare but serious side effects, including increased risk of infections and cancer. The study analyzed data from 163 studies involving over 50,000 patients, highlighting the importance of comparative safety research.
Scientists at Virginia Tech have discovered key molecular events in the immune system that contribute to inflammatory bowel disease. The study identifies peroxisome proliferator-activated receptor-gamma as a crucial regulator of inflammation and offers potential targets for repurposed drugs and naturally occurring compounds.
Researchers at Virginia Tech have created a mathematical model of colon inflammation that identifies pro-inflammatory macrophages as key culprits for unregulated inflammation in inflammatory bowel disease. The model allows scientists to explore cellular and molecular changes underlying chronic inflammation, identify intervention points...
A study found that standard CRP tests are not informative enough for pediatric IBD patients, while hs-CRP detects low levels of CRP and correlates with ileal inflammation. However, hs-CRP did not help distinguish between active intestinal inflammation and quiescent disease or response to treatment.
A study published in the World Journal of Gastroenterology found that colonoscopy in Hong Kong Chinese children has a high safety yield and can effectively diagnose inflammatory bowel disease. The procedure also provided therapeutic value by successfully removing colonic polyps, with no complications reported.
Patients with active inflammatory bowel disease are at a significantly increased risk of developing venous thromboembolism, especially when ambulatory. The study found that non-hospitalized patients with active IBD have a relative risk of 16 times higher than the general population, highlighting the need for prophylaxis strategies.
Dr. Daniel K. Podolsky, UT Southwestern president, has been elected to the Institute of Medicine for his scientific and medical achievements. He joins 19 current UT Southwestern faculty members as a national member.
Dr. Daniel K. Podolsky receives the 2009 Julius Friedenwald Medal for his lifelong contributions to gastroenterology and groundbreaking scientific achievements. He credits his colleagues and mentors for his success, highlighting UT Southwestern's role in his career.
Dr. Casey Weaver receives the HudsonAlpha Prize for his groundbreaking work on T cell studies and immune disease. His research has identified a new class of T cells, called Th17 cells, linked to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Researchers have developed biodegradable polymers called polyketals that can deliver drugs, proteins, and snippets of ribonucleic acid to specific areas in the body. The microparticles degrade quickly into biocompatible compounds, reducing inflammation.
Research suggests tricyclic antidepressant desmethylimipramine can restore vagal function and reduce intestinal inflammation in individuals with inflammatory bowel disease and depression. Decreased vagal signaling and increased macrophage presence in the intestine are key factors in increasing susceptibility to intestinal inflammation.
T cells activated during IBD found in PSC livers, re-routed by aberrant attractant protein. Long-lived memory cells may explain delayed liver disease onset after IBD resolution.
A study by Ohio State University researchers found that children with mild inflammatory bowel disease (IBD) are more likely to experience behavioral and emotional problems, including being withdrawn or anxious. The study also showed a link between the severity of IBD and social functioning.
Researchers have discovered a key molecule involved in regulating the immune system that may contribute to stomach cancer. Mutations to this molecule, gp130, induced cellular changes reminiscent of early gastric cancer in mice, highlighting a potential new target for treatment.