Researchers at Helmholtz Munich have identified FKBP10 as a potential new target molecule for treating idiopathic pulmonary fibrosis (IPF), a chronic lung disease. Analysis of patient data revealed elevated levels of the protein in IPF patients, which may lead to a new therapeutic approach.
A study of 14,348 Swiss individuals found that those with depressive symptoms have a higher risk of developing physical diseases, especially arthrosis and arthritis. The researchers suggest that lack of interest in physical activity or inflammatory processes may be key factors in this association.
A new study from NYU Langone Health has identified the most common causes of hospital readmissions following total hip and knee arthoplasty procedures. The study found that surgical complications accounted for 54% of readmissions, with an average cost of $36,038 for total hip replacements and $61,049 for total knee replacements.
Lupus and other rheumatologic diseases can initially present as neurological disorders such as headaches and seizures, leading to delayed diagnoses. Treatments for these conditions can also cause adverse neurological effects.
A new study finds that most men with gout have severe erectile dysfunction, highlighting the importance of screening for this condition. The study suggests that all men with gout should be routinely screened for erectile dysfunction to detect possible silent coronary artery disease.
New data show that biosimilar CT-P13 achieves statistically similar improvements in disease activity, disability, and mobility in patients with Ankylosing Spondylitis compared to its original reference product infliximab. The results demonstrate comparable efficacy and safety for CT-P13 as an alternative treatment option.
Lupus patients can successfully stop immunosuppressant therapy without triggering a flare by slowing down the tapering process and checking for positive serology. The study found that within two years, about 70% of clinically stable patients were able to stop their medication.
Ultrasound-guided injections of growth factors-containing platelet-rich plasma (PRP) have been shown to be no more effective than saline injections in treating recently developed epicondylitis, also known as tennis elbow. However, pain scores decreased significantly over the course of the trial.
EULAR has achieved recognition for Rheumatic and Musculoskeletal Diseases from the European Commission's Horizon 2020 initiative. The organization also launched the Foundation for Research in Rheumatology, FOREUM, which has awarded grant funding to four osteoarthritis projects.
A phase II study shows romosozumab significantly increases bone mineral density and bone content in the spine and hip compared to teriparatide and placebo. Romosozumab stimulates bone formation and decreases resorption by inhibiting sclerostin, a promising new treatment for postmenopausal osteoporosis.
A study identifies three microRNAs as biomarkers for predicting severe osteoarthritis, allowing for early detection and preventative measures. The findings could significantly reduce the socio-economic burden of the disease.
A third of all work-related disability worldwide is attributed to low back pain, primarily affecting agricultural sector workers and individuals between 35-65. The study analyzed data from the Global Burden of Disease 2010 study, indicating that these groups are almost four times more likely to develop low back pain disability.
A novel study reveals a severe shortage of rheumatologists in smaller micropolitan US regions, where patients often have to travel over 200 miles for care. The research highlights the need for interventions to increase the supply of rheumatologists in underserved areas.
Research suggests that fibromyalgia is associated with disrupted brain signals for reward and punishment, contributing to hyperalgesia. Fibromyalgia patients exhibit altered brain responses to pain anticipation and relief, which may explain the heightened sensitivity to pain and lack of effectiveness of pain medications.
A new study published in Arthritis & Rheumatism found that headaches in lupus patients are not linked to disease activity or specific autoantibodies. The study of over 1,700 lupus patients showed that nearly all headache episodes resolved on their own without treatment.
A new study found that young black women in Southeastern Michigan have the highest rate of developing lupus and are more likely to experience serious health complications. Lupus prevalence was three times higher among black females compared to white women, with a higher risk of kidney and neurologic complications.
The 2013 classification criteria for systemic sclerosis are more sensitive than the 1980 measures, enabling earlier identification and treatment of this autoimmune disease. The new criteria improve the classification of systemic sclerosis by clustering items and simplifying the weighting of different criteria.
Current estimates of rheumatic heart disease deaths globally are likely underestimates, with new studies underway to address data gaps and inform control strategies. The authors propose re-evaluating the burden of disease in two categories: symptomatic and asymptomatic disease.
The World Heart Federation is publishing a special issue to raise awareness about rheumatic heart disease (RHD), which is highly preventable but remains neglected globally. The special issue explores the burden of RHD, current challenges, and innovative solutions for prevention and treatment.
The American College of Rheumatology has released new guidelines for the treatment of systemic juvenile idiopathic arthritis (JIA). The update includes over 1,200 clinical scenarios and covers various medication options, including biologics. The new recommendations aim to enhance care for children with this disabling disease.
A Penn study found that psoriasis patients with more severe skin disease are at higher odds of having major medical diseases, including lung disease, heart problems, and kidney issues. The researchers identified a common pathway involving TH-1 cytokines promoting inflammation and insulin resistance.
A new study describes imaging findings in H7N9 influenza, including rapidly progressive changes in lungs and pulmonary connective tissues. The severity of these findings is associated with the clinical condition of patients.
A randomized trial found that the MMR booster vaccination did not worsen disease activity in patients with juvenile idiopathic arthritis. The researchers also observed higher antibody concentrations and seroprotection rates after vaccination.
A new study found a high prevalence of NSAID prescriptions in patients with ischaemic heart disease or risk factors, highlighting the need for safer alternatives and physician guidelines to prevent cardiovascular harm. Diclofenac was commonly prescribed in 56% of cases, raising concerns about its safety.
Patients with Systemic Juvenile Idiopathic Arthritis (SJIA) who received canakinumab successfully tapered off corticosteroids, achieving a CS-free status in 42 out of 128 patients. This reduction in corticosteroid use has significant long-term health benefits for children suffering from SJIA.
The CHERISH trial demonstrates the effectiveness of tocilizumab in reducing symptoms and signs of juvenile idiopathic arthritis. Patients with polyarticular JIA achieved significant clinical responses, including ACR30/50/70 responses, with as many as 65% attaining an ACR70 response.
A new study reveals that one in eight high-risk patients using over-the-counter NSAIDs take the medication despite knowing the risks. The most common reasons for use were musculoskeletal complaints, with 67% citing this as a reason.
A study demonstrates that brodalumab effectively reduces PsA symptoms and improves quality of life. The treatment also shows promise for those with prior biologic exposure, indicating a potential new therapeutic approach for this progressive disease.
Apremilast administered to patients with psoriatic arthritis showed significant clinical responses beyond 24 weeks, with up to 65% achieving ACR20 response rates at week 52. The novel PDE-4 inhibitor was well-tolerated with an acceptable long-term safety profile.
A study presented at EULAR 2013 found that a progressive muscle strengthening programme using a Swiss ball significantly improves functional capacity, muscle strength, and mobility in patients with Ankylosing Spondylitis. The programme also showed no harmful effects on disease activity, leading to improved treatment satisfaction.
The European Rheumatology Research Foundation was launched to support high-quality, peer-reviewed research on rheumatic and musculoskeletal diseases. The foundation aims to improve diagnosis and treatment of SSc by introducing revised classification criteria.
A new study shows that rapid evaluation for Giant Cell Arteritis (GCA) using Color Doppler Ultrasound (CDUS) followed by immediate treatment significantly reduces permanent vision loss. The 'fast track' approach led to 11.1% transient visual manifestations, with none suffering from permanent visual loss.
Scientists have discovered that cartilage cells have a functioning body clock that can be reset by imposing an artificial rhythm, which could lead to new treatments for osteoarthritis. The research found that older mice had weaker body clocks, and that resetting the clock may alleviate symptoms.
New research published in Arthritis & Rheumatism found that vitamin C supplementation had a weak effect on lowering uric acid levels in gout patients. The study suggests that vitamin C may not be a viable therapy for reducing uric acid levels in patients with established gout.
Researchers have identified a gene mutation that causes a spectrum of disorders affecting the bones and connective tissue, including SEMD-JL1 and Ehlers-Danlos syndrome. The study reveals that B3GALT6 is essential for the development and maintenance of these tissues.
Researchers found that mobility shoes significantly reduced knee loading and improved gait in patients with knee osteoarthritis. Long-term use of the shoes helped participants adapt their walking pattern, leading to a 18% reduction in knee adduction moment.
A new urine test using protein biomarkers may enable early diagnosis and treatment of Kawasaki disease, a rare but increasingly prevalent condition that can cause inflammation of blood vessels and lead to heart attacks. The test has shown promising results in distinguishing children with Kawasaki disease from those with other conditions.
A new study found that cherry consumption lowered gout attack risk by 35% compared to non-consumers, while combined with allopurinol it decreased risk by 75%. The findings suggest cherries may be a preventive option for patients with gout.
Rhode Island Hospital has been awarded a $10.8 million grant from the National Institutes of Health to support translational research on cartilage and joint health. The five-year project aims to develop treatments and preventative tactics for diseases such as arthritis, osteoporosis, and bone-related cancers.
The $100,000 Taubman Prize is awarded to Dr. Harry Dietz for his pioneering work on modifying genetic defects in connective tissue, potentially leading to new treatments for Marfan syndrome and other disorders. The prize recognizes the clinician-researcher who has transformed laboratory discoveries into clinical applications.
Research suggests that functional disability in juvenile idiopathic arthritis (JIA) patients affects their ability to achieve educational success and secure employment. Patients with JIA often experience joint damage, disability, and lowered quality of life, leading to higher rates of unemployment compared to healthy counterparts.
Research shows that adult JIA patients with higher functional disability have lower educational achievement and job stability, while those with oligoarticular JIA perform better. Education is key to success for these individuals, suggesting that career guidance and disease management are crucial for employment outcomes.
Researchers found Bartonella infection in 62% of patients with conditions like arthritis, chronic fatigue, and Lyme disease. The study suggests a possible link between Bartonella bacterium and rheumatoid illnesses in humans.
Research finds that children with JIA have a significantly increased cancer risk, with rates 3.9 times higher for methotrexate-only patients and 4.4 times higher overall compared to peers without the disease. The study suggests that treatment, including TNF inhibitors, may not be directly linked to this increased risk.
A large study found that overweight and obese adults are more likely to have disc degeneration than those with a normal body mass index. Disc degeneration was associated with an increased number of levels of degenerated disks and greater severity of disc degeneration, including narrowing of the disc space.
A recent study published in Arthritis & Rheumatism found a rapid increase in knee replacement surgeries among women aged 50-59, with incidences higher in younger age groups. The study's findings suggest that more data is needed on the long-term effects of knee replacement surgeries in younger patients.
A phase II clinical trial demonstrated that rilonacept significantly reduced acute gout flares by 81% compared to a placebo. The treatment was found to be well-tolerated with no serious infections or adverse events reported.
A recent trial shows cognitive-behavioral therapy (CBT) is effective in reducing functional disability and depressive symptoms in adolescents with juvenile fibromyalgia. The study also found CBT to be safe and superior to disease management education, improving daily functioning and overall wellbeing.
Researchers found a link between large-scale wind patterns and Kawasaki disease outbreaks in Japan, Hawaii, and San Diego. Wind currents carrying potential infectious agents may be triggering the disease, with seasonal shifts in winds exposing regions to air masses from Central Asia.
Dr. Abramson is recognized for his research and contributions to the field of rheumatology, with over 200 publications in top-tier journals. He has also held key positions in academic institutions and regulatory agencies.
A study found that patients with juvenile idiopathic arthritis who responded well to etanercept treatment had lower disability scores, younger age at onset, and fewer disease-modifying antirheumatic drugs used before treatment. These factors are associated with a better long-term outcome.
A BUSM researcher has received two NIH grants totaling over $11 million to study systemic sclerosis (SSc), a rare and complex rheumatic disease. The funding will support clinical research, molecular studies, and identification of biomarkers to accelerate the understanding of SSc and develop new treatments.
Research suggests African Americans have a higher burden of multiple large-joint osteoarthritis, with significant racial differences in OA phenotypes. The study found that African Americans are more likely to have knee OA and have a greater risk of joint involvement, particularly hip and spine OA.
A Northwestern University study reveals that people with arthritis are not engaging in physical activity critical to their health. The research found that more than half of women and 40 percent of men with arthritis were inactive.
Research shows significantly higher osteoarthritis (OA) incidence rates among US military personnel compared to the general population, with differences increasing with advancing age category. Black service members have higher OA rates than white military personnel or those in other racial categories.
A new study found that systemic sclerosis is an independent determinant for moderate to severe coronary calcification or atherosclerosis in patients. The research team discovered that 57% of patients with systemic sclerosis had high coronary calcification scores, compared to 29% of healthy controls.
The European Alliance of Associations for Rheumatology (EULAR) welcomes the EU Council's Conclusions on chronic diseases, which call for coordinated measures to address these conditions. EULAR highlights the importance of innovative approaches, patient-centred policies, and integrated healthcare systems to manage musculoskeletal diseases.
The European Union has recognized the importance of addressing rheumatic and musculoskeletal diseases, which affect over 100 million Europeans. The conference called for an EU Musculoskeletal Disease Strategy and national action plans to improve healthcare and treatment.
Patients with necrotizing myopathies who test positive for novel autoantibodies against 200-kd and 100-kd proteins may benefit from immunosuppressive therapy due to their autoimmune nature. Researchers also found a unique association between statin use and muscle symptoms in this patient group.
Researchers developed lists of physical features to aid in early detection of Marfan and Loeys-Dietz syndromes, which can be life-threatening if left untreated. These lists are reliable without imaging tests and can help doctors spot the disorders during a physical exam.