Articles tagged with Rheumatology
Researchers at the University of Texas Health Science Center at Houston have identified two genes, ARTS1 and IL23R, that contribute to the development of ankylosing spondylitis, a chronic and disabling form of arthritis. This discovery is expected to lead to new therapies and potentially allow for early identification of patients at risk.
Researchers at the University of Pittsburgh School of Medicine are conducting a worldwide study on treating myositis, a rare autoimmune disorder. The study will evaluate the effectiveness of rituximab in improving symptoms of dermatomyositis and polymyositis, with 202 participants from North America and Europe involved.
Researchers found a genetic link between high levels of interferon-alpha and an increased risk of developing lupus. The study suggests that individuals with high interferon-alpha levels may be more likely to develop the disease, especially if triggered by environmental factors.
A study by USF Health found that rheumatologists consistently rate their patients' functional disability higher than the patients themselves, particularly in advanced stages of the disease. The researchers used the Stanford Health Assessment Questionnaire-Disability Index (HAQ-DI) and evaluated 223 patients, finding that rheumatologist...
A study published at EULAR 2007 found that longer-term breastfeeding is associated with a lower risk of developing rheumatoid arthritis in mothers. The study, which involved 136 women with RA and 544 controls, suggested that naturally-induced hormones during breastfeeding may offer protective benefits against the disease.
Researchers tracked 172 patients with hand osteoarthritis for two years, showing a significant increase in pain intensity and functional limitations. Radiological progression was also detected in 20% of subjects, highlighting the need for early intervention to prevent irreversible progression.
Preliminary results show that 59% of patients receiving certolizumab pegol 200mg plus methotrexate achieved a 20% improvement in symptoms after 24 weeks, compared to 14% for those taking methotrexate alone. The treatment combination also resulted in higher ACR70 responses and lower discontinuation rates due to adverse events.
A study of 1041 RA patients found obese participants reported significantly increased ratings for pain and fatigue compared to normal weight counterparts. Obese patients also experienced worse physical functioning, with lower overall quality of life assessments.
A study at EULAR 2007 found that taking x-rays of the semi-flexed knee is the most reliable and responsive way to determine structural severity in knee OA. Measuring joint space width was shown to be more able to detect change over time or after treatment than other techniques.
Women with rheumatoid arthritis receive anti-TNF treatments at a higher level of disease symptoms than men, despite similar disease activity measurements. The study suggests that physicians often rely on objective markers rather than subjective measures, leading to unequal treatment.
A study published in Arthritis Care & Research found that older and lower-income patients with SLE are less likely to see a rheumatologist. Despite access to healthcare through Medicare and Medicaid, these patients face additional barriers to accessing specialized care.
Researchers at University of Michigan confirm fibromyalgia as a real condition characterized by lower pain threshold and associated with genetic factors. Studies using neuroimaging techniques reveal abnormalities in central brain structures and increased neural activity in patients.
A Mayo Clinic study found a significant association between rheumatoid arthritis and chronic lung diseases, with cumulative incidence rates increasing over time. The study followed 603 patients with RA for up to 30 years, revealing higher rates of obstructive lung disease and diffuse parenchymal infiltrative lung disease.
Repeat MabThera treatment improves physical and mental aspects of quality of life measures in RA patients, with significant improvements in disease symptoms and structure. The therapy also inhibits joint structural damage, providing evidence of radiographic progression inhibition.
The American College of Rheumatology and John Wiley & Sons launch The Rheumatologist, a monthly newsmagazine providing breaking news and information to rheumatology professionals. The publication will cover general research topics, clinical trends, and people-focused content.
A new study found that many primary care trusts in the UK are refusing to fund adequate treatment for rheumatoid arthritis (RA) patients, despite NICE approval. The study revealed a postcode lottery, where funding and access to effective treatments like anti-TNF therapy vary widely across the country.
A new study found that steroid injections can improve pain and stiffness in patients with late-stage hip osteoarthritis. The treatment was more effective than placebo in primary and secondary endpoints, offering hope for patients who have not responded to conservative therapy.
The study found that HAQ responsiveness decreases with increasing RA duration, suggesting an irreversible disability component. This makes it challenging to detect functional improvement and distinguish it from placebo effects.
A large patient group observed for five years found that women with rheumatoid arthritis (RA) had a more aggressive disease course compared to men. Only 32% and 31% of women were in remission at 2 and 5 years, respectively, whereas 49% and 52% of men achieved remission during the same period.
A double-blind phase III study found tocilizumab improved signs and symptoms of active rheumatoid arthritis by 80.3% at 24 weeks, compared to 25.0% for methotrexate. The treatment was well-tolerated, with few adverse events reported.
A study across 5 Norwegian departments found that anti-TNF treatments worked better in patients with PsA and AS compared to RA. The combination of anti-TNF and MTX was shown to improve adherence and outcomes in these groups, while monotherapy was more effective for RA patients.
The European Alliance of Associations for Rheumatology (EULAR) is urging governments to recognize the extraordinary burden of rheumatic diseases, which affect over 100 million Europeans. The campaign aims to secure a disability-specific EU directive to prevent discrimination across all services.
The European Alliance of Associations for Rheumatology (EULAR) has developed core recommendations for rheumatology care in Europe, focusing on key disease areas such as musculoskeletal disorders and gout. These guidelines aim to enhance the standard of care across the continent and provide valuable resources for healthcare professionals.
A recent study found that methotrexate can delay and prevent the progression of rheumatoid arthritis in patients. Patients who showed a positive anti-CCP test benefited the most from the treatment, indicating a lower risk of developing full-blown RA.
A study found rodeo athletes recover from whiplash injuries faster and report fewer symptoms compared to spectators, suggesting a different attitude toward injury. The team plans to investigate why rodeo athletes can continue working despite being trampled by bulls.
Researchers explore rheumatic pain mechanisms, debunking common misconceptions. Comprehensive treatment approaches are discussed, including exercise, dietary supplements, and opioid analgesics.
Golimumab, a fully-human anti-TNF-alpha monoclonal antibody, achieves primary endpoint and shows significant improvement in signs and symptoms of moderately to severely active rheumatoid arthritis. Patients receiving golimumab plus MTX achieved higher ACR response rates compared to placebo.
Researchers have identified a link between lupus patients and an overabundance of specific immune cells in their tonsils, which may lead to the disease's characteristic auto-reactivity.
The hospital will train four fellows a year in pediatric rheumatology, addressing the shortage of specialists due to limited certification. Dr. Raphael Hirsch's lab is working on finding new targets for therapy and improving diagnosis.
Researchers in The Netherlands found a positive trend in rheumatoid arthritis disease activity over the last decade, coinciding with more aggressive treatment strategies. The study showed that patients diagnosed with RA within the last ten years had less severe disease activity and a more favorable course of their disease.
The study found marked differences among countries, with Turkey, Brazil, and Mexico showing the highest number of women faculty. Despite increasing numbers of female physicians, disparities persist in specialties like rheumatology, influenced by factors such as family vs. career emphasis and cultural norms.
A large study by the University of Michigan Health System found that entrenched attitudes, lack of communication, and limited data contribute to the controversy. The researchers surveyed nearly 1,000 doctors and analyzed state-by-state variation in hand surgery rates.
A study by Yale University found that older adults' disability scores worsen by 11.2% for every month of curtailed activity. The association between restricted activity and functional decline differs significantly in risk groups, with adjusted disability scores increasing by 18.7% and 7.5% for low- and intermediate-risk groups, respect...
Interleukin-1.com provides updated information on IL-1 role in RA, meeting a need for rheumatologists and health care professionals. The site offers resources, including a primer book and presentation materials, to enhance understanding of cytokine biology and its relevance to RA.
A series on rheumatology highlights key steps for diagnosing arthritis and managing related conditions. The series aims to address the growing need for accurate diagnoses and treatment plans in an aging population.