Articles tagged with Antibiotic Resistance
The Wellcome Trust extends its Seeding Drug Discovery initiative with a £110 million investment over five years. This support enables the progression of promising drug discovery projects to attract follow-on investors and develop novel medicines.
Bacteria recognize and develop resistance to vancomycin through a specific sensing mechanism. The discovery provides new understanding of the molecular basis of vancomycin resistance and represents an essential first step in developing new antibiotics that can evade bacterial sensing mechanisms.
UT Southwestern researchers found that a type of blood pressure medication shows promise in overcoming some drug-resistant tuberculosis. However, the Mycobacterium tuberculosis bacterium may be resistant to treatment in more people than previously thought. The studies challenge current thinking on how TB works and how best to kill it.
The emergence of multidrug-resistant gonococcal bacteria threatens to make gonorrhoea extremely difficult to treat. Current treatment antibiotics may soon lose effectiveness due to rapid resistance development.
The Infectious Diseases Society of America calls for the development of 10 new antibiotics by 2020 due to rising antibiotic-resistant bacterial infections. The urgency is underscored by heartbreaking patient stories of those who have suffered and died from these infections.
Scientists at University of Zurich, Switzerland discover approach to resensitize multidrug-resistant ALL cells to glucocorticoids and other cytotoxic agents. Treatment with obatoclax induces autophagy-dependent necroptosis, bypassing mitochondrial apoptosis block.
Evolutionary theory is being applied to various medical questions, from aging and mental illnesses to cancer and antibiotic resistance. Future physicians may face tests on evolution, with increased emphasis on incorporating evolutionary concepts into medical practice.
McGill researcher discovers a link between contaminated chicken and E. coli bacteria causing urinary tract infections in young women. The study highlights the need for better food safety measures and antibiotic use regulations in agriculture.
A new study reports a significant surge in drug-resistant Acinetobacter infections among US hospitals, with over 300% increase in cases resistant to imipenem. The findings highlight the need for comprehensive solutions to address this growing public health threat.
A new study identifies two antibiotics, linezolid and moxifloxacin, as effective against the virulent community-associated MRSA strain. Meanwhile, clindamycin and doxycycline are found to induce rapid resistance development in this new strain.
A new strain of antibiotic-resistant tuberculosis has been identified as thriving in the presence of rifampin, a front-line drug. The bacteria grew poorly without rifampin and worsened with treatment regimens containing the drug, but recovered once rifampin was removed from the regimen.
A new study suggests that medical liability concerns may be driving doctors to overprescribe antibiotics in healthcare settings. The research found a strong correlation between antibiotic use and attorney density in European countries, but no such link with physician density.
Researchers are gaining insights into how Gram-negative bacteria infect host cells and spread antibiotic resistance. The crystal structure of the outer membrane part of type IV secretion systems has been revealed, offering potential targets for novel antibiotics.
A new study reveals a seven-fold increase in community-associated MRSA strains in hospital outpatients between 1999 and 2006. This poses a significant threat to patient safety as these strains can spread rapidly into hospitals.
A new study by Henry Ford Hospital finds that a specific MRSA strain, USA600, causes significantly higher mortality rates compared to other strains. The researchers believe this strain's unique characteristics may be the key to understanding its high lethality.
Researchers at McMaster University have identified a novel chemical compound that targets drug-resistant bacteria, offering a promising solution to combat resistant infections. The discovery provides a new approach to tackle antibiotic resistance by blocking a specific step in the development of bacterial cell surfaces.
The National Institute of Allergy and Infectious Diseases (NIAID) has launched two new clinical trials to investigate the optimal use of antimicrobial drugs in various clinical settings. The trials aim to determine if shorter treatment durations can be effective while reducing the risk of bacterial resistance.
A study found that typhoid fever cases in the US are often associated with international travel to the Indian subcontinent and are increasingly resistant to common treatments. The majority of cases were linked to travelers who visited friends or family, highlighting the need for improved vaccination coverage and prevention measures.
Anton Y. Peleg receives the American Society for Microbiology's ICAAC Young Investigator Award for his groundbreaking work on carbapenemase genes, tigecycline resistance, and prokaryote-eukaryote interactions in multidrug-resistant bacteria.
A new study found that antibiotic-resistant TB strains cause longer-lasting infections but with lower transmission rates. The research team estimated the rate of evolution of drug resistance and compared the relative reproductive fitness of resistant and drug-sensitive strains.
Research reveals that bacteria's survival rate increases when resistant to two antibiotics, contrary to expected outcomes. This discovery highlights the importance of understanding genetic interactions in determining antibiotic resistance.
Research on clarithromycin resistance in Helicobacter pylori isolates from Malaysian patients revealed low prevalence rates and specific mutations. The study found transitions of adenine to guanine at positions 2142 and 2143 of the 23S rRNA gene, detectable through restriction fragment length polymorphism analysis.
Researchers studied DNA from 1,930 pneumococcus strains and found a link between bacterial recombination and antibiotic resistance. Bacteria that undergo sex with other species are more likely to develop resistance to antibiotics, making treatment increasingly difficult.
A soil microbe uses an enzyme to produce a herbicidal compound by breaking a non-activated carbon-carbon bond in a single step. The study provides the first three-dimensional structure of the enzyme and proposes a mechanism for its task.
Researchers have detected vancomycin resistant enterococci (VRE) in Swedish sewage sludge, highlighting the potential for antibiotic resistance genes to spread through the food chain. The study emphasizes the need for more efficient treatment of sewage sludge to prevent the spread of antimicrobial resistance.
A national survey reveals that nearly all oncologists and ID specialists are highly concerned about the negative impact of infection on treatment outcomes in chemotherapy patients. Infections among chemotherapy patients are common, with one in four patients experiencing an infection in the last 12 months.
Infection control methods could reduce hospital-acquired neonatal infections, which account for one-third of global child deaths. Multidrug-resistant GNRs were found in over 1,900 colonizing and infecting neonates, with high-risk factors including mechanical ventilation and prematurity.
A new study by Uppsala University reveals a mechanism to delay the development of antibiotic resistance in bacteria. Inhibiting drug efflux pumps can mask the effect of mutations that reduce antibiotic binding, providing clues to delaying resistance development.
A new combination of antimicrobial drugs and peptides has been developed to target MRSA, resulting in a 99.97% kill rate and 1000x increased effectiveness compared to existing treatments. This approach also prevents bacteria from producing toxins and is unlikely to lead to resistance.
Researchers have developed a new generation of natural antibiotics using bioengineering, targeting harmful micro-organisms like MRSA and Listeria monocytogenes. These enhanced nisin variants possess greater activities against clinical pathogens and could become acceptable alternatives to current antimicrobials.
Severe injuries on battlefields increase risk of multidrug-resistant bacterial infections in war-wounded soldiers. Effective personal protective equipment and medical care have improved survival rates but not mitigated the risk of wound infections.
A new study found that a rigorous environmental cleaning intervention can reduce the transmission of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) in hospital intensive care units (ICUs). The multi-modal cleaning protocol reduced MRSA acquisition by 61%, while VRE acquisition decreased by...
A 6-part CMAJ series tackles antibiotic resistance in hospitals, clinics, and homes, providing practical treatment guidelines. Enhanced monitoring, hand washing, and infection control measures can help limit the spread of resistant microbes in Canada.
Researchers find increasing risk of staph infections from ocean beach users, but also discover sponge and coral-derived chemicals that could break down antibiotic-resistant compounds. New tools to fight antibiotic resistance have been identified, including novel antibiotics and chemicals with potential for personalized medicine.
A study found a significant increase in quinolone-resistant gonorrhea from 2% to 28% in Ontario between 2001 and 2006. Infections among heterosexual men are linked to the rising rate of resistance.
Resources for the Future launches Global Antibiotic Resistance Partnership to explore incentives for slowing antibiotic resistance development and spread. The three-year initiative will build on the Extending the Cure project, focusing on five emerging economies with rapidly rising antibiotic use.
Researchers identified the structure of a key component facilitating the exchange of antibiotic resistance genes between bacteria. This discovery sheds light on how type IV secretion systems, which also transport toxins, contribute to disease-causing properties and public health concerns.
Northwestern University researchers have discovered a CRISPR locus that can impede the spread of antibiotic resistance in pathogenic staphylococci by blocking plasmid transfer. This mechanism could provide a means to limit the spread of antibiotic resistance genes and virulence factors in bacteria.
A new strategy targets the cooperation among pathogens, which is more effective than killing individual cells with traditional drugs. By disrupting the teamwork, the immune system can combat any remaining infection.
The Lancet Infectious Diseases review highlights the growing concern of Acinetobacter baumannii infections, which can be caused by environmental exposure, skin colonization, or hospital-acquired conditions. Researchers emphasize the need for strict hygiene compliance and further research on antibiotic treatment options to prevent major...
Scientists have obtained visual evidence of how deadly 'superbugs' acquire and disseminate antibiotic resistance. The discovery sheds light on the role of conjugative pili in spreading antibiotic resistance.
Researchers have developed a new grape called Improved Chancellor that is resistant to the popular herbicide 2,4-D. The discovery of the gene that makes this grape resistant came about by accident, and it has the potential to help salvage the wine and grape industry in the Midwest.
Research found that low levels of disinfectants can make Staphylococcus aureus remove toxic chemicals from the cell more efficiently, potentially making it resistant to antibiotics. This increase in efflux pumps may lead to the emergence of resistant bacteria, threatening patients with infections.
A study published in World Journal of Gastroenterology found that HeF A expression levels are significantly higher in multidrug-resistant strains of H. pylori compared to their susceptible counterparts. The HeF A mutant was more susceptible to four out of ten antibiotics, confirming its role in multidrug resistance.
UVA researchers have developed a method to reduce MRSA infections by rotating antibiotics every three months, resulting in a significant decrease in infection rates from 1.9 to 1.4 patients per 100 admissions. In-hospital mortality from surgical ICU-acquired MRSA infections also fell to zero.
Researchers at Kansas State University have developed a rapid test that can detect multiple diseases and antibiotic resistance in a single sample, reducing the diagnosis time from days to just 24 hours. The test has the potential to improve clinical diagnosis of animal and human infections, as well as enhance our response to bioterrori...
California officials have identified 18 cases of extensively drug-resistant tuberculosis (XDR TB) between 1993 and 2006. The state has also seen a rising trend of multidrug-resistant tuberculosis (MDR TB) cases, with XDR TB being resistant to multiple classes of antibiotics.
A study of 174 tuberculosis patients found that extensively drug-resistant TB patients were almost eight times as likely to die as those with multi-drug resistant TB. The study emphasizes the critical importance of optimal management of multi-drug resistant cases to prevent progression to XDR-TB and associated poorer outcomes.
Current TB treatment regimens are insufficient in countries with high MDR-TB prevalence, leading to significantly higher failure and relapse rates. Studies reveal that for every 1% increase in MDR-TB, there's a corresponding 0.3% rise in new case treatment failure and a 1.1% increase in retreatment failure rate.
Researchers have discovered two new β-Lactam antibiotics that target MRSA, a major global health threat responsible for approximately 20,000 US deaths annually. The novel compounds interact with the MRSA cell wall enzyme PBP 2a, inhibiting its function and leading to bacterial cell death.
The study reveals stark differences in antibiotic resistance between European countries, with major antibiotics being less effective in certain nations. Resistance to oxacillin and cephalosporins is of particular concern, suggesting the presence of MRSA in some countries.
Researchers at Rockefeller University tested Ceftobiprole against multidrug-resistant Staphylococcus aureus (MRSA) bacteria, achieving a 100% kill rate. The new antibiotic successfully targeted the gene that confers resistance, offering hope in combating staphylococcal infections worldwide.
A new laser-powered treatment has been shown to kill a wide range of bacteria, including antibiotic-resistant strains, without causing significant heat damage. The treatment uses indocyanine green dye activated by near-infrared light, which penetrates deep wounds and increases the area cleansed.
Researchers identified Mfd as a key factor promoting fluoroquinolone resistance in Campylobacter. Eliminating Mfd from the bacteria resulted in a 100-fold reduction in antibiotic-resistant mutants.
A study found that using silver-coated endotracheal tubes reduced ventilator-associated pneumonia (VAP) rates by nearly 40% and highly resistant infection rates by less than half. The average costs associated with VAP treatment were also significantly reduced due to the impact on length of stay in ICU.
The genome of Steno, a newly emerging superbug, has been sequenced, revealing an organism with exceptional drug resistance. Understanding its genetic makeup may help researchers develop biochemical compounds to combat this resistance.
A recent study found that proteins in alligator blood have potent antimicrobial properties, effective against MRSA and Candida albicans yeast infections. Researchers believe these proteins could be used to develop new treatments for diabetic ulcers, severe burns, and other infections
A team of researchers has identified a molecular switch controlling multidrug resistance in fungi, which could lead to novel therapies for resistant fungal infections. The discovery was made using genetic, biochemical, and molecular approaches, and found to be similar to the regulatory switches controlling drug detoxification in humans.
Scientists warn of an impending crisis due to superbugs like Acinetobacter that have become resistant to all available antibiotics, including those thought safe. The bacteria cause severe infections, pneumonia, skin, and wound infections, and even meningitis, leading to significant patient mortality.
A standard sampling regime is being developed to identify superbug genes in intensive care unit environments. The technique uses polymerase chain reaction (PCR) to characterise micro-organism genes and spot antibiotic resistance, allowing for the detection of MRSA and other drug-resistant bacteria.