Articles tagged with Glucocorticoid Receptors
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Researchers discovered TBX2 drives therapy resistance by shifting signaling from the androgen receptor to the glucocorticoid receptor. The study identified a strategy to target this switch, potentially predicting patient risk and offering new treatment approaches.
Researchers are studying the role of stress hormones and mineralocorticoid receptors in bone health as we age. The goal is to understand how balance between these factors affects our skeletons. By investigating this complex relationship, scientists hope to develop new insights into osteoporosis and other age-related bone disorders.
Researchers found that stress responses differ between patients living in high-violence areas and those in lower-crime zones. The study suggests glucocorticoid receptors play a key role in driving adverse tumor outcomes in patients with chronically high environmental stress.
Researchers at the University of Eastern Finland have identified coregulator proteins as an alternative target to prevent drug resistance in prostate cancer. By inhibiting these proteins, the growth of drug-resistant cancer cells can be inhibited, and the activity of the glucocorticoid receptor can be limited.
Researchers investigated the cardiovascular effects of glucocorticoids on chicken embryos, finding that Betamethasone (Beta) caused more severe growth restriction, cellular stress, and cardiac dysfunction compared to Dexamethasone (Dex). Dex triggered oxidative stress, while Beta sustained glucocorticoid receptor activation
Researchers at the University of Barcelona reveal that the glucocorticoid receptor can form up to 20 different dimers, which can associate to form functional tetramers when binding to DNA. This discovery may lead to the development of more selective and less toxic drugs.
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
Researchers found that stressed mice exhibited decreased neuron excitability in the dorsal hippocampus, which may drive social avoidance, while resilient mice showed increased excitability. This difference was linked to changes in stress hormone receptors and HCN1 protein expression.
Researchers identified glucocorticoids as a key factor inhibiting cardiac regenerative capacity after heart attacks. The study showed that deleting or blocking the glucocorticoid receptor increased heart muscle cell replication and regeneration.
Researchers found that prenatal exposure to nicotine and its by-products produces long-term effects on sleep and stress-response in mice. This early-life exposure can lead to alterations in the hippocampus, a sensitive structure that develops after birth.
Researchers have found that blocking mineralocorticoid receptors, a key factor in bone health, may help protect against bone loss and osteoporosis. This new target is thought to be more effective than previously believed logical targets, such as reducing glucocorticoid receptor activity.
A study in mice showed that reducing a particular hormone signal can prevent the growth and spread of Ewing sarcoma, a bone cancer mainly found in teenagers. The findings suggest a potential treatment approach using existing drugs to neutralize glucocorticoid receptors.
Two proteins, glucocorticoid receptor and mineralocorticoid receptor, work together to support heart health in mice. The study's findings may lead to the development of therapeutic compounds that help people with an increased risk of a heart attack by regulating cortisol levels.
Researchers at Max Planck Institute discovered that DNA segment to which a transcription factor binds can assume various spatial arrangements, altering the transcription factor's shape and controlling its activity. Neighboring DNA segments also play a significant role in modulating gene activity.
A novel, non-invasive treatment strategy for Cushing Disease has been discovered using silibinin from milk thistle seeds. The active compound binds to heat shock protein 90, allowing glucocorticoid receptor molecules to dissolve and restore normal ACTH production.
Researchers at Mount Sinai Hospital discovered a biomarker linked to PTSD development, centered around the glucocorticoid receptor. This receptor is found in stressed animals with PTSD and may be targeted for new treatments.
Researchers found that mannotriose improves hippocampal neuron survival rates after corticosterone-induced injury. Mannotriose also restored protein levels of glucocorticoid receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor.
Researchers discovered that DNA changes the form and activity of transcription factors, such as the glucocorticoid receptor, allowing for precise control over gene expression. This adaptation enables genes to be transcribed to varying degrees.
A study found that a specific polymorphism in the glucocorticoid receptor gene is associated with lung disease progression in cystic fibrosis. Patients with the BclI GG genotype showed more pronounced deterioration in lung function, suggesting they may benefit from inhaled steroids.
Researchers found that HIV's Vpr protein disables host immunity by interacting with PARP-1 through the glucocorticoid receptor. This discovery provides potential novel approaches for designing new drugs to combat AIDS and inflammatory disorders.
Researchers engineered mice to lose glucocorticoid receptors, showing an increase in depression-like behaviors and impaired regulation of stress response. This study suggests that genetic makeup may play a role in triggering depression by affecting the brain's ability to regulate adrenal hormones.