Articles tagged with Phenylalanine
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A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
The American College of Medical Genetics and Genomics has published a new evidence-based clinical guideline for phenylalanine hydroxylase deficiency diagnosis and management. The guideline provides recommendations for treatment, implementation considerations, research priorities, and economic considerations to improve patient outcomes.
SYNB1618 demonstrates dose-responsive, non-saturated increases in gastrointestinal Phe consumption, suggesting therapeutic potential for Phenylketonuria (PKU). A mechanistic model predicts SYNB1618's function in PKU patients and informs clinical development.
Researchers develop stable capsule shell for L-phenylalanine ammonium-liasis (PAL) enzyme, improving its effectiveness and stability in the body. The treatment has potential applications beyond phenylketonuria, including other amino acid metabolism disorders.
Researchers at IKBFU developed a stable capsule composition for the L-phenylalanine-ammonium lyase enzyme to treat phenylketonuria. The study found that storage temperatures above 25°C significantly decrease enzyme activity, but the optimal temperature remains unknown.
A single amino acid change in the light-sensing rhodopsin protein is crucial for herring adaptation to the Baltic Sea. Over 1/3 of all fish in brackish or freshwater carry this genetic change, enabling them to thrive in the region.
Researchers found that green tea and red wine compounds can prevent the accumulation of toxic metabolites, which cause severe developmental disorders. This discovery could pave the way for new therapies to treat inborn congenital metabolic diseases.
A new study found that phenylalanine reduces food intake by affecting the gut and brain, suggesting it may be used to treat or prevent obesity. The amino acid suppressed appetite by releasing hormones in the gut and activating areas of the brain involved in appetite regulation.
Researchers at Princeton University have revealed new insights into the mechanism of phenylalanine hydroxylase, a critical liver enzyme for human health. By applying unique approaches combining small-angle x-ray scattering and chromatography, they provided evidence for a model of the active structure of the enzyme.
Researchers used MRI to study the effects of PKU on gray matter in the brain. They found evidence of abnormalities in individuals with early-treated PKU, particularly in posterior regions. The study's findings highlight the importance of maintaining dietary treatment throughout life to prevent irreversible damage.
Researchers solved the first X-ray crystal structure of full-length PAH, an enzyme defective in PKU patients. The structure will help understand molecular origins of PKU and inform drug development.
Researchers have identified two groups of ancient bacteria as the source of a critical amino acid pathway used by plants to create essential compounds. This breakthrough sheds light on the complex evolution of plant chemical pathways and may lead to increased production of valuable nutrients and medicinal compounds.
Researchers used computer simulations to investigate the energy landscape of ion channels, identifying a critical amino acid that regulates their function. The study provides new insights into ion channel mechanisms, which are essential for developing targeted therapies.
Researchers at Purdue University have identified the last undiscovered gene responsible for producing phenylalanine, a crucial amino acid in plant proteins and flower scent. This discovery could enable the control of phenylalanine production to boost plant nutritional values and improve biofuel feedstocks.
Researchers at Purdue University have identified a hidden plant pathway that produces an essential amino acid called phenylalanine. This discovery could lead to increased nutritional value in food and improved biofuel production by reducing lignin content.
Researchers at UW-Madison have found a safe and acceptable protein option for people with phenylketonuria (PKU), allowing them to liberalize their diet. The GMP protein derived from whey has been shown to improve protein metabolism and lower blood phenylalanine levels.
Researchers at University of Wisconsin-Madison discover a unique protein in whey that supports growth and reduces phenylalanine levels in mice with PKU, opening possibilities for dietary liberalization.
Cornell researchers identified a natural amino acid called meta-tyrosine in fescue lawn grass that inhibits weed growth and suppresses plant development. The discovery may lead to the development of new varieties of fescue grasses with improved weed-suppressing properties.
UF researchers discovered that high levels of phenylalanine in the brains of mice with PKU interfere with brain cell communication, leading to potential developmental delays and disorders. The findings may lead to new treatments for PKU and other neurological disorders.
A study of younger and older children with phenylketonuria (PKU) reveals significantly poorer adherence to recommended dietary controls in older children, affecting blood phenylalanine levels. Biochemical control can be challenging even in young patients, emphasizing the need for improved treatment options.