Articles tagged with Repressors
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Researchers at CU Cancer Center have discovered a way to activate the p53 tumor suppressor gene, which can kill cancer cells. By inhibiting two repressors of p53, the Integrated Stress Response is activated, leading to cancer cell death in multiple cancer types.
Scientists developed a CRISPR-Cas9-based tool that induces long-term gene silencing by epigenetic editing, offering potential treatment options for cancer and genetic ailments. The innovative dCas9-KAL construct achieves stable repression of target genes.
Researchers discovered that the monkeyflower's distinctive spots are controlled by a reaction-diffusion mechanism involving two proteins. The study used mathematical modeling and experimentation to validate the theory, shedding light on how natural patterns arise.
Researchers developed programmable repressor elements that can switch off protein production in response to specific stimuli, enabling sophisticated diagnostic, environmental and biofabrication approaches. The new tools have the potential to improve applications in next-generation diagnostics, environmental reporting and biomanufacturing.
Researchers discovered that highly robust regulatory proteins can acquire binding to new promoters in response to mutations, challenging the long-held assumption that robustness and evolvability are mutually exclusive. This finding has significant implications for understanding gene regulation and evolution.
A study by Stanford researchers identifies a near-global repressor protein, Myt1l, that works to block many cell fates but one. This discovery suggests the possibility of a network of master regulators specific to each cell type.
The study reveals that the loss of cilia on facial cells impairs the function of developmental repressors, leading to increased Hedgehog signaling and facial widening. This discovery provides insights into the mechanisms of midfacial development and sheds light on the underlying causes of ciliopathies.
A new study reveals that food components can significantly influence the intestinal immune system by binding to an important controller, the Ah receptor. The researchers found that the interaction between the Ah receptor and its repressor is crucial for balancing the immune response.
A new mathematical model predicts tunable gene expression levels in fruit fly embryos, and experimental results validate its accuracy. The study shows that enhancers can adapt to new transcription factors, enabling precise manipulation of gene expression.
Researchers at Rice University have designed a sophisticated synthetic genetic circuit that signals increases in the degradation of proteins by the cell's ubiquitin proteasome system (UPS). The Deg-On circuit produces a green fluorescent signal linked to UPS degradation, allowing researchers to monitor proteasomal activity.
A novel high-throughput screening method has identified agents that can block EZH2 methyltransferase, a key enzyme in tumor development. This approach uses AlphaLisa technology to detect methylation and accelerates the identification of small molecule inhibitors for cancer treatment.
Biologists have discovered how a transcriptional repressor makes its way into the nucleus of plant cells to control jasmonate signaling, which is crucial for maintaining balance between growth and defense. This finding could lead to more efficient crop yields with less harm to the environment.
Researchers at Ohio State University have discovered two essential repressor genes, E2f7 and E2f8, that control cell proliferation in the placenta. The absence of these genes leads to overcrowded and poorly organized cells, hindering embryonic development.
Scientists have discovered two new genes that could help control Staphylococcus aureus, a drug-resistant bacterium. The genes encode copper- and sulfur-binding repressors that regulate the expression of copper resistance genes.
Scientists have used single-molecule techniques to study the tethered lactose repressor protein, revealing how flexibility within the protein influences its ability to form DNA loops. The results suggest that limiting flexibility limits protein function in this case.
Researchers created a tunable genetic switch to regulate gene expression, overcoming limitations of existing technologies. The switch enables precise control over gene function, offering potential applications in basic research, gene therapy, and cell and gene therapy.
A study of over 100 patients hospitalized for a heart attack found that repressive coping style can promote adjustment to traumatic stress in the short and long term. The repressive participants had lower rates of acute stress disorder and post-traumatic stress disorder compared to highly anxious participants.
Researchers at Brandeis University have pinpointed a genetic repressor that can transform diphtheria into a lethal parasite. The discovery could lead to a novel class of antibiotics that prevent bacterial virulence without inducing resistance.