Articles tagged with Synthetic Peptides
Researchers developed an AI platform, PeptiVerse, to predict key properties of peptides, enabling early assessment of drug potential. The open-source platform allows users to evaluate ordinary and chemically modified peptides, streamlining the discovery process.
Researchers at the University of Pennsylvania and Chinese University of Hong Kong created TD3B, an AI framework guiding peptide generation toward candidates predicted to have a desired effect. The tool predicts binding likelihood and determines activation or deactivation of associated cellular machinery.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
Injectable peptides marketed online for enhancement purposes are raising concern due to lack of regulation and limited research. The use of these substances is blurring the line between legitimate treatment and enhancement use, complicating enforcement and creating uncertainty for clinicians, regulators, and consumers alike.
Researchers at EPFL have discovered a way to generate and screen large libraries of synthetic cyclic peptides that can both enter cells and block disease-related protein interactions. This breakthrough could broaden access to previously difficult targets for drug development, enabling the creation of orally available peptide drugs.
Researchers from the University of Ottawa have developed a groundbreaking biomaterial that combines strength, adaptability, and biological compatibility for soft tissue repair. The hydrogel is made from synthetic peptides and can be precisely tailored through chemical design, making it an attractive alternative to existing biomaterials.
A new strategy uses self-assembling peptide nanotubes to deliver doxorubicin into the nucleus of chemotherapy-resistant cancer cells, preserving antitumor activity. The approach utilizes cyclic peptides to stack and self-assemble into hollow cylindrical structures that facilitate drug delivery.
Researchers at the University of Gothenburg found that semaglutide reduced both cocaine use and relapse in rats, with motivation to keep taking cocaine decreasing by 52%. The study suggests that semaglutide may blunt cocaine's ability to raise dopamine levels in the brain.
Researchers at CUNY ASRC discover that simple tripeptides can encapsulate proteins and protect them from stress, opening up possibilities for protein preservation without refrigeration. This breakthrough could lead to innovative vaccine distribution methods and smart materials.
Researchers have discovered a synthetic peptide that attracts Crown-of-Thorns Starfish at low concentrations and with no toxicity, offering an efficient pest-management solution. This breakthrough may lead to the development of potent attractins to control CoTS outbreaks, protecting coral reefs from devastating damage.
Scientists at Brain Chemistry Labs discovered a promising compound called kalata B1 from violets that enhances the activity of chemotherapy TMZ against glioblastoma cells. The synthetic version of kalata B1 showed equal efficacy to the natural molecule, offering a potential new treatment option for patients.
Researchers investigated peptide clumping behavior using molecular dynamics simulations and AI techniques. They discovered that aromatic amino acids enhance aggregation, while hydrophilic ones inhibit it, offering insights into peptide structure and function.
Researchers have developed a new anticoagulant with an on-off switch, providing rapid control of bleeding risks in surgery and blood clots. The supramolecular approach combines a tsetse fly protein with a synthetic peptide, allowing for the anticoagulant to be rapidly deactivated by introducing correctly matched strands of free PNA.
Researchers at University of Texas M. D. Anderson Cancer Center have developed a new method for developing immunotherapy drugs using engineered peptides. The approach improved tumor control and prolonged survival in preclinical models of breast cancer.
Researchers at Xi'an Jiaotong-Liverpool University developed a new method that enables the efficient production of cysteine-rich peptides and microproteins in their naturally folded 3D structure. The approach uses organic solvents to mimic nature's oxidative folding process, resulting in speeds of over 100,000 times faster than aqueous...
Researchers discovered a potential treatment for Alzheimer's disease also prevents Type 2 diabetes by blocking the formation of toxic IAPP clusters. A synthetic peptide was shown to bind and neutralize these clusters, keeping beta cells alive.
A novel synthesis method enables easy linkage of therapeutic oligonucleotides to peptide markers, streamlining the process and making it more accessible and cost-effective. This breakthrough has the potential to produce more effective and targeted RNA-based drugs.
Researchers have developed a synthetic peptide that could help reduce vascular problems associated with acute respiratory distress syndrome in COVID-19. The peptide, called TIP, works by binding to a subunit of the epithelial sodium channel, which helps maintain barrier function and prevent damage from viral proteins.
Researchers developed human calprotectin ligands based on peptides to detect and quantify the protein in stool samples or serum levels, offering a more accurate and controlled way of detecting biomarkers.
Researchers have discovered a compound that can combat multidrug-resistant bacteria within one hour, including the ESKAPE group of pathogens. The compound, Pln149-PEP20, is a synthetic peptide inspired by molecules secreted by Lactobacillus plantarum and has been found to be highly active against MDR bacteria.
Researchers developed synthetic peptide nanonets that selectively entrap bacteria, rendering them vulnerable to antimicrobial components. The nanonets displayed both trapping and killing functionalities, demonstrating potential as an anti-infective strategy.
Scientists have developed stable peptide mimics called peptoids to treat viruses and prevent infections. Peptoids, such as those tested against SARS-CoV-2 and HSV-1, could one day cure or prevent many kinds of infections, including COVID-19.
Researchers have developed synthetic peptides that target and inhibit small, toxic aggregates of amyloid beta, implicated as the toxic elements behind Alzheimer's disease. The peptides reduce amyloid beta-triggered toxicity in human neural cells and inhibit oligomers in laboratory animal models.
A study published in Scientific Reports reveals that the Na/K-ATPase oxidant amplification loop plays a key role in aging and may be targeted for anti-aging interventions. Researchers successfully demonstrated the therapeutic potential of pNaKtide, a synthetic peptide, in improving impaired physiological functions.
BioSET Inc. has been issued a patent for improved second-generation technology to design synthetic peptides that communicate growth signals to cells, fostering efficient healing. The technology has applications in numerous tissue repair cases, including orthopedic markets and sports medicine injuries.
Researchers at Medical College of Georgia have developed a synthetic peptide that mimics the body's natural ability to reduce excess fluid accumulation in lung transplant patients. The peptide, called TIP, has been shown to improve oxygenation and reduce inflammation, potentially reducing mortality rates.
Researchers developed a synthetic peptide, B2A2, that unlocks synergy with BMP-2, increasing its effectiveness in bone formation. The peptide is part of a series of growth factors being developed by Brookhaven/BioSET collaboration.