Articles tagged with Cellular Organization
Researchers at MBL propose a model for how properties of individual molecules emerge to form liquid droplets called condensates. By combining imaging and computer simulations, they reveal the importance of linker DNA in determining condensate structure.
Researchers discovered that mitochondrial dysfunction triggers a sophisticated metabolic response in brown fat cells, rewiring key enzymes to produce D-2HG. This metabolite modifies the cell nucleus, changing gene expression and nuclear structure, promoting adaptation and altering cellular identity.
Researchers developed a systems approach to measuring organelle changes in living cells as they grow. The study found that certain organelles grow faster than others and that the vacuole plays a key role in buffering the cell against randomness.
A novel combination of cell biology and molecular computer simulations reveals that sterols' interactions with lipids shape membrane domains in yeast cells. This finding refines a 50-year-old textbook model, suggesting the complexity of sterol metabolism resulted from balancing lipid interactions for membrane organization.
The ERA4TB project aims to develop new antibiotics against TB, while TAINT-TB focuses on contrast agents for precise diagnosis. The TCOLF-TC312 project uses humanized mice to study TB and its interactions with the immune system.
Researchers at MPI-DS discovered that non-reciprocal interactions between particles can homogenize mixtures and control particle organization. This study offers a new route to understanding how complex patterns and structures emerge and maintain cellular functions.
A study from the Marine Biological Laboratory proposes that physical forces, such as fluid dynamics, played a key role in the evolution of multicellular life. The researchers found that cooperative feeding among Stentor cells increased the flow rate of water into their mouths, allowing them to capture more prey. However, the benefits o...
Researchers at MD Anderson Cancer Center made several key discoveries, including the spatial organization of cancer-associated fibroblasts across various cancers and a study on treatment resistance in SMARCA4-mutant lung cancer. These findings highlight the importance of investigating cell populations in their spatial context to better...
Researchers discovered that gamma-actin increases the rigidity of cell membranes while beta-actin filaments are less stiff. This mechanism may contribute to hearing loss by affecting the apical membrane's stiffness essential for auditory function.
A new study reveals a previously unexplored mode of protein regulation in cystic fibrosis, opening up a target for future therapies. The research finds that CFTR proteins form clusters on cell membranes, which are disrupted in people with the condition.
Researchers discovered that the activity of place cells in large spaces follows universal mathematical principles, challenging long-held assumptions about neural circuits and spatial cognition. The findings suggest that randomness is key to encoding information about experiences.
Researchers Navdeep Rana and Ramin Golestanian investigated non-reciprocal interaction and defect formation in active systems, finding well-ordered wave patterns emerge when non-reciprocity exceeds a certain level. This property opens avenues for applications of non-reciprocal active matter systems.
The American Heart Association warns hunters about the increased risk of heart attack and stroke due to exertion, cold temperatures, and excitement. Hunters should recognize symptoms, take breaks, and have a plan in case of emergencies. Learning Hands-Only-CPR can also save lives.
Researchers have created detailed 3D maps of multiple tumor types, revealing how cells are organized within the tumor and how it changes when spreading to other organs. These maps could lead to new approaches in therapy and transform the way cancer is understood and treated.
Scientists have identified a novel molecular mechanism underlying brain cell communication, regulating excitatory synapse maturation and contributing to anxiety disorders. The study reveals the TrkC-PTPσ complex governs synaptic protein phosphorylation, leading to abnormal synapse organization and behavioral defects in mice.
Researchers have found that variability in when and how cells divide during embryo development leads to more optimal arrangements of cells, promoting robust tissue formation. This study challenges traditional views on the role of cell division variability in embryonic development.
A mouse model study led by Ohio State University researchers reveals the importance of DNA loops and protein complex cohesin in nerve cell regeneration. The study's findings could lead to new treatments for nerve injuries by understanding how chromatin organization affects gene expression.
Researchers at Göttingen and Warwick Universities studied the structure and mechanics of cytoskeletal networks composed of actin isoforms. The study found that gamma actin forms rigid networks near the cell apex, while beta actin preferentially forms parallel bundles with distinct organizational patterns.
Researchers discovered that CAMSAP2 proteins utilize phase separation to form an 'aster' structure, which then organizes into a microtubule network. This process is crucial for the formation of specialized cell shapes, such as those found in heart muscle and nerve cells.
A UNIGE team discovered that cells in curved tissues swell by 50% before returning to normal, opening avenues for in vitro organ culture. This active phenomenon can be harnessed to control spontaneous growth of organoids and develop new materials with volume increase upon folding.
Researchers discovered that bacterial biofilms employ a developmental patterning mechanism similar to plants and animals. The 'clock and wavefront' mechanism creates intricate composite patterns of repeating segments of distinct cell types.
Researchers at Johns Hopkins Medicine used food science concepts to study membrane-free droplets in cells, finding they are highly organized and respond to the environment. They discovered a protein called MEG-3 that stabilizes these droplets, allowing them to separate and react quickly to changes.
A new 3D bioprinting technique uses multicompartmental bioprinting to direct cell orientation within deposited hydrogel fibers. The method provides favorable environments for cell proliferation and morphological cues to guide cell alignment.
A team of Université de Montreal researchers has visualized RNA molecule organization in cells using super-resolution microscopy. They found that messenger RNAs exist in multiple configurations, contradicting the long-standing model of a stable closed-loop conformation.
A study by Babraham Institute and Weizmann Institute reveals genes are constantly rearranged in cells, changing their positions to fine-tune gene expression. Researchers collected data from over 4,000 individual cells using single-cell Hi-C technology, providing unique insights into genome organisation.
The Chromos EP captures microscopic elegance of gene organisation using moving soundscapes, revealing how genes interact and influence each other. Researchers from the Babraham Institute's nuclear dynamics research are changing our understanding of biology with their findings.
Researchers found that Prkci gene plays a crucial role in organizing cells into balls and tubes during early embryo and organ formation. By mixing functional Prkci with cells lacking it, they restored normal polarity, suggesting an unknown molecular signal was transmitted to disoriented cells.
Researchers have found that random distribution of organelles in cells is an energy-dependent activity, utilizing ATP to transport organelles along cytoskeleton fibers. This study has implications for understanding human disorders, such as Zellweger syndrome, and highlights the importance of interdisciplinary research.
Sophie Martin received the 2014 EMBO Gold Medal for her groundbreaking research on cellular polarity, which has renewed interest in mechanisms of cell size regulation. Her work revealed a potential mechanism by which microtubules direct actin cytoskeleton-driven cell growth.
Researchers at Johns Hopkins Medicine have identified a critical gene that guides the separation of two types of motion-sensing cells in the retina, shedding light on cellular layering and its implications for brain function.
Researchers at Hebrew University have successfully identified and isolated 'organizer' cells in human embryos, which are responsible for determining the shape of the embryo during development. This breakthrough could lead to better understanding of embryonic development and potential applications in treating spinal damage.
Brown University physicists discover that chemical bonding and mechanical instability lead to the formation of zebra-striped patterns in microtubules. This finding provides insight into how shapes are created in living organisms.
Researchers have discovered that the human circadian clock is organized in a complex network of groups performing different functions, contrary to previous beliefs. This new understanding has significant implications for health, safety, and economic benefits, particularly in addressing jet lag and sleep-related issues.