Articles tagged with Chondrocytes
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A new study identifies miR-101a as a critical suppressor of chondrocyte hypertrophy, reducing Cox-2 expression and attenuating structural damage in an OA mouse model. This highlights miR-101a's potential as a therapeutic candidate for osteoarthritis intervention.
Researchers identified two distinct subpopulations of human tissue chondrocytes, HTC-1 and ProFC-2, which play pivotal roles in OA pathogenesis through apoptosis and inflammation. The study also highlights homeostatic chondrocytes, a subpopulation known for its protective effects against cartilage degeneration.
This study found that SIRT6 activation improves DNA damage repair efficiency and reduces baseline DNA damage in chondrocytes from older donors. MDL-800 treatment also lowered p16 promoter activity and decreased DNA damage in murine cartilage explants, supporting the concept of SIRT6 as a critical regulator of DNA repair.
The University of Basel has successfully treated over 100 patients with focal lesions and two advanced cases of knee OA, reporting beneficial outcomes. The N-TEC procedure uses autologous cartilage cells to grow new cartilage grafts for repairing damaged joints, offering an alternative to knee joint replacements.
Researchers developed a DNA damage-induced senescence model in osteoarthritic chondrocytes, which reliably induces cellular senescence and accumulates senescent cells in OA joint tissues. The study provides a useful model to develop therapeutic approaches targeting senescence in osteoarthritis.
A Kyoto University study has discovered that c-type natriuretic peptide facilitates intracellular calcium signaling in chondrocytes to stimulate long bone growth. This finding may lead to the development of new bone growth-stimulating agents for treating developmental disorders.
Researchers found that chronic inflammation in osteoarthritis triggers a harmful 'feed-forward' loop in cartilage cells, making them more sensitive to pressure and leading to further breakdown of the cartilage. This discovery opens the door for disease-modifying treatments for osteoarthritis.
A new study has discovered the cellular pathway leading to osteoarthritis and found that paroxetine slows down cartilage degeneration while promoting cartilage health in mice and human cartilage. The drug may be the first-ever treatment for this debilitating disease, which affects over 30 million adults.
Researchers identified cytoplasmic localized histone deacetylase 6 (HDAC6) as a promising therapeutic target for OA. The study shows that Tubastatin A administration can postpone development of OA and improve cartilage degradation, suggesting it as a potential treatment.
A collaborative research team has developed a multi-component biomaterial-based screening approach that identifies material compositions and mechanical stimuli enabling human stem cells to differentiate into cells capable of generating higher-quality articular cartilage. The study uses high-throughput screening with multiple combinatio...
A study in The American Journal of Pathology reveals the connection between endoplasmic reticulum stress and pseudoachondroplasia, a severe inherited dwarfing condition. Disrupting a self-perpetuating cellular loop of ER stress, inflammation, and oxidative stress may lead to therapeutic advances.
A new study suggests that microgravity can be less damaging to cartilage than previously thought, thanks to the up-regulation of a key gene. Cartilage cells in space showed moderate changes but remained stable, offering hope for new treatments on Earth.
Researchers have developed a scaffold-free method to generate hyaline cartilage from iPS cells, offering a promising alternative to traditional autologous chondrocyte transplantation. The new protocol avoids fibrous tissue formation and allows for the direct transplantation of chondrocytes with high purity.
Researchers discovered a subset of cartilage-making cells that replicate themselves and drive bone growth, offering new hope for children with facial deformities. The findings could lead to the development of new treatments for corrective facial surgery in children.
Cartilage cells have multiple sensory systems that respond to mechanical strain, leading to cell death. Researchers found two ion channels, Piezo1 and Piezo2, that are critical for sensing forceful injury, and a substance from tarantula venom extract can block these channels, preventing cell death.
The study found that statins promote bone growth in mice with achondroplasia symptoms by rescuing degraded cartilage and increasing chondrocyte proliferation. Statin treatment also accelerated the degradation of the FGFR3 protein, a key factor in skeletal dysplasia.
Researchers at UTHealth discovered a potential treatment window for pseudoachondroplasia by creating genetically engineered mice with the human COMP gene mutation. They found that administering certain medications at age 2 could reduce damage to chondrocyte cells in the growth plate, offering new hope for this disorder.
Researchers at IDIBELL have identified a key component of the complement system that plays a major role in rejecting xenotransplanted porcine chondrocytes. Inhibiting this component, C5, protects cartilage tissue from rejection and inflammation.
Researchers have found a naturally occurring molecule, Urocortin, which protects cells in the joints from being destroyed in osteoarthritis. The discovery could lead to the development of new medicines to prevent joint degradation.
Researchers from IDIBELL have discovered that human NK cells play a crucial role in rejecting porcine chondrocytes. By understanding this process, they aim to develop a method to reduce rejection and enable successful xenotransplantation of pig cartilage cells.
Researchers successfully transformed adult mouse skin cells into cartilage-producing cells, paving the way for potential therapy to repair cartilage injuries. The innovative method involves expressing proteins that induce pluripotency and promoting chondrocyte fate in fibroblasts from human skin.
Researchers found that cryo-preserved amniotic membrane is useful as a scaffold for growing human chondrocytes and repairing human cartilage injuries. The membrane bonds well with native cartilage, forming tissue with high cellular density.
Researchers successfully engineered human cartilage using tissue engineering methods, demonstrating potential for therapeutic applications. The study also found that osteogenic protein-1 enhances cartilage production when added to chondrocytes on scaffolds.
Research reveals cartilage cells can die outside the direct impact zone due to leukocyte-mediated damage. Anti-CD18 antibodies and desferoxamine show promise in blocking this process.
Researchers induce indefinite organ allograft survival in rhesus monkeys by stimulating recipient T cells with donor cells, generating immunosuppressive anergic T cells. These cells suppress renal allograft rejection without additional immunosuppressive agents.