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SAMSUNG T9 Portable SSD 2TB

SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

DNA damage-induced senescence model in osteoarthritic chondrocytes

Researchers developed a DNA damage-induced senescence model in osteoarthritic chondrocytes, which reliably induces cellular senescence and accumulates senescent cells in OA joint tissues. The study provides a useful model to develop therapeutic approaches targeting senescence in osteoarthritis.

Aranet4 Home CO2 Monitor

Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.

Pumping calcium for bigger bones

A Kyoto University study has discovered that c-type natriuretic peptide facilitates intracellular calcium signaling in chondrocytes to stimulate long bone growth. This finding may lead to the development of new bone growth-stimulating agents for treating developmental disorders.

Common anti-depressant may be first-ever treatment for osteoarthritis

A new study has discovered the cellular pathway leading to osteoarthritis and found that paroxetine slows down cartilage degeneration while promoting cartilage health in mice and human cartilage. The drug may be the first-ever treatment for this debilitating disease, which affects over 30 million adults.

Combinatorial screening approach opens path to better-quality joint cartilage

A collaborative research team has developed a multi-component biomaterial-based screening approach that identifies material compositions and mechanical stimuli enabling human stem cells to differentiate into cells capable of generating higher-quality articular cartilage. The study uses high-throughput screening with multiple combinatio...

Davis Instruments Vantage Pro2 Weather Station

Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.

Scaffold-free iPS cell-based hyaline cartilage for joint repair

Researchers have developed a scaffold-free method to generate hyaline cartilage from iPS cells, offering a promising alternative to traditional autologous chondrocyte transplantation. The new protocol avoids fibrous tissue formation and allows for the direct transplantation of chondrocytes with high purity.

How cartilage cells sense forceful injury

Cartilage cells have multiple sensory systems that respond to mechanical strain, leading to cell death. Researchers found two ion channels, Piezo1 and Piezo2, that are critical for sensing forceful injury, and a substance from tarantula venom extract can block these channels, preventing cell death.

Apple iPhone 17 Pro

Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

UTHealth researchers gain insights into severe form of dwarfism

Researchers at UTHealth discovered a potential treatment window for pseudoachondroplasia by creating genetically engineered mice with the human COMP gene mutation. They found that administering certain medications at age 2 could reduce damage to chondrocyte cells in the growth plate, offering new hope for this disorder.

Preventing cell death in osteoarthritis

Researchers have found a naturally occurring molecule, Urocortin, which protects cells in the joints from being destroyed in osteoarthritis. The discovery could lead to the development of new medicines to prevent joint degradation.

Apple AirPods Pro (2nd Generation, USB-C)

Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.

Transforming skin cells into cartilage

Researchers successfully transformed adult mouse skin cells into cartilage-producing cells, paving the way for potential therapy to repair cartilage injuries. The innovative method involves expressing proteins that induce pluripotency and promoting chondrocyte fate in fibroblasts from human skin.

Amniotic membrane used to repair human articular cartilage

Researchers found that cryo-preserved amniotic membrane is useful as a scaffold for growing human chondrocytes and repairing human cartilage injuries. The membrane bonds well with native cartilage, forming tissue with high cellular density.

Sony Alpha a7 IV (Body Only)

Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.

Scientists progress in successful tissue engineering

Researchers successfully engineered human cartilage using tissue engineering methods, demonstrating potential for therapeutic applications. The study also found that osteogenic protein-1 enhances cartilage production when added to chondrocytes on scaffolds.

JCI table of contents July 1, 2005

Researchers induce indefinite organ allograft survival in rhesus monkeys by stimulating recipient T cells with donor cells, generating immunosuppressive anergic T cells. These cells suppress renal allograft rejection without additional immunosuppressive agents.