Articles tagged with Tight Junctions
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Researchers discovered a unique probiotic strain, Bifidobacterium bifidum BB1, that strengthens intestinal barrier function and protects against harmful bacteria. This strain may lead to the development of novel therapies for patients with inflammatory bowel disease and other inflammatory conditions.
Researchers discovered that tight junctions regulate conformation change of ZO-1 protein in response to mechanical force, enabling cells to resist stress. This finding highlights the importance of tight junctions in maintaining body integrity under mechanical stress.
A study by Gladstone Institutes researchers found that tight junctions between cells may play a critical role in gastrulation in human embryos. By suppressing tight junction formation, the team was able to create primordial germ cell-like cells, which are stem cells resembling human precursors of sperm and egg cells.
A recent study published in Frontiers in Cell and Developmental Biology has found that the unique checkerboard pattern of cells in the organ of Corti is essential for proper hearing. The researchers discovered that when hair cells adhere to each other abnormally, it leads to apoptosis and a decrease in hair cell numbers, resulting in h...
Researchers have discovered that physical forces, such as centrifugal force, play a crucial role in enhancing cell-to-cell attachment and increasing tissue stiffness during embryonic development. The study reveals that the FGF receptor/Erk2 signaling pathway is essential for this process.
Epithelial cells lack claudins but maintain barrier against large molecules via JAM-A; removal of JAM-A disrupts barrier, expanding space between cells. The study challenges traditional views on tight junctions and epithelial barriers.
A study published in Cell Systems has characterized global phosphorylation and protein abundance changes in response to physical force in Xenopus embryos. The research team identified precise modulatory points in response to force, highlighting the importance of mechanical forces in tissue homeostasis.
The study found that the EGF receptor is crucial for tight junction barrier formation in the epidermis, a process previously understood to be limited to lower layers of the skin. Mechanobiology also plays a role, with cells sensing pressure and tension through connections between each other.
Scientists at Case Western Reserve University have found that a leaky gut is the underlying cause of non-AIDS complications in HIV-positive patients. The study, published in PLOS Pathogens, reveals that bacterial products seep out of the colon and trigger inflammation throughout the body.
A mutation in the TRIC gene disrupts tight cell junctions, creating a toxic environment that leads to cochlear hair cell loss. Researchers have created a mouse model to study human TRIC-associated deafness and explore potential treatments for restoring tight junction function.
West Nile virus infection causes breakdown of two vital proteins, claudin and JAM, leading to accelerated degradation of the blood-brain barrier. Researchers hope to design drugs that prevent brain infection by understanding this mechanism.
A new study published in the Journal of Allergy and Clinical Immunology found that both the stratum corneum and tight junctions play a crucial role in eczema development. Tightening both leaky barriers may be an effective treatment approach, targeting the faulty tight junction protein claudin-1.
Researchers found that claudin 11 prevents charged ion leakage through myelin layers, increasing resistance and affecting signal conduction. This defect may be linked to cognitive deficits and neurodegenerative diseases, particularly in neurons with thin myelin sheaths.
Research shows that lubiprostone and PEG 3350 can enhance mucosal barrier function in ischemic-injured intestine. Lubiprostone stimulates chloride secretion via ClC-2, recruiting tight junction proteins to the apical-lateral membrane, while PEG 3350 generates an osmotic gradient that drags electrolytes and fluid into the lumen.
Researchers at the University of Chicago discovered how neighboring skin cells adhere to form sealed barriers, a critical function for maintaining body fluids and keeping germs out. The study found that calcium concentration plays a crucial role in this process, enabling the formation of adherence junctions and 'puncta' between cells.