Articles tagged with Tumor Development
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Researchers found that JNK signaling suppresses tumor development, but its absence actually promotes tumor growth. This discovery could lead to new treatment strategies for certain types of cancer.
Research suggests that tobacco smoke exposure can transform follicular lymphoma into an aggressive large cell lymphoma with poor prognosis. Genetic mutations in the p53 tumor suppressor gene and microsatellite instability may play a role in this process.
Dr. Paskett will lead a study comparing the effects of low-fat and low-sugar diets on breast cancer risk in pre-menopausal women. The study aims to explore potential biomarkers for nutrition's role in preventing breast cancer.
Research suggests that smoking during adolescence increases the risk of breast cancer in women by 70%, particularly those who start smoking within five years of menarche. This is due to the sensitivity of human breast tissue to environmental carcinogens during periods of rapid cell proliferation, such as puberty.
A study by Dr. G. Paolo Dotto and colleagues found that decreased Notch1 expression enables the increased expression of HPV viral proteins E6 and E7, promoting malignant cell transformation.
Two conditional mouse models of human lung adenocarcinoma have been developed, shedding new light on the disease's development. The models replicate spontaneous mutations found in human lung cancer, enabling researchers to track cancer progression and test therapeutic agents.
Researchers identified Dmp1 as a critical tumor suppressor gene that promotes tumorigenesis when mutated, providing new insights into cancer development. The study found that even one defective copy of the Dmp1 gene is sufficient to drive lymphoma progression in cells with normal p53 status.
A team of researchers has shown that oltipraz, a chemopreventive agent, can alter the disposition of aflatoxin in people at high risk for liver cancer. The study establishes proof of principle that chemo-preventive agents can work by changing the metabolism of environmental carcinogens.
A study by researchers at Ohio State University found that genes involved in detoxifying cancer-causing chemicals play a role in the development of colorectal tumors. People with certain genetic mutations tend to develop tumors at younger ages or in the distal area of the large intestine.
Researchers found that women with the p53Arg gene variation are seven times more likely to develop cervical cancer due to HPV infection. The study suggests that this genetic variation may confer a strong susceptibility to skin cancers linked to HPV and ultra-violet radiation exposure.
Researchers have identified a new source of sulforaphane, a compound that helps mobilize the body's natural cancer-fighting resources and reduces cancer risk. Studies show that consuming broccoli sprouts daily may provide similar chemoprotection as eating large amounts of mature broccoli weekly.
Researchers at Thomas Jefferson University found that two missing cancer-suppressor genes play a crucial role in female development, leading to catastrophic cell death. The study suggests that the combination of missing genes is lethal to female mouse embryos, offering new insights into cancer mechanisms and potential therapeutic strat...