Articles tagged with Tumor Development
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The first series of debates on cancer development explores two major theories: Somatic Mutation Theory and Tissue Organization Field Theory. Researchers propose focusing on explaining paradoxes to advance cancer research.
Scientists have developed a new magnetic resonance imaging (MRI) method to evaluate the cellular proliferation of breast cancer tumor models. This non-invasive technique assesses water diffusion in tumor tissue, correlating it with growth rates.
Researchers found that genetic diversity in natural killer cells contributes to lung cancer susceptibility. In mice, manipulating the immune system can significantly block tumor growth. The study suggests a key role for natural killer cells in lung cancer, potentially offering new targets for therapy.
A new 'Multi-Hit' mouse model has been developed to study interactions between gene mutations that cause cancer, revealing key findings about the role of Ras and other genes in tumour development. The research suggests that combinations of mutations can lead to cancer, making it a crucial step towards understanding treatment options.
A study published in the Journal of the National Cancer Institute found that a plant-based compound called phenethyl isothiocyanate (PEITC) slowed breast cancer growth in mice. PEITC was shown to reduce mammary carcinoma lesions by 56.3% and suppress tumor progression.
A study by the Trudeau Institute has identified key mechanisms in controlling gamma-herpesvirus infections and their implications for treating and preventing cancer. Researchers found that immune responses differ between initial active phase and long-term latent infection phases.
Scientists isolated a protein called periostin that plays a major role in metastasis development. Blocking this protein can prevent the formation of secondary cancers, offering a promising therapeutic option for late-stage cancers.
Researchers found a significant reduction in glioma risk among people with borderline elevated IgE levels. However, the protective effect couldn't be measured in people with higher IgE levels. The study suggests an immune response to allergies may affect brain tumors.
Researchers found a sub-group of cutaneous human papillomaviruses (beta HPV types) associated with skin carcinogenesis in a novel experimental animal model. Chronic skin UV irradiation promoted the formation of skin lesions resembling squamous cell carcinoma precursor lesions, closely mimicking human observations.
Researchers at Queensland University of Technology found a mushroom compound, polysaccharopeptide (PSP), to be 100% effective in suppressing prostate tumor development in mice. PSP targets prostate cancer stem cells and prevents tumour formation without causing side effects.
Researchers found that apigenin in parsley and celery can delay and reduce breast cancer tumor formation by blocking blood vessel growth. The study suggests incorporating these plant-based compounds into daily diets may help prevent breast cancer progression in women taking hormone replacement therapies.
A study of roundworm chromosomes may provide insight into large-scale genome duplications that occur in developing tumors. The research found that chromosome ends erode and fuse, creating genome rearrangements that contribute to tumor development.
A study by Georgetown University Medical Center researchers suggests that activation of the beta-catenin oncogene is key to understanding why many women with HPV infection do not develop cervical cancer. The discovery could lead to new screening methods and therapeutic approaches, including targeting the Wnt pathway.
Researchers suggest that transcriptional mutagenesis, a process where damaged DNA leads to mutant proteins, could contribute to tumor growth. The study highlights the importance of understanding this process to develop new cancer treatments.
Research suggests that smoking before menopause may be associated with an increased risk of developing breast cancer. Women who smoked more or longer had a higher risk of breast cancer, while passive smoking was not linked to an increased risk.
Researchers have identified a novel type of papillomavirus, EcPV-2, linked to equine genital cancer. The virus is closely related to human genital cancers and its presence in affected horses suggests a potential cause and cure.
New research from the University of Alabama at Birmingham suggests that Celebrex may help prevent some non-melanoma skin cancers. The study found that celecoxib was highly effective in preventing cancer development from pre-cancerous actinic keratoses lesions, especially in patients with large numbers of lesions.
Neonatal mice separated from their mothers for a prolonged period developed mammary tumors twice as fast as those with short or no maternal separation. Estrogen receptor alpha levels were also significantly higher in mice exposed to prolonged separation, increasing breast cancer risk.
A new study identifies a novel cancer-specific protein present in various types and stages of tumors. The PL2L protein might play a role in tumor initiation and progression, offering a potential target for anticancer therapies.
Researchers found that human breast cancer cells overexpress the alpha 9 subunit of the nAchR, promoting tumor growth. Reducing α9-nAchRs inhibited tumor growth in laboratory experiments.
Researchers at Yale University have discovered a genetic marker that can help predict ovarian cancer risk. The KRAS-variant was found in 25% of all ovarian cancer patients and 61% of those with a family history of breast and ovarian cancer, suggesting it may be a new marker for high-risk families.
Research at the University of Cincinnati found that individuals with the CHEK2*1100delC gene variant are more susceptible to developing cancer, particularly in women. The study suggests a stronger link between the gene and breast cancer in females compared to males.
Researchers found that gastrin stimulates gastric acid secretion and plays a significant role in the development of Helicobacter-induced stomach cancer. High levels of gastrin may increase cancer risk, while low levels may lead to more tumors in specific parts of the stomach.
A comprehensive review of case-control studies links gene polymorphisms in alcohol dehydrogenase and aldehyde dehydrogenase enzymes to an increased risk of upper aerodigestive tract cancers. Polymorphisms ADH1B and ALDH2 are associated with a higher risk, but data on other variants is insufficient for meta-analysis.
A gene variant has been linked to an increased risk of developing brain tumors at a younger age, with 20.6% of young people with glioblastoma multiforme having the Pro/Pro variant of the TP53 gene compared to 5.9% of healthy participants.
Researchers found that lapatinib delayed tumor development and reduced the number of tumors in a mouse model of hormone receptor-negative breast cancer. Lapatinib is a small-molecule inhibitor that blocks tyrosine kinase activities associated with tumor formation.
Research identified common variants in ABCB1 and ABCC1 genes that increase lung cancer risk. Variants were found more often in patients than controls, particularly in women and younger individuals. These findings may help prevent tobacco-related cancers.
Researchers at USC have discovered a novel approach to suppressing prostate cancer development by inactivating a specific protein biomarker. By blocking the glucose-regulated protein GRP78, they found that prostate tumor progression can be halted in animal models.
Researchers at the University of Toronto have discovered that the EBNA1 protein of Epstein-Barr virus disrupts structures in nasopharyngeal carcinoma cells, interfering with cellular processes that prevent cancer development. The study provides a novel mechanism by which viral proteins contribute to carcinogenesis.
Researchers have discovered a link between Epstein-Barr virus (EBV) protein and cancer development. EBNA1 protein disrupts structures in the nucleus of nasopharyngeal carcinoma cells, interfering with tumor-suppressive processes. This finding raises the possibility that EBV could play a role in other cancers.
Researchers found that genetic programs forming the prostate in embryos are similar to those driving tumor growth in prostate cancers. They identified genes involved in cell survival, growth, and movement that are activated in both normal development and aggressive prostate cancers.
Cervical cancer control is becoming feasible in developing countries due to highly effective vaccines and promising new screening tests. The monograph presents the best global thinking on cervical cancer prevention with vaccination and screening, evaluating cost-effectiveness and affordability.
Researchers have developed a high-fidelity animal model of osteosarcoma by genetically modifying mice to lack the p53 and Rb tumor suppressor genes. This model closely recapitulates human osteosarcomagenesis, providing valuable insights into the disease's genetic contributions.
Researchers found that prompt antibiotic treatment of H. pylori infections can reverse damage to the stomach lining and prevent gastric cancer. Treating mice with antibiotics at an early point of infection delayed the development of severe lesions that can lead to cancer.
Research suggests common viruses, such as human papillomavirus (HPV) and measles virus, may play a role in lung cancer development, particularly in smokers. Studies have found that five out of 22 non-small-cell lung cancer samples were positive for HPV.
The IL-11 protein is identified as the primary driver of tumor development in the stomach, promoting chronic inflammation and tumorigenesis by inducing excessive activation of Stat3. Inhibiting this signaling pathway prevents or reduces tumorigenesis in a mouse model of gastric cancer, offering hope for the development of new treatments.
A restricted-calorie diet inhibited the development of precancerous growths in skin cancer, while an obesity-inducing diet activated pathways contributing to cancer growth and development.
A concentrated broccoli sprouts extract cut bladder tumor development in animal models, with isothyiocyanates delivering potent protective action. The study's results reinforce associations between cruciferous vegetable intake and reduced bladder cancer risk.
Researchers found that a TNF-alpha antagonist can stop inflammation-induced colon cancer in mice with ulcerative colitis. The study used mice treated with azoxymethane and dextran sulfate sodium, which developed tumors due to increased TNF-alpha expression.
Current oral contraceptive users have a higher risk of developing cervical cancer, but this risk returns to normal after 10 years of not using the contraceptives. The study also found that women who test positive for high-risk human papillomavirus are more likely to develop in-situ or invasive cervical cancer.
Researchers have identified IL6 as a protein that stimulates tumor growth when activated by Ras, leading to increased blood vessel formation. Suppressing IL6 activity has shown promising results in fighting tumor formation in preclinical models.
Researchers identified p38-regulated/activated protein kinase (PRAK) as an essential component mediating ras-induced senescence and tumor suppression. The study found that PRAK activation inhibits tumor development, laying the groundwork for new cancer therapy.
Inhibiting ERK1 enhances ERK2 activity, promoting cell proliferation, while ERK2 knockdown almost completely abolishes it. Mouse tumour cells expressing only ERK1 grow into small tumours.
Research found that exercising mice took longer to develop skin tumors and had fewer tumors than sedentary mice exposed to ultraviolet B light. Exercise was also linked to lower body fat, which decreased the risk of skin cancer.
Researchers developed a prototype model to gauge lung cancer risk based on medical history and genetics. The model predicts increased risk in heavy smokers with emphysema, as well as those with inefficient DNA repair capacity.
A study published at the AACR annual meeting found that a history of allergies and asthma significantly reduces the risk of developing brain tumors. Individuals with allergies or asthma had a lower risk of glioblastoma, mid-grade anaplastic astrocytoma, and low-grade gliomas compared to those without these conditions.
Researchers found a higher frequency of genus beta type HPV antibodies in patients with squamous cell carcinoma (SCC) than control subjects, especially HPV 5. No association was found between HPV and basal cell carcinomas.
Researchers found that people exposed to loud noise over several years were 1.5 times more likely to develop acoustic neuroma, a slow-growing tumor that presses the cranial nerve responsible for sensing sound and balance. Wearing ear protection was associated with similar risk levels as non-exposure.
Researchers at the National Institute of Environmental Health Sciences discovered that the TLR4 gene plays a critical role in protecting against tumor development and chronic inflammation. This finding suggests targeting the innate immune system may be a useful tool in fighting various human diseases, including cancer.
Researchers found that enzyme EZH2 has two forms, one promoting oncogenesis and the other inhibiting cell growth. This discovery offers new insights into the role of EZH2 in cancer development and potentially leads to more effective treatments.
Researchers have identified a new protein, Ptprv, that plays a crucial role in preventing and counteracting cancer. The protein works with p53 to halt the cell cycle and block tumor formation, offering new perspectives for cancer treatment.
A new study found that anal cancer precursors are common among HIV-negative, sexually active men who have sex with men, regardless of age. The study also identified risk factors for these precancerous lesions, including HPV infection and having multiple male sex partners.
University scientists have discovered ways to detect areas of instability in DNA that can lead to cancer. By applying this technology to pre-cancerous lesions, they've found that DNA damage occurs very early in the carcinogenic process, highlighting those at risk of developing cancer.
Researchers found that new blood vessels and immune system cells are essential to tumor formation, making them promising drug targets; however, brain images used for diagnosis may not be informative.
Researchers have developed 'supermice' with an extra copy of the Ink4a/Arf tumor suppressor locus, revealing increased resistance to cancer. The study implies that differences in gene expression levels of tumor suppressors significantly contribute to the risk of developing cancers and may influence therapeutic development.
Researchers used a mouse model to show that TGF-b production in tumor-infiltrating T lymphocytes is crucial for colon cancer progression. Inhibition of IL-6 trans-signaling prevented tumor growth, suggesting novel therapeutic approaches for colorectal cancer.
Studies identified 13 mutations on the PIK3CA gene in various types of brain tumors, including anaplastic oligodendrogliomas and glioblastomas. The findings suggest a link between PIK3CA mutations and brain cancer development.
Researchers found that early exposure to environmental toxins reprograms the uterus to promote tumor growth in genetically susceptible rats. This new model of gene-environment interaction may explain why some people develop cancer while others don't, especially considering inherited BRCA1 mutations.
Researchers developed a novel method to compare genetic changes in developing mice with those in medulloblastoma, revealing common features with early developmental stages. This study provides a foundation for further research into tumor diagnosis and prognosis.
A new tumour growth model views the tumour as an integral part of the body, dependent on host metabolic rate and food intake. The model predicts that tumours develop faster in younger hosts and have higher life expectancy with low-calorie diets.