Articles tagged with Cytomegalovirus
A recent study found that human lung tissue contains a vast reservoir of tissue-resident memory T cells (T RM cells) capable of targeting a range of viruses, bacteria, and fungi. These cells reside only in the lungs and can live for years, providing a vital line of defense against severe respiratory infections.
A University of Minnesota Medical School research team led by Dr. Mark Schleiss has received a $3.87 million NIH grant to investigate congenital CMV transmission during pregnancy. The study aims to develop preventive and therapeutic strategies to improve pregnancy outcomes and prevent lifelong disabilities in children.
A recent study assessed long-term trends in TORCH infections in a region of India with reliable data lacking. The researchers found that exposure to CMV remained constant, while immunity to rubella was consistently high. However, susceptibility to toxoplasmosis and other congenital infections persisted despite vaccination initiatives.
Researchers at Ohio State University have discovered that dust can be used to track viral outbreaks in indoor settings. The team identified 54 distinct viruses, including SARS-CoV-2 and influenza, using a novel sequencing technique. This method has the potential to provide quick and high-resolution insights into what is happening withi...
Researchers developed an engineered antibody that outsmarts cytomegalovirus by avoiding its immune evasion strategies and activating immune cells to attack infected cells. This breakthrough could lead to safer and more effective treatments for vulnerable populations.
A new study confirms that testing for congenital CMV using the routine dried blood spot (DBS) method is a reliable and effective way to identify newborns at risk for long-term developmental challenges. The test detects over 90% of symptomatic CMV cases, effectively identifying babies in need of early interventions.
Researchers have found a way to use antibodies to direct T cells to kill Cytomegalovirus-infected cells, offering an alternative treatment for life-threatening infections without expensive and side-effect-prone drugs.
A University of Minnesota Medical School research team has launched a groundbreaking study on infants born with congenital cytomegalovirus (cCMV). The five-year, $3.3 million grant will track the development of 200 infants over three years to better understand the virus's impact on long-term health and inform medical providers' clinica...
Researchers discovered a previously unappreciated mechanism by which CMV infects cells lining blood vessels and contributes to vascular disease. The finding highlights a new potential avenue for developing antiviral drugs and suggests other herpes viruses could use similar molecular structures to evade immune detection.
A recent study by Shinshu University researchers found that 1.62 per 1,000 live births have congenital deafness, with bilateral HL affecting 0.84% and unilateral HL affecting 0.77%. The main causes of these conditions were identified as hereditary factors and cochlear nerve deficiency.
Researchers successfully implemented pooled saliva testing to detect congenital cytomegalovirus (cCMV) infection in newborns, achieving an empirical efficiency of 6 and reducing required tests by 83%. The study highlights the significance of early detection through this method, particularly for asymptomatic cases.
Researchers at Tulane University discovered that prior exposure to Cytomegalovirus (CMV) significantly reduces the risk of birth defects and miscarriage during pregnancy. The study found that pre-existing immunity effectively limits transmission and protects against associated birth defects.
Researchers investigated SARS-CoV-2 responses in 222 donors from Central Africa, Europe and East Asia. They found disparities in immune responses due to blood cell composition, latent cytomegalovirus infection and human genetic factors. These population differences may help improve patient management in future epidemics.
Researchers at University of Bristol found that Long Covid is not caused by an immune inflammatory reaction to COVID-19. Instead, persistent immune activation and inflammation may persist for months after COVID-19, correlating with severe disease. The study suggests a new direction for understanding and potentially treating this debili...
The study found that the number of babies born in Minnesota with CMV decreased from 1 in every 200 births to 1 in every 1,000 births between August 2020 and December 2021. This decline is attributed to strict hygienic precautions such as masking, hand-washing, and infection prevention behaviors.
Researchers found that mothers who didn't transmit HCMV to their infants had higher levels of antibody-dependent cellular phagocytosis, suggesting a non-neutralizing immunity mechanism. This finding has implications for the development of effective HCMV vaccines.
Researchers at Gladstone Institutes have developed a novel class of therapeutics called feedback disruptors that target viral proteins' negative feedback loops. These drugs break the genetic feedback circuits, causing infected cells to self-destruct and stopping infection in its tracks.
Researchers at the University of Córdoba discovered that cytomegalovirus (CMV) accelerates immune system decline in all ages, not just the elderly. CMV reactivation leads to pro-inflammatory cell expansion, increasing cardiovascular disease risk by 20%.
Infants who contract cytomegalovirus (CMV) before age 12 months are at a significantly higher risk of developing TB later in their childhood. The study found that babies infected with CMV were more than three times more likely to develop TB after age 1 than children who had not become infected with CMV.
A new saliva test for congenital cytomegalovirus (cCMV) has been shown to be feasible and well-received by parents, with high uptake and accuracy rates. The test could lead to early diagnosis and treatment of cCMV-related hearing loss and neurodevelopmental disorders.
Researchers discover that cytomegalovirus enters a dormant state by varying protein levels in viral particles, allowing the virus to survive and persist for life. This 'bet-hedging' strategy enables the virus to balance between infectiousness and latency.
A new study has found that cystic fibrosis patients who have a common virus may experience faster disease progression. Cytomegalovirus infection was the most important factor linked to disease progression, with patients having the virus referred for lung transplants at a much younger age and dying ten years earlier on average.
Researchers identified a potential pathway for creating effective treatments against CMV, a common viral infection that can be deadly for stem cell transplant patients. A serum containing antibodies matched to the infecting viral strain prevented CMV reactivation after periods of dormancy.
Researchers found that HIV-infected infants were four times more likely to acquire congenital CMV infection compared to uninfected counterparts. Infants born to HIV-positive mothers had high rates of congenital CMV, with a sixfold greater chance of acquiring the virus during pregnancy.
Researchers discovered that cytomegalovirus uses protein IE1 to replicate after PP71 proteins decay, offering potential therapeutic avenues for treatment
Researchers found a close connection between Cytomegalovirus (CMV) infection and the accumulation of immune cells damaging cardiovascular tissue. The study suggests that CMV infection may be an important clinical factor in coronary heart disease, and treatment of the virus could be effective in preventing or managing the condition.
Researchers discovered that cytomegalovirus can infect the iris of mouse eyes, causing chronic inflammation and long-lasting eye problems. The virus remains dormant for months after infection, prompting a reevaluation of its effects on healthy individuals and potentially misdiagnosed conditions.
A human protein called valosin containing protein (VCP) is crucial for human cytomegalovirus (HCMV) replication. Reducing VCP expression in infected cells significantly reduced viral replication.
A retrospective observational study of 323 children with cerebral palsy reveals that 9.6% had cytomegalovirus (CMV) DNA in their blood, six times higher than previously reported
Researchers at Princeton University discovered that cytomegalovirus manipulates fatty acid elongation, a process essential for virus replication. The virus induces the expression of elongase enzyme 7, which is necessary for efficient replication.
A study by Lynn Butler and colleagues found that cytomegalovirus infection inhibits erythropoietin production, leading to lower red blood cell counts. The researchers suggest targeting CMV as a potential treatment for anemia in patients with kidney disease.
Research reveals long-term consequences of chronic CMV infection on the immune system, including weakened responses to other viruses and increased susceptibility to infections. The study shows that prolonged CMV presence contributes to immune ageing, making older individuals more prone to infectious diseases.
A type of herpesvirus infection of the eye has been found to be associated with neovascular age-related macular degeneration (AMD), a leading cause of blindness in the elderly. The virus triggers the production of vascular endothelial growth factor, leading to retinal tissue destruction and vision loss.
A new study found that extending preventive treatment for CMV infection post-kidney transplant reduces the risk of disease by nearly two-thirds. This approach also proves cost-effective, offsetting increased costs with reduced cases of CMV disease.
Researchers have identified a key enzyme, TRC8, that enables cytomegalovirus to shut down an antiviral defense by destroying the MHC I protein. This allows the virus to evade immune system surveillance and trigger an immune response.
Researchers are studying the mechanisms behind cytomegalovirus-induced cell death in the retina, which may lead to new treatment targets. Understanding this process could also provide insights into how the retina responds to other insults such as diabetes or infection.
A study finds that cytomegalovirus infection triggers an autoimmune response, causing endothelial cell damage and exacerbating atherosclerosis. The immune system mistakenly attacks healthy cells, leading to inflammation and further disease progression.
Researchers at La Jolla Institute for Allergy & Immunology have made an important finding on cytomegalovirus transmission by reducing the virus in salivary glands using antibodies. The study may have implications for other chronic virus infections like hepatitis and HIV.
A study of 374 people with HIV-1 infection found that CMV-positive status was significantly associated with accelerated progression to AIDS and death. Randomised clinical trials are needed to investigate the role of CMV in HIV disease progression.
A team of scientists has developed a laboratory system to study the virus in its latent stage, discovering genes that may give it stealth capabilities. This could lead to the development of new drugs to clear the virus from infected individuals.