Articles tagged with Alzheimer Disease
A novel PET radiotracer detects increases in brain tau, a hallmark of Alzheimer's disease, up to 12 months before symptoms emerge. This allows for effective selection of patients for clinical trials, potentially speeding the development of treatments.
Researchers developed a super-resolution technique that harnesses unwanted head motion to enhance brain PET image resolution. This method shows promise in detecting neurological disorders like Alzheimer's disease at their earliest stages, enabling quicker diagnosis and treatment.
The study identifies a correlation between the progression of Alzheimer's disease and nuclear aggregates in brain cells. The findings suggest that these aggregates have a function in manipulating gene expression and may be part of AD pathology.
Researchers mapped misfolded tau proteins' brain journey, finding they resist spread in certain areas. This discovery could lead to new therapies targeting specific brain regions.
A novel tau protein conformation, cis P-tau, is a toxic early driver of Alzheimer's disease and related dementias. Silencing of this protein through immunotherapy has been shown to prevent disease pathology and memory loss in preclinical models.
A large-scale brain epigenetics study has identified 84 new genes linked to dementia, providing new insights into the disease. The study found that epigenetic changes in the brain can be consistently distinguished from those without the disease, with over 70% accuracy.
A new study identified mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia. Researchers found close network relationships between SARS-CoV-2 and genes/proteins associated with several neurological diseases, including Alzheimer's.
Researchers found that plasma CTSB levels increased following aerobic exercise training in older adults at risk for AD, correlating positively with verbal learning and memory. Exercise also modified lipid metabolites relevant to AD, potentially offering neuroprotective effects.
A study found tiny deposits of elemental copper and iron in the brains of two deceased patients with Alzheimer's disease. The presence of these metallic elements, previously observed only in microorganisms, suggests a new aspect of metal neurochemistry.
A study published in Cell Reports has pinpointed a small group of immune cells in the brain that play a crucial role in Alzheimer's disease progression. By targeting these senescent microglia, researchers may be able to slow down disease acceleration and develop new treatment options.
Researchers discovered weaker gamma brain waves in people with mild cognitive impairment or Alzheimer's disease compared to healthy peers. This finding suggests a potential new way to diagnose these conditions and may lead to earlier intervention.
Researchers are developing innovative computational tools to illuminate how genetic factors impact brain structure and function, particularly in Alzheimer's disease. The goal is to accelerate the discovery of robust imaging biomarkers of neurological disorders.
Researchers at the University of Kentucky have developed a new technology that can simultaneously measure glutamate and gamma-aminobutyric acid (GABA) in the brain on a second-by-second basis. The study aims to explore the balance of these neurotransmitters in the aging brain and could lead to new treatments for Alzheimer's disease.
Researchers found that secondary infections trigger a heightened brain immune response, affecting memory and cognitive function in Alzheimer's disease. This over-response leads to knock-on effects on brain rhythms and cognition, similar to acute psychiatric disturbances like delirium.
Researchers found that patients with dementia and especially Alzheimer's are three times more likely to die from COVID-19. The risk is six times greater for those over 80. Chronic inflammatory conditions or defective immune responses may contribute to the increased vulnerability of these patients.
Research finds sleep-dependent global brain activity plays a crucial role in clearing Alzheimer's disease-related toxin buildup, with weaker connection seen in individuals at higher risk or with existing disease. The study suggests this activity could serve as a future marker for clinical evaluation.
Alzheimer's disease disorganises blood vessels around amyloid plaques, causing loss of vessels and worsening pathology. This mechanism aggravates the disease by reducing the brain's ability to clean toxic substances, leading to increased strain on oxygen and nutrient supply.
Researchers from the University of Sussex found that blood flow and oxygen levels in the hippocampus are lower than those in other brain regions, making it vulnerable to damage. Increasing blood flow in the hippocampus may be effective in preventing damage from happening.
A research team identified the structure of hetero-oligomers causing Alzheimer's and Parkinson's diseases to overlap. The study reveals that these aggregates have more degrees of freedom, allowing peptides to be loosely packed on their surface.
Researchers from the Netherlands Institute for Neuroscience have discovered a small molecule that can be used to rejuvenate the brain and counteract memory loss in Alzheimer's disease. The molecule, microRNA-132, regulates adult hippocampal neurogenesis and is required for the neurogenic process in the adult hippocampus.
A simple diagnostic tool has been developed to predict the individual risk of developing Alzheimer's disease with over 90% accuracy. The algorithm combines data from a simple blood test and brief memory tests, and has been shown to be significantly more accurate than clinical predictions by dementia experts.
A study published in Nature Aging suggests that low oxygen levels in senile plaques reduce immune system's defensive capacity against Alzheimer's disease. Reduced oxygen supply also compromises microglial activity, leading to increased pathology associated with the disease.
A team of scientists has found the gene expression signatures underlying microglia associated with amyloid plaque phagocytosis. The findings suggest a new target for interventions to address the underlying disease mechanism of Alzheimer's Disease.
A new study from the University of Eastern Finland found that people with Alzheimer's disease are less likely to undergo cataract surgery compared to those without the condition. This decrease in procedure rate starts one year after diagnosis, highlighting a concerning trend that may impact patients' quality of life.
Researchers discovered that phosphorylation of MECP2 protein decreases in brain cells as Alzheimer's disease progresses, while abolishing this phosphorylation enhances neuronal viability and gene expression. The study suggests that modifications of MECP2 could be a therapeutic target for developing specific therapies against AD.
Researchers at MGH have discovered the role of mitochondria-associated endoplasmic reticulum membranes (MAMs) in forming amyloid beta in axons and neuronal processes. The study suggests that targeting sigma-1 receptors or inhibiting palmitoylation may reduce Abeta production, providing a potential therapeutic strategy for Alzheimer's d...
Research led by Ulrike Müller found that APP protein plays a crucial role in normal brain development, learning, memory formation, and social communication. The absence of APP during brain development led to malformations in critical brain regions and impaired behavior tests, including autistic-like behavior.
A study published in the Journals of Gerontology: Series A found that a combination of low body mass index and high genetic risk for Alzheimer's disease predicts greater disease progression in men. The research suggests that lower BMI may be a consequence of neurodegeneration, rather than a preventive factor.
A new mathematical model provides unique insights into the multiscale biological alterations in the elderly and neurodegenerative brain, linking genetic changes to cognitive decline. The study identified genes contributing to healthy aging and Alzheimer's disease progression, with implications for future treatment targets.
The Alzheimer's Drug Discovery Foundation and The Association for Frontotemporal Degeneration recommend adopting best practices in designing exploratory trials, including rigorous statistical analyses and biomarker selection. These recommendations aim to reduce costs and improve patient engagement in clinical trials.
Researchers at UC Davis found a link between traffic-related air pollution and an increased risk for age-related dementia, including Alzheimer's disease. Exposure to polluted air accelerated Alzheimer's disease characteristics in both rats with and without the risk gene.
A large study of plasma proteins and dementia found abnormal blood levels of dozens of proteins up to five years earlier may predict dementia, including Alzheimer's disease. High levels of one protein, SVEP1, are linked to the disease process.
A new study reveals that retinal scans can identify early signs of Alzheimer's disease by detecting changes in blood vessels associated with the APOE4 gene. The research provides a potential path forward for early detection and treatment of neurodegenerative diseases.
Researchers found that 18:1 LPE promotes neurite outgrowth and protects neurons from glutamate toxicity, suggesting a key role for LPE in brain function. The study provides new insights into the physiological importance of LPE and its potential as a therapeutic agent for cranial nerve damage.
Researchers at Massachusetts General Hospital have discovered that sevoflurane can cause tau to leave neurons and enter microglia, stimulating inflammation and cognitive impairment. The study suggests that inhibiting tau phosphorylation or extracellular vesicle generation could prevent this tau spreading.
Researchers discovered a correlation between decreased Rbbp7 levels and increased tau protein tangle formation in Alzheimer's brains. Restoring Rbbp7 levels reversed tangle formation and cell loss, offering a new avenue for effective treatments.
Researchers will investigate potential mechanisms using mouse models and systems biology approach to identify new drug targets for Alzheimer's disease. The study aims to understand how altered mitochondrial calcium transport contributes to neurodegeneration and disease progression.
Scientists have found that a Mediterranean-like dietary pattern with high intake of vegetables, legumes, and fish may reduce protein deposits in the brain and prevent brain atrophy. The study suggests that adhering to this diet could lower the risk of Alzheimer's disease and dementia.
Scientists identify apoE protein's role in regulating immune-response molecules within neurons, leading to selective neurodegeneration. High levels of apoE trigger the expression of MHC-I genes, marking neurons for destruction and contributing to Alzheimer's disease progression.
A new study suggests that consuming a Mediterranean diet rich in fish, vegetables, and olive oil can help prevent protein build-up and brain shrinkage associated with Alzheimer's disease. The research found that individuals who followed the Mediterranean diet more closely had lower levels of amyloid and tau biomarkers and improved cogn...
Researchers will use whole genome sequencing to identify genetic variants associated with plaques and tangles in the brain, which begin accumulating years before symptoms appear. The goal is to develop early diagnosis methods and potential treatments for Alzheimer's disease.
Researchers used gene therapy to introduce a therapeutic compound into the hippocampus of AD mice, preserving learning and memory. The approach restored normal neural function and reversed neurodegenerative processes by promoting neuronal and synaptic plasticity.
A $3.5 million grant will support the Aging Brain Cohort Dedicated to Diversity (ABCD2) study, a research and training initiative aiming to create one of the largest neuroimaging cohorts of Black individuals. The study aims to enhance understandings of Alzheimer's disease relationships with cognitive decline and identify risk factors.
A new study using 7T brain scans suggests that compromised energy metabolism may be an early indicator of mild cognitive impairment and Alzheimer's disease. The researchers found a correlation between the energy reserve index and cognition levels, providing new insights into the disease.
A recent Baycrest-Sunnybrook pilot study found that low-dose radiation therapy showed remarkable improvements in behavior and cognition within days in individuals living with severe Alzheimer's. The treatment used a CT scanner to deliver low doses of radiation, stimulating the body's natural protection systems to work harder.
Researchers have identified four distinct patterns of tau pathology in Alzheimer's disease, each leading to unique symptoms and prognoses. These subtypes include variant one, which primarily affects memory, and variants two, three, and four, which impact executive functions, visuospatial processing, and language ability, respectively.
Researchers found that treating mice with experimental Alzheimer's drugs paired with a treatment to improve brain drainage reduced amyloid deposits more effectively than the anti-amyloid drugs alone.
A new NIH-funded study in mice suggests that enhancing the brain's lymphatic system may lead to better clinical outcomes for Alzheimer's disease patients. The study found that treatments such as immunotherapies BAN2401 or aducanumab might be more effective when the brain's lymphatic system can better drain amyloid-beta protein.
Researchers at the University of California, Irvine have developed a new genetically engineered mouse model that mimics the most common form of late-onset Alzheimer's disease. The model, which embodies the remaining 95% of cases, holds promise for understanding causes of the disease and developing new treatments.
Researchers at the Salk Institute have developed a new technique to model brain cells in older patients with Alzheimer's disease. The study reveals that affected neurons lose their cellular identity and exhibit changes similar to those seen in cancer cells, providing potential targets for therapeutics.
A new study used autopsy data to evaluate the AT(N) framework, a standard tool for assessing Alzheimer's risk. The researchers found that even in the highest-risk group, a third of individuals did not develop dementia, highlighting the complexity of Alzheimer's disease and the need for additional biomarkers.
A new study finds that traumatic brain injuries (TBIs) share similar degenerative changes in the brain as Alzheimer's disease, particularly in memory and decision-making areas. The research identified comparable patterns of gray and white matter degradation after TBI, which may help predict Alzheimer's risk.
Researchers developed a novel drug that increases LAMP2A receptors, revitalizing chaperone-mediated autophagy and removing toxic protein aggregates. In mouse models of Alzheimer's, the drug reversed key symptoms, suggesting potential for human treatment.
Researchers at Karolinska Institutet have developed a new astrocyte-specific PET tracer, BU99008, which detects reactive astrogliosis in the brain. This finding could improve early diagnosis of Alzheimer's disease, with potential implications for other disorders related to astroglial dysfunction.
Researchers at Mainz University discovered how fetuin-B binds to meprin beta, a protein released from cell membranes controlling physiological functions. The binding prevents excessive protein release, potentially treating Alzheimer's and cancer by inhibiting the enzyme.
Researchers discovered a new molecule, K162, that inhibits beta-amyloid toxicity and protects neurons from damage. The study provides hope for alternative therapeutic strategies against Alzheimer's disease.
Researchers analyzed tissue samples from 385 brains with Alzheimer's disease, identifying the SERPINA5 gene as strongly associated with tau protein tangle progression. The study aimed to clarify the relevance of gene expression changes in Alzheimer's disease and provide new targets for treatment.
A University of Colorado Boulder study reveals that tau aggregates interfere with RNA splicing, leading to neurodegeneration in Alzheimer's disease and other tauopathies. The findings provide new insights into the mechanism of action of tau tangles, shedding light on potential therapeutic targets.
Researchers find that microglia promote the formation of dense-core plaques as part of a defense mechanism, clearing debris from neurons and potentially causing cell death. This discovery suggests that treatments targeting these protective plaques may be more effective than destroying them.
Researchers developed a photo-oxygenation catalyst that destabilizes and removes amyloid plaques, enhancing immune system clearance. The treatment significantly reduced amyloid protein in mouse brains, with human brain samples supporting its potential use in humans.