Articles tagged with Hippocampal Neurons
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Researchers at UT Southwestern Medical Center have created a small molecule, Isx-9, that can stimulate nerve stem cells to mature into nerve cells. This breakthrough could lead to new treatments for diseases such as Huntington's disease and brain cancer.
Scientists at Schepens Eye Research Institute have identified specific molecules that awaken dormant brain stem cells, which can transform into neurons and repair damaged brain tissue. The findings suggest that tapping the brain's regenerative potential may be a promising approach for treating neurodegenerative diseases.
A new study reveals that protein-destroying machines in nerve cells play a crucial role in how memories are formed. The researchers found that blocking activity in these machines could potentially strengthen synapses and improve memory, offering new hope for treating Alzheimer's and other brain diseases.
Reducing the nogo receptor in the brain results in stronger brain signaling in mice, effectively boosting signal strength between synapses. The findings suggest that enhancing synaptic plasticity can partially counter the effects of an injury like stroke or traumatic brain injury.
A new technique allows researchers to identify the specific neural connections and molecular tags that sustain a particular fear memory in mice. The study reveals how proteins called AMPA receptors strengthen memories by becoming part of the synapses encoding them.
A team of scientists has made a significant breakthrough in understanding conscious perception by showing how single neurons react to perceived and nonperceived images. The study found that neurons respond with an 'all-or-none' firing rate when pictures are recognized, enabling the prediction of recognition beyond chance.
Researchers found that mice genetically engineered to lack a particular protein have profound deafness and seizures, suggesting a pathway for exploring the hereditary causes of deafness and epilepsy in humans. The study also provides new insight into the role of glutamate, a chemical messenger involved in virtually every brain function.
A new study from the University of California, Irvine, has found that neural stem cells can enhance memory in mice with brain injuries. The treatment promotes neuronal connections and protects existing cells, suggesting hope for a potential drug to restore memory in patients with neuronal loss.
Neurobiologist Rachel Wilson has been awarded the 2007 International Grand Prize in Neurobiology for decoding a pattern of impulses from receptor neurons to identify an odor. Her research reveals complexities in how odors are processed by the brain, using genetic tools and measurements of neural activity in living flies.
Researchers at the University of California, Irvine have discovered a novel molecular switch that modulates nerve cell activity, offering new possibilities for treating mood disorders and epilepsy. The study shows a link between gut protein cholecystokinin and brain's natural marijuana-like compounds.
Adult neural stem cells give rise to three major brain cell types, but are specified to produce specific subtypes of neurons. The discovery suggests that creating specific neuron types may require replacing combinations of different neuronal types for effective reestablishment of neural function.
A study suggests that new adult brain cells play a crucial role in lifelong learning by exhibiting plasticity similar to young brains. The researchers found that these cells have a critical period of adaptability before settling into mature properties, enabling them to contribute to specific brain functions throughout life.
Researchers at Johns Hopkins Medicine have found that newly made nerves in an adult brain's learning center experience a one-month period of child-like learning. This discovery suggests that new adult nerves play a deeper role than simply replacing dead ones, and may help explain how adults adapt to new experiences.
Researchers at the Salk Institute found that newborn neurons tend to form connections with mature brain cells, rather than randomly connecting throughout the network. This allows them to compete out older neurons and ensure proper integration into the existing circuitry.
Research suggests that estrogen's effects on the hippocampus can lead to increased excitatory synapses and enhanced learning, but also suppress inhibitory synapses, resulting in seizure activity. The study proposes novel therapeutic targets for anti-epileptic drugs, exploiting estrogen's rapid impact on neurotransmitter vesicles.
Research reveals lead exposure reduces new neuron birth and survival, and alters their development in the hippocampus, a crucial region for learning and memory. This impairment affects the formation of new connections between neurons, leading to decreased communication and learning abilities.
Researchers at the University of Pennsylvania School of Medicine have found a link between microglia activation and Alzheimer's disease, suggesting a new approach to fighting the disease. The study also shows promise for immunosuppressant FK506 as a potential treatment for neurodegenerative disorders.
Researchers found that new neurons generated in response to epilepsy have reduced excitability and increased inhibitory connectivity, potentially alleviating the disorder. These findings suggest that therapies aimed at inducing neurogenesis could prove effective.
Researchers discovered that stem cell activity decreases with age due to reduced division, not a lack of starting material. The finding offers new avenues for combating cognitive decline and neurodegenerative disorders like Alzheimer's disease.
Researchers found that adult-born hippocampal neurons have similar properties to mature neurons, including excitatory and inhibitory input responses. This suggests that these cells can form connections indistinguishable from those developed in early life, potentially leading to new treatments for brain disorders.
MIT researchers confirm the existence of long-term potentiation (LTP) in the hippocampus when learning occurs. Using advanced techniques, they found that certain key connections among neurons strengthen with learning, providing conclusive evidence for a fundamental learning mechanism.
Researchers discovered that the brain's endocannabinoid system provides 'on-demand' protection against seizures by modulating glutamatergic transmission in neurons. The study suggests that this system might be a prime target for drugs against epilepsy and neurodegenerative diseases.
A study published in Nature identifies a subunit of the NMDA receptor as crucial for young neurons to survive and integrate into adult brain circuits. The discovery sheds light on how newborn nerve cells in adult brains live or die.
Researchers at MIT's Picower Institute for Learning and Memory have developed a state-of-the-art imaging system that allows them to directly visualize molecular activity within individual neurons in the brain of live animals. This breakthrough enables the observation of changes in neuronal activity in response to environmental stimuli,...
Researchers found that mutant mice displayed major abnormalities in social interactions, including reduced interest in new mice and impaired nest-forming behavior. The mice also showed hyperactivity, anxiety-like behaviors, seizures, and decreased learning, all characteristic of autism spectrum disorder (ASD).
Researchers have made a breakthrough in understanding the role of AMPA receptors in strokes, with potential to prevent brain damage and improve learning and memory. By modifying one part of the genetic blueprint of these receptors, they aim to protect neurons from lethal calcium flows, which can cause irreversible brain damage.
Researchers created a simple biophysical model of an axon that reproduced catastrophic oxidative stress-induced collapse, characteristic of neurodegenerative diseases. The study also revealed the role of free radicals and antioxidants in axon degradation.
Researchers have found a way to protect vulnerable neurons in the hippocampus from stroke damage by correcting a specific molecular malfunction. By targeting the AMPA receptor subunit editing machinery, they can prevent calcium influx and subsequent neuronal injury.
Researchers have discovered that Alzheimer's disease is caused by abnormal cell division in neurons, which starts months before amyloid plaques form. The study suggests that another cellular problem triggers the disease process after abnormal cell cycling begins.
Researchers identified Staufen2 as essential for maintaining synapses in nerve cells. The absence of Staufen2 leads to impaired signal transmission and altered synapse structure, suggesting mRNA transport is crucial for their maintenance.
The study found that T cells recognize brain proteins and recruit resident immune cells to fight off toxic substances, enabling neurogenic regions like the hippocampus to form new nerve cells. This process is linked to local immune activity and may play a role in maintaining learning and memory abilities in adulthood.
Researchers at UCSF have discovered that the brain refreshes its supply of memory-making molecules by migrating receptors along neurons to synapses. This process supports rapid changes in the number of receptors during learning and memory formation, contradicting previous assumptions about receptor replacement.
Researchers identified EAAC1 protein as the main transporter of cysteine into neurons, providing vital antioxidant protection. The study found that mice deficient in EAAC1 exhibited signs of senility and oxidative stress, supporting the idea that oxidative stress contributes to brain aging.
Researchers found that GABA-triggered neurons contribute to the development of epilepsy in immature brains through fast oscillations. As brain maturity increases, glutamate's excitatory effects dominate, reducing GABA's impact on epilepsy.
Researchers discovered that a Jekyll-and-Hyde enzyme plays a crucial role in Alzheimer's disease. Transient production of the enzyme p25 enhances learning and memory, whereas chronic expression impairs these cognitive functions. The study uses mice to demonstrate the dual effects of p25 on neural mechanisms.
Scientists have discovered that ion channels in dendritic membranes change during simulated learning tasks, requiring rapid protein synthesis. This finding supports the idea that learning involves changes in dendrites, which could lead to advances in understanding conditions like epilepsy and age-related memory loss.
Researchers at the Salk Institute have identified Wnt3 signaling molecules as crucial for controlling the fate of adult brain stem cells, leading to neuron differentiation. This finding has significant implications for regenerative medicine and our understanding of neurogenesis.
The study reveals that Rnf6 targets LIMK1 for degradation, controlling actin dynamics and axonal growth. Changes in Rnf6 levels can be restored by compensatory changes in LIMK1 expression.
The study found that Apoer2, a receptor interacting with the NMDA receptor, plays a crucial role in regulating synaptic signaling and learning. Mutant mice lacking this receptor had difficulties with learning and memory tasks.
Fragile X syndrome is caused by a defect in the Fmr1 gene, which produces a nonfunctioning protein. Researchers found that mice lacking this gene only in specific neurons showed deficits in a motor learning task. The study also revealed abnormalities in signaling connections and dendrites of Purkinje cells in the cerebellum.
A research team at UCLA and Caltech found that individual neurons can recognize specific images, including faces and letter strings of names. The discovery suggests a consistent code for transforming complex visual representations into long-term memories.
A study found that gene UCHL1 is consistently low in replaceable neurons, associated with increased survival and reduced neuronal death. Researchers discovered UCHL1 levels increase when birds sing, suggesting a link to improved neuron replacement.
Research suggests that moderate drinking enhances new nerve cell formation in adult brains, which may contribute to long-term effects of alcohol on the brain. The study's findings have sparked interest in understanding the role of these new cells in cerebral activity and their potential link to addiction.
Researchers have successfully cloned meat and milk from bulls and cows, showing no significant differences in quality compared to naturally bred animals. Meanwhile, a study suggests that early humans may have driven elephant extinctions on multiple continents.
Scientists at NIMH have discovered newborn neurons in adult rat cortex that communicate via GABA, suggesting potential new treatments for depression and anxiety. The discovery adds to the scientific debate over adult neurogenesis and has implications for understanding brain disorders such as Alzheimer's and schizophrenia.
Researchers at UNC's Bowles Center discovered that new brain cells develop during alcohol abstinence, reversing damage caused by chronic alcohol dependency. The study found a twofold burst in brain cell proliferation after four-to-five weeks of abstinence.
A new protein called mBDNF has been found to play a crucial role in forming long-term memories. The discovery opens up possibilities for studying the protein in people with disorders of learning and memory, as well as developing new medications to compensate for these problems.
Research suggests that cardiac arrest can cause structural changes in neurons, leading to memory deficits and behavioral changes. The study found that mice with a heart attack had difficulty learning new spatial tasks compared to healthy mice.
Researchers at Brown University have discovered that recycling endosomes store and transport AMPA receptors, which are essential for memory formation. The study provides new targets for treatments for disorders such as Alzheimer's disease and mental retardation.
A team of scientists has identified a protein called Dasm1 that plays a crucial role in regulating dendritic spine growth and synapse maturation. The discovery sheds light on the mechanisms underlying brain development and memory formation, suggesting a potential control molecule for both processes.
Researchers have found a new therapeutic target for stroke by blocking calcium-permeable AMPA receptors, which cause neuronal death. Introducing a form of GluR2 that renders AMPA receptors impermeable to calcium protects vulnerable neurons from ischemia.
A UCSD study uncovers how neurons in the brain sort information from electrical impulses, enabling coherent perception. Different neurons specialize in processing specific portions of the information, mimicking a musician reading their part in an orchestra.
A new study investigates curcumin's ability to induce heme oxygenase-1 (HO-1) in rat astrocytes and neurons, suggesting a potential neuroprotective effect. The research found increased expression of HO-1 protein and detoxification enzymes in response to curcumin treatment.
A study found that exposure to terbutaline and chlorpyrifos in early development can lead to brain damage and increased susceptibility to pesticide injury. The combination of the two chemicals caused significant loss of brain cells and nerve cell projections, particularly in regions critical for learning and memory.
Researchers found that apoE4 produced by neurons is susceptible to fragmentation, leading to increased tau phosphorylation and damaging brain cells. The study suggests targeting a neuron-specific enzyme to prevent Alzheimer's disease progression.
A UCI study reveals that newborn neurons in the adult brain mature by growing neural signaling appendages similar to those found in developing brains. This finding may aid in understanding how stem cells can be used to treat neurological diseases.
Researchers identified cypin, a protein in the brain that regulates nerve cell branching, and found it increases dendrite growth enhancing communication. The discovery opens up new avenues for treating serious neurological disorders by designing targeted drug therapies.
Researchers discovered a gene, CREST, crucial for normal brain connections formed in response to sensory experiences. The study revealed that mice lacking the CREST gene develop abnormally in response to calcium ions and experience learning disorders.
A recent study published in Molecular Psychiatry reveals that cell death promotes learning and growth in the brain. The research found that rats with lower levels of cell death performed better in spatial learning tasks, suggesting a positive correlation between cell death and cognitive function.
Researchers found that anti-inflammatory drugs can help new neurons form in the hippocampus, a memory center damaged by radiation. The study suggests that these drugs could be used to prevent long-term brain damage after radiation therapy.