Articles tagged with Hippocampal Neurons
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Researchers discovered ultrafast recycling of synaptic vesicles in nerve cells, allowing for rapid signal transmission and potentially protecting against neurodegenerative diseases. This process enables the brain and muscles to function continuously without interruption.
Researchers found TLR4 signaling increases apoptotic ratio in hippocampal neurons stimulated by lipopolysaccharide. Inhibiting AKT and GSK-3β pathways decreases active Caspase-3 and Bax/Bcl-2 ratios, suggesting a new target for neurodegenerative disease treatment.
St. Jude Children's Research Hospital scientists have identified an enzyme that can halt or reverse the build-up of toxic protein fragments in mice with Alzheimer's disease. Gene therapy increased activity of the enzyme neuraminidase 1, reducing plaques in the brain involved in learning and memory.
5-hydroxymethylfurfural, extracted from wine-processed Fructus corni, protects against H2O2-induced rat hippocampal neuron apoptosis by regulating apoptosis-related genes. This finding provides evidence for the clinical prevention and treatment of oxidative injury-related diseases in the brain.
Researchers found that chronic fluoxetine administration can induce a 'juvenile-like' state in specific neurons of the prefrontal cortex, potentially leading to improved plasticity and neural function. This discovery may revolutionize the prevention and treatment of depressive disorders.
Researchers at the DZNE and Charité-Universitätsmedizin Berlin have discovered a gradient of inhibition within the entorhinal cortex, which may play a crucial role in creating synchronous rhythms and oscillations. This finding has implications for understanding Alzheimer's disease, where the entorhinal cortex is affected early on.
Researchers have developed an animal model to simulate the pathological process of Alzheimer's disease, focusing on the locus coeruleus. This study shows that degenerative alterations in noradrenergic neurons of the locus coeruleus are consistent with pathological changes observed in patients with Alzheimer's disease.
Researchers at MIT have identified a key brain circuit that controls anxiety levels, providing new insights into the development of effective treatments. The study found that manipulating this circuit can boost or reduce anxiety in mice, suggesting a promising avenue for future research.
A team of researchers has discovered that healthy brain cells segregate amyloid precursor protein (APP) and beta-secretase enzyme (BACE-1) into distinct compartments, preventing their combination and triggering Alzheimer's disease. This separation mechanism may hold the key to understanding how AD develops in some individuals.
Recent research reveals that Toll-like receptor 4 expressed in cerebral cortical neurons stimulates inflammatory pathways, suggesting that neurons may be both passive victims and activators of neuroinflammation. Lipopolysaccharide triggers the Toll-like receptor 4/nuclear factor-κB pathway, leading to neuroinflammatory responses.
Regular exercise reduces brain's stress response and anxiety by strengthening mechanisms that prevent excited neurons from firing. The study finds that physical activity enhances local inhibitory mechanisms in the ventral hippocampus, leading to a boost of activity in inhibitory neurons.
A team of neuroscientists mapped brain-cell activity in fruit flies to understand smell recognition. They found that a small number of neurons are required to distinguish between different odors, suggesting the importance of sparseness in signal transmission.
Researchers have found that a small portion of the human brain involved in memory makes new neurons well into adulthood, according to data from nuclear weapons testing of the 1950s and '60s. The study supports the importance of investigating the therapeutic potential of adult neurogenesis for age-related cognitive disorders.
Researchers used carbon-14 dating to determine if adult humans generate new neurons, finding that up to 1,400 new cells are added daily. This neurogenesis may contribute to human brain function and potentially inform depression treatments.
Researchers successfully mobilize brain's native stem cells to replenish neurons lost in Huntington's disease. The study demonstrates the feasibility of a completely new concept to treat the disease by recruiting endogenous neural stem cells to regenerate cells, significantly extending survival of treated mice.
Researchers found that mice with functional serotonin produce more of this hormone during exercise, increasing cell proliferation in the hippocampus. Serotonin is essential for exercise-induced neurogenesis, while baseline neurogenesis occurs without it.
Researchers at University of Wisconsin-Madison successfully transplanted human embryonic stem cells into mouse brains to repair damaged neural circuits. The study demonstrates the potential for stem cell therapy to treat neurological disorders such as Alzheimer's and depression.
New research by Daniela Kaufer and Elizabeth Kirby found that acute stress doubles the proliferation of new brain cells in the hippocampus, leading to improved mental performance two weeks later. The study suggests that moderate stress can help individuals perform better when alert, but excessive stress can be harmful.
A new study found that prolonged exposure to an enriched environment activates brain receptors, preventing amyloid beta protein from weakening nerve cell communication. This provides a molecular mechanism for why a richer environment can help lessen the memory-eroding effects of Alzheimer's disease.
Researchers at the University of Oxford have identified a natural biological mechanism that allows brain cells to survive during a stroke, enabling the development of potential neuroprotective drugs. The 'endogenous neuroprotection' discovered in rats has shown to increase cell survival by stimulating production of hamartin protein.
Researchers at Stanford University have developed a technique to observe hundreds of neurons firing in the brain of a live mouse in real-time. The tool uses fluorescent protein and calcium ions to decipher patterns in brain activity, offering insights into long-term information storage and spatial memory.
A team of scientists from the German Cancer Research Center has discovered that silencing Dickkopf-1, a signaling molecule that promotes age-related cognitive decline, leads to increased neurogenesis in the hippocampus. This results in improved spatial orientation and memory performance in mice, even in advanced adult age.
A study by Brown University researchers found that the protein apoE4 is surprisingly useful in promoting neuron growth, even though it's associated with Alzheimer's disease. The findings suggest a better method for growing neurons outside the body, which could be used to treat neurodegenerative diseases.
A study found that older brains struggle to filter out unnecessary information, leading to reduced learning and memory capabilities. The researchers discovered a link between the NMDA receptor and long-term depression, which is essential for sculpting memories and eliminating unnecessary information.
Research reveals that Pannexin1 channel protein is critical for synaptic plasticity, a key process in learning and memory. Mice lacking Pannexin1 display autistic-like behavior and impaired spatial orientation, highlighting the importance of this channel for brain function.
Scientists have identified a gene expression that initiates a protective electrical response after seizures, which could prevent recurrent seizures and the onset of devastating epilepsy. This discovery also has implications for relief from chronic pains, cardiovascular disease, and recovery from mood disorders.
A new study in rats identifies a region called the postrhinal cortex that links objects to places in the brain, integrating spatial and nonspatial information upstream of the hippocampus. This finding has implications for treating traumatic brain injuries and neuropsychiatric diseases such as schizophrenia and depression.
Dendritic spines play a vital role in isolating and amplifying electrical signals received at synapses, enabling neurons to communicate with each other. The discovery sheds light on the brain's complex processing mechanisms and may lead to advances in treating diseases like Alzheimer's and Huntington's.
Researchers at Sanford-Burnham Medical Research Institute have successfully transplanted human stem cell-derived neurons into a rodent hippocampus, stimulating existing neurons to fire high-frequency oscillations. This breakthrough may lead to the restoration of brain activity and motor function in patients with neurodegenerative condi...
A new study suggests that moderate drinking can decrease brain cell production by up to 40% in adults, leading to potential harm on learning and memory. Researchers found that rats exposed to low levels of alcohol showed reduced nerve cells in the hippocampus, a crucial area for new learning.
Researchers identified molecular pathway associated with schizophrenia, potentially leading to new treatment options. The study found that a protein called Serca2 is elevated in people with schizophrenia and those with a rare genetic disorder, suggesting a novel therapeutic target.
Swedish researchers at Uppsala University have discovered a new group of nerve cells called OLM-alpha2 cells that act as gatekeepers in the hippocampus. These cells prioritize local circuit signals, altering memory formation when activated by nicotine or light stimulation.
A new class of small molecules, P7C3 series, has been identified to block cell death in animal models of Parkinson's disease and amyotrophic lateral sclerosis. The compounds protect newborn neurons from cell death and correlate with improvement of disease symptoms.
Scientists at the Max Planck Institute of Psychiatry found that effective signal transmission in the hippocampus requires theta-frequency impulses, generating waves that propagate through the brain. This discovery explains why we are more productive after drinking coffee or experiencing stress.
Researchers at Cold Spring Harbor Laboratory have discovered that the protein DOCK7 regulates the fate decision of radial glial cells, determining whether they proliferate or differentiate into neurons. DOCK7 interacts with TACC3 to control interkinetic nuclear migration, a mechanism essential for cortical development.
Recent studies from the Norwegian Institute of Public Health reveal that long-term methadone treatment can affect nerve cells in the brain, leading to changes in cognitive functioning. However, a separate study found no alteration in the formation of new nerve cells, providing some relief for methadone patients.
Researchers at KAIST used triangular shapes to guide axon growth in a dish, finding that smaller vertices were more effective in inducing growth. The study aims to develop a reproducible neural circuit model for learning and memory studies as well as drug screening applications.
Researchers found that the human olfactory bulb, a brain structure processing sensory input from the nose, lacks new neuron generation like other mammals. This discovery may explain why humans have a poorer sense of smell compared to other animals.
Researchers found that a high-fat diet encourages more eating and fat storage by spurring new neurons in the hypothalamus, a key area for regulating hunger and body weight. This neurogenesis is critical in regulating weight gain and fat storage.
Researchers identify precise genetic links between nature and nurture in schizophrenia risk. Defects in DISC1 protein and environmental stress after birth increase brain development abnormalities and schizophrenia likelihood by 1.4 times.
Researchers identified a genetic manipulation that increases brain cell development in mice, leading to improved sensitivity to antidepressant drugs. The study found that deleting the Nf1 gene results in long-lasting improvements in neurogenesis, enhancing anti-depressive and anti-anxiety effects.
A new study reveals that an overactive enzyme called HDAC2 is responsible for memory problems in Alzheimer's disease. When genetically blocked, the enzyme 'reawakens' neurons and restores cognitive function in mice. The findings suggest that drugs inhibiting HDAC2 could be effective treatments for some devastating effects of the disease.
Research reveals that AgRP neurons drive feeding behaviors and undergo anatomical changes during fasting, becoming more active and responsive to hunger-promoting stimuli. The study provides insight into the neural mechanisms controlling weight gain and obesity.
Researchers have identified beta-arrestin, a protein that supports connections between neurons, as a crucial link to short-term memory. By regulating synaptic plasticity, beta-arrestin plays a key role in the formation and disassembly of neural connections, which can help prevent Alzheimer's disease.
Researchers at the University of Bristol identified a novel cellular mechanism underlying age-related cognitive decline, revealing that changes to sodium channels contribute to decreased neuronal excitability. The study found that aged brain cells struggle to generate action potentials due to altered sodium channel activation properties.
New Tel Aviv University research reveals glia cells' pivotal role in brain plasticity, adapting to new stimuli and regulating neural activity. Glia cells sort information for learning purposes, controlling the transfer of signals between neurons.
A study by Eleanor Maguire found that taxi driver training increases gray matter in the hippocampus, a brain area responsible for memory and spatial navigation. The brain's plasticity allows it to adapt to new tasks, even in adulthood.
Acquiring London's complex street layout causes structural changes in the brain and improvements in memory, particularly for capital-based information. This suggests that even adult life can lead to brain plasticity and adaptation through learning.
A preliminary study found that children with autism had an average 67% more prefrontal brain neurons and a larger than average brain weight compared to children without autism. The researchers also discovered significant differences in neuron counts in the PFC, with 79% more neurons in one subdivision.
Scientists at Cold Spring Harbor Laboratory discovered that OPHN1 plays a crucial role in mediating long-term depression at synapses, a phenomenon linked to cognitive disorders. The study reveals that OPHN1 interacts with EndophilinA2/3 to remove AMPA receptors, leading to persistent removal of receptors and onset of LTD.
Researchers discovered zinc's critical role in regulating neuronal communication, affecting memories formation and learning. The study found that removing zinc interferes with long-term potentiation, a process important for memory and learning.
Researchers found that passive viewing of 2D images can lead to sustained changes in nerve cell connections, facilitating the expression of persistent hippocampal long-term depression. This discovery has implications for developing strategies to improve digital learning and reduce apathy towards traditional teaching methods.
A study by Duke University researchers found that zinc plays a critical role in regulating communication between brain cells, particularly in the hippocampus. The discovery could lead to a better understanding of memory formation and epilepsy.
Researchers found that substances in old mice's blood inhibit new nerve cell generation and impair cognitive function in young brains. Eotaxin, a protein attracting immune cells to areas where it has been secreted, was identified as a key factor contributing to aging-related changes.
Researchers at Ohio State University have developed a cell-culture system that mimics the coating of nerve cells with protective myelin, opening up new possibilities for studying multiple sclerosis. The study found that myelin regulates key protein placement and activity in sending electrical signals along hippocampal axons.
Scientists have identified a mechanism that protects the brain from degeneration and aging processes. The discovery of CB1 receptors' role in preserving nerve cells and memory capabilities opens up new possibilities for developing therapies to combat age-related brain changes.
Researchers found that exposure to large amounts of alcohol interferes with key receptors in the brain, inhibiting long-term potentiation and memory formation. The steroids manufactured by neurons inhibit synaptic plasticity, causing amnesia.
A new study by UCLA neurophysicists found that brain rhythms associated with learning grow stronger as running speed increases. The research team monitored gamma rhythms in mice brains using specialized microelectrodes and discovered a link between the strength of these rhythms and movement.
Researchers at Michigan Medicine observed key aspects of brain circuit development in living organisms, revealing two distinct types of competition between cells that shape memory circuits. The findings suggest that the brain eliminates inactive connections to maintain efficient neural networks, which is crucial for learning and memory.
New research by UC Berkeley scientists reveals that fear and emotional experiences lead to stronger memories through the activation of newborn neurons in the hippocampus. The amygdala induces the generation of new neurons, which provide a 'blank slate' for imprinting fearful memories.