Research on the heart and how it stays healthy. Covers light exposure, tissue maintenance, trauma-related cardiovascular risk, and circadian effects.
Researchers developed a non-invasive imaging method to track new blood vessel growth in the heart after a heart attack. The technique uses a radioactively labeled protein to detect changes in damaged areas over time, providing clear visualization of healing processes.
Researchers used 3D technology to map the electrical pathways in patients with atrial flutter, revealing additional abnormal circuits that could be missed by conventional methods. Radiofrequency heat energy was then used to destroy these tissues, curing the patients and improving treatment outcomes.
Researchers found that high levels of lead and cadmium in adults were associated with a 2.8 times greater risk of developing peripheral arterial disease (PAD). Smoking was also found to increase the risk of PAD, possibly due to cadmium's damage to blood vessel linings.
A new system, PEWS, measures vital signs to predict life-threatening events in children, identifying deteriorating conditions up to 4 hours prior. Experienced nurses can detect subtle changes, but less experienced ones rely on an objective tool for early intervention.
Researchers are exploring innovative treatments for atrial fibrillation, including radio frequency ablation and gene transfer techniques. These methods aim to regulate the heart's irregular rhythm without the dangerous side effects of current medications.
The University of Pittsburgh is developing a heart assist device for infants with severe congenital heart defects, utilizing suspended magnetic levitation technology and miniaturization. The goal is to create a bridge-to-transplant device that allows infants to recover or survive until a donor heart becomes available.
Duke researchers found that slower rewarming reduces brain temperature and hyperthermia risks after coronary artery bypass surgery. This leads to improved cognitive outcomes for patients six weeks post-surgery. A seven-year analysis of 6,334 patients showed significant reductions in hyperthermic episodes.
A Temple University study found that patients with diseased aortic valves before receiving an LVAD have significantly lower survival to transplant rates. Conversely, those with normal aortic valves have higher survival rates, suggesting the importance of valve repair or upgrade in heart transplant optimization.
A randomized, prospective study found that tacrolimus + mycophenolate mofetil and steroids significantly reduce incidence of treated rejection and improve graft function compared to other regimens. The combination therapy also showed better lipid profiles and reduced risk of certain infections.
A 24-month study found that everolimus reduced intimal thickening and cardiovascular events, while sirolimus showed plaque regression. The results suggest that intravascular ultrasound measurements can be used as a valid surrogate for therapeutic intervention.
Researchers found that everolimus, when combined with cyclosporine and steroids, prevents transplant rejection and lowers risk of infection and complications more effectively than traditional anti-rejection therapy. A two-year study demonstrated the drug's improved safety and efficacy in preventing heart transplant rejection.
A new study further reinforces CellCept's cardioprotective profile, demonstrating lower rates of coronary artery disease in patients treated with CellCept compared to azathioprine. This finding could explain the superior survival benefits observed with CellCept.
A recent study found that mycophenolate mofetil reduces intimal thickening and improves long-term outcomes for heart transplant patients compared to azathioprine. The study used a site-to-site IVUS analysis of 196 patients, showing significantly less progression of vascular disease in CellCept-treated patients.
A study found that off-pump coronary artery bypass grafting (OPCAB) had similar graft patency and clinical outcomes as conventional CABG with cardiopulmonary bypass. OPCAB also resulted in lower hospitalization costs, with a mean savings of $2,272 at discharge and $1,955 at 1 year.
Researchers are investigating the safety of heart and lung transplants for HIV-positive patients when viral infections are well-controlled. Transplant teams must balance anti-rejection drugs with anti-retroviral therapies to avoid complications.
Dr. Magdi Yacoub will receive the ISHLT Lifetime Achievement Award for his pioneering work in heart recovery using support devices. His approach, known as 'bridge to recovery,' has broadened the usage of heart assist devices and improved patient outcomes.
A new analysis of 4,657 patients undergoing coronary artery bypass surgery found that discontinuing beta blockers and ACE inhibitors can lead to abnormal accelerations in heart pumping known as atrial fibrillation. However, these medications also appear to offer protection against the condition. The study identified a risk index that c...
A new AAN guideline has resolved debate surrounding the role of Patent Foramen Ovale (PFO) in stroke risk. The guideline found no evidence to support or refute closing PFOs, but notes an increased risk for younger patients with both a PFO and atrial septal aneurysm (ASA). Further research is needed to determine the best treatment options.
A new study found that children who stayed in the ICU for more than 48 hours after cardiac surgery were at a higher risk of developing post-traumatic stress disorder (PTSD). Five out of 43 children met diagnostic criteria for PTSD, with symptoms including disorganized behavior, nightmares, and concentration problems.
A team of researchers from Cornell University and Gene Network Sciences Inc. has developed a 3D computer model of the canine heart to simulate ventricular fibrillation. The model aims to help understand the causes of this life-threatening condition, currently treated with electrical shocks that can damage the heart.
A 40-minute surgical procedure called left cardiac sympathetic denervation (LCSD) reduces the risk of cardiac arrest and fainting episodes in people with long QT syndrome, a rare heart disorder. The study found that LCSD surgery reduced cardiac events by 91 percent compared to pre-surgery rates.
Researchers at Scripps Research Institute have discovered a way to block fluid leakage that causes long-term tissue injury after a heart attack. A single dose of a compound can drastically reduce tissue injury and increase long-term survival following a heart attack.
Researchers found a strong relationship between increasing blood pressure and CVD risk in women, with even borderline elevations associated with an increased risk. The study of 5,218 female health professionals showed that for each 10 mm Hg increase in systolic blood pressure, CVD risk rose by 9 percent.
A 12-week lifestyle intervention program helped 64% of patients achieve their blood pressure goal and 67% reach their diastolic blood pressure goal. The program also showed significant reductions in LDL cholesterol and fasting glucose levels.
Emory researchers discovered significant racial and gender disparities in heart attack treatment, with African-American women receiving the least aggressive care. The study analyzed records of over 672,000 white and black patients younger than 75 and found no trend towards improvement in recent years.
The STARR program improves patient knowledge of exercise and diet goals by 56.7%, while also increasing exercise and diet compliance to 67%. The program shows positive trends in weight loss, stress, blood pressure, diabetes control, and lipid goals.
A recent study published by the NIH found that implantable defibrillators significantly reduce deaths in patients with moderate to severe heart failure. The study, which included over 2,500 participants, showed that implanted defibrillator therapy reduced deaths by 22%, while amiodarone therapy did not have a significant impact.
A twin study found a possible connection between depression and heart disease, with decreased heart rate variability (HRV) being a key factor. The study suggests that treating clinical depression, including minor forms, may help reduce the risk of heart disease by normalizing HRV.
A study of 32,372 patients found that coronary artery aneurysms are associated with a high 5-year mortality rate of 29.1%. Experts emphasize the need for aggressive monitoring and modification of coronary risk factors for all patients with angiographic evidence of aneurysms, regardless of size.
A study of 11,645 patients in community hospitals found that only 18.7% were transferred to tertiary facilities with invasive care capabilities within 48 hours, highlighting a crucial weakness in cardiac care delivery. Non-transferred patients were more likely to have comorbidities and receive suboptimal medications.
Researchers found improved heart function in some patients treated with stem cells and G-CSF after a heart attack. However, the treatment also led to an unexpected high rate of complications, prompting further investigation before its use in humans.
Researchers develop vaccine that prevents tumor growth in mice, while also reversing cardiac dysfunction through gene therapy. These breakthroughs demonstrate the potential of combinatorial approaches to vaccination and gene therapy for treating neoplastic lesions and heart disease.
Researchers are studying how the heart changes its energy source from fat to glucose in end-stage heart failure, which may improve pumping function and treatment outcomes. The new program aims to bridge the gap between basic genetic data and clinical trials for heart failure patients.
The Children's Hospital of Philadelphia has received a federal grant to advance research on infant heart disease. The grant will support five projects aimed at developing new treatments for congenital heart defects, including gene-based diagnoses and improved biologically-based materials for heart surgery.
A UH-led group of experts has developed new stent designs to minimize complications in the treatment of aortic abdominal aneurysm (AAA) and coronary artery disease (CAD). These innovative stents feature genetically engineered cartilage cell-coated designs and novel mechanical properties that mimic human arteries.
Researchers tested a cooling helmet on patients with severe ischemic stroke, finding that it preferentially cools the brain rapidly and profoundly. The study showed excellent functional recovery in younger patients but only 20% in elderly patients.
A membrane protein called NCX1 plays a crucial role in regulating the frequency and strength of heartbeats by transporting calcium into and out of heart cells. The protein generates electrical currents that contribute to excitation and contraction, making it an important key to understanding cardiac function.
Researchers found that children carrying the epsilon2 version of the apolipoprotein E gene had worse neurodevelopmental outcomes at age one compared to those without the gene. The study suggests a potential genetic link between the APOE ε2 gene variant and increased risk of neurologic injury in infants after heart surgery.
A new study suggests that using CT scans to measure coronary artery calcium scores can help evaluate risk and determine preventative therapy for patients at middle risk of coronary disease. This improvement allows doctors to make faster and more aggressive treatment decisions, such as prescribing drugs or lifestyle changes.
A randomized, double-blind study found that dietary supplements containing ephedra and caffeine increased the QTc interval duration and systolic blood pressure in healthy volunteers. The authors recommend patients avoid these supplements until more information is known about their safety.
Researchers developed a new ultrasound probe at Mayo Clinic that allows for better visualization of PFO defects, enabling more effective closure with catheter techniques. The results show a 93% success rate in closing the defect without complications.
A recent study found that air pollution significantly increases the risk of cardiovascular deaths, with a 45% mortality rate attributed to heart disease, compared to 8.2% for respiratory diseases. The researchers propose that inflammation and nervous system changes may be key mechanisms behind this association.
The American College of Physicians released guidelines for treating atrial fibrillation, an abnormal heart rhythm that can lead to stroke if uncontrolled. Researchers also reviewed 18 studies on melanoma and sunscreen use, finding no link between the two conditions.
The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) have released joint clinical guidelines to manage atrial fibrillation, a common heart condition. The guidelines focus on controlling heart rate and stroke prevention with blood thinners, rather than restoring sinus rhythm.
A five-year study found that mechanical assist devices increased survival rates to hospital discharge for 77% of supported children. External mechanical hearts and ECMO provided the safest forms of support in urgent situations.
Vanderbilt University researchers find that damped propagating waves, not fully extinguished by low voltage defibrillation shocks, could lead to cardiac arrhythmia. These waves, difficult to detect and study, may be a cause of defibrillation failure.
Researchers successfully restored heart cell function by inhibiting the ßARK1 enzyme in laboratory-dish experiments using a gene therapy approach. The study's findings suggest that blocking this enzyme could increase signaling and improve heart function in individuals with end-stage heart failure.
The use of clopidogrel in addition to aspirin significantly reduces the risk of recurrent heart attacks, strokes, or cardiovascular death. The cost-effectiveness analysis suggests that at least one year of therapy with clopidogrel is an attractive value for patients at risk.
A new pathway has been discovered at Stanford that provides insight into heart disease, with apelin-APJ signaling potentially holding key to treatment for heart failure. The study used microarrays to scan thousands of genes and found a previously unnoticed connection between apelin and APJ receptors.
A study found that 25% of patients who require emergency heart surgery after failed angioplasty are at risk of harm or death if delayed. The researchers estimated one to two patients per 1,000 angioplasties could be harmed by additional delays.
Researchers at the Emory Heart Center found that oral tetrahydrobiopterin can significantly lower blood pressure in patients with poorly controlled hypertension. The study showed a significant reduction in blood pressure after just three weeks of therapy, likely due to increased availability of nitric oxide and enhanced vasodilation.
A recent study by the American Heart Association found that hospital staff preparedness significantly impacts survival rates for cardiac arrests during night shifts. The research indicates that patients experiencing cardiac arrest at night have a lower survival rate compared to those who experience it during the day or evening shifts.
Atrial fibrillation is associated with decreased endocardial nitric oxide in the left atrial appendage, leading to increased superoxide levels and higher risk of blood clots. The study's findings may provide new avenues for therapeutic interventions in humans with AF.
Researchers found that women with coronary artery disease and an implantable cardioverter-defibrillator have a lower rate of sustained ventricular tachycardia or fibrillation compared to men. Additionally, automated external defibrillators (AEDs) in health clubs reversed sudden cardiac death in six out of eight victims, supporting the ...
A recent study by the American Heart Association found that heart failure patients often leave the hospital without receiving life-prolonging therapies or complete discharge instructions. The study, which analyzed data from over 33,000 patients, highlights the need for hospitals to improve their adherence to established guidelines.
The study found that public access defibrillation increased from 0.82% to 2.05% between 1999 and 2002, with a 50% survival rate for those treated. Over 4,000 people were trained to use the devices, and 457 AEDs were registered.
A new study published in the CREST trial found that cilostazol significantly reduces stent restenosis by 39.5% compared to standard therapy alone. The drug showed promise in patients with diabetes and small blood vessels, a subgroup previously difficult to treat.
A study found that nearly a quarter of families with deceased individuals had inherited heart disease, increasing the risk of sudden cardiac death among relatives. The researchers suggest screening 12-lead ECGs for first-degree relatives of those who died suddenly and unexpectedly.
A Canadian study compared outcomes for patients with elevated cardiac markers who received a home health nurse-delivered disease management program versus those without. The results showed significant reductions in hospitalization days for congestive heart failure and angina. A commentary highlighted the need for a national program to ...
A study of 27 women aged 35-44 found that 50% of their deaths were due to undetermined causes, a stark contrast to men of the same age group. Researchers are now focusing on novel, unorthodox causes for these unexpected deaths.