Articles tagged with Heart
Emory researchers discovered significant racial and gender disparities in heart attack treatment, with African-American women receiving the least aggressive care. The study analyzed records of over 672,000 white and black patients younger than 75 and found no trend towards improvement in recent years.
The STARR program improves patient knowledge of exercise and diet goals by 56.7%, while also increasing exercise and diet compliance to 67%. The program shows positive trends in weight loss, stress, blood pressure, diabetes control, and lipid goals.
A recent study published by the NIH found that implantable defibrillators significantly reduce deaths in patients with moderate to severe heart failure. The study, which included over 2,500 participants, showed that implanted defibrillator therapy reduced deaths by 22%, while amiodarone therapy did not have a significant impact.
A twin study found a possible connection between depression and heart disease, with decreased heart rate variability (HRV) being a key factor. The study suggests that treating clinical depression, including minor forms, may help reduce the risk of heart disease by normalizing HRV.
A study of 32,372 patients found that coronary artery aneurysms are associated with a high 5-year mortality rate of 29.1%. Experts emphasize the need for aggressive monitoring and modification of coronary risk factors for all patients with angiographic evidence of aneurysms, regardless of size.
A study of 11,645 patients in community hospitals found that only 18.7% were transferred to tertiary facilities with invasive care capabilities within 48 hours, highlighting a crucial weakness in cardiac care delivery. Non-transferred patients were more likely to have comorbidities and receive suboptimal medications.
Researchers found improved heart function in some patients treated with stem cells and G-CSF after a heart attack. However, the treatment also led to an unexpected high rate of complications, prompting further investigation before its use in humans.
Researchers develop vaccine that prevents tumor growth in mice, while also reversing cardiac dysfunction through gene therapy. These breakthroughs demonstrate the potential of combinatorial approaches to vaccination and gene therapy for treating neoplastic lesions and heart disease.
Researchers are studying how the heart changes its energy source from fat to glucose in end-stage heart failure, which may improve pumping function and treatment outcomes. The new program aims to bridge the gap between basic genetic data and clinical trials for heart failure patients.
The Children's Hospital of Philadelphia has received a federal grant to advance research on infant heart disease. The grant will support five projects aimed at developing new treatments for congenital heart defects, including gene-based diagnoses and improved biologically-based materials for heart surgery.
A UH-led group of experts has developed new stent designs to minimize complications in the treatment of aortic abdominal aneurysm (AAA) and coronary artery disease (CAD). These innovative stents feature genetically engineered cartilage cell-coated designs and novel mechanical properties that mimic human arteries.
Researchers tested a cooling helmet on patients with severe ischemic stroke, finding that it preferentially cools the brain rapidly and profoundly. The study showed excellent functional recovery in younger patients but only 20% in elderly patients.
A membrane protein called NCX1 plays a crucial role in regulating the frequency and strength of heartbeats by transporting calcium into and out of heart cells. The protein generates electrical currents that contribute to excitation and contraction, making it an important key to understanding cardiac function.
Researchers found that children carrying the epsilon2 version of the apolipoprotein E gene had worse neurodevelopmental outcomes at age one compared to those without the gene. The study suggests a potential genetic link between the APOE ε2 gene variant and increased risk of neurologic injury in infants after heart surgery.
A new study suggests that using CT scans to measure coronary artery calcium scores can help evaluate risk and determine preventative therapy for patients at middle risk of coronary disease. This improvement allows doctors to make faster and more aggressive treatment decisions, such as prescribing drugs or lifestyle changes.
Researchers developed a new ultrasound probe at Mayo Clinic that allows for better visualization of PFO defects, enabling more effective closure with catheter techniques. The results show a 93% success rate in closing the defect without complications.
A randomized, double-blind study found that dietary supplements containing ephedra and caffeine increased the QTc interval duration and systolic blood pressure in healthy volunteers. The authors recommend patients avoid these supplements until more information is known about their safety.
A recent study found that air pollution significantly increases the risk of cardiovascular deaths, with a 45% mortality rate attributed to heart disease, compared to 8.2% for respiratory diseases. The researchers propose that inflammation and nervous system changes may be key mechanisms behind this association.
The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) have released joint clinical guidelines to manage atrial fibrillation, a common heart condition. The guidelines focus on controlling heart rate and stroke prevention with blood thinners, rather than restoring sinus rhythm.
The American College of Physicians released guidelines for treating atrial fibrillation, an abnormal heart rhythm that can lead to stroke if uncontrolled. Researchers also reviewed 18 studies on melanoma and sunscreen use, finding no link between the two conditions.
A five-year study found that mechanical assist devices increased survival rates to hospital discharge for 77% of supported children. External mechanical hearts and ECMO provided the safest forms of support in urgent situations.
Vanderbilt University researchers find that damped propagating waves, not fully extinguished by low voltage defibrillation shocks, could lead to cardiac arrhythmia. These waves, difficult to detect and study, may be a cause of defibrillation failure.
Researchers successfully restored heart cell function by inhibiting the ßARK1 enzyme in laboratory-dish experiments using a gene therapy approach. The study's findings suggest that blocking this enzyme could increase signaling and improve heart function in individuals with end-stage heart failure.
The use of clopidogrel in addition to aspirin significantly reduces the risk of recurrent heart attacks, strokes, or cardiovascular death. The cost-effectiveness analysis suggests that at least one year of therapy with clopidogrel is an attractive value for patients at risk.
A new pathway has been discovered at Stanford that provides insight into heart disease, with apelin-APJ signaling potentially holding key to treatment for heart failure. The study used microarrays to scan thousands of genes and found a previously unnoticed connection between apelin and APJ receptors.
A study found that 25% of patients who require emergency heart surgery after failed angioplasty are at risk of harm or death if delayed. The researchers estimated one to two patients per 1,000 angioplasties could be harmed by additional delays.
Researchers at the Emory Heart Center found that oral tetrahydrobiopterin can significantly lower blood pressure in patients with poorly controlled hypertension. The study showed a significant reduction in blood pressure after just three weeks of therapy, likely due to increased availability of nitric oxide and enhanced vasodilation.
A recent study by the American Heart Association found that hospital staff preparedness significantly impacts survival rates for cardiac arrests during night shifts. The research indicates that patients experiencing cardiac arrest at night have a lower survival rate compared to those who experience it during the day or evening shifts.
Atrial fibrillation is associated with decreased endocardial nitric oxide in the left atrial appendage, leading to increased superoxide levels and higher risk of blood clots. The study's findings may provide new avenues for therapeutic interventions in humans with AF.
Researchers found that women with coronary artery disease and an implantable cardioverter-defibrillator have a lower rate of sustained ventricular tachycardia or fibrillation compared to men. Additionally, automated external defibrillators (AEDs) in health clubs reversed sudden cardiac death in six out of eight victims, supporting the ...
A recent study by the American Heart Association found that heart failure patients often leave the hospital without receiving life-prolonging therapies or complete discharge instructions. The study, which analyzed data from over 33,000 patients, highlights the need for hospitals to improve their adherence to established guidelines.
The study found that public access defibrillation increased from 0.82% to 2.05% between 1999 and 2002, with a 50% survival rate for those treated. Over 4,000 people were trained to use the devices, and 457 AEDs were registered.
A new study published in the CREST trial found that cilostazol significantly reduces stent restenosis by 39.5% compared to standard therapy alone. The drug showed promise in patients with diabetes and small blood vessels, a subgroup previously difficult to treat.
A study found that nearly a quarter of families with deceased individuals had inherited heart disease, increasing the risk of sudden cardiac death among relatives. The researchers suggest screening 12-lead ECGs for first-degree relatives of those who died suddenly and unexpectedly.
A Canadian study compared outcomes for patients with elevated cardiac markers who received a home health nurse-delivered disease management program versus those without. The results showed significant reductions in hospitalization days for congestive heart failure and angina. A commentary highlighted the need for a national program to ...
A study of 27 women aged 35-44 found that 50% of their deaths were due to undetermined causes, a stark contrast to men of the same age group. Researchers are now focusing on novel, unorthodox causes for these unexpected deaths.
Elevated G-alpha-i levels in aging hearts lead to decreased cardiac function, but beta-blockers show promise in reducing these levels and improving heart function. The study's findings suggest that targeting G-alpha-i could be an effective way to protect the heart from age-related decline.
Researchers discovered that a single dose of erythropoietin may provide acute protection after myocardial infarction or cardiac surgery. The treatment also preserves the ischemic and infarcted heart in the long term, showing promise for preventing future heart attacks.
A study found that disrupting PI3Kgamma preserves beta-adrenergic receptors on heart cells, leading to improved heart function and longer survival in mice. The loss of beta-adrenergic receptors contributes to heart failure, but this intervention may provide a new therapeutic approach.
A global physician survey found that six in ten doctors believe men are more likely to die from stroke than women, despite women being 11% more likely to die from the condition. The study highlights the importance of addressing hypertension as a major risk factor for strokes and improving awareness among women about their risk factors.
Researchers Drs. Michael Brown, Joseph Goldstein, and Eric Olson recognized for their contributions to cardiovascular disease management and treatment. Their groundbreaking research led to the development of statins used by 13 million Americans to treat high cholesterol.
Researchers have discovered that oral medications commonly used to treat hypertension are also effective in preventing iron overload from causing permanent damage to the heart. The study suggests that these drugs may offer a new treatment option for patients with hereditary hemochromatosis and other genetic disorders
A study by the University of Iowa and Michigan found that defibrillators in high-risk locations, such as hospitals and airports, are cost-effective. However, low-risk sites like schools and hotels are not economically viable options due to low usage rates.
Researchers discovered that 'hot pepper' receptors on the heart trigger symptoms of heart attack and may lead to new treatments for angina pectoris. The study found that these receptors cause blood vessels to constrict and increase blood pressure, leading to chest pain.
A study published in the New England Journal of Medicine found that everolimus significantly reduced the incidence of acute rejection and cardiac allograft vasculopathy in heart transplant patients. The medication also lowered rates of cytomegalovirus infection, a major risk factor for these complications.
A study by Mary A. Whooley and colleagues found that depressive symptoms are a better predictor of poor quality of life in patients with coronary disease than previously thought. The researchers measured depressive symptoms using the Patient Health Questionnaire (PHQ) and found that these patients were more likely to report lower healt...
A recent study has identified GATA4 gene mutations as a primary cause of human cardiac septal defects, which are characterized by the incomplete formation of the heart's four chambers. The discovery is significant, as it may one day enable doctors to prevent congenital heart defects by fixing the problem before birth.
Researchers found a significant reduction in micro-emboli during off-pump coronary bypass surgery compared to traditional pump-assisted procedures. This decrease was associated with lower rates of neurological complications and cognitive decline after surgery.
The Georgia Tech research aims to develop advanced Computational Fluid Dynamics (CFD) techniques to study blood flow turbulence in heart valves. The team will create a virtual environment that accurately models the turbulent flow environment, which could lead to better design and reduced thromboembolic complications.
Researchers found that patients with combined devices showed significant improvements in quality of life, physical functioning, and exercise capacity compared to those without the devices. The study's findings have implications for treating heart failure, a disease with a five-year mortality rate of 50 percent after diagnosis.
Research shows that omega-3 fish oils stored in heart cells can prevent sudden cardiac death and fatal arrhythmias. Studies found a 29% reduction in deaths among men who ate fish at least twice a week, attributed to fewer fatal arrhythmias.
Researchers highlight importance of controlling blood pressure and vascular risks in heart failure management. They propose a new classification system for heart failure stages, emphasizing the need for early intervention.
A Northwestern Memorial HealthCare-led study presents data demonstrating calcification in human tissue as the primary cause of aortic valve blockages. Statin therapy may delay progression and reduce need for surgical replacement.
A new study by NYU Langone Health's cardiac surgeons found that off-pump coronary artery bypass grafting (OPCAB) reduces hospital mortality, stroke risk, and complication rates in high-risk patients with severe aortic atherosclerosis. OPCAB results in lower mortality rates (6.5% vs 11.4%) and shorter hospital stays compared to conventi...
Researchers studied 987 patients and found that those with multiple potential causes of syncope died earlier than those with a single cause. The study identified predictors such as older age, atrial fibrillation, and cardiac medication use.
A new study analyzed data from the Nurses' Health Study and found that 69% of sudden cardiac deaths in women were the first sign of heart disease. Women with smoking, diabetes, hypertension, or obesity had significantly increased risk of SCD, while high cholesterol was not associated with elevated risk.
Researchers discovered that one out of six patients with a history of atrial fibrillation had asymptomatic episodes, highlighting the need for regular blood thinning to prevent stroke. The study suggests doctors should assume the worst when treating patients at risk of atrial fibrillation and stroke.
A study found that men with high CRP levels were 3.8 times more likely to experience a stroke over 10-15 years compared to those with low CRP levels. The researchers also discovered that inflammation may trigger stroke by causing cell growth, cholesterol accumulation, and plaque formation in blood vessels.
A six-month public smoking ban in Helena, Montana, significantly reduced acute myocardial infarction hospital admissions by nearly 60%. The study found that smoke-free environments not only protect against long-term secondhand smoke effects but also rapidly prevent heart attacks.
A new Emory University study reveals that depression has a negative impact on CABG outcomes, with depressed patients experiencing less improvement in physical function. The research emphasizes the importance of treating symptoms of clinical depression aggressively in cardiovascular disease patients.