Articles tagged with Joints
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Researchers at Tel Aviv University and New York University have developed a non-invasive MRI technique that detects the earliest signs of osteoarthritis, enabling early diagnosis and treatment. The test is cost-effective and can provide results within one day.
A landmark study conducted at The University of Western Ontario found that arthroscopic surgery provides no additional therapeutic value for patients with moderate osteoarthritis of the knee. Physical therapy and medication proved equally effective in reducing joint pain and improving function.
A new study confirms Pycnogenol's effectiveness in reducing knee osteoarthritis symptoms, with a 20.9% improvement rate and significant reductions in pain and joint stiffness. After treatment cessation, the joints showed no relapse, suggesting a potential lasting effect on joint health.
A team of researchers found definitive genetic proof of how osteoarthritis destroys joint cartilage in nearly 21 million aging Americans. The study used genetically engineered mice to show that high levels of beta-catenin lead to cartilage destruction and bony growths, providing a new foundation for treating OA.
A comprehensive study of hip and knee replacement surgeries in England found that one in seventy-five patients require revision after three years. The research suggests that different patterns may emerge over a longer follow-up period, emphasizing the need for further research to evaluate surgical procedures and types of implants.
Research reveals that elephant legs are much bendier than Shakespeare's depiction, with joints flexing significantly during locomotion. Studies also show that the animals' mobility range is comparable to that of trotting horses.
A new medical imaging technology could provide a long-awaited test for early diagnosis of osteoarthritis, allowing doctors to prevent or reduce permanent damage. The method uses modified MRI to determine the concentration of glycosaminoglycan, a biomarker for OA and cartilage disorders.
A retrospective analysis of postmenopausal women with early-stage breast cancer found that previous use of hormone replacement therapy (HRT), hormone-receptor positivity, and treatment with anastrozole versus tamoxifen were associated with joint symptoms. Obesity was also linked to increased joint symptoms in these patients.
A study by Indiana University researchers reveals a significant communication gap between older adults and their surgeons, with only half of concerns discussed during consultations. This mismatch can lead to poorly tailored treatment recommendations, emphasizing the need for effective communication.
A CU-Boulder study using a space-age, low-gravity training machine found it reduced impacts on muscles and joints by nearly half when subjects ran at 50% of their body weight. The G-Trainer, built by Alter-G Inc., was retrofitted with force-measuring technology to quantify its effects.
Older adults with severe hip or knee osteoarthritis who undergo joint replacement surgery experience significant improvements in osteoarthritis symptoms, with most patients returning to regular activities within a month. The study's findings support the use of joint replacement as an option for older adults with severe osteoarthritis.
Researchers at Wageningen University used special horseshoes to measure accelerations of horses undergoing aquatraining and walking normally, revealing lower impact forces during 'aquatic walking'. However, rising trot may not be as advantageous as previously thought, with similar back extension in both sitting and rising trot.
A study found that certain single nucleotide polymorphisms within the IL2RA gene region are associated with juvenile idiopathic arthritis. Three specific SNPs were investigated and one was significantly associated with UK cases of JIA, especially in female patients and those positive for antinuclear antibodies.
A new surgical technique called joint distraction has been shown to promote cartilage repair in patients with severe knee osteoarthritis. The study found that patients experienced significant improvements in functional ability and pain scores, with cartilage volume and thickness increasing by up to 50% and 40%, respectively.
A microarray screening study revealed significant gene expression changes in adult human joint cartilage after injury. The study identified the Wnt-16 signaling pathway as a key player in the molecular response, which may be relevant to osteoarthritis progression.
Researchers found that using a cane significantly reduced the peak knee adduction moment, alleviating destructive load on affected knees. The study suggests that canes may be an effective short-term solution for knee OA patients.
A new review of 28,000 patients undergoing joint replacement surgery found that potent anticoagulants may actually lead to more deaths. The authors argue that these drugs have significant side effects and do not prevent pulmonary embolism effectively.
Analysis of ancient Hadropithecus stenognathus hand bones reveals a novel joint configuration on the little finger, differing from other primates. The discovery highlights the diversity of lemurs that existed over 2,000 years ago.
Researchers developed a new test to detect bacterial infections in prosthetic joints, which can help spare patients from unnecessary surgery. The test uses mRNA detection and has shown promising results in clinical trials.
Researchers discovered that watery pools of osteoclast precursors in the bone marrow near affected joints may be responsible for the erosion of bones in psoriatic arthritis. This finding provides clues on how to prevent this process and offers a promising direction for developing new treatments with fewer side effects.
Researchers at the University of Michigan have developed a wearable mechanism that captures energy lost during walking to generate electricity. The device, which works similarly to regenerative braking in hybrid vehicles, has shown promise in powering devices with minimal user effort.
Researchers found a significant association between the index-to-ring finger length ratio and the risk of knee osteoarthritis. Women with a 'male' pattern of longer ring fingers were more likely to develop knee OA, while those with smaller 2D:4D ratios had a greater risk of tibiofemoral knee joint OA.
A double-blind study published in Nutrition Research reveals Pycnogenol improves physical function by 52 percent in patients suffering from OA. The antioxidant plant extract also controls inflammation and complements existing strategies for treating osteoarthritis.
Researchers found that joint inflammation persists in patients with antibiotic-refractory Lyme arthritis, despite the spirochetes being killed. Antibody titers declined to similar levels after 4-6 months of antibiotic therapy, regardless of treatment response.
Researchers found combining methotrexate with a biologic medication works better than using either alone. The combination also shows short-term results in reducing joint inflammation and improving quality of life.
A study by Cincinnati Children's reveals that fibrin plays a crucial role in the inflammatory response and development of rheumatoid arthritis. Researchers suggest that therapies targeting the interaction between fibrin and a specific integrin receptor may help treat arthritis patients.
In a Phase 3 biologic study, golimumab significantly improved joint and skin manifestations of psoriatic arthritis in patients with active disease. The treatment achieved primary and major secondary endpoints, demonstrating sustained improvements through six months.
Researchers found that mice without lubricin experienced early wear and increased friction in their joints, highlighting the protein's role as a boundary lubricant. The study's findings suggest injecting lubricin or its close cousin could prevent wear in joints, reducing the need for joint replacement surgery.
A study found that 82% of entheses have a synovio-entheseal complex (SEC), which is involved in triggering inflammation in OA. The SEC's formation is linked to fibrocartilage degeneration and cell clustering, suggesting a novel mechanism for synovial inflammation.
Researchers at Case Western Reserve University discovered a natural product derived from the Amazon rainforest that prevents tissue destruction by blocking matrix metalloproteinases. The findings have potential therapeutic applications in various joint, skin, and gastrointestinal diseases.
A clinical trial aims to identify individuals at risk of osteoarthritis through the analysis of Smurf2 enzyme expression in cartilage cells. The study seeks to develop a diagnostic test and potential injection to prevent or slow disease progression.
Researchers at the University of Missouri-Columbia have developed an in vitro model that mimics actual joints, eliminating the need for animal testing. This 'joint in a test tube' model can investigate causes and mechanisms of arthritis and screen new treatments.
Regular physical activity is linked to increased tibial cartilage volume and reduced cartilage defects in healthy adults. Moderate exercise also shows promise in lowering the incidence of bone marrow lesions, a potential indicator of knee OA progression.
A new study suggests that training programs promoting balanced activity of the inner and outer thigh muscles may help protect the ACL from injury. The research found that women tend to activate their outer thigh muscles more than their inner thigh muscles when preparing to land from a jump, leading to a larger valgus knee angle.
Researchers at Duke University Medical Center found that blocking two immune system proteins, IL-1 and TNF, can promote healing in damaged meniscus tissue. The study, published in Arthritis & Rheumatism, suggests a new approach to treating knee injuries and osteoarthritis.
Researchers found that whiplash trauma increases the risk of developing temporomandibular joint (TMJ) symptoms, which can be painful and affect daily life. In a study of 60 patients, 34% developed TMJ pain within a year after the accident, compared to 7% in uninjured controls.
Mayo Clinic researchers have discovered a new diagnostic test to detect infection in prosthetic joints, which samples bacteria adhering to the prosthesis surface. The new method detected more infected cases (78.5%) than conventional tests (60.8%), offering improved treatment options and patient outcomes.
Engineers at the University of Bath have developed a diagnostic test that measures sound frequencies produced when the femur bone is vibrated, enabling earlier detection of loosened joints. This method is more sensitive than traditional x-rays and can diagnose smaller gaps, reducing unnecessary surgery.
Researchers found that oral calcitonin effectively protects against articular cartilage degradation and surface erosions in ovariectomized rats, a model for postmenopausal women. Calcitonin worked better than estrogen therapy, preventing cartilage erosions completely.
Research found 28 out of 33 young elite tennis players had spinal abnormalities, including disc degeneration, herniated discs, and stress fractures. The study highlights the need to modify training techniques to minimize musculoskeletal damage in young athletes.
A walking robot, RunBot, has been engineered to mimic human gait and adapt to different environments, including mountainous terrain. The robot's ability to learn from trial and error allows it to adjust its gait in response to visual input, ensuring stability and balance on slopes.
Researchers tracked 172 patients with hand osteoarthritis for two years, showing a significant increase in pain intensity and functional limitations. Radiological progression was also detected in 20% of subjects, highlighting the need for early intervention to prevent irreversible progression.
A new gene therapy has been shown to completely eliminate osteoarthritic pain and significantly reduce long-term joint damage in genetically engineered mice. The therapy works by increasing opioid receptors on nerve cells, making them more responsive to naturally occurring painkillers.
A new study suggests that green tea compound epigallocatechin-3-gallate (EGCG) inhibits production of molecules that cause destruction of cartilage and bone in people with rheumatoid arthritis. EGCG also suppresses inflammatory products in connective tissue.
A study found that green tea compound epigallocatechin-3-gallate (EGCG) inhibits production of inflammatory molecules involved in joint damage. EGCG also blocks the production of interleukin-6 and prostaglandin E2, reducing inflammation in joints.
A new method predicts hip joint decay in pediatric leukemia and lymphoma survivors, with over 30% of bone deterioration linked to high risk of collapse requiring surgical repair. Researchers found that genetic or other tests may be developed to help identify at-risk patients, improving quality of life.
Researchers used dGEMRIC MRI to measure GAG distribution and correlate it with indentation stiffness. The study found a significant relationship between the dGEMRIC index and mechanical stiffness, suggesting its potential as a predictive measure of cartilage stiffness in osteoarthritis patients.
A new treatment developed by a pediatric orthopaedic surgeon at Washington University School of Medicine has shown early success in correcting congenital vertical talus with minimal surgery. The treatment involves gentle manipulation and long leg casts to gradually correct the deformity.
New research led by Gregory Jay at Brown University shows that protein lubricin, not just hyaluronate, is crucial for protecting joints from wear and reducing arthritis risk. The study found that adding lubricin to supplements could restore elasticity in synovial fluid.
A new study estimates that 6.9 million US adults have arthritis-attributable work limitation (AAWL), with 1 in 20 working age adults reporting AAWL, and 1 in 3 among those with arthritis. Adults with AAWL have poor physical health and function, including high body mass index, joint pain, and frequent doctor's office visits.
Women in their 70s who engage in moderate physical activity may reduce their risk of developing frequent arthritis symptoms. The study found that increasing exercise to 2 ½ hours per week can further decrease the likelihood of these symptoms appearing.
Researchers at Duke University have found that lubricin helps reduce friction and maintain joint cartilage integrity, suggesting its potential as a treatment for osteoarthritis. The study used precise measurement of biomechanical properties to compare lubricin-deficient joints to normal ones.
Researchers found that etanercept, a TNF inhibitor, had no impact on new cartilage or bone formation in mice with spontaneous arthritis. The study suggests that joint fusion and joint inflammation are separate processes, which should be considered as distinct therapeutic targets.
Researchers identified 9 clinical variables that independently predict the development of rheumatoid arthritis in early arthritis patients. The formula allows physicians and patients to make evidence-based treatment choices, potentially avoiding serious complications associated with disease-modifying antirheumatic drugs.
A new backpack design reduces force on the wearer's body by 86%, allowing for more comfortable running with heavy loads. The suspended-load ergonomic backpack is designed to benefit soldiers, emergency workers, and schoolchildren who often carry heavy items.
Researchers found that a single ligament in birds' shoulders stabilizes their wings during flight, making it a linchpin for modern bird flight. However, this ligament-based system evolved gradually over time, suggesting early birds may have flown differently.
Men with knee osteoarthritis who smoke experience greater cartilage loss and more severe pain than non-smokers. Smoking is a potentially modifiable risk factor for worsening knee osteoarthritis.
Bioengineering researchers at UC San Diego have shown that sliding forces on cartilage surfaces increase the production of proteoglycan 4, an important step towards growing healthy joint tissue. This discovery has significant implications for the treatment of osteoarthritis and the development of artificial joints.
Mayo researchers found that stronger quadriceps muscles can help reduce cartilage loss in the knee joint. Participants with greater quadriceps strength had less cartilage loss in the patellofemoral joint, which is frequently affected by osteoarthritis.
Repeat MabThera treatment improves physical and mental aspects of quality of life measures in RA patients, with significant improvements in disease symptoms and structure. The therapy also inhibits joint structural damage, providing evidence of radiographic progression inhibition.