Articles tagged with Joints
Scientists discover 'synoviolin', an enzyme that contributes to RA progression by over-growing synovial cells. Reducing synoviolin levels could halt joint destruction, offering new insights into RA etiology and innovative therapies.
A study by Yamamoto and colleagues found that the SLAYGLR sequence of osteopontin facilitates monocyte migration to arthritic joints, leading to inflammation and arthritis suppression. The findings support a critical role for osteopontin in rheumatoid arthritis pathogenesis.
A new study suggests radiosynoviorthesis is effective in treating osteoarthritis, providing significant pain relief to 2/3 of patients with proven synovitis. The procedure, which involves removing inflamed membrane using beta-emitting radionuclides, shows promise as a treatment option for OA.
Eighty percent of patients treated with combination therapy experienced no radiographic progression, compared to 68% on ENBREL alone and 57% on methotrexate. Combination therapy and ENBREL monotherapy provided significant inhibition of joint damage.
A study published in Arthritis & Rheumatism reveals that cartilage oligometic matrix protein (COMP) is present in blacks, with average levels higher in patients and men than in whites. COMP may serve as a biomarker for osteoarthritis progression.
A study found that individuals with lower incomes and education levels are more likely to have severe arthritis but less likely to be on waiting lists for joint replacement surgery. Women from lower socio-economic backgrounds are also less likely to discuss joint replacement with their doctors.
A phase 3 study found Enbrel inhibited radiographic progression in patients with active psoriatic arthritis. The drug reduced the progression of bone erosions and joint space narrowing associated with the disease.
Researchers have found a link between flexible joints and chronic fatigue syndrome (CFS), with 60% of CFS patients exhibiting joint hypermobility. This discovery may provide insight into the development of CFS symptoms, which appear in early childhood.
Researchers have discovered that certain types of naturally occurring carbohydrates in the body may cause rheumatoid arthritis by triggering an immune response and leading to inflammation and joint damage. The study found that glycosaminoglycans, a major component of joint cartilage and skin, activate inflammatory cells in the joints.
A new study by Duke University researchers found that even small degrees of malalignment in knee surgery patients can cause dramatic alterations in pressures within the joint. Proper alignment is crucial for preventing future development of severe arthritis.
Researchers at Cardiff University discover that Cod Liver Oil's Omega-3 fatty acids can slow cartilage degradation and inflammation, offering a potential cure for osteoarthritis. The study suggests that taking Cod Liver Oil in early adulthood may prevent the onset of osteoarthritis and reduce its symptoms.
Researchers at Northwestern University have developed a gene therapy that reduces inflammatory cytokines involved in joint inflammation. The treatment, which uses the IL-13 gene, has been shown to suppress joint inflammation and prevent the development of arthritis in rat models.
A team of researchers at Case Western Reserve University is developing computer simulated models to predict the performance of new implant designs before they are implanted into patients. They aim to uncover how damage occurs in plastic used in total joint replacements and identify potential design concerns.
UCSD bioengineers have fabricated cartilage tissue that mimics the structure and function of natural articular cartilage. The tissue is made entirely from biological materials and has shown promise in laboratory tests, with cells effectively secreting a key lubricant molecule.
Engineers at Johns Hopkins University invented a globe-shaped motor that can rotate in any direction, giving robotic arms greater flexibility and precision. The device could also be used to create a computer mouse that interacts with the user, or as a three-dimensional wheel with omnidimensional characteristics.
A major review reveals osteoarthritis is a complex disease, but outlines new approaches to understanding, preventing, and treating the condition. The study emphasizes the importance of a healthy lifestyle, including exercise and weight management, in reducing disability and slowing disease progression.
Two new research studies have shown significant promise for reducing joint damage in rheumatoid arthritis, with a combination of infliximab and methotrexate halting progression and improving symptoms in patients. Etanercept also demonstrates efficacy in slowing joint damage and decreasing symptoms.
A nationwide study found that etanercept significantly slows or stops rheumatoid arthritis progression in nearly three-quarters of patients, with fewer side effects than methotrexate. The new use of etanercept as an early treatment offers a promising alternative for patients with advanced RA.
Researchers discovered that COMP significantly increases in the blood of people with hip or knee osteoarthritis even before X-rays reveal joint damage. Elevated levels of COMP correspond strongly with reports of joint pain and may indicate an early stage of osteoarthritis.
New data suggest anakinra accelerates joint damage progression slowdown and improves health-related quality of life for RA patients. Studies found accelerated slowing of joint destruction with treatment, leading to nearly twice the rate of reduction in joint destruction as placebo groups.
Researchers have identified a protein that governs the flow of mineral-reducing pyrophosphate into joint tissues. This finding could provide powerful new insights into the basic mechanisms underlying some forms of arthritis, a group of diseases affecting half of people 65 and older.
A clinical trial of Enbrel in children with polyarticular juvenile rheumatoid arthritis found significant improvement in joint pain, stiffness, and inflammation. The drug was well-tolerated, with a 74% response rate among treated patients.
Physicist Jacquelyn Yanch has devised a new method to combat severe rheumatoid arthritis by injecting boron compounds and exposing joints to neutron beams, killing the synovium lining. Early results on rabbits are promising, but human trials are still needed.
Researchers at Colorado State University are exploring a promising new technique for treating osteoarthritis in horses, which may also benefit humans. The 'microfracture' procedure involves creating small holes in the bone to stimulate cartilage growth, and has shown positive results in long-term studies on horses.
A study at Oregon Health Sciences University found that an unloader brace can relieve pain, improve mobility, and delay or even avoid surgery in patients with unicompartmental osteoarthritis of the knee. The device improved walking times, reduced pain medication use, and increased patient activity levels.
Researchers at UNC Chapel Hill reduce arthritis severity in laboratory rats by turning off the molecular switch NF-kappa B, which controls inflammatory genes. The study demonstrates feasibility of new treatments, including gene therapy, and suggests potential systemic therapeutic effects.
Scientists have developed a stripped-down gene therapy approach using naked DNA to treat rheumatoid arthritis in rats. The treatment, which injected TGF-ß plasmids into muscle tissue, significantly reduced chronic arthritis symptoms and joint inflammation.
Researchers found that localized gene therapy can produce widespread, systemic effects on rheumatoid arthritis. The study used an adenovirus to carry therapeutic genes for altered cell receptors, which lessened inflammation and cartilage destruction in both diseased and distant joints.
Researchers at University of Pittsburgh Medical Center have made significant progress in treating rheumatoid arthritis using gene therapy. They successfully expressed the interleukin-1 receptor antagonist (IL-1Ra) gene in synovial cells within joints treated with the approach.
Researchers at UPMC's Musculoskeletal Research Center found that the oral prescription drug alendronate can prevent bone destruction around failed joint implants. This breakthrough could reduce the need for repeat surgeries and save an estimated $200 million annually.