Articles tagged with Joints
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Researchers at UCI identified natural compounds that block autoimmune T-cell activity, potentially developing new treatments for type-1 diabetes and rheumatoid arthritis. The study found the compounds suppressed autoimmune T-cell function without affecting other immune cells.
Researchers found that turmeric extract inhibited joint destruction and inflammation, altering gene expression and preventing osteoclast activation. A dose of 1.5 milligrams per day may be effective for humans, suggesting a potential mechanism similar to anti-inflammatory drugs.
Researchers at the University of Rochester Medical Center have received a $7.8 million grant to develop new treatments for bone fractures and arthritis. The team will explore ways to predict who is likely to suffer from osteoarthritis after injury and create targeted drug therapies to prevent it.
A clinical trial is underway to assess the effectiveness of Reparagen in treating moderate osteoarthritis, with findings that it 'silences' genes promoting joint damage while activating the repair gene IGF-1.
Researchers at Duke University have devised a new way to prolong the effects of an anti-inflammatory drug, potentially making it useful for providing longer-lasting treatment for osteoarthritis. The modified drug could last for several weeks rather than just hours, offering a significant clinical gain and fewer negative side effects.
Researchers at Harvard University found that the dynamic elastic and dampening roles of ankles, feet, and other distal extremities help legged animals maintain stability on uneven terrain after stumbling. By modulating limbs dynamically, selectively, and quickly, animals can recover from falls and maintain forward momentum.
A study found that patients who exercised prior to hip and knee replacement required significantly less inpatient rehabilitation, walking more than 50 feet at discharge. The exercise program improved lower-extremity muscle strength and function before and after surgery.
A new study published in Arthritis Care & Research found that weight training did not improve knee strength in patients with osteoarthritis, but may slow progression of joint space narrowing on X-rays. Patients who participated in strength training showed less joint space narrowing than those in a range-of-motion regimen.
A comprehensive study of 2,128 individuals found that openness to surgery and higher education level significantly influenced the likelihood of undergoing joint replacement surgery. Education was a key factor in increasing willingness to consider TJA, regardless of socioeconomic status or disability.
A new study published in PLoS Medicine suggests that delivering rheumatoid arthritis drugs directly into the central nervous system improves treatment outcomes. Researchers found that blocking a protein called p38 with spinal cord administration reduced inflammation, arthritis, and joint destruction in arthritic rats.
A study by UCSD researchers shows that the central nervous system can sense and modulate inflammation in joints, reducing symptoms of rheumatoid arthritis. Blocking key signaling enzymes in the CNS resulted in decreased joint inflammation and destruction.
Researchers identified a platelet-regulating gene mutation involved in lupus nephritis, and a novel adhesion molecule implicated in rheumatoid arthritis. The study suggests links between the mutations, loss of protein expression, defect in platelet function, and regression of kidney damage.
A Case Report warns travelers of exposure to the rare chikungunya virus in Indian Ocean Islands, which causes fever, joint pain, and rash. The authors advise preventive measures against mosquito bites and recommend avoiding travel for vulnerable groups like pregnant women and older adults.
The REFLEX study demonstrated that MabThera can inhibit structural joint damage in patients with an inadequate response to TNF inhibitors. Repeated treatment courses provided continued improvement of symptoms across all clinical measures, increasing remission rates and symptom improvement.
Rituximab plus methotrexate treatment significantly inhibits joint structural damage, reducing bone erosions and joint space narrowing in patients. The study's findings offer new hope for those who do not respond to current treatments.
A recent study involving 56 children with Juvenile Idiopathic Arthritis (JIA) found that tocilizumab improved symptoms in 68% of patients, with over 85% showing a 50% improvement rate. The treatment was generally well-tolerated, with only two serious adverse events reported.
Researchers found that GM-CSF and TNF-alpha induce the phosphorylation of a serine residue on NADPH oxidase, priming it for action at sites of inflammation. This prime may be targeted with drugs to prevent exaggerated neutrophil responses in inflammatory conditions like rheumatoid arthritis.
Researchers discovered that octopuses generate two waves of muscle contraction to create joint-like bends in their arms, allowing for precise point-to-point movements. This human-like strategy suggests that articulated limbs controlled by joints are the optimal solution for achieving such movements.
Liposome technology has been shown to improve tissue delivery of therapeutic compounds, achieving effects equivalent to 10-fold higher doses. Specific targeting of liposomes to inflamed cells in the synovium has also been successfully demonstrated, reducing synovial inflammation without conventional side effects.
A team of researchers found that a component of joint fluid called lubricin forms a thin barrier to prevent contact between joint surfaces, reducing wear and tear. The combination of lubricin and hyaluronic acid produces an even greater protective effect than either substance alone.
A recent study conducted by Virginia Tech researchers found that the Swedish Autologous Chondrocyte Implantation (ACI) method produces repairs with excellent durability. The study, which used a controlled biotribology device, compared the wear of ACI-repaired cartilage to normal cartilage from the same joint.
Researchers find that histamine contributes to joint blood vessel leakage in rheumatoid arthritis, potentially leading to more effective treatments. The discovery may also apply to other autoimmune conditions and infectious diseases.
A new study using bone SPECT test shows that the test can identify patients with lower back pain who would benefit from facet joint injections, leading to significant pain reduction and cost savings. The test can help doctors avoid unnecessary injections in patients who may not respond well to them.
A two-year study of patients with early, aggressive RA demonstrates the superiority of anti-TNF plus DMARD therapy over either treatment alone. Nearly half of participants in the combined therapy group achieved major clinical remission after 2 years.
A study found that chemical modification of Type II Collagen creates a self-antigen, leading to immune system activation in rheumatoid arthritis patients. The modification of this protein contributes significantly to the disease's progression.
A phase III study shows Actemra significantly reduces radiographic joint destruction and disease activity scores in patients with early aggressive rheumatoid arthritis. The treatment was generally well-tolerated, with a low incidence of adverse events.
The TEMPO study demonstrated that over three-quarters of patients treated with Enbrel plus methotrexate experienced no progression of joint damage. Additionally, patients treated with this combination therapy showed a significant improvement in physical function compared to those receiving either treatment alone.
Initial combination therapy with either prednisone or infliximab significantly reduces progression of radiographic joint damage and improves functional outcomes compared to DMARDs alone or step-up combination therapy. Patients treated with initial combination therapy also experience earlier relief from symptoms.
The study provides evidence-based medical practices for juvenile idiopathic arthritis, enabling physicians to determine the type of arthritis and develop an appropriate treatment plan. The guidelines highlight the need for individualized patient care due to the complexity of the disease.
Researchers at Johns Hopkins University discovered that plant-derived compounds can block the activity of an enzyme that triggers inflammation in joints. These phytochemicals, also known as phase 2 enzyme inducers, may provide a new approach to treating arthritis and preventing joint pain.
Researchers found that endomorphin 1, a natural painkiller, had no effect on chronic arthritis pain. The study suggests the need for alternative pain management strategies for long-term arthritis sufferers.
A study published in BMC found that regular exercise can significantly reduce musculoskeletal pain in older adults. Participants who exercised regularly experienced 25% less pain than those who were less active, with the reduction persisting until age 62-76.
Recent evidence suggests a link between estrogen deprivation and joint pain, particularly in women undergoing hormone therapy for breast cancer. Studies have shown that aromatase inhibitors and other estrogen-depleting treatments can increase the risk of musculoskeletal symptoms, including joint pain.
A study published in Arthritis & Rheumatism found that doxycycline slowed joint space narrowing by 40-33% compared to a placebo. While it didn't reduce joint pain severity, it did decrease frequent increases in knee pain. The treatment was well-tolerated with minimal side effects.
A study published in the American Journal of Pathology reveals that Wnt-7b is significantly upregulated in arthritic knee tissues, particularly in areas of high inflammation. The findings suggest a potential role for Wnt-7b in rheumatoid arthritis progression and may lead to new therapeutic strategies.
A new study from the University of Colorado found that walking at a leisurely pace can increase calorie burn by up to 25% for obese adults. Additionally, reducing walking speed from 3 miles per hour to 2 miles per hour can decrease knee joint loads by up to 25%.
A life impact study found that adults with childhood onset ankylosing spondylitis experience more serious physical deformity and work-related disability than those who develop the disease as adults. Early diagnosis and treatment can significantly improve symptoms and prevent long-term effects.
Researchers successfully introduced a gene that blocks joint inflammation, reducing IL-1 and IL-6 production. The study's nine patients showed no clinical side effects after five years, paving the way for new gene-based therapies.
The study found that patients with ankylosing spondylitis who took NSAIDs continuously experienced less spinal joint damage than those who only used them for pain management. This suggests that inflammation and progression of joint damage may be separate processes in AS, and NSAIDs may have unexplored disease-controlling properties.
A new pet food, Prescription Diet Canine j/d TM, improves dogs' quality of life by enhancing joint health. With a unique formula containing EPA, glucosamine, and L-carnitine, this food helps dogs run better, play better, and experience less stiffness.
Researchers found that disabling Foxo3a gene prevents the development of arthritis-like disorder by inducing neutrophil apoptosis. This discovery may lead to new treatment options for immune dysfunction-related arthritic conditions.
Dr Hylander's pioneering research on mandible mechanics and jaw joint loading has significantly advanced the field of craniofacial biology. His work has been widely applied and recognized with awards including the NIH Merit Award.
UCSD researchers discovered that titanium particles weaken artificial joints by affecting bone-building and -destroying cells. The study's findings suggest improved implant material with enhanced wear resistance and fatigue properties to reduce particle generation.
A study published in Arthritis & Rheumatism reveals a significant association between serum hyaluronan (HA) levels and osteoarthritis severity. The research, conducted on over 3,000 volunteers, suggests that HA levels may serve as a biomarker for diagnosing osteoarthritis.
Researchers uncover how alpha-defensin-1 inhibits HIV infection in CD4+ T cells and how lubricin protects cartilage surfaces. These findings provide insights into innate immunity against HIV and may lead to the development of defensin-like drugs for prevention and treatment.
Researchers found a significant link between elevated hyaluronic acid levels and severity of osteoarthritis, particularly in the knees and hips. The study, involving 753 participants from diverse ethnic backgrounds, suggests that hyaluronic acid measurements may be useful for assessing overall OA load.
A recent study found that very early treatment with infliximab plus methotrexate reduced synovitis and bone erosions in patients with rheumatoid arthritis. The treatment showed sustained benefits even after one year, improving function and quality of life.
Acupuncture was found to be effective in treating osteoarthritis of the knee, while its effectiveness for chronic neck pain was no better than placebo. A third study identified a clinical prediction rule that can predict which patients with low-back pain are most likely to benefit from spinal manipulation.
A study published in Arthritis & Rheumatism found that weight gain significantly increases the risk of disease progression in knees with moderate malalignment, but has no impact in neutrally aligned or severely malaligned legs. Researchers suggest targeting weight loss efforts for patients with moderate malalignment to slow disease pro...
A mouse model of osteoarthritis has been developed, revealing that bone morphogenetic protein (BMP) signaling is essential for the maintenance of healthy articular cartilage. The study found that inactivating BMP signaling in mice led to severe arthritis, mimicking human osteoarthritis conditions.
A team of UBC scientists aims to use stem cells to regenerate bone cells and improve the success rate of artificial joint replacements. By combining minerals and slow-release growth factors, they hope to create a strong, organic environment to secure prosthetic joints.
Researchers found a strong correlation between a peptide fragment of type II collagen (CTX-II) and the prevalence and progression of osteoarthritis (OA), particularly at the knee and hip. CTX-II levels were associated with increased risk and severity of OA, including rapid joint destruction.
A new study evaluates patients with rheumatoid arthritis to understand their perception of treatment improvements and develop patient-based criteria for evaluating new treatments. The study will recruit 300 participants who have been diagnosed with RA and are currently treated with various medications.
Researchers develop a novel treatment to stimulate natural cartilage tissue growth in knee joint defects, providing a potential solution for osteoarthritis treatment. The hyaluronan-based polymer creates a protective cap and enables new cartilage tissue to grow, filling the defect and promoting healing.
Researchers at the University of Illinois Chicago have successfully created a human-shaped articular condyle using adult stem cells. The tissue-engineered structure retained both bone-like tissue underneath and cartilage-like tissue on top, similar to a natural articular condyle.
Researchers developed gene therapy using dendritic cells pulsed with TRAIL to inhibit collagen-induced arthritis. The treatment reduced T cell infiltration and inflammation, suggesting a safe and effective method for inhibiting arthritis development.
Scientists discover 'synoviolin', an enzyme that contributes to RA progression by over-growing synovial cells. Reducing synoviolin levels could halt joint destruction, offering new insights into RA etiology and innovative therapies.
A study by Yamamoto and colleagues found that the SLAYGLR sequence of osteopontin facilitates monocyte migration to arthritic joints, leading to inflammation and arthritis suppression. The findings support a critical role for osteopontin in rheumatoid arthritis pathogenesis.
A new study suggests radiosynoviorthesis is effective in treating osteoarthritis, providing significant pain relief to 2/3 of patients with proven synovitis. The procedure, which involves removing inflamed membrane using beta-emitting radionuclides, shows promise as a treatment option for OA.
Eighty percent of patients treated with combination therapy experienced no radiographic progression, compared to 68% on ENBREL alone and 57% on methotrexate. Combination therapy and ENBREL monotherapy provided significant inhibition of joint damage.