Articles tagged with Joints
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A recent study found that patient treatment preferences play a significant role in racial disparities in total joint replacement utilization. African-American patients were less likely to receive a recommendation for the procedure and undergo surgery compared to white patients, despite similar disease severity.
Arthritis disproportionately affects African Americans and Hispanics, with higher prevalence of activity limitation, work limitation, and severe joint pain. Simple steps like weight loss and physical activity can make a big difference in managing arthritis.
Researchers found that hormone replacement therapy in joint fluid may be beneficial for treating late-stage human osteoarthritis by regenerating damaged cartilage tissue. Estrogen and testosterone were shown to influence the expression of genes in chondrogenic progenitor cells, which are present in arthritic tissue.
A study by Rush University Medical Center found that flat, flexible footwear reduces the load on knee joints compared to supportive shoes. This can be a significant factor in preventing osteoarthritis, which is characterized by higher-than-normal loading on the knees during walking.
Researchers at the University of Southampton are exploring the use of patient-derived stem cells to mend damaged hips. The study aims to improve outcomes for revision hip replacement therapy, a procedure where surgeons introduce donor bone to provide support for the new hip stem.
Researchers evaluated outcomes of 218 patients who participated in non-recommended activities after TKA surgery and found no significant differences in implant durability or radiological results. The study showed that such activities might actually improve clinical scores, contradicting industry recommendations.
A new study found that joint replacement surgeries often fail to align patient and doctor expectations, resulting in higher dissatisfaction rates. The study suggests that educational interventions like preoperative classes can be used to improve dialogue between patients and surgeons.
A study presented at the American Academy of Orthopaedic Surgeons meeting found correlations between maternal and infant cobalt and chromium levels in patients with metal-on-metal hip implants. Elevated ion levels were detected in infants, suggesting the placenta modulates metal ion transfer to the fetus.
A study by American Academy of Orthopaedic Surgeons reveals that majority of shoulder dislocations occur during sports and recreational activities, with young males being at higher risk. Elderly women also show a high rate of shoulder dislocation, especially among those aged 80 to 90 years old.
Research found fluoxetine (Prozac) and citalopram (Celexa) significantly inhibited disease progression of collagen-induced arthritis in mice. The study suggests potential drug development opportunities for arthritic conditions like rheumatoid arthritis.
A new study compared two common treatment options for clubfoot – Ponseti method and surgical treatment. The Ponseti method was found to be more effective, with a lower recurrence rate and less invasive treatment required. Patients treated with the Ponseti method needed significantly less revision surgery.
Researchers at Hospital for Special Surgery used a novel technique involving transplanted bone and cartilage to treat an 18-year-old man's severe femoral head fracture. The patient successfully recovered from the surgery and delayed his need for a total hip replacement, avoiding multiple revision surgeries.
Researchers have identified several cytokines that increase significantly prior to rheumatoid arthritis disease onset, indicating immune system activation. Early diagnosis and treatment may prevent disease progression and improve quality of life for patients.
A recent study by researchers at Hospital for Special Surgery identifies four key areas of need for orthopedic training programs: addressing compromised learning experiences due to work-hour restrictions, developing core knowledge with specific goals, establishing common benchmarks for program effectiveness, and adapting to generationa...
A new study published in the Journal of Bone and Joint Surgery found that the risk of early postoperative mortality following knee and hip replacement surgeries is slightly increased for the first 26 days after surgery. However, the risk of mortality drops to negligible levels 26 days post-op. The study included data from over 188,000 ...
A new study published in the Journal of Bone and Joint Surgery found that patients undergoing surgery within three weeks of a multiple-ligament knee injury have comparable outcomes to those who undergo delayed surgery. Early mobility is also associated with better outcomes than immobilization in patients treated within this timeframe.
A study found that rural Medicare beneficiaries were 27% more likely to undergo total knee or hip replacement surgeries compared to urban recipients. Women and minorities showed significant disparities in both rural and urban areas. The study used the 2005 Medicare data and included over 6 million rural and nearly 38 million urban part...
Scientists have discovered a potential therapeutic strategy for reversing rheumatoid arthritis and osteoporosis by manipulating the levels of NF-κB p100, a key inhibitory protein. The study found that increasing NF-κB p100 levels can limit bone destruction and inflammation in both diseases.
Researchers have discovered a potential treatment for osteoarthritis using parathyroid hormone, which may regenerate lost cartilage in joints. The treatment delays cartilage loss and improves its volume in diseased joints, offering hope for patients with joint injuries.
Researchers at Boston University have developed new computer tomography contrast agents that selectively bind to glycosaminoglycans in articular cartilage, improving visualization and sensitivity for diagnosing osteoarthritis. The study's findings show that these cationic agents are three times more sensitive than current contrast agents.
Researchers found a Chinese herbal remedy to be more effective than standard treatment in reducing symptoms of rheumatoid arthritis. In contrast, elective induction of labor may reduce cesarean deliveries and improve fetal outcomes for pregnant women at term.
Researchers have developed a new oral anti-clotting drug called Apixaban that is effective in preventing blood clots and reducing bleeding risk by half. The treatment was tested in a double-blind study of over 3,000 patients and proved to be a major step forward in preventing deadly blood clots after joint replacement surgery.
A new study identifies vascular cell adhesion molecule 1 (VCAM-1) as a strong predictor of hip and knee joint replacement due to severe osteoarthritis. Elevated VCAM-1 levels were found in individuals who underwent joint replacement, mirroring active cartilage damage or an inflammatory component in OA.
Researchers at UAB will explore next-generation technology to improve the service life of total joint replacements, potentially reducing recurrent surgical procedures. The partnership with Smith and Nephew Inc. will provide access to state-of-the-art testing equipment and expertise.
A new study found that approximately 94% of patients who underwent total shoulder arthroplasty can return to sports and 85% can return to their type-specific sport. Activity modification until the six-month point in rehabilitation protected the shoulder from injury.
A study published in The Journal of Bone and Joint Surgery found that controlled glucose levels significantly reduce complications after total joint replacement surgery for diabetic patients. Patients with uncontrolled glucose were more likely to experience surgical complications, infection, blood transfusions, and longer hospital stays.
Researchers found that screening all babies with a physical clinical exam and ultrasound can significantly decrease the chance of developing early arthritis. Infants with hip dysplasia are at risk of long-term complications if left untreated, emphasizing the importance of early detection and treatment.
Researchers analyzed joint fluid samples from patients with Lyme arthritis, identifying bacterial strains and finding correlations between OspC typing and clinical outcomes. The study suggests that certain B. burgdorferi genotypes, particularly RST1, may induce a more marked immune response leading to persistent joint inflammation.
A meta-analysis of 6,316 patients found that clinical pathways significantly reduced postoperative complications and shortened hospital stays. This led to lower hospital costs due to better-organized care, which prevents inappropriate care and its associated costs.
Prof. Noam Eliaz's electrochemical coating process improves implant functionality, longevity, and integration into the body. The new coating reduces materials failure by 33% and has potential to spur new bone growth.
A new study published in Nature Medicine suggests that the signal molecule tenascin-C can trigger chronic inflammation in rheumatoid arthritis. High levels of tenascin-C in joints may cause the activated immune system to attack and lead to persistent inflammation.
The UK has launched a £41 million initiative to develop innovative medical solutions for osteoarthritis, aging populations, and imaging technologies. Four new Centres of Excellence will integrate clinicians, biomedical scientists, and engineers to create high-tech treatments.
Researchers at the University of Missouri are developing biological joints using living tissue that can mimic normal cartilage in a healthy joint. These new joints have shown promising results in dogs and aim to be used for human patients with similar physical characteristics, potentially reducing complications from repeat surgeries.
Researchers at the SNM's 56th Annual Meeting found that PET scans can accurately diagnose infections in prosthetic knee joints, outperforming traditional methods. This breakthrough could lead to improved treatment outcomes for patients undergoing joint replacements.
A new study identified biomarkers associated with inflammation and joint erosion in early rheumatoid arthritis. Levels of sYKL-40 and sMMP3 were consistently linked to disease activity measures, suggesting their potential use as predictors of bone and cartilage damage.
The study found that canakinumab significantly improved symptoms of systemic juvenile idiopathic arthritis (sJIA) in children, achieving an ACR Pedi 50 score within 15 days. Steroid tapering was also observed in the majority of responders, and 'inactive' disease status was reached in 4 cases.
Dogs can be diagnosed with osteoarthritis early on through synovial fluid analysis, which could help prevent the disease or reduce its progression. Researchers found altered synovial fluid quantity and quality in injured joints, suggesting potential biomarkers for early detection.
Azellon has raised £1.6 million in funding for trials of its cell bandage technology, which aims to regenerate damaged knee joints and prevent osteoarthritis. The technology uses a patient's own stem cells to create a 'cell bandage' that can be transplanted into the knee joint.
Researchers are assessing a new surgical procedure for regenerating cartilage in damaged knee joints. The Cartilage Autograft Implantation System (CAIS) involves extracting healthy tissue and implanting it into the damaged area, potentially producing tougher hyaline cartilage.
Mid-level shoulder separations, also known as acromioclavicular joint injuries, are common athletic injuries. Nonsurgical treatment is often favored for type III injuries, but surgical reconstruction may be recommended for certain patients with persistent instability. Both approaches require rehabilitation to restore motion and strength.
A study published in the International Journal of Biometrics proposes using knee X-rays for biometric validation, providing a unique and secure method for identifying individuals. The Wnd-charm algorithm rapidly analyzes X-ray images to identify specific knees and match them with a database, making it difficult for fraudsters to spoof ...
A study found that increased waist circumference and body mass index are associated with a higher risk of primary knee and hip joint replacement. Obesity is recognized as the most important modifiable risk factor for osteoarthritis.
A Mayo Clinic study found significant effects of obesity on total hip replacements, with a 50% higher complication rate in superobese patients. The study also reported complications with knee implants under extreme weight stress, highlighting the need for weight loss management prior to surgery.
Researchers at Duke University Medical Center found a strain of laboratory mice with 'superhealing' powers that resist inflammation and arthritis after a knee injury. The study revealed the mechanisms of post-traumatic arthritis and could lead to therapies for this condition, which affects younger people.
A randomized, double-blind study found ustekinumab to be effective in treating moderate-to-severe psoriatic arthritis, with significant improvements in pain and stiffness. The treatment showed sustained benefits up to 36 weeks after initial dosing.
A randomized, double-blind, placebo-controlled study found that long-term administration of chondroitin sulfate can prevent joint structure degradation in patients with knee OA. The study also showed significant reductions in joint space loss, pain, and adverse events in the treatment group compared to the placebo group.
A recent study has identified Placental Growth Factor (PIGF) as a key player in the inflammatory process of rheumatoid arthritis. Researchers found that PIGF stimulates the production of pro-inflammatory cytokines TNFα and IL-6, contributing to joint destruction.
A review of studies on exercise and osteoarthritis found no harm in regular, low-impact physical activity. Vigorous exercise is beneficial for both physical and mental well-being, with body weight being the largest modifiable risk factor for knee OA.
Researchers have demonstrated that gene therapy can reduce pain and swelling in patients with advanced rheumatoid arthritis. The therapy involves implanting a normal gene to compensate for a defective gene, resulting in lower amounts of disease-related proteins and reduced symptoms.
A new study found that stronger quadriceps muscles protect against cartilage loss in the lateral compartment of the patellofemoral joint, a site of frequent cartilage loss and pain in patients with knee OA. Greater quadriceps strength also showed to have less knee pain and better physical function than those with weaker muscles.
Scripps research scientists discover that loss of HMGB2 protein causes progressive cartilage deterioration, a hallmark of osteoarthritis. The study provides a promising avenue for new treatment options and may lead to prevention or reversal of the disease.
Researchers found that tiny structures in the joint lining mimic antibody-producing lymph nodes and support specific antibody production, potentially leading to joint destruction. The processes can occur independently of the body's lymph nodes, suggesting a new treatment modality for rheumatoid arthritis targeting lymphoid structures.
Researchers at Johns Hopkins University have invented wireless microgrippers that can be used to grab and remove living cells from hard-to-reach places. The devices are actuated by thermal or biochemical signals, eliminating the need for electrical wires, tubes, or batteries.
A recent study published in Redox Report reveals that Pycnogenol significantly lowers plasma levels of C-reactive protein (CRP) in osteoarthritis patients. This finding suggests that Pycnogenol's anti-inflammatory potency may be potent enough to arrest the spread of inflammation from osteoarthritic joints to the whole organism.
Researchers at the University of Utah have developed a synthetic version of sandcastle worm glue, which has shown promise in repairing shattered bone fragments. The glue performs 37% as well as commercial superglue in lab tests and may be used to align small bone fragments in joints and the face before they heal.
Scientists at the University of Liverpool will use models and tissue samples to understand ochronosis development. A potential therapy may be developed if the underlying mechanisms are understood, reducing arthritis risk for Alkaptonuria sufferers.
A recent US study found that hip resurfacing surgery is not suitable for all patients, particularly those over 55 or female. The procedure's success depends on a patient's age and gender due to differences in bone quality.
A new study suggests that standardized patient prioritization and wait-list sharing among surgeons are more effective ways to reduce wait times for joint replacement surgery. Even with increased surgical capacity, it may take almost a decade to ensure 90% of patients receive surgery within recommended wait times.
A two-year multicenter study on dietary supplements found no significant effect on slowing cartilage loss in osteoarthritis patients. The study, published in Arthritis & Rheumatism, compared the effects of glucosamine and chondroitin sulfate to placebo, but found none had a clinically significant impact.
Researchers found that pain signals from arthritic joints worsen and expand the disease by transferring inflammation to the spinal cord. New treatments aim to interrupt 'crosstalk' between joints and the spinal cord to treat osteoarthritis.