Articles tagged with Lymph
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Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
A study published in The New England Journal of Medicine found that nearly 4 million children and adolescents were at higher risk of developing blood cancers due to radiation exposure from medical imaging. The researchers estimated that up to 10% of pediatric blood and bone marrow cancers may be attributable to radiation exposure.
Researchers developed a new imaging technique using shortwave-infrared (SWIR) imaging to visualize the lymphatic system, improving resolution and sensitivity compared to traditional near-infrared (NIR) imaging. SWIR imaging with silver sulfide quantum dots offers superior image resolution and outperforms NIR-I imaging techniques.
A large trial enrolling nearly 2,800 patients from five countries has clarified the situation for patients with larger metastases. The study found that leaving most of the lymph nodes intact resulted in similar recurrence rates as completion axillary dissection, but with fewer arm-related complications.
A team from Osaka University has uncovered the importance of Polydom and Tie1 in cell migration during lymphatic vessel remodeling. The study found that binding between these proteins facilitates lymphatic endothelial cell migration, highlighting a crucial role in lymphangiogenesis.
Scientists made a groundbreaking discovery that lymphatic vessels can produce both red and white blood cells, challenging the long-held belief that blood cells come solely from bone marrow. The study suggests that lymphatic vessels may play a role in fighting infection and could be important for treating certain blood cancers.
Researchers found a significant increase in Kaposi's sarcoma incidence among young Black men in the South, with rates jumping by 3.3% per year. The study suggests that HIV infection and social determinants like poverty and lack of access to medical care contribute to this disparity.
A study found that resiliency and family support play a crucial role in helping Hispanic breast cancer survivors manage lymphedema. Adaptations such as modifying work tasks and seeking support from family members enable survivors to maintain their quality of life.
A study by Cedars-Sinai researchers confirms that counting metastatic lymph nodes is a dominant predictor of cancer death, improving staging and treatment for solid tumors. The simple process can be applied in virtually all medical settings without increased cost or complexity.
A recent study has found that Black women are significantly more likely to develop lymphedema following breast cancer treatment compared to white women. The study, which analyzed data from 304 breast cancer patients, also found that Hispanic women had a higher risk of developing the condition.
A study found that chronic stress, measured by allostatic load, was associated with a lower likelihood of completing chemotherapy and lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer. Allostatic load may be a better predictor than genetic ancestry for chemothe...
A USF Health study found that deleting a single gene, Foxo1, promotes the growth of functional lymphatic valves in both young and adult mice. This discovery offers a promising early treatment approach for hereditary lymphedema, a chronic condition characterized by fluid accumulation under the skin.
A new study reveals that melanoma cells that pass through lymph nodes pick up a protective coating, allowing them to survive high levels of oxidative stress in the blood. This coating, composed of oleic acid, protects cancer cells from ferroptosis and enables them to form distant tumors.
Researchers at the University of South Florida have identified key signaling pathways involved in lymphatic valve development and maintenance. The study suggests targeting these pathways may one day be a viable therapy for patients with lymphedema, a debilitating disease characterized by chronic swelling and fluid buildup.
Researchers discovered T follicular helper cells in blood can reveal immune system events in distant parts of the body. The 'periscope' approach enables a snapshot of whole-body immunity from blood samples, paving the way for personalized treatment plans.
Researchers at EPFL developed a dynamic test method that replicates blood and lymphatic systems, allowing for more accurate nanoparticle testing. This method reduces discrepancies between in vitro and in vivo tests, providing valuable insights into nanoparticle behavior.
Researchers found that the early flow of lymph fluid triggers maturation in developing lymphatic vessels. In mice without lymph flow, valves failed to form and remodeling phase was disrupted, leading to improper development of smooth muscle cells.
A pilot study found that a 12-month self-care program reduced lymphedema risk in 97% of breast cancer survivors by promoting lymph flow and optimizing body mass index (BMI). The Optimal Lymph Flow program empowered patients to take proactive steps, dispelling fear and anxiety.
Researchers discovered a unique immune gene signature linked to microscopic lymph node-like structures in metastatic melanoma, which may predict better survival and enable personalized immunotherapy.
The study found that the lymphatic vasculature arises directly and solely from the embryonic veins in mammals, contradicting a competing theory. This discovery holds promise for developing new therapies for lymphatic system disorders and promoting the growth of new lymphatic vessels.
A laboratory model with defective lymphatic vessels has been found to exhibit abnormal fat accumulation and obesity in adulthood. The researchers discovered that adipocytes near leaking lymphatic vessels can store more lipids, leading to increased fat storage and subsequent obesity.
Researchers have identified tadpoles as a suitable model system for studying the lymphatic vessel network, essential for regulating fluid in the body and supporting the immune system. This breakthrough could lead to new solutions for illnesses caused by faults in the lymphatic vessel network, including cancer and lymphedema.
A randomized trial found that adding chemotherapy to tamoxifen significantly increases disease-free and overall survival rates for postmenopausal women with lymph node-negative, ER-negative breast cancer. In contrast, no survival benefit was observed for those with ER-positive tumors.
A new approach reduces lymph node removal in breast cancer patients, reducing surgical trauma and complications. The technique uses a radioactive tracer to locate the sentinel node, allowing for targeted biopsy and minimizing false negatives.