Articles tagged with Neoplasms
A Danish study found that metformin use is associated with a reduced risk of developing certain types of myeloproliferative neoplasms, including all subtypes. Long-term metformin users had the strongest protective effect against MPN development.
A recent study published in Hypertension reveals that aldosterone-producing adenomas are composed of multiple cell types that work together to promote tumor growth. The research identified two distinct cell fates involved in hormone production, with cells expressing genes associated with aldosterone synthesis and cortisol production.
Imetelstat, a telomerase inhibitor, successfully treated anaemia in MDS patients for up to one year, reducing the need for red blood cell transfusions. The drug offers a novel mechanism of action for patients with lower-risk MDS who do not respond to standard treatment.
A new clinical trial has found luspatercept to be significantly more effective than epoetin alfa in treating MDS anaemia, reducing the need for blood transfusions. The results have implications for treatment algorithms and may establish luspatercept as a first-line treatment option.
Researchers tracked immune cell clusters in the aging mouse prostate using highly multiplexed immune profiling. Early adulthood sees myeloid cells, while between 6-12 months old, there's a profound shift to T and B lymphocyte-dominance. The study reveals new insight into prostatic inflammaging and the window for interventions.
Researchers evaluate an integrated NGS system, delivering accurate diagnoses in under 24 hours and expanding targeted treatments available to patients with myeloid neoplasms. The assay identified 80-92% of genetic variants, demonstrating promising results for accelerating precision therapies.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
Dr. Elaine S. Jaffe is being recognized for her pioneering work in hematopathology, including the discovery of novel pathological entities and her development of standardized diagnostic criteria for lymphoma and leukemia. She has also made significant contributions to advancing cancer research, diagnosis, treatment, and prevention.
A multicenter study validates the accuracy and reliability of NS-RADS for classifying and grading peripheral neuropathies, with high interrater agreement across different reader experience levels. The study shows promising results for routine practice, suggesting NS-RADS as a standardized guideline for reporting peripheral neuropathies.
Women treated for cervical neoplasia grade 3 show declining risks of preterm birth, neonatal sepsis, and infant death after treatment. The study suggests that these high-risk pregnancies should be managed with careful consideration.
A study found that risks of preterm birth, infant sepsis, and other adverse outcomes associated with CIN-3 treatment have decreased over time. Pregnancies after CIN-3 treatment should be managed as 'high risk' to reduce these risks.
A Colorado State University study analyzed global health data to identify the leading causes of deaths and disabilities in the state from 1990 to 2019. Cardiovascular disease and cancers accounted for half of the deaths, while musculoskeletal disorders and tobacco use were also significant contributors.
A team of researchers from Japan has developed a platform using nanofibers to capture and control the migration of brain tumor cells, including glioblastoma multiforme. The study found that varying fiber densities can slow or speed up cell movement, leading to the creation of 'cell traps' that can restrict tumor cell growth.
Researchers have developed a new integrative genetic test, LYNX, that analyzes standard and novel molecular markers in common lymphoid neoplasms. The test provides accurate detection of mutations, identification of large genome-wide chromosomal aberrations, and assessment of immunoglobulin and T-cell receptor gene rearrangements.
A recent study by prof. Tone Bjørge and her team reveals a strong link between in-utero exposures and an increased risk of thyroid cancer later in life. Maternal hypothyroidism, hyperthyroidism, goiter, and benign thyroid neoplasms are associated with higher risk.
Researchers inhibited a specific protein to decrease megakaryocyte numbers in an experimental model, showing promise for treating myeloproliferative neoplasms. The study's findings suggest a potential complementary or alternative therapy for this debilitating disease.
A Columbia study published in Obstetrics & Gynecology found that patients using copper intrauterine devices (Cu IUDs) had a lower risk of high-grade cervical neoplasms compared to those using levonorgestrel-releasing intrauterine systems (LNG-IUS). The study analyzed data from over 10,000 patients and found the diagnosis rate of high-g...
Researchers found PRRT to be safe and effective for patients with grade 3 neuroendocrine neoplasms, with a median progression-free survival rate of 9.6 months and overall survival rate of 19.9 months. Patients with low Ki-67 index responded more favorably to PRRT.
The Association for Molecular Pathology recommends a minimum of 34 critical genes for high-throughput pan-myeloid sequencing tests to standardize clinical practice and improve patient care. The report provides evidence-based guidelines for the management of chronic myeloid neoplasms, including diagnostic and prognostic information.
A study published in JAMA Oncology found that patients with autoimmune diseases taking azathioprine had a higher risk of developing therapy-related myeloid neoplasms. Researchers also identified other medications used by these patients, but only azathioprine showed a statistically significant association.
A large single-center study found that EUS-FNA is beneficial for diagnosing malignant BD-IPMNs, particularly those with suspicious features missed by CT/MRI. The procedure also improved long-term outcomes for patients with malignant lesions, reducing recurrence risk.
Neoplasia and Translational Oncology, two leading open-access cancer research journals, are now published by Elsevier. These peer-reviewed journals feature studies on novel investigations in oncology research, providing important data for advancing cancer diagnosis and treatment.
Researchers discovered that tamoxifen blocks symptoms and progression of myeloproliferative neoplasms by targeting hematopoietic stem cells, potentially leading to effective therapy for certain blood disorders.
Patients with chronic constipation may be at higher risk of developing colorectal cancer and benign neoplasms. The study found a consistent association between chronic constipation and the development of these conditions.
A new study supports CT colonography as a screening tool for colon cancer in Medicare-aged patients, detecting 9.3% of abnormal growths of cells. The procedure also identified extracolonic findings in 2.9% of patients and may increase screening compliance rates by 15% if covered.
Researchers found unsedated transnasal endoscopy to be a safe and well-tolerated method for screening esophageal disease in a primary care population. The study showed high diagnostic yields, low procedure times, and minimal anxiety, making it an attractive alternative to standard upper endoscopy.
A study published in The Lancet Oncology found that CT colonography significantly increased participation in colorectal cancer screening, with a more than 50% increase compared to traditional colonoscopy. This non-invasive technique has the potential to positively impact overall patient outcomes and reduce complications and costs.
A new study published in the Journal of the National Cancer Institute found that HPV vaccination benefits decline with age and frequent screening for women over 41 is likely to be low. The study suggests that newly detected HPV infections do not progress to cervical intraepithelial neoplasia grade 2 or worse, regardless of age.
A large retrospective cohort study found that women with precancerous Cervical Intraepithelial Neoplasia (CIN) are at higher risk of developing invasive cervical cancer and recurrent severe CIN, especially after treatment. The study suggests the need for long-term follow-up of these patients.
A new study by Johns Hopkins researchers found a significant association between passive smoking and an increased risk of developing cervical neoplasia. Women who lived with smokers had a 40% or greater risk of developing cervical neoplasia, highlighting the importance of reducing secondhand smoke exposure to prevent cervical cancer.
Women with a BMI of 40 or more are 5.2 times more likely to have significant colonic neoplasia detected during colonoscopy compared to those with a healthy weight. The study highlights the importance of physicians counseling overweight and obese women about colorectal cancer screening due to their increased risk.