Articles tagged with Neoplasms
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identified statins as a potential booster for cancer immunotherapy by preventing the release of PD-L1-containing sEVs. Statin treatment suppressed UBL3 modification, reduced PD-L1 sorting into sEVs, and improved survival outcomes in lung cancer patients.
Researchers explore microneedle technology as a novel delivery system for efficient and minimally invasive intradermal drug delivery. The review highlights the design of functional microneedles with specific structures to overcome biological barriers in various tissues, improving therapeutic outcomes.
A national clinical trial found that abemaciclib, an oral cancer drug, may slow tumor growth in patients with aggressive meningiomas with specific genetic mutations. The trial showed promising results, with a median progression-free survival of 10 months and a median overall survival of 29 months.
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
A study of 101 glioma cases reveals that one-third of patients develop permanent paralysis after surgery. High tumor grade, pre-operative motor deficits, and larger tumor volume are key predictors. The work underscores the importance of careful surgical planning to maximize survival while safeguarding motor function.
Researchers at the University of Plymouth will receive a £2.8 million funding boost to accelerate new treatments for low-grade brain tumors. The center aims to deepen understanding and translate knowledge into life-changing therapies.
Research highlights the connection between fungi and cancer, revealing that fungal microbiome can promote tumour progression and activate immunosuppressive pathways. Modulating the fungal microbiome may enhance antitumour immunity, with preliminary validation from preclinical and clinical trials.
Researchers at Arizona State University discovered that SerpinB3 plays a natural role in the body's wound-healing process, helping skin recover after damage. The protein helps activate keratinocytes to rebuild tissue and improve skin strength.
AI accelerates discovery and validation of novel therapeutic targets by integrating multi-omics data and advanced computational models, reducing the traditional decade-long research and development cycle to two to three years. AI also enhances drug efficacy, predicts resistance mechanisms and improves clinical translation.
Researchers developed a novel technology to attach 'fake targets' to tumor cells, enabling immune cells to attack regardless of antigen presence. The Univody platform showed promising results in animal models, suppressing tumor growth and triggering broader immune activation.
Researchers developed a small-molecule substrate-based fluorescent probe to visualize the nanoscale organization of glucose and serine transporters in breast cancer cells. The study found that SerT clustering correlates positively with function and is crucial for maintaining cellular serine homeostasis.
Researchers at the University of Arizona are developing a new optical technology that can image deep into biological tissues without invasive procedures. This approach aims to overcome current challenges in skin cancer imaging, allowing for earlier detection, precise evaluation, and real-time monitoring of treatment response.
Researchers developed a new imaging method using multiphoton microscopy to rapidly identify pancreatic neuroendocrine tumors with high accuracy. Machine learning algorithms achieved 80.6% accuracy, while convolutional neural networks outperformed with accuracies ranging from 90.8% to 96.4%.
A study published in The New England Journal of Medicine found that nearly 4 million children and adolescents were at higher risk of developing blood cancers due to radiation exposure from medical imaging. The researchers estimated that up to 10% of pediatric blood and bone marrow cancers may be attributable to radiation exposure.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
Researchers identify three tumor-reactive T cell subpopulations that exhibit selective expansion in ovarian cancer patients. CD8+ TCF7-expressing Tpex cells demonstrate self-renewal capacity and generate stem-like progenies, which may enhance persistence and specificity in current TIL therapy.
A new deep learning model, MSI-SEER, achieves high accuracy in predicting microsatellite instability-high tumors and their responsiveness to immunotherapy. The model combines tumor MSI status with stroma-to-tumor ratio for highly accurate ICI response prediction.
A recent study published in JAMA Otolaryngology–Head & Neck Surgery found an association between cannabis use disorder and benign salivary gland tumors. The researchers call for further prospective research to confirm this association and understand the relationship between cannabis use and these tumors.
This study evaluated the surgical outcomes of median sternotomy (MST) in treating intrathoracic tracheal malignancies, with MST providing superior surgical exposure and results in fewer complications. MST was found to preserve vascular integrity, protect the left recurrent laryngeal nerve, and achieve longer resectable tracheal lengths.
A cohort study found that obesity in childhood cancer survivors is linked to an increased risk of developing multiple subsequent neoplasms. Conversely, high levels of physical activity are associated with a reduced risk of these cancers.
Researchers from the University of Southampton engineered a new type of super-strong antibody that triggers a stronger response from the immune system compared to naturally produced antibodies. The study confirms that making subtle increases in rigidity stimulates immune activity, creating a powerful immune response against disease.
A cross-sectional study found that perceived stress, inadequate social support, racial discrimination, and neighborhood deprivation negatively impacted systemic and tumor immunity in Black women. These findings may inform prevention and public health interventions for cancer health disparities.
A new case report reveals a rare and aggressive form of leukemia developing from donor cells nine years after a stem cell transplant. The disease, driven by genetic mutations in key genes, progresses despite intensive treatment and ultimately proves fatal.
Researchers discovered that Prostaglandin E2 drives skin cells to age and enables some of these cells to become pre-cancerous, leading to increased cancer risk. The study found that blocking PGE2 reduced the chances of aged cells becoming precancerous.
Recent clinical trials of neoadjuvant therapy before radical prostatectomy, such as the ACDC-RP trial, have struggled to show significant survival benefits. Researchers recommend maximal androgen blockade with an androgen receptor pathway inhibitor as the 'backbone' of neoadjuvant therapy trials.
Adult childhood cancer survivors experience elevated fear of cancer recurrence, emphasizing the importance of routine screening and timely symptom intervention. The study's findings suggest that fear of cancer recurrence should be a significant concern in survivorship care.
Non-Communicable Diseases (NCDs) are a major global health issue, characterized by their chronic nature and long-term impact on quality of life. In China, understanding the extent and distribution of NCDs is essential for developing effective public health strategies.
Researchers highlight DDX41's distinct contribution to myeloid neoplasms with germline predisposition. The discovery sheds light on unique pathogenesis and disease phenotype associated with DDX41 variants.
The article reviews recent advances in applying artificial intelligence to oncology, showcasing promising improvements in cancer care. The authors emphasize the need for interdisciplinary collaboration, rigorous validation, and ethical principles to harness AI's potential.
Researchers review Silibinin's efficacy in managing inflammation, a key factor in tumour development and aging. The molecule may reduce drug-related toxicity and increase therapeutic potential in integrated cancer therapies.
Research highlights varied associations between social isolation and mortality risk across demographic groups, including socioeconomic disparities. The study emphasizes the importance of considering sociodemographic heterogeneity in understanding the impact of social isolation on health outcomes.
A Danish study found that metformin use is associated with a reduced risk of developing certain types of myeloproliferative neoplasms, including all subtypes. Long-term metformin users had the strongest protective effect against MPN development.
A recent study published in Hypertension reveals that aldosterone-producing adenomas are composed of multiple cell types that work together to promote tumor growth. The research identified two distinct cell fates involved in hormone production, with cells expressing genes associated with aldosterone synthesis and cortisol production.
Imetelstat, a telomerase inhibitor, successfully treated anaemia in MDS patients for up to one year, reducing the need for red blood cell transfusions. The drug offers a novel mechanism of action for patients with lower-risk MDS who do not respond to standard treatment.
A new clinical trial has found luspatercept to be significantly more effective than epoetin alfa in treating MDS anaemia, reducing the need for blood transfusions. The results have implications for treatment algorithms and may establish luspatercept as a first-line treatment option.
Researchers tracked immune cell clusters in the aging mouse prostate using highly multiplexed immune profiling. Early adulthood sees myeloid cells, while between 6-12 months old, there's a profound shift to T and B lymphocyte-dominance. The study reveals new insight into prostatic inflammaging and the window for interventions.
Researchers evaluate an integrated NGS system, delivering accurate diagnoses in under 24 hours and expanding targeted treatments available to patients with myeloid neoplasms. The assay identified 80-92% of genetic variants, demonstrating promising results for accelerating precision therapies.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
Dr. Elaine S. Jaffe is being recognized for her pioneering work in hematopathology, including the discovery of novel pathological entities and her development of standardized diagnostic criteria for lymphoma and leukemia. She has also made significant contributions to advancing cancer research, diagnosis, treatment, and prevention.
A multicenter study validates the accuracy and reliability of NS-RADS for classifying and grading peripheral neuropathies, with high interrater agreement across different reader experience levels. The study shows promising results for routine practice, suggesting NS-RADS as a standardized guideline for reporting peripheral neuropathies.
Women treated for cervical neoplasia grade 3 show declining risks of preterm birth, neonatal sepsis, and infant death after treatment. The study suggests that these high-risk pregnancies should be managed with careful consideration.
A study found that risks of preterm birth, infant sepsis, and other adverse outcomes associated with CIN-3 treatment have decreased over time. Pregnancies after CIN-3 treatment should be managed as 'high risk' to reduce these risks.
A Colorado State University study analyzed global health data to identify the leading causes of deaths and disabilities in the state from 1990 to 2019. Cardiovascular disease and cancers accounted for half of the deaths, while musculoskeletal disorders and tobacco use were also significant contributors.
A team of researchers from Japan has developed a platform using nanofibers to capture and control the migration of brain tumor cells, including glioblastoma multiforme. The study found that varying fiber densities can slow or speed up cell movement, leading to the creation of 'cell traps' that can restrict tumor cell growth.
Researchers have developed a new integrative genetic test, LYNX, that analyzes standard and novel molecular markers in common lymphoid neoplasms. The test provides accurate detection of mutations, identification of large genome-wide chromosomal aberrations, and assessment of immunoglobulin and T-cell receptor gene rearrangements.
A recent study by prof. Tone Bjørge and her team reveals a strong link between in-utero exposures and an increased risk of thyroid cancer later in life. Maternal hypothyroidism, hyperthyroidism, goiter, and benign thyroid neoplasms are associated with higher risk.
Researchers inhibited a specific protein to decrease megakaryocyte numbers in an experimental model, showing promise for treating myeloproliferative neoplasms. The study's findings suggest a potential complementary or alternative therapy for this debilitating disease.
A Columbia study published in Obstetrics & Gynecology found that patients using copper intrauterine devices (Cu IUDs) had a lower risk of high-grade cervical neoplasms compared to those using levonorgestrel-releasing intrauterine systems (LNG-IUS). The study analyzed data from over 10,000 patients and found the diagnosis rate of high-g...
Researchers found PRRT to be safe and effective for patients with grade 3 neuroendocrine neoplasms, with a median progression-free survival rate of 9.6 months and overall survival rate of 19.9 months. Patients with low Ki-67 index responded more favorably to PRRT.
The Association for Molecular Pathology recommends a minimum of 34 critical genes for high-throughput pan-myeloid sequencing tests to standardize clinical practice and improve patient care. The report provides evidence-based guidelines for the management of chronic myeloid neoplasms, including diagnostic and prognostic information.
A study published in JAMA Oncology found that patients with autoimmune diseases taking azathioprine had a higher risk of developing therapy-related myeloid neoplasms. Researchers also identified other medications used by these patients, but only azathioprine showed a statistically significant association.
A large single-center study found that EUS-FNA is beneficial for diagnosing malignant BD-IPMNs, particularly those with suspicious features missed by CT/MRI. The procedure also improved long-term outcomes for patients with malignant lesions, reducing recurrence risk.
Neoplasia and Translational Oncology, two leading open-access cancer research journals, are now published by Elsevier. These peer-reviewed journals feature studies on novel investigations in oncology research, providing important data for advancing cancer diagnosis and treatment.
Researchers discovered that tamoxifen blocks symptoms and progression of myeloproliferative neoplasms by targeting hematopoietic stem cells, potentially leading to effective therapy for certain blood disorders.
Patients with chronic constipation may be at higher risk of developing colorectal cancer and benign neoplasms. The study found a consistent association between chronic constipation and the development of these conditions.
A new study supports CT colonography as a screening tool for colon cancer in Medicare-aged patients, detecting 9.3% of abnormal growths of cells. The procedure also identified extracolonic findings in 2.9% of patients and may increase screening compliance rates by 15% if covered.
Researchers found unsedated transnasal endoscopy to be a safe and well-tolerated method for screening esophageal disease in a primary care population. The study showed high diagnostic yields, low procedure times, and minimal anxiety, making it an attractive alternative to standard upper endoscopy.
A study published in The Lancet Oncology found that CT colonography significantly increased participation in colorectal cancer screening, with a more than 50% increase compared to traditional colonoscopy. This non-invasive technique has the potential to positively impact overall patient outcomes and reduce complications and costs.
A new study published in the Journal of the National Cancer Institute found that HPV vaccination benefits decline with age and frequent screening for women over 41 is likely to be low. The study suggests that newly detected HPV infections do not progress to cervical intraepithelial neoplasia grade 2 or worse, regardless of age.
A large retrospective cohort study found that women with precancerous Cervical Intraepithelial Neoplasia (CIN) are at higher risk of developing invasive cervical cancer and recurrent severe CIN, especially after treatment. The study suggests the need for long-term follow-up of these patients.