Articles tagged with Progesterone
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Researchers are optimizing progesterone for treating traumatic brain injuries by combining it with vitamin D and developing more water-soluble analogues. These compounds showed equivalent ability to reduce brain swelling in animal models, suggesting potential for improved treatment outcomes.
Progesterone exposure may increase breast cancer risk by activating genes involved in cell adhesion, survival, and inflammation. The study reveals targets for future work in reducing progesterone's influence on breast cancer development.
The ProTECT III study aims to enroll 1,140 patients across 15 states to confirm preliminary findings on progesterone's effectiveness in reducing mortality and disability in acute traumatic-brain-injured patients. Researchers believe progesterone's neuroprotective properties could lead to life-saving benefits.
A randomized trial of 500 women with twin pregnancy found that progesterone treatment did not reduce the likelihood of delivery or intrauterine death before 34 weeks. The meta-analysis also confirmed that progesterone does not prevent early preterm birth in twin pregnancies.
A University of Michigan study identified a likely reason why dishing with a girlfriend does wonders for a woman's mood: increased levels of the hormone progesterone. Progesterone, linked to social bonding, boosted well-being and reduced anxiety in women who engaged in emotionally close tasks.
The study reveals that ERK1 and ERK2 proteins trigger a chain of chemical sequences that bring about the release of the egg, transformation of granulosa cells into luteal cells, and production of progesterone. The finding has implications for treating infertility and developing new means to prevent pregnancy.
A new study confirms that estrogen and progesterone increase the risk of breast cancer more than estrogen alone. The study suggests a two-year safe period for hormone replacement therapy.
Research finds that genetic variation in progesterone receptor affects 17P treatment response, with predictive SNPs identified for African-American and non-African-American women. Progesterone treatment may be less effective in some women due to genetic predisposition.
Researchers have found that a common contraceptive pill ingredient, progesterone, can improve neurologic outcomes for patients with severe head injuries. Progesterone was linked to increased survival and favorable outcomes at six months after treatment, with no complications reported.
A recent study has found that progesterone has limited benefits for mice with Alzheimer's symptoms, but inhibits some of estrogen's beneficial effects when taken together. The study suggests that the constant daily dosage of progesterone may be antagonizing its potential benefits.
Researchers found that vaginal progesterone gel reduced the need for intensive care and decreased hospital stays for premature infants. The treatment may also help prevent early preterm birth among women with a short cervix, according to the study's results.
Two studies published in The New England Journal of Medicine found that progesterone treatment reduced the rate of preterm birth among women with short cervix. However, weekly injections of 17P did not show similar benefits for women carrying twins. Researchers hope to identify underlying causes of prematurity to improve progesterone t...
Researchers found that progesterone treatment did not decrease the risk of premature birth in women carrying twins compared to placebo injections. In contrast, earlier studies showed a significant reduction in preterm birth among pregnant women with a history of preterm delivery and single-baby pregnancies.
Researchers found that TRAIL limits inflammation and brain cell death in bacterial meningitis by regulating the host immune response. In contrast, mice lacking TRAIL exhibited increased inflammation and brain cell death, which was reversed by administering recombinant TRAIL.
Chronic obstructive pulmonary disease (COPD) is a growing global health epidemic affecting millions. Childhood conditions can influence adult progesterone levels, according to recent studies. Additionally, research on AML1/RUNX1 reveals its role in potentiating stem and progenitor cell engraftment for successful clinical transplantation.
Researchers found genetic polymorphisms associated with hormone levels, including lower progesterone levels and increased testosterone, linked to hotter flashes. Obesity was also linked to higher testosterone and lower estrogen levels, while moderate alcohol consumption reduced hot flash severity in some women.
Researchers at Yale University have discovered four genetic variants associated with spontaneous preterm birth in Hispanic women. The study found that mothers carrying these polymorphisms were significantly more likely to experience preterm birth. Notably, the ENPP1 variant was linked to the highest risk of preterm birth.
A new study by the March of Dimes Foundation finds that high-dose progesterone treatment can significantly reduce the risk of preterm delivery in pregnant women who have previously experienced premature labor. The treatment appeared to prevent cervical shortening and inflammation, key factors contributing to premature birth.
A study at NIMH found that brain reward circuit activity ebbs and flows with a woman's hormonal cycle. Women exhibited more active circuitry during the pre-ovulation phase dominated by estrogen compared to the post-ovulatory phase, suggesting links between hormone fluctuations and mood disorders.
UCI scientists discovered that mifepristone, a chemical compound used in abortion pills, can prevent breast tumor growth by inhibiting progesterone in breast tissue cells. This finding may lead to new prevention methods for women with a genetic predisposition to breast and ovarian cancers.
A study at Emory University Health Sciences Center found that giving progesterone to trauma victims shortly after a brain injury may reduce the risk of death and disability. The researchers also found a 50% reduction in death rate and significant improvement in functional outcome among patients who received progesterone.
A commercial progesterone therapy appears to prevent some premature births, with a 33% reduction in preterm birth rate for women who had a previous premature baby. The March of Dimes estimates that if all eligible women received the therapy, nearly 10,000 premature births might have been prevented.
Researchers at the University of Texas at Austin have discovered a link between estrogen, progesterone, and allergic responses in women. High levels of IgE antibodies against these hormones are associated with symptoms such as premenstrual asthma, menstrual migraines, and fibromyalgia.
The March of Dimes has awarded $2.4 million in grants to six innovative scientists working on new ways to identify women at increased risk for premature birth and understand the role of inflammation and progesterone in triggering labor. The goal is to prevent premature births, which are the leading cause of newborn death in the US.
The study found that the BRCA1 gene interacts with progesterone receptors to inhibit growth, but its absence leads to increased growth in response to estrogen and progestin. This understanding could lead to new treatment options for hormone-dependent cancers and ordinary cancers resulting from under-expressed BRCA1 genes.
A recent study published in The Journal of Clinical Pharmacology found that use of over-the-counter (OTC) topical progesterone results in significant drug exposure through skin absorption, comparable to prescribed oral progesterone products. The study revealed similar rates of adverse effects among women taking both types of progesterone.
Researchers at Cornell University found that higher-than-normal progesterone levels in female chickens during the first meiosis significantly produce more females. The study suggests that female birds manipulate sex ratios to adapt to their environment and ensure the next generation has enough females to care for.
Research reveals that female sex hormones, particularly estradiol, play a crucial role in defense against sexually transmitted diseases. Estradiol-treated mice showed 100% protection from herpes virus infection, while those with progesterone or no hormone showed extensive infection and increased inflammation.
A study by Emory University researchers found that a sex hormone metabolite, allopregnanolone, reduces stress and anxiety in female rats. The findings suggest that progesterone may inhibit the effect of CRF on the acoustic startle response.
Researchers examine how and why hormone therapy affects cognition, finding that treatment regimen influences memory performance. Continuous versus cyclical estrogen regimens show differing effects on cognitive function, with cyclical regimens leading to more errors in reference and working memory tests.
Researchers found that estrogen combined with MPA caused increased aggression and anxiety, reduced sexual activity, and altered brain chemistry. The study provides insight into the behavioral effects of HRT and its potential links to depression, anxiety disorders, and premenstrual mood changes.
A new progesterone receptor antagonist may reduce tumor mass in patients with breast cancer, while a plant virus-based vaccine shows promise in preventing cervical and breast cancers. The novel vaccines aim to block the initial infection of HPV viruses that cause these cancers.
The American College of Obstetricians and Gynecologists (ACOG) has released new guidelines on using progesterone to prevent preterm birth. Preliminary results show promise in reducing the risk of preterm birth by one-third and half. However, more research is needed to fully understand its effectiveness.
Researchers at UT Southwestern discovered that administering the drug trichostatin A can effectively delay the start of labor in mice by allowing progesterone to continue functioning. This is significant because mice have a short gestation period, and pre-term birth affects over 460,000 infants annually.
Researchers found that progesterone receptor knockout mice showed a complete lack of infanticide and exhibited active paternal care, frequently contacting and retrieving pups. In contrast, control mice committed 74% infanticide and displayed less paternal behavior.
A recent clinical trial found that a combination of estrogen and micronized progesterone causes fewer days and less intense bleeding than commonly used hormone replacement therapies. The study suggests that estrogen plus micronized progesterone (MP) may be the form of HRT with the least bleeding and potentially lower health risks.
A new study suggests that the placenta produces high levels of progesterone to interact with the sigma receptor, which disables the mother's immune system. This mechanism allows the fetus to survive without being rejected by the mother's immune system.
Researchers at Emory University Health Sciences Center are launching a three-year pilot study to evaluate the effectiveness of progesterone in treating traumatic brain injury. The study aims to determine whether giving progesterone to victims of moderate to severe traumatic brain injury can save lives and preserve mental function.
A recent study found that female patients have higher levels of the anti-inflammatory cytokine IL-10 during and after heart surgery, which may explain why girls recover more easily than boys. However, no association was found between progesterone levels and patient recovery.
A Northwestern University study found that women with sexually transmitted diseases or elevated progesterone levels are more susceptible to HIV infection after unprotected sex with an HIV-positive partner. The research suggests that blocking chemokine receptors in genital tissues could be a key strategy for preventing male-to-female HI...
Scientists from Ligand Pharmaceuticals Incorporated have discovered two novel non-steroidal progestin compounds, (S)-LG120746 and (S)-LG120747, that selectively stimulate tissues within the body. These compounds demonstrate a protective activity in the uterus without concomitant stimulation of breast-cell growth.