A new class of photoswitchable small molecule drugs has been developed to restore key visual functions in animal models of blindness. These compounds mimic the function of photoreceptor cells and show remarkable effectiveness at restoring sight using a simple and potentially patient-friendly approach.
SourceInstitute for Bioengineering of Catalonia (IBEC)·JournalJournal of the American Chemical Society·TypeExperimental study·DateJul 15, 2026
Researchers have identified PEG400 as a potential antimalarial therapy by targeting the malaria parasite's enzyme Falcipain-2. This study offers hope for selective and cumulative benefits in reducing malaria treatment challenges.
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Scientists have captured detailed images of NMDA receptors held open by natural gatekeepers and synthetic regulators, revealing how they control ion flow. This understanding can inform the design of safe and effective therapies for conditions like Alzheimer's disease and stroke.
SourceCold Spring Harbor Laboratory·JournalNature·DateOct 29, 2025
Researchers at CCM Biosciences have discovered novel enzyme activators that fully restore the activity of Sirtuin-3, a master regulator of cellular energy production. These compounds hold significant potential for addressing age-related disorders such as Alzheimer's and Parkinson's diseases.
SourceCactus Communications·JournalPhysical Review X·TypeComputational simulation/modeling·DateJan 8, 2025
Researchers have identified a potential compound that enhances naloxone's effectiveness in reversing opioid overdoses by making it more potent and longer-lasting. The compound, dubbed compound 368, was found to improve naloxone's ability to counteract opioid overdoses in mice and enable reversal at lower doses.
SourceWashU Medicine·JournalNature·TypeExperimental study·DateJul 3, 2024
Researchers found that obesity increases allosteric regulation during feeding and decreases it when fasting in mice livers. This disruption may lead to metabolic disorders like nonalcoholic fatty liver disease and Type 2 diabetes.
SourceUniversity of Tokyo·JournaliScience·TypeExperimental study·DateFeb 26, 2024
The study reveals a quantum switching mechanism of LHCII, which regulates energy transfer quantum channel in response to lateral pressure and conformational change. This mechanism enables high efficiency in photosynthesis and balanced photoprotection.
SourceChinese Academy of Sciences Headquarters·JournalNature Plants·TypeExperimental study·DateSep 1, 2023
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Scientists at the Max Planck Institute have uncovered how ExoY toxin becomes activated in human cells by binding to actin filaments, leading to devastating enzymatic activity. This discovery sheds light on a crucial molecular mechanism that underlies the pathogenicity of various toxins.
SourceMax Planck Institute of Molecular Physiology·JournalNature Communications·TypeExperimental study·DateNov 17, 2021
A Nagoya University team has discovered a process called allosteric regulation in plants, which helps maintain the balance of phytohormones gibberellin and auxin. This finding could lead to improved rice crop productivity and provide a solution for food security.
SourceNagoya University·JournalNature Communications·DateJul 15, 2020
Recent studies have highlighted the significant role of Shp2, a phosphatase protein, in governing signaling response amplitude and regulating cell differentiation and growth. Dysregulation of Shp2 has been linked to various types of leukemia, including acute myeloid, juvenile myelomonocytic, and B-cell acute lymphoblastic leukemia.
SourceBentham Science Publishers·JournalCurrent Pharmaceutical Design·DateDec 27, 2018
A previously unpublished work by Francis Crick and Jeffries Wyman from 1965 is now available, proposing a different formulation of the Monod-Wyman-Changeux hypothesis. The paper analyzes how regulatory performances of monomeric proteins are enhanced by assembly into cooperative structures.
SourceElsevier·JournalJournal of Molecular Biology·DateApr 18, 2013